| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tengyu Gu, Jing Dong, Jing Ge, Jialu Feng, Xiaoliu Liu, Yun Chen, Jianfeng Li. Neurotoxic lesions of the anterior claustrum influence cued fear memory in rats. Frontiers in psychiatry. vol 15. 2024-05-06. PMID:38707622. |
however, the role of the cla in fear memory and anxiety disorders remains largely understudied. |
2024-05-06 |
2024-05-08 |
rat |
| Hongrui Zhu, Ao Guan, Jiayuan Liu, Li Peng, Zhi Zhang, Sheng Wan. Noteworthy perspectives on microglia in neuropsychiatric disorders. Journal of neuroinflammation. vol 20. issue 1. 2023-10-04. PMID:37794488. |
numerous studies have demonstrated a pivotal involvement of microglia in neuropsychiatric disorders, including negative affection, social deficit, compulsive behavior, fear memory, pain and other symptoms associated with major depression disorder, anxiety disorder, autism spectrum disorder and schizophrenia. |
2023-10-04 |
2023-10-07 |
human |
| Xiaohan Peng, Panpan Chen, Yang Zhang, Ke Wu, Ningning Ji, Jinghua Gao, Hui Wang, Yong-Mei Zhang, Tie Xu, Rong Hu. MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice. CNS neuroscience & therapeutics. 2023-07-20. PMID:37469037. |
the basolateral amygdala (bla) plays an integral role in anxiety disorders (such as post traumatic stress disorder) stem from dysregulated fear memory. |
2023-07-20 |
2023-08-14 |
mouse |
| Jinfeng Su, Pingping Li, Qishuai Zhuang, Xing Chen, Xiaoning Zhang, Xiaobing Li, Jingxian Wang, Xiaohan Yu, Yue Wan. Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala. Frontiers in molecular neuroscience. vol 14. 2021-12-20. PMID:34924954. |
abnormality of fear memory is one of the important pathogenic factors leading to post-traumatic stress disorder (ptsd), anxiety disorder, and other mental disorders. |
2021-12-20 |
2023-08-13 |
mouse |
| Shawn Zheng Kai Tan, Chi Him Poon, Ying-Shing Chan, Lee Wei Li. Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D British journal of pharmacology. vol 178. issue 17. 2021-09-21. PMID:33899943. |
prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine d anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy and toxicity of the medications. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xin Cheng, Yan Zhao, Shuyu Zheng, Panwu Zhao, Jin-Lin Zou, Wei-Jye Lin, Wen Wu, Xiaojing Y. Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-09-11. PMID:34508226. |
maintaining appropriate levels of fear memory specificity is crucial for individual's survival and mental health, whereas overgeneralized fear commonly occurs in neuropsychiatric disorders, including posttraumatic stress disorder and generalized anxiety disorder. |
2021-09-11 |
2023-08-13 |
mouse |
| Henry L Hallock, Henry M Quillian, Kristen R Maynard, Yishan Mai, Huei-Ying Chen, Gregory R Hamersky, Joo Heon Shin, Brady J Maher, Andrew E Jaffe, Keri Martinowic. Molecularly Defined Hippocampal Inputs Regulate Population Dynamics in the Prelimbic Cortex to Suppress Context Fear Memory Retrieval. Biological psychiatry. vol 88. issue 7. 2021-03-03. PMID:32560963. |
context fear memory dysregulation is a hallmark symptom of several neuropsychiatric disorders, including generalized anxiety disorder and posttraumatic stress disorder. |
2021-03-03 |
2023-08-13 |
Not clear |
| Fariborz Manteghi, Mohammad Nasehi, Mohammad-Reza Zarrindas. Precondition of right frontal region with anodal tDCS can restore the fear memory impairment induced by ACPA in male mice. EXCLI journal. vol 16. 2020-10-01. PMID:28337114. |
fear memory and learning cause behavioural patterns such as fight or flight responses, which increase survival probability, but unfit processing of fear memory and learning can lead to maladaptive behaviours and maladies such as phobias, post-traumatic stress disorder (ptsd) and anxiety disorders. |
2020-10-01 |
2023-08-13 |
mouse |
| Chia-Sheng Pai, Pranao K Sharma, Hsien-Ting Huang, Srivaishnavi Loganathan, Heng Lin, Yu-Luan Hsu, Sarayut Phasuk, Ingrid Y Li. The Activating Transcription Factor 3 ( Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29515366. |
the activating transcription factor 3 ( the genetic and molecular basis underlying fear memory formation is a key theme in anxiety disorder research. |
2020-10-01 |
2023-08-13 |
Not clear |
| Marie Yokoyama, Naoki Matsu. Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization. Frontiers in behavioral neuroscience. vol 10. 2020-09-30. PMID:27872586. |
proper generalization may underlie the formation and assimilation of semantic memories and enable animals to adapt to ever-changing environments, whereas overgeneralization of fear memory evokes maladaptive fear responses to harmless stimuli, which is a symptom of anxiety disorders such as post-traumatic stress disorder (ptsd). |
2020-09-30 |
2023-08-13 |
mouse |
| Malgorzata H Kolodziejczyk, Markus Fend. Corticosterone Treatment and Incubation Time After Contextual Fear Conditioning Synergistically Induce Fear Memory Generalization in Neuropeptide S Receptor-Deficient Mice. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32231512. |
while fear generalization has adaptive value, overgeneralization of fear memory is a characteristic feature of the pathology of anxiety disorders. |
2020-09-28 |
2023-08-13 |
mouse |
| Dharani Keyan, Richard A Bryan. The capacity for acute exercise to modulate emotional memories: A review of findings and mechanisms. Neuroscience and biobehavioral reviews. vol 107. 2020-08-31. PMID:31562922. |
these fear memory mechanisms are central to the development and treatment of anxiety disorders. |
2020-08-31 |
2023-08-13 |
human |
| Dharani Keyan, Richard A Bryan. The capacity for acute exercise to modulate emotional memories: A review of findings and mechanisms. Neuroscience and biobehavioral reviews. vol 107. 2020-08-31. PMID:31562922. |
this accumulative evidence suggests that the role of acute exercise in fear memory modulation may have significant potential benefits for how anxiety disorders are managed. |
2020-08-31 |
2023-08-13 |
human |
| Yan-Wei Shi, Bu-Fang Fan, Li Xue, Xiao-Guang Wang, Xue-Ling O. Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus. Brain and behavior. vol 9. issue 8. 2020-05-01. PMID:31313894. |
the dentate gyrus (dg) has emerged as a critical locus of plasticity with relevance to memory, anxiety disorders, and depression, and it contributes to fear memory retrieval. |
2020-05-01 |
2023-08-13 |
Not clear |
| Branden J Stansley, Nicole M Fisher, Rocco G Gogliotti, Craig W Lindsley, P Jeffrey Conn, Colleen M Niswende. Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 12. 2019-11-12. PMID:29136107. |
dysregulated fear memory can lead to a broad spectrum of anxiety disorders. |
2019-11-12 |
2023-08-13 |
mouse |
| Azusa Sugiyama, Misa Yamada, Hiroki Furuie, Leo Gotoh, Akiyoshi Saitoh, Hiroshi Nagase, Jun-Ichiro Oka, Mitsuhiko Yamad. Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats. Journal of pharmacological sciences. vol 139. issue 3. 2019-06-14. PMID:30686587. |
strategies to facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. |
2019-06-14 |
2023-08-13 |
rat |
| Lizeth K Pedraza, Rodrigo O Sierra, Marcelo Giachero, Walquiria Nunes-Souza, Fernanda N Lotz, Lucas de Oliveira Alvare. Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation. Translational psychiatry. vol 9. issue 1. 2019-06-10. PMID:30705259. |
fear memory overgeneralization contributes to the genesis and persistence of anxiety disorders and is a central hallmark in the pathophysiology of post-traumatic stress disorder (ptsd). |
2019-06-10 |
2023-08-13 |
rat |
| Da-Wei Li, Jin-Zhi Liu, Shu-Chen Li, Jin-Bin Yang, Huan-Huan Sun, Ai-Hua Wan. Fear conditioning downregulates miR-138 expression in the hippocampus to facilitate the formation of fear memory. Neuroreport. vol 29. issue 16. 2019-04-10. PMID:30199441. |
fear memory is important for the survival of animals and is associated with certain anxiety disorders, such as posttraumatic stress disorder. |
2019-04-10 |
2023-08-13 |
Not clear |
| Ryo Okubo, Hiroko Noguchi, Kei Hamazaki, Masayuki Sekiguchi, Takayuki Kinoshita, Noriko Katsumata, Tomomi Narisawa, Yasuhito Uezono, Jinzhong Xiao, Yutaka J Matsuok. Fear of cancer recurrence among breast cancer survivors could be controlled by prudent dietary modification with polyunsaturated fatty acids. Journal of affective disorders. vol 245. 2019-04-03. PMID:30699854. |
n-3 polyunsaturated fatty acids (pufas) have beneficial effects on psychiatric disorders, including depressive disorder and anxiety disorders, and are involved in fear memory processing. |
2019-04-03 |
2023-08-13 |
Not clear |
| C L Bender, A Otamendi, G D Calfa, V A Molin. Prior stress promotes the generalization of contextual fear memories: Involvement of the gabaergic signaling within the basolateral amygdala complex. Progress in neuro-psychopharmacology & biological psychiatry. vol 83. 2019-01-03. PMID:29223783. |
stress exposure is a major risk factor for the occurrence of anxiety disorders and it is well established that it influences different phases of fear memory; nevertheless, its impact on the generalization of contextual fear memories has been less studied. |
2019-01-03 |
2023-08-13 |
rat |