| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivienne Ann Russel. Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864734. |
these findings are consistent with the hypothesis that the behavioral disturbances of adhd are the result of an imbalance between noradrenergic and dopaminergic systems in the prefrontal cortex, with inhibitory dopaminergic activity being decreased and noradrenergic activity increased relative to controls. |
2002-05-16 |
2023-08-12 |
rat |
| S Jiang, R Xin, S Lin, Y Qian, G Tang, D Wang, X W. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. American journal of medical genetics. vol 105. issue 8. 2002-03-05. PMID:11803531. |
molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in adhd, e.g., several reports have found association between adhd and the dopamine receptor gene drd-4, the dopamine transporter gene dat1, and the catecholamine clearance enzyme catechol-o-methyltransferase. |
2002-03-05 |
2023-08-12 |
Not clear |
| T Spencer, J Biederman, J Heiligenstein, T Wilens, D Faries, J Prince, S V Faraone, J Rea, J Witcher, S Zerva. An open-label, dose-ranging study of atomoxetine in children with attention deficit hyperactivity disorder. Journal of child and adolescent psychopharmacology. vol 11. issue 3. 2002-01-24. PMID:11642475. |
the goal of this study was to evaluate the tolerability and effectiveness of the experimental, noradrenergic specific reuptake inhibitor atomoxetine in the treatment of children with attention deficit hyperactivity disorder (adhd). |
2002-01-24 |
2023-08-12 |
Not clear |
| V A Russell, T M Wiggin. Increased glutamate-stimulated norepinephrine release from prefrontal cortex slices of spontaneously hypertensive rats. Metabolic brain disease. vol 15. issue 4. 2001-10-18. PMID:11383554. |
the results are consistent with the suggestion that the noradrenergic system is overactive in prefrontal cortex of shr, the animal model for adhd. |
2001-10-18 |
2023-08-12 |
rat |
| D E Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, H Blake, F Chiu, E Wang, K Farwell, S Darakjy, R Baker, G Dietz, G Saucier, J P MacMurra. Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. Clinical genetics. vol 58. issue 1. 2001-03-01. PMID:10945659. |
comparison of the role of dopamine, serotonin, and noradrenergic genes in adhd, odd and conduct disorder. |
2001-03-01 |
2023-08-12 |
Not clear |
| D E Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, H Blake, F Chiu, E Wang, K Farwell, S Darakjy, R Baker, G Dietz, G Saucier, J P MacMurra. Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. Clinical genetics. vol 58. issue 1. 2001-03-01. PMID:10945659. |
these results indicate that even with the inclusion of these additional genes the noradrenergic genes still played a greater role in adhd than any other group. |
2001-03-01 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Non-stimulant treatments for ADHD. European child & adolescent psychiatry. vol 9 Suppl 1. 2001-02-22. PMID:11140780. |
in addition, the atypical antidepressant bupropion and the novel noradrenergic specific antidepressant tomoxetine have also been documented to be effective in the treatment of adhd in controlled clinical trials. |
2001-02-22 |
2023-08-12 |
human |
| D E Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, H Blake, M B Mann, G Dietz, G Saucier, J P MacMurra. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clinical genetics. vol 58. issue 5. 2001-02-22. PMID:11140838. |
comparison of the role of dopamine, serotonin, and noradrenergic genes in adhd, odd and conduct disorder. |
2001-02-22 |
2023-08-12 |
Not clear |
| J Biederman, T J Spence. Genetics of childhood disorders: XIX. ADHD, Part 3: Is ADHD a noradrenergic disorder? Journal of the American Academy of Child and Adolescent Psychiatry. vol 39. issue 10. 2000-11-15. PMID:11026191. |
adhd, part 3: is adhd a noradrenergic disorder? |
2000-11-15 |
2023-08-12 |
Not clear |
| T S Hale, A R Hariri, J T McCracke. Attention-deficit/hyperactivity disorder: perspectives from neuroimaging. Mental retardation and developmental disabilities research reviews. vol 6. issue 3. 2000-10-16. PMID:10982499. |
current etiologic theories suggest that adhd stems from abnormalities in dopaminergic and possibly noradrenergic brainstem nuclei that act to regulate a cortico-striato-thalamo-cortical network, believed to be critical for executive functions and the regulation of behavioral responses such as arousal, attention, and inhibition. |
2000-10-16 |
2023-08-12 |
Not clear |
| D E Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, H Blake, G Dietz, G Saucier, J P MacMurra. Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes. Clinical genetics. vol 57. issue 3. 2000-06-28. PMID:10782925. |
we have examined the effect of 20 genes for dopamine, serotonin, and noradrenergic metabolism on a quantitative score for attention deficit hyperactivity disorder (adhd) in 336 unrelated caucasian subjects. |
2000-06-28 |
2023-08-12 |
human |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
attention-deficit/hyperactivity disorder (adhd) as a noradrenergic disorder. |
1999-12-15 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
this review revisits the thesis that a dysregulation of the central noradrenergic networks may underlie the pathophysiology of adhd. |
1999-12-15 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
noradrenergic activation is known to profoundly affect the performance of attention, especially the maintenance of arousal, a cognitive function known to be deficient in adhd. |
1999-12-15 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
brain imaging studies fit well with the idea that dysfunction in fronto-subcortical pathways occurs in adhd with its underlying dysregulation of noradrenergic function. |
1999-12-15 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
a wealth of pharmacological data (within and without the stimulant literature) provides strong evidence for selective clinical activity in adhd for drugs with noradrenergic and dopaminergic pharmacological profiles. |
1999-12-15 |
2023-08-12 |
Not clear |
| J Biederman, T Spence. Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biological psychiatry. vol 46. issue 9. 1999-12-15. PMID:10560028. |
neurobiological and pharmacological data provide compelling support for a noradrenergic hypothesis of adhd and suggest that drugs with noradrenergic activity may play an important role in the therapeutics of this disorder. |
1999-12-15 |
2023-08-12 |
Not clear |
| D E Comings, R Gade-Andavolu, N Gonzalez, H Blake, S Wu, J P MacMurra. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clinical genetics. vol 55. issue 3. 1999-06-18. PMID:10334470. |
newcorn jh, koda vh, pick l, mckay ke, knott p. noradrenergic mechanisms in adhd children with and without reading disabilities: a replication and extension. |
1999-06-18 |
2023-08-12 |
human |
| D E Comings, R Gade-Andavolu, N Gonzalez, H Blake, S Wu, J P MacMurra. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clinical genetics. vol 55. issue 3. 1999-06-18. PMID:10334470. |
we examined the hypothesis that adhd + ld was associated with ne dysfunction at a molecular genetic level by testing for associations and additive effects between polymorphisms at three noradrenergic genes the adrenergic alpha2a receptor (adra2a), adrenergic alpha2c receptor (adra2c), and dopamine beta-hydroxylase (dbh) genes. |
1999-06-18 |
2023-08-12 |
human |
| T Spencer, J Biederman, T Wilens, J Prince, M Hatch, J Jones, M Harding, S V Faraone, L Seidma. Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder. The American journal of psychiatry. vol 155. issue 5. 1998-05-28. PMID:9585725. |
the authors assessed the experimental noradrenergic compound tomoxetine as an alternative treatment for adult attention deficit hyperactivity disorder (adhd). |
1998-05-28 |
2023-08-12 |
Not clear |