| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J E Denning, Lauren E Madory, Jessica N Herbert, Ryan A Cabrera, Karen K Szumlinsk. Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339206. |
taken together, these data indicate that a relatively brief history of oral ma is sufficient to induce some signs of anxiety-like behavior and cognitive dysfunction during early withdrawal that reflect, at least in part, ma-induced changes in the corticolimbic expression of certain glutamate receptor subtypes of potential relevance to treating symptoms of ma use disorder. |
2024-02-10 |
2024-02-12 |
mouse |
| Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. |
the results revealed that cognitive dysfunction in the morris water maze task became more severe and decreased glutamate and glutamine level in middle-aged crmp1 ko mice. |
2024-01-04 |
2024-01-07 |
mouse |
| Kazuyuki Fujihar. Beyond the γ-aminobutyric acid hypothesis of schizophrenia. Frontiers in cellular neuroscience. vol 17. 2023-05-11. PMID:37168420. |
in particular, the reduction of one of the gaba-synthesizing enzymes, the 67-kda isoform of glutamate decarboxylase (gad67), has garnered interest among researchers because of its role in the formation of γ-oscillations and its potential involvement in the cognitive dysfunction observed in schizophrenia. |
2023-05-11 |
2023-08-14 |
rat |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
memantine/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal creb/bdnf signaling and glutamate homeostasis. |
2023-03-15 |
2023-08-14 |
human |
| Xingxing Xu, Jiaojiao Wang, Siyu Du, Xiya Shen, Jiashu Lian, Jian Zhou, Mianxian Wang, Wenjin Feng, Zhaoting Lv, Junzhe Zhu, Lingting Jin, Huankun Sun, Lihao Wu, Xiaoning Wang, Haoyu Qiu, Wei Wang, Honglin Teng, Ying Wang, Zhihui Huan. Yes-associated protein regulates glutamate homeostasis through promoting the expression of excitatory amino acid transporter-2 in astrocytes via β-catenin signaling. Glia. 2023-01-09. PMID:36617748. |
excessive glutamate in the synaptic cleft caused by dysfunction or dysregulation of eaat2 can lead to excitotoxicity, neuronal death and cognitive dysfunction. |
2023-01-09 |
2023-08-14 |
Not clear |
| Hagar Bauminger, Inna Gaisler-Salomo. Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955750. |
beyond nmda receptors: homeostasis at the glutamate tripartite synapse and its contributions to cognitive dysfunction in schizophrenia. |
2022-08-12 |
2023-08-14 |
Not clear |
| Hagar Bauminger, Inna Gaisler-Salomo. Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955750. |
here, we delineate the role of glutamate homeostasis at the tripartite synapse in schizophrenia-related cognitive dysfunction. |
2022-08-12 |
2023-08-14 |
Not clear |
| Xin-Hua Zhou, Cheng-Cheng Zhang, Ling Wang, Shan-Liang Ji. Remimazolam induced cognitive dysfunction in mice via glutamate excitotoxicity. Translational neuroscience. vol 13. issue 1. 2022-06-23. PMID:35734308. |
remimazolam induced cognitive dysfunction in mice via glutamate excitotoxicity. |
2022-06-23 |
2023-08-14 |
mouse |
| Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Won. Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction. Biomolecules. vol 12. issue 4. 2022-04-23. PMID:35454185. |
cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction. |
2022-04-23 |
2023-08-13 |
Not clear |
| Francesca Mottarlini, Giorgia Targa, Giorgia Bottan, Benedetta Tarenzi, Fabio Fumagalli, Lucia Caffin. Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: impact on cognition. Journal of neurochemistry. 2022-03-08. PMID:35257377. |
of note, after a 7-day recovery period, body weight was recovered and the mpfc structure normalized but aba rats still exhibited reduced post-synaptic stability of ampa and nmda glutamate receptors associated with cognitive dysfunction. |
2022-03-08 |
2023-08-13 |
rat |
| Mounica Reddy-Thootkur, Nina Vanessa Kraguljac, Adrienne Carol Laht. The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders - A systematic review of magnetic resonance spectroscopy studies. Schizophrenia research. 2021-08-25. PMID:32107102. |
the role of glutamate and gaba in cognitive dysfunction in schizophrenia and mood disorders - a systematic review of magnetic resonance spectroscopy studies. |
2021-08-25 |
2023-08-13 |
Not clear |
| Xiao-Qin Zhang, He-Jia Jiang, Le Xu, Si-Yu Yang, Gao-Zhe Wang, Hong-De Jiang, Teng Wu, Han Du, Zhi-Peng Yu, Qi-Qi Zhao, Yu Ling, Zhong-Yu Zhang, Hao-Wei She. The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation. Neuropharmacology. vol 177. 2021-08-12. PMID:32693006. |
given the critical role of metabotropic glutamate receptors (mglurs) in synaptic homeostasis of the prefrontal cortex (pfc), pharmacological intervention on mglurs has been attempted in order to improve cognitive dysfunction in animal models of neurodevelopmental disorder, as well as in clinical trials. |
2021-08-12 |
2023-08-13 |
mouse |
| Xiaoqiong Li, Wen Wen, Ping Li, Ying Fu, Hao Chen, Fushun Wang, Yuan Dai, Shijun X. Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signaling Pathway to Ameliorate Cognitive Dysfunction by Kaixin San in Multi-Infarct Dementia Rats. Oxidative medicine and cellular longevity. vol 2021. 2021-07-27. PMID:34306310. |
mitochondrial protection and against glutamate neurotoxicity via shh/ptch1 signaling pathway to ameliorate cognitive dysfunction by kaixin san in multi-infarct dementia rats. |
2021-07-27 |
2023-08-13 |
rat |
| Beata R Godlewska, Amedeo Minichino, Uzay Emir, Ilinca Angelescu, Belinda Lennox, Masa Micunovic, Oliver Howes, Philip J Cowe. Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case-control study at 7 T. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34226485. |
abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. |
2021-07-14 |
2023-08-13 |
human |
| Qiongqiong Wu, Jing Huang, Renrong W. Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia. Frontiers in neuroscience. vol 15. 2021-04-30. PMID:33912003. |
we then summarize their effects on negative symptoms and cognitive dysfunction and analyze the unsatisfactory outcomes of these clinical studies according to the improved glutamate hypothesis that has been revealed in animal models. |
2021-04-30 |
2023-08-13 |
Not clear |
| Laura L Giacometti, Jacqueline M Barke. Comorbid HIV infection and alcohol use disorders: Converging glutamatergic and dopaminergic mechanisms underlying neurocognitive dysfunction. Brain research. vol 1723. 2020-10-27. PMID:31421128. |
chronic alcohol exposure and hiv infection independently promote cognitive dysfunction and further may interact to exacerbate neurocognitive deficits through effects on common targets, including corticostriatal glutamate and dopamine neurotransmission. |
2020-10-27 |
2023-08-13 |
human |
| Francesca Nardecchia, Rosamaria Orlando, Luisa Iacovelli, Marco Colamartino, Elena Fiori, Vincenzo Leuzzi, Sonia Piccinin, Robert Nistico, Stefano Puglisi-Allegra, Luisa Di Menna, Giuseppe Battaglia, Ferdinando Nicoletti, Tiziana Pascucc. Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615849. |
targeting mglu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria. |
2020-10-01 |
2023-08-13 |
mouse |
| Kathleen F Holton, Sara L Hargrave, Terry L Davidso. Differential Effects of Dietary MSG on Hippocampal Dependent Memory Are Mediated by Diet. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31572118. |
a good number of food additives which contain glutamate are found in the western diet, and this diet has also been linked to increased risk of cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Guoqiang Xing, Ming Ren, Ajay Verm. Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29764289. |
because increased pbckd would lead to increased bcka accumulation, bcka-mediated astrocyte activation, cell death, and cognitive dysfunction as found in maple syrup urine disease; thus, tbi may potentially induce cognitive deficit through diverting bcaa from glutamate production in neurons to bcka production in astrocytes through the pbckd-dependent mechanism. |
2019-12-20 |
2023-08-13 |
rat |
| Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara, Kunimasa Arima, Tetsuro Ohmori, Toru Nishikaw. Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study. BMC psychiatry. vol 17. issue 1. 2018-02-20. PMID:28701225. |
it has been reported that drugs which promote the n-methyl-d-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. |
2018-02-20 |
2023-08-13 |
Not clear |