| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamie M Walker, William Goette, Kurt Farrell, Megan A Iida, Esma Karlovich, Charles L White, John F Crary, Timothy E Richardso. The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-04. PMID:36738450. |
neurofibrillary degeneration in alzheimer's disease (ad) typically involves the entorhinal cortex and ca1 subregion of the hippocampus early in the disease process, whereas in primary age-related tauopathy (part), there is an early selective vulnerability of the ca2 subregion. |
2023-02-04 |
2023-08-14 |
Not clear |
| Evgenia Salta, Orly Lazarov, Carlos P Fitzsimons, Rudolph Tanzi, Paul J Lucassen, Se Hoon Cho. Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell stem cell. vol 30. issue 2. 2023-02-03. PMID:36736288. |
adult hippocampal neurogenesis in alzheimer's disease: a roadmap to clinical relevance. |
2023-02-03 |
2023-08-14 |
Not clear |
| Evgenia Salta, Orly Lazarov, Carlos P Fitzsimons, Rudolph Tanzi, Paul J Lucassen, Se Hoon Cho. Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell stem cell. vol 30. issue 2. 2023-02-03. PMID:36736288. |
adult hippocampal neurogenesis (ahn) drops sharply during early stages of alzheimer's disease (ad), via unknown mechanisms, and correlates with cognitive status in ad patients. |
2023-02-03 |
2023-08-14 |
Not clear |
| Zachery D Morrissey, Jin Gao, Liang Zhan, Weiguo Li, Igor Fortel, Takaomi Saido, Takashi Saito, Arnold Bakker, Scott Mackin, Olusola Ajilore, Orly Lazarov, Alex D Leo. Hippocampal functional connectivity across age in an Frontiers in aging neuroscience. vol 14. 2023-01-30. PMID:36711209. |
hippocampal functional connectivity across age in an alzheimer's disease (ad) is a progressive neurodegenerative disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Laura E M Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya Nasrallah, John A Detre, Paul A Yushkevich, David A Wol. Aging and Alzheimer's Disease Have Dissociable Effects on Medial Temporal Lobe Connectivity. medRxiv : the preprint server for health sciences. 2023-01-30. PMID:36711782. |
instead, patients with symptomatic alzheimer's disease displayed reduced hippocampal connectivity within the medial temporal lobe as well as hypoconnectivity within the posterior-medial system. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yuanhong Tang, Yan Yan, Jian Mao, Junjun Ni, Hong Qin. The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease. Ageing research reviews. 2023-01-30. PMID:36716975. |
the hippocampus associated gabaergic neural network impairment in early-stage of alzheimer's disease. |
2023-01-30 |
2023-08-14 |
Not clear |
| Hyunah Lee, Jack Price, Deepak P Srivastava, Sandrine Thure. In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis. Hippocampus. 2023-01-29. PMID:36709412. |
hippocampal neurogenesis (hn) is considered an important mechanism underlying lifelong brain plasticity, and alterations in this process have been implicated in early alzheimer's disease progression. |
2023-01-29 |
2023-08-14 |
human |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
ikzf1 levels were increased in the hippocampus of these neurological models, as well as in postmortem hippocampal samples from alzheimer's disease patients. |
2023-01-26 |
2023-08-14 |
mouse |
| Aleksandra Maruszak, Edina Silajdžić, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J Nevado, Charlotte E Teunissen, Pieter J Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thure. Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum. Brain : a journal of neurology. 2023-01-26. PMID:36703180. |
predicting progression to alzheimer's disease with human hippocampal progenitors exposed to serum. |
2023-01-26 |
2023-08-14 |
human |
| Aleksandra Maruszak, Edina Silajdžić, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J Nevado, Charlotte E Teunissen, Pieter J Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thure. Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum. Brain : a journal of neurology. 2023-01-26. PMID:36703180. |
adult hippocampal neurogenesis is important for learning and memory and is altered early in alzheimer's disease. |
2023-01-26 |
2023-08-14 |
human |
| Aleksandra Maruszak, Edina Silajdžić, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J Nevado, Charlotte E Teunissen, Pieter J Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thure. Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum. Brain : a journal of neurology. 2023-01-26. PMID:36703180. |
as hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for alzheimer's disease progression. |
2023-01-26 |
2023-08-14 |
human |
| Aleksandra Maruszak, Edina Silajdžić, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J Nevado, Charlotte E Teunissen, Pieter J Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thure. Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum. Brain : a journal of neurology. 2023-01-26. PMID:36703180. |
a human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to alzheimer's disease or remained cognitively stable. |
2023-01-26 |
2023-08-14 |
human |
| Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A Bennett, Li-Huei Tsai, Andreas R Pfennin. Cell type-specific histone acetylation profiling of Alzheimer's disease subjects and integration with genetics. Frontiers in molecular neuroscience. vol 15. 2023-01-23. PMID:36683855. |
we profile genome-wide histone 3 lysine 27 acetylation (h3k27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlpfc) of subjects with and without alzheimer's disease (ad). |
2023-01-23 |
2023-08-14 |
human |
| Peyton L Delgorio, Lucy V Hiscox, Grace McIlvain, Mary K Kramer, Alexa M Diano, Kyra E Twohy, Alexis A Merritt, Matthew D J McGarry, Hillary Schwarb, Ana M Daugherty, James M Ellison, Alyssa M Lanzi, Matthew L Cohen, Christopher R Martens, Curtis L Johnso. Hippocampal subfield viscoelasticity in amnestic mild cognitive impairment evaluated with MR elastography. NeuroImage. Clinical. vol 37. 2023-01-22. PMID:36682312. |
hippocampal subfields (hcsf) are brain regions important for memory function that are vulnerable to decline with amnestic mild cognitive impairment (amci), which is often a preclinical stage of alzheimer's disease. |
2023-01-22 |
2023-08-14 |
Not clear |
| Suresh B Rangasamy, Malabendu Jana, Sridevi Dasarathi, Madhuchhanda Kundu, Kalipada Paha. Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain, behavior, and immunity. 2023-01-22. PMID:36682514. |
treadmill workout activates pparα in the hippocampus to upregulate adam10, decrease plaques and improve cognitive functions in 5xfad mouse model of alzheimer's disease. |
2023-01-22 |
2023-08-14 |
mouse |
| Suresh B Rangasamy, Malabendu Jana, Sridevi Dasarathi, Madhuchhanda Kundu, Kalipada Paha. Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain, behavior, and immunity. 2023-01-22. PMID:36682514. |
regular exercise has multiple beneficial effects on human health and here, we describe the importance of regular mild treadmill exercise in upregulating pparα in vivo in the hippocampus of 5xfad mouse model of alzheimer's disease. |
2023-01-22 |
2023-08-14 |
mouse |
| Sungjun Lee, Yonghyun Choi, Eunseo Jeong, Jongjun Park, Jiwon Kim, Masayoshi Tanaka, Jonghoon Cho. Physiological significance of elevated levels of lactate by exercise training in the brain and body. Journal of bioscience and bioengineering. 2023-01-21. PMID:36681523. |
in addition, it is possible to improve stress-related symptoms, such as depression, by regulating the function of hippocampal mitochondria, and with an increasingly aging society, lactate is being investigated as a preventive agent for brain diseases such as alzheimer's disease. |
2023-01-21 |
2023-08-14 |
Not clear |
| Kun Zhao, Yanhui Ding, Ying Han, Yong Fan, Aaron F Alexander-Bloch, Tong Han, Dan Jin, Bing Liu, Jie Lu, Chengyuan Song, Pan Wang, Dawei Wang, Qing Wang, Kaibin Xu, Hongwei Yang, Hongxiang Yao, Yuanjie Zheng, Chunshui Yu, Bo Zhou, Xinqing Zhang, Yuying Zhou, Tianzi Jiang, Xi Zhang, Yong Li. Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis. Science bulletin. vol 65. issue 13. 2023-01-20. PMID:36659162. |
independent and reproducible hippocampal radiomic biomarkers for multisite alzheimer's disease: diagnosis, longitudinal progress and biological basis. |
2023-01-20 |
2023-08-14 |
human |
| Kun Zhao, Yanhui Ding, Ying Han, Yong Fan, Aaron F Alexander-Bloch, Tong Han, Dan Jin, Bing Liu, Jie Lu, Chengyuan Song, Pan Wang, Dawei Wang, Qing Wang, Kaibin Xu, Hongwei Yang, Hongxiang Yao, Yuanjie Zheng, Chunshui Yu, Bo Zhou, Xinqing Zhang, Yuying Zhou, Tianzi Jiang, Xi Zhang, Yong Li. Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis. Science bulletin. vol 65. issue 13. 2023-01-20. PMID:36659162. |
hippocampal morphological change is one of the main hallmarks of alzheimer's disease (ad). |
2023-01-20 |
2023-08-14 |
human |
| Yang Du, Shaowei Zhang, Qi Qiu, Jianye Zhang, Yuan Fang, Lu Zhao, Wenjing Wei, Jinghua Wang, Jinhong Wang, Xia L. The effect of hippocampal radiomic features and functional connectivity on the relationship between hippocampal volume and cognitive function in Alzheimer's disease. Journal of psychiatric research. vol 158. 2023-01-16. PMID:36646036. |
the effect of hippocampal radiomic features and functional connectivity on the relationship between hippocampal volume and cognitive function in alzheimer's disease. |
2023-01-16 |
2023-08-14 |
Not clear |