| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Liang, Zhenyu Yin, Renyuan Liu, Hui Zhao, Sichu Wu, Jiaming Lu, Zhao Qing, Yongyue Wei, Qingxian Yang, Bin Zhu, Yun Xu, Bing Zhan. The Role of MRI Biomarkers and Their Interactions with Cognitive Status and APOE ε4 in Nondemented Elderly Subjects. Neuro-degenerative diseases. vol 18. issue 5-6. 2019-10-02. PMID:30673663. |
(1) to investigate atrophy patterns of hippocampal subfield volume and alzheimer's disease (ad)-signature cortical thickness in mild cognitive impairment (mci) patients; (2) to explore the association between the neuropsychological (np) and the brain structure in the mci and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein e (apoe) ε4 gene and cognitive status. |
2019-10-02 |
2023-08-13 |
human |
| Javed Iqbal, Kaoyuan Zhang, Na Jin, Yuxi Zhao, Qiong Liu, Jiazuan Ni, Liming She. Effect of Sodium Selenate on Hippocampal Proteome of 3×Tg-AD Mice-Exploring the Antioxidant Dogma of Selenium against Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29641182. |
effect of sodium selenate on hippocampal proteome of 3×tg-ad mice-exploring the antioxidant dogma of selenium against alzheimer's disease. |
2019-09-30 |
2023-08-13 |
mouse |
| Jean-Michel Paumier, Nathalie A Py, Laura García-González, Anne Bernard, Delphine Stephan, Laurence Louis, Frédéric Checler, Michel Khrestchatisky, Kévin Baranger, Santiago River. Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-09-30. PMID:30332299. |
we previously demonstrated that membrane type 1 (mt1) matrix metalloproteinase (mmp) was up-regulated in the hippocampus of the model of transgenic mice bearing 5 familial mutations on human amyloid precursor protein (app) and presenilin 1 of alzheimer disease (ad), and that the proteinase increased the levels of amyloid β peptide (aβ) and its app c-terminal fragment of 99 aa in a heterologous cell system. |
2019-09-30 |
2023-08-13 |
mouse |
| Jan-Oliver Hollnagel, Shehabeldin Elzoheiry, Karin Gorgas, Stefan Kins, Carlo Antonio Beretta, Joachim Kirsch, Jochen Kuhse, Oliver Kann, Eva Kis. Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PloS one. vol 14. issue 1. 2019-09-30. PMID:30645585. |
early alterations in hippocampal perisomatic gabaergic synapses and network oscillations in a mouse model of alzheimer's disease amyloidosis. |
2019-09-30 |
2023-08-13 |
mouse |
| Shouri Lahiri, Giovanna C Regis, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Elizabeth H Kim, Mitra Mastali, Jennifer E Van Eyk, Padmesh S Rajput, Patrick D Lyden, Keith L Black, E Wesley Ely, Heather D Jones, Maya Koronyo-Hamaou. Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer's disease mice. Critical care (London, England). vol 23. issue 1. 2019-09-30. PMID:30795776. |
we sought to test the hypothesis that short-term mechanical ventilation contributes to the neuropathology of cognitive impairment by (i) increasing cerebral amyloid-β accumulation in mice with pre-existing alzheimer's disease pathology, (ii) increasing neurologic and systemic inflammation in wild-type mice and mice with pre-existing alzheimer's disease pathology, and (iii) increasing hippocampal blood-brain barrier permeability in wild-type mice and mice with pre-existing alzheimer's disease pathology. |
2019-09-30 |
2023-08-13 |
mouse |
| Usman Saeed, Saira S Mirza, Bradley J MacIntosh, Nathan Herrmann, Julia Keith, Joel Ramirez, Sean M Nestor, Qinggang Yu, Jo Knight, Walter Swardfager, Steven G Potkin, Ekaterina Rogaeva, Peter St George-Hyslop, Sandra E Black, Mario Maselli. APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 9. 2019-09-27. PMID:29782824. |
apoe-ε4 associates with hippocampal volume, learning, and memory across the spectrum of alzheimer's disease and dementia with lewy bodies. |
2019-09-27 |
2023-08-13 |
Not clear |
| Jessica Colenutt, Bryony McCann, Michael J Knight, Elizabeth Coulthard, Risto A Kauppine. Incomplete Hippocampal Inversion and Its Relationship to Hippocampal Subfield Volumes and Aging. Journal of neuroimaging : official journal of the American Society of Neuroimaging. vol 28. issue 4. 2019-09-17. PMID:29575376. |
the volume loss of hippocampus is an inevitable consequence of aging, and when accelerated it is commonly considered an imaging biomarker of alzheimer's disease dementia. |
2019-09-17 |
2023-08-13 |
Not clear |
| John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29916037. |
the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. |
2019-09-17 |
2023-08-13 |
human |
| Ekaterina A Rudnitskaya, Tatiana A Kozlova, Alena O Burnyasheva, Natalyia G Kolosova, Natalia A Stefanov. Alterations of hippocampal neurogenesis during development of Alzheimer's disease-like pathology in OXYS rats. Experimental gerontology. vol 115. 2019-09-17. PMID:30415068. |
alterations of hippocampal neurogenesis during development of alzheimer's disease-like pathology in oxys rats. |
2019-09-17 |
2023-08-13 |
rat |
| Olivier Beauchet, Cyrille P Launay, Harmehr Sekhon, Maxime Montembeault, Gilles Allal. Association of hippocampal volume with gait variability in pre-dementia and dementia stages of Alzheimer disease: Results from a cross-sectional study. Experimental gerontology. vol 115. 2019-09-17. PMID:30447261. |
association of hippocampal volume with gait variability in pre-dementia and dementia stages of alzheimer disease: results from a cross-sectional study. |
2019-09-17 |
2023-08-13 |
Not clear |
| Olivier Beauchet, Cyrille P Launay, Harmehr Sekhon, Maxime Montembeault, Gilles Allal. Association of hippocampal volume with gait variability in pre-dementia and dementia stages of Alzheimer disease: Results from a cross-sectional study. Experimental gerontology. vol 115. 2019-09-17. PMID:30447261. |
decreased hippocampal volume is a biomarker of alzheimer disease (ad). |
2019-09-17 |
2023-08-13 |
Not clear |
| Rebecca Deering Brose, Elin Lehrmann, Yongqing Zhang, Roger H Reeves, Kirby D Smith, Mark P Mattso. Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 72. 2019-09-16. PMID:30245242. |
hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of alzheimer's disease. |
2019-09-16 |
2023-08-13 |
mouse |
| Vanessa Cattaud, Charlotte Bezzina, Christophe C Rey, Camille Lejards, Lionel Dahan, Laure Verre. Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment. Neurobiology of aging. vol 72. 2019-09-16. PMID:30273829. |
early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the tg2576 mouse model of alzheimer's disease can be rescued by enriched environment. |
2019-09-16 |
2023-08-13 |
mouse |
| Yu Zhang, Zhu Zhu, Hai-Ying Liang, Lei Zhang, Qi-Gang Zhou, Huan-Yu Ni, Chun-Xia Luo, Dong-Ya Zh. nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages. Aging cell. vol 17. issue 3. 2019-09-12. PMID:29577585. |
in models of alzheimer's disease, increased nnos-capon interaction was detected after treatment with amyloid-β in vitro, and a similar change was found in the hippocampus of app/ps1 mice (a transgenic mouse model of alzheimer's disease), compared with age-matched background mice in vivo. |
2019-09-12 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Malabendu Jana, Avik Roy, Grant T Corbett, Madhuchhanda Kundu, Sujyoti Chandra, Susanta Mondal, Sridevi Dasarathi, Elliott J Mufson, Rama K Mishra, Chi-Hao Luan, David A Bennett, Kalipada Paha. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. The Journal of clinical investigation. vol 128. issue 10. 2019-09-11. PMID:29990310. |
we have found that tlr2 and myd88 levels are elevated in the hippocampus and cortex of patients with alzheimer's disease (ad) and in a 5xfad mouse model of ad. |
2019-09-11 |
2023-08-13 |
mouse |
| Harini Eavani, Mohamad Habes, Theodore D Satterthwaite, Yang An, Meng-Kang Hsieh, Nicolas Honnorat, Guray Erus, Jimit Doshi, Luigi Ferrucci, Lori L Beason-Held, Susan M Resnick, Christos Davatziko. Heterogeneity of structural and functional imaging patterns of advanced brain aging revealed via machine learning methods. Neurobiology of aging. vol 71. 2019-09-11. PMID:30077821. |
another subgroup showed focal hippocampal atrophy and lower posterior-cingulate functional coherence, low white matter hyperintensity burden, and higher medial-temporal connectivity, potentially reflecting high brain tissue reserve counterbalancing brain loss that is consistent with early stages of alzheimer's disease. |
2019-09-11 |
2023-08-13 |
human |
| Cara M Hueston, James D O'Leary, Alan E Hoban, Danka A Kozareva, Lauren C Pawley, Olivia F O'Leary, John F Cryan, Yvonne M Nola. Chronic interleukin-1β in the dorsal hippocampus impairs behavioural pattern separation. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30217534. |
the hippocampus is particularly vulnerable to increases in the pro-inflammatory cytokine interleukin-1β (il-1β), a mediator of neuroinflammation, with elevated levels implicated in the aetiology of neurodegenerative diseases such as alzheimer's and parkinson's, and in stress-related disorders such as depression. |
2019-09-10 |
2023-08-13 |
rat |
| Lindsey A Smith, Lori L McMaho. Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model. Neurobiology of disease. vol 110. 2019-09-06. PMID:29199135. |
alzheimer's disease (ad) pathology begins decades prior to onset of clinical symptoms, and the entorhinal cortex and hippocampus are among the first and most extensively impacted brain regions. |
2019-09-06 |
2023-08-13 |
human |
| Isabel H Salas, Akila Weerasekera, Tariq Ahmed, Zsuzsanna Callaerts-Vegh, Uwe Himmelreich, Rudi D'Hooge, Detlef Balschun, Takaomi C Saido, Bart De Strooper, Carlos G Dott. High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease. Neurobiology of disease. vol 113. 2019-09-06. PMID:29427755. |
high fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of alzheimer disease. |
2019-09-06 |
2023-08-13 |
mouse |
| Alberto Cordella, Paraskevi Krashia, Annalisa Nobili, Annabella Pignataro, Livia La Barbera, Maria Teresa Viscomi, Alessandro Valzania, Flavio Keller, Martine Ammassari-Teule, Nicola Biagio Mercuri, Nicola Berretta, Marcello D'Ameli. Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of disease. vol 116. 2019-09-06. PMID:29778899. |
in particular, the dopaminergic innervation from the vta to the hippocampus is critical for hippocampal-related memory function and alterations in the midbrain dopaminergic system are frequently reported in alzheimer's disease (ad), contributing to age-related decline in memory and non-cognitive functions. |
2019-09-06 |
2023-08-13 |
mouse |