| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thekla J Hemstedt, K Matthew Lattal, Marcelo A Woo. Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom. Neurobiology of learning and memory. vol 142. issue Pt A. 2018-03-26. PMID:28119018. |
these two behavioral approaches are used in the laboratory to investigate how fear memory can be attenuated, which becomes important when searching for therapeutic intervention to treat anxiety disorders and post-traumatic stress disorder. |
2018-03-26 |
2023-08-13 |
Not clear |
| Jessica L Maples-Keller, Matthew Price, Tanja Jovanovic, Seth D Norrholm, Lydia Odenat, Loren Post, Liza Zwiebach, Kathryn Breazeale, Robin Gross, Sae-Jin Kim, Barbara Olasov Rothbau. Targeting memory reconsolidation to prevent the return of fear in patients with fear of flying. Depression and anxiety. vol 34. issue 7. 2018-03-13. PMID:28380277. |
exposure therapy for anxiety disorders involves accessing a fear memory and modifying it with less fearful information. |
2018-03-13 |
2023-08-13 |
Not clear |
| F Huang, Z Yang, C-Q L. The Melatonergic System in Anxiety Disorders and the Role of Melatonin in Conditional Fear. Vitamins and hormones. vol 103. 2017-11-03. PMID:28061973. |
there has been an available effective means of extinction-based exposure psychotherapy for the treatment of anxiety disorders, such as posttraumatic stress disorder (ptsd) that has been hypothesized to result from impaired extinction of fear memory. |
2017-11-03 |
2023-08-13 |
Not clear |
| Margaret F Keil, George Briassoulis, Constantine A Stratakis, T John W. Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review. Frontiers in endocrinology. vol 7. 2016-07-22. PMID:27445986. |
the amygdala is critical for adaptive responses leading to fear learning and aberrant fear memory and its heightened activation is widely thought to underpin various anxiety disorders. |
2016-07-22 |
2023-08-13 |
mouse |
| Azusa Sugiyama, Akiyoshi Saitoh, Masatoshi Inagaki, Jun-Ichiro Oka, Mitsuhiko Yamad. Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats. Neuropharmacology. vol 97. 2016-05-24. PMID:26116528. |
strategies to enhance recognition memory and facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. |
2016-05-24 |
2023-08-13 |
rat |
| M B Young, R Andero, K J Ressler, L L Howel. 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning. Translational psychiatry. vol 5. 2016-05-11. PMID:26371762. |
these findings suggest that mdma enhances fear memory extinction through a bdnf-dependent mechanism, and that mdma may be a useful adjunct to exposure-based therapies for ptsd and other anxiety disorders characterized by altered fear learning. |
2016-05-11 |
2023-08-13 |
mouse |
| Saravana R K Murthy, Tessi Sherrin, Chad Jansen, Ingrid Nijholt, Michael Robles, Amalia M Dolga, Nicolas Andreotti, Jean-Marc Sabatier, Hans-Guenther Knaus, Reinhold Penner, Cedomir Todorovic, Thomas Blan. Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory. PloS one. vol 10. issue 5. 2016-04-25. PMID:25938421. |
the modulation of fear memory by down-regulating sk2 c-terminal cleavage might have applicability in the treatment of anxiety disorders in which fear conditioning is enhanced. |
2016-04-25 |
2023-08-13 |
Not clear |
| Raphael Lamprech. The Role of Actin Cytoskeleton in Memory Formation in Amygdala. Frontiers in molecular neuroscience. vol 9. 2016-04-12. PMID:27065800. |
the actin cytoskeleton may serve as a target for pharmacological treatment of fear memory associated with fear and anxiety disorders and drug addiction to prevent the debilitating consequences of these diseases. |
2016-04-12 |
2023-08-13 |
Not clear |
| P J Fitzgerald, C R Pinard, M C Camp, M Feyder, A Sah, H C Bergstrom, C Graybeal, Y Liu, O M Schlüter, S G Grant, N Singewald, W Xu, A Holme. Durable fear memories require PSD-95. Molecular psychiatry. vol 20. issue 7. 2016-03-24. PMID:25510511. |
although overly persistent fear memories underlie anxiety disorders, such as posttraumatic stress disorder, the key neural and molecular mechanisms underlying fear memory durability remain unclear. |
2016-03-24 |
2023-08-13 |
mouse |
| Merel Kindt, Marieke Soeter, Dieuwke Sevenste. Disrupting reconsolidation of fear memory in humans by a noradrenergic β-blocker. Journal of visualized experiments : JoVE. issue 94. 2016-01-28. PMID:25549103. |
although the clinical applications are still in their infancy, disrupting reconsolidation of fear memory seems to be a promising new technique with the prospect to persistently dampen the expression of fear memory in patients suffering from anxiety disorders and other psychiatric disorders. |
2016-01-28 |
2023-08-13 |
human |
| Wei Wang, Song-Lin Liu, Kuan Li, Yu Chen, Bo Jiang, Yan-Kun Li, Jun-Li Xiao, Si Yang, Tao Chen, Jian-Guo Chen, Jia-Geng Li, Fang Wan. Leptin: a potential anxiolytic by facilitation of fear extinction. CNS neuroscience & therapeutics. vol 21. issue 5. 2016-01-15. PMID:25645604. |
anxiety disorders are characterized by a deficient extinction of fear memory. |
2016-01-15 |
2023-08-13 |
Not clear |
| Merel Kind. A behavioural neuroscience perspective on the aetiology and treatment of anxiety disorders. Behaviour research and therapy. vol 62. 2015-10-15. PMID:25261887. |
this paper presents 1) a selection of fear conditioning studies on the generalization and persistence of associative fear memory as intermediate phenotypes of fear and anxiety disorders, and 2) insights from neuroscience on the malleability of fear memory with the potential to provide a long-term cure for anxiety and related disorders. |
2015-10-15 |
2023-08-13 |
Not clear |
| Janine L Kwapis, Marcelo A Woo. Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder. Trends in neurosciences. vol 37. issue 12. 2015-09-02. PMID:25220045. |
post-traumatic stress disorder (ptsd) and other anxiety disorders stemming from dysregulated fear memory are problematic and costly. |
2015-09-02 |
2023-08-13 |
Not clear |
| Gisele Pereira Dias, Mário Cesar do Nascimento Bevilaqua, Anna Claudia Domingos Silveira da Luz, Renata Lopes Fleming, Lítia Alves de Carvalho, Graham Cocks, Danielle Beckman, Lucas Costa Hosken, William de Sant'Anna Machado, Ana Carolina Corrêa-e-Castro, Felippe Mousovich-Neto, Vítor de Castro Gomes, Gilmara de Nazareth Tavares Bastos, Regina Célia Cussa Kubrusly, Vânia Maria Corrêa da Costa, Deepak Srivastava, Jesus Landeira-Fernandez, Antonio Egidio Nardi, Sandrine Thuret, Patricia Franca Gardin. Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder. Behavioural brain research. vol 263. 2014-12-03. PMID:24462725. |
hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder. |
2014-12-03 |
2023-08-12 |
rat |
| Jörg Lesting, Thiemo Daldrup, Venu Narayanan, Christian Himpe, Thomas Seidenbecher, Hans-Christian Pap. Directional theta coherence in prefrontal cortical to amygdalo-hippocampal pathways signals fear extinction. PloS one. vol 8. issue 10. 2014-08-05. PMID:24204927. |
one form of inhibitory learning allowing adaptive control of fear memory is extinction, a deficit of which leads to maladaptive fear expression potentially leading to anxiety disorders. |
2014-08-05 |
2023-08-12 |
mouse |
| Marieke Soeter, Merel Kind. High trait anxiety: a challenge for disrupting fear memory reconsolidation. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260096. |
a relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to develop an anxiety disorder. |
2014-07-07 |
2023-08-12 |
human |
| Marieke Soeter, Merel Kind. High trait anxiety: a challenge for disrupting fear memory reconsolidation. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260096. |
vulnerable individuals with the propensity to develop anxiety disorders may need higher dosages of propranolol hcl or more retrieval trials for targeting and changing fear memory. |
2014-07-07 |
2023-08-12 |
human |
| Jennifer L McGuire, Hadley C Bergstrom, Clarissa C Parker, Thien Le, Maria Morgan, Haiying Tang, Reed G Selwyn, Afonso C Silva, Kwang Choi, Robert J Ursano, Abraham A Palmer, Luke R Johnso. Traits of fear resistance and susceptibility in an advanced intercross line. The European journal of neuroscience. vol 38. issue 9. 2014-06-20. PMID:23968228. |
genetic variability in the strength and precision of fear memory is hypothesised to contribute to the etiology of anxiety disorders, including post-traumatic stress disorder. |
2014-06-20 |
2023-08-12 |
mouse |
| Ashley C Chen, Amit Etki. Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 10. 2014-03-24. PMID:23673864. |
as the hippocampus is implicated in both general anxiety and fear memory, it may be an important brain locus for mapping the similarities and differences among anxiety disorders. |
2014-03-24 |
2023-08-12 |
human |
| Melissa E Wang, Nicolas P Fraize, Linda Yin, Robin K Yuan, Despina Petsagourakis, Ellen G Wann, Isabel A Muzzi. Differential roles of the dorsal and ventral hippocampus in predator odor contextual fear conditioning. Hippocampus. vol 23. issue 6. 2014-02-10. PMID:23460388. |
the study of fear memory is important for understanding various anxiety disorders in which patients experience persistent recollections of traumatic events. |
2014-02-10 |
2023-08-12 |
mouse |