| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramsey Najm, Antara Rao, Yadong Huan. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell stem cell. vol 26. issue 3. 2020-07-15. PMID:32142656. |
understanding why adult hippocampal neurogenesis (ahn) is impaired in alzheimer's disease (ad) is essential for unravelling its role in pathogenesis. |
2020-07-15 |
2023-08-13 |
mouse |
| Liang Kong, Xue-Tao Li, Ying-Nan Ni, Hong-He Xiao, Ying-Jia Yao, Yuan-Yuan Wang, Rui-Jun Ju, Hong-Yan Li, Jing-Jing Liu, Min Fu, Yu-Tong Wu, Jing-Xian Yang, Lan Chen. Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice. International journal of nanomedicine. vol 15. 2020-07-13. PMID:32425521. |
osthole (ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of alzheimer's disease (ad). |
2020-07-13 |
2023-08-13 |
mouse |
| Kaori Hata, Kazunori Nakamoto, Akihiko Nunomura, Daichi Sone, Norihide Maikusa, Masayo Ogawa, Noriko Sato, Hiroshi Matsud. Automated Volumetry of Medial Temporal Lobe Subregions in Mild Cognitive Impairment and Alzheimer Disease. Alzheimer disease and associated disorders. vol 33. issue 3. 2020-07-10. PMID:31135455. |
hippocampal subfield volumetry should be more useful than whole hippocampal (wh) volumetry for diagnosing alzheimer disease (ad). |
2020-07-10 |
2023-08-13 |
Not clear |
| David Alcantara-Gonzalez, Benjamín Villasana-Salazar, Fernando Peña-Orteg. Single amyloid-beta injection exacerbates 4-aminopyridine-induced seizures and changes synaptic coupling in the hippocampus. Hippocampus. vol 29. issue 12. 2020-07-10. PMID:31381216. |
accumulation of amyloid-beta (aβ) in temporal lobe structures, including the hippocampus, is related to a variety of alzheimer's disease symptoms and seems to be involved in the induction of neural network hyperexcitability and even seizures. |
2020-07-10 |
2023-08-13 |
Not clear |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of alzheimer's disease. |
2020-07-06 |
2023-08-13 |
human |
| Xiaoke Hao, Xiaohui Yao, Shannon L Risacher, Andrew J Saykin, Jintai Yu, Huifu Wang, Lan Tan, Li Shen, Daoqiang Zhan. Identifying Candidate Genetic Associations with MRI-Derived AD-Related ROI via Tree-Guided Sparse Learning. IEEE/ACM transactions on computational biology and bioinformatics. vol 16. issue 6. 2020-07-02. PMID:29993890. |
experimental studies on simulation data and the alzheimer's disease neuroimaging initiative (adni) data show that our method not only achieves better predictions than competing methods on the mri-derived measures of ad-related region of interests (rois) (i.e., hippocampus, parahippocampal gyrus, and precuneus), but also identifies sparse snp patterns at the block level to better guide the biological interpretation. |
2020-07-02 |
2023-08-13 |
Not clear |
| Mona Lei, Jonathan D Teo, Huitong Song, Holly P McEwen, Jun Yup Lee, Timothy A Couttas, Thomas Duncan, Rose Chesworth, Josefine Bertz, Magdalena Przybyla, Janet Van Eersel, Benjamin Heng, Gilles J Guillemin, Lars M Ittner, Thomas Fath, Brett Garner, Arne Ittner, Tim Karl, Anthony S Do. Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31641049. |
sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of alzheimer's disease. |
2020-07-02 |
2023-08-13 |
mouse |
| Mona Lei, Jonathan D Teo, Huitong Song, Holly P McEwen, Jun Yup Lee, Timothy A Couttas, Thomas Duncan, Rose Chesworth, Josefine Bertz, Magdalena Przybyla, Janet Van Eersel, Benjamin Heng, Gilles J Guillemin, Lars M Ittner, Thomas Fath, Brett Garner, Arne Ittner, Tim Karl, Anthony S Do. Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31641049. |
we have reported pronounced loss of s1p and sk2 activity early in alzheimer's disease (ad) pathogenesis, and an inverse correlation between hippocampal s1p levels and age in females, leading us to speculate that loss of s1p is a sensitizing influence for ad. |
2020-07-02 |
2023-08-13 |
mouse |
| Ting Zhang, Wei Ke, Xuan Zhou, Yun Qian, Su Feng, Ran Wang, Guizhong Cui, Ran Tao, Wenke Guo, Yanhong Duan, Xiaobing Zhang, Xiaohua Cao, Yousheng Shu, Chunmei Yue, Naihe Jin. Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease. Stem cell reports. vol 13. issue 6. 2020-06-30. PMID:31761676. |
human neural stem cells reinforce hippocampal synaptic network and rescue cognitive deficits in a mouse model of alzheimer's disease. |
2020-06-30 |
2023-08-13 |
mouse |
| Kamil A Grajski, Steven L Bressle. Differential medial temporal lobe and default-mode network functional connectivity and morphometric changes in Alzheimer's disease. NeuroImage. Clinical. vol 23. 2020-06-29. PMID:31158694. |
in mild alzheimer's disease, but not early mild cognitive impairment, characteristic brain atrophy was detected in freesurfer estimates of subcortical and hippocampal subfield volumes and cortical thinning. |
2020-06-29 |
2023-08-13 |
human |
| Kamil A Grajski, Steven L Bressle. Differential medial temporal lobe and default-mode network functional connectivity and morphometric changes in Alzheimer's disease. NeuroImage. Clinical. vol 23. 2020-06-29. PMID:31158694. |
in early mild cognitive impairment these changes involved medial temporal lobe regions of transentorhinal, perirhinal and entorhinal cortices (associated with the earliest stages of neurofibrillary changes in alzheimer's disease), hippocampus, parahippocampal gyrus and temporal pole, and cortical regions comprising or co-activated with the default-mode network, including rostral and medial prefrontal cortex, anterior cingulate cortex, precuneus and inferior temporal cortex. |
2020-06-29 |
2023-08-13 |
human |
| Amrutha H Chidananda, Anand Kumar Sharma, Radhika Khandelwal, Yogendra Sharm. Secretagogin Binding Prevents α-Synuclein Fibrillation. Biochemistry. vol 58. issue 46. 2020-06-29. PMID:31617346. |
a significantly reduced level of expression of scgn has been reported in the hippocampus of a mouse model of alzheimer's disease (ad) and in parkinson's patients, although the biochemical implications and mechanistic underpinnings of the altered scgn expression in neurodegenerative diseases remain unknown. |
2020-06-29 |
2023-08-13 |
mouse |
| Zhi-Xue Yang, Cheng-Lin Tang, Xiao-Hong Li, Zheng-Wei Zhu, Li Qiu, Hui-Yu An, Meng-Jia Wu, Yun-Hao Yan. [Effect of electroacupuncture combined with Donepezil on learning-memory ability and expression of hippocampal β-amyloid clearance-related genes in SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 4. 2020-06-25. PMID:32333532. |
to investigate the effect of electroacupuncture (ea) combined with donepezil on learning-memory ability and gene expression of β-amyloid (aβ) clearance-related factors in the hippocampus in senescence-accelerated mouse prone 8 (samp8) mice, so as to explore their synthetic effect in improving dementia of alzheimer's disease (ad)．. |
2020-06-25 |
2023-08-13 |
mouse |
| Samantha L Allison, Rebecca L Koscik, Robert P Cary, Erin M Jonaitis, Howard A Rowley, Nathaniel A Chin, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sanjay Asthana, Barbara B Bendlin, Sterling C Johnso. Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum. NeuroImage. Clinical. vol 23. 2020-06-25. PMID:31252287. |
several neurodegeneration (n) metrics using structural mri are used for the purpose of alzheimer's disease (ad)-related staging, including hippocampal volume, global atrophy, and an "ad signature" composite consisting of thickness or volumetric estimates derived from regions impacted early in ad. |
2020-06-25 |
2023-08-13 |
Not clear |
| Pascual Torres, Pol Andrés-Benito, Anna Fernàndez-Bernal, Marta Ricart, Victòria Ayala, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Oti. Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy. Brain : a journal of neurology. vol 143. issue 3. 2020-06-24. PMID:32016361. |
selected cryptic exons accumulate in hippocampal cell nuclei in alzheimer's disease with and without associated tdp-43 proteinopathy. |
2020-06-24 |
2023-08-13 |
Not clear |
| Peter T Nelso. Reply: Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy. Brain : a journal of neurology. vol 143. issue 3. 2020-06-24. PMID:32016396. |
reply: selected cryptic exons accumulate in hippocampal cell nuclei in alzheimer's disease with and without associated tdp-43 proteinopathy. |
2020-06-24 |
2023-08-13 |
Not clear |
| Maria-Adelaide Micci, Balaji Krishnan, Elizabeth Bishop, Wen-Ru Zhang, Jutatip Guptarak, Auston Grant, Olga Zolochevska, Batbayar Tumurbaatar, Whitney Franklin, Claudia Marino, Steven G Widen, Arjun Luthra, Steven G Kernie, Giulio Taglialatel. Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31200742. |
we reported that higher numbers of neural stem cells (nsc) in the hippocampus of cognitively-intact individuals with high alzheimer's disease (ad) pathology (plaques and tangles) is associated with decreased synaptic amyloid beta oligomers (aβο), an event linked to onset of dementia in ad. |
2020-06-23 |
2023-08-13 |
Not clear |
| Sarah C Conner, Laurent Benayoun, Jayandra J Himali, Stephanie L Adams, Qiong Yang, Charles DeCarli, Jan K Blusztajn, Alexa Beiser, Sudha Seshadri, Ivana Delall. Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-22. PMID:30775993. |
genome-wide association studies identified a single nucleotide polymorphism (snp) in the msrb3 gene encoding methionine sulfoxide reductase-b3 (msrb3) to be associated with the risk for low hippocampal volume and late onset alzheimer's disease (ad). |
2020-06-22 |
2023-08-13 |
human |
| Keith A Josephs, Melissa E Murray, Nirubol Tosakulwong, Stephen D Weigand, David S Knopman, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell, Dennis W Dickso. Brain atrophy in primary age-related tauopathy is linked to transactive response DNA-binding protein of 43 kDa. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 6. 2020-06-22. PMID:31056344. |
transactive response dna-binding protein of 43 kda (tdp-43), a third protein, has recently garnished a lot of attention in alzheimer's disease where it is associated with memory loss and amygdala and hippocampal atrophy. |
2020-06-22 |
2023-08-13 |
Not clear |
| Min Kim, Stuart Snowden, Tommi Suvitaival, Ashfaq Ali, David J Merkler, Tahmina Ahmad, Sarah Westwood, Alison Baird, Petroula Proitsi, Alejo Nevado-Holgado, Abdul Hye, Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Charlotte Teunissen, Mara Ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Isabel Sala, Alberto Lléo, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni B Frisoni, José L Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Frederik Barkhof, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter J Visser, Simon Lovestone, Cristina Legido-Quigle. Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 6. 2020-06-22. PMID:31078433. |
primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the european medical information framework for alzheimer's disease biomarker discovery cohort. |
2020-06-22 |
2023-08-13 |
Not clear |