| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha R Pierson, Louis J Kolling, Thomas D James, Selvakumar Govindhasamy Pushpavathi, Catherine A Marcinkiewc. Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease. Pharmacological research. 2024-04-10. PMID:38599469. |
serotonergic dysfunction may mediate the relationship between alcohol consumption and alzheimer's disease. |
2024-04-10 |
2024-04-13 |
Not clear |
| Shahnaz Saednia, Saeed Emami, Masoud Moslehi, Seyed Jalal Hosseinimeh. Insights into the development of European journal of medicinal chemistry. vol 270. 2024-03-31. PMID:38555856. |
insights into the development of serotonergic (5-hydroxytryptamine; 5-ht) receptors play critical roles in neurological and psychological disorders such as schizophrenia, anxiety, depression, and alzheimer's diseases. |
2024-03-31 |
2024-04-03 |
Not clear |
| Kanchan Bhardwaj, Rashi Bhargav, Jiri Patocka, Ruchi Sharma, Zdenka Navratilova, Patrik Oleksak, Kamil Kuc. Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review. Mini reviews in medicinal chemistry. 2024-02-07. PMID:38321903. |
the compound dendrobine activates neuro synapses, serotonergic synapse and signaling pathways during neurotransmission playing important role in alzheimer's disease, parkinson's disease, anxiety and long-term depression. |
2024-02-07 |
2024-02-09 |
Not clear |
| Emad H M Hassanein, Hanan S Althagafy, Mohammad A Baraka, Esraa K Abd-Alhameed, Islam M Ibrahi. Pharmacological update of mirtazapine: a narrative literature review. Naunyn-Schmiedeberg's archives of pharmacology. 2023-11-09. PMID:37943296. |
mtz is hypothesized to have antidepressant effects because of the synergy between noradrenergic and serotonergic actions and is effective in treating major depressive disorder and depression associated with epilepsy, alzheimer's disease, stroke, cardiovascular disease, and respiratory disease. |
2023-11-09 |
2023-11-20 |
Not clear |
| Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharm. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend. Neuroscience and biobehavioral reviews. 2023-11-04. PMID:37925093. |
network pharmacology analysis reveals that these compounds protect against long-term depression, aging-associated diseases, alzheimer's disease, and other addictions through interactions with cholinergic, dopaminergic, and serotonergic proteins, validated in animal studies only. |
2023-11-04 |
2023-11-08 |
Not clear |
| Anna-Lena Richter, Marlies Diepeveen-de Bruin, Michiel G J Balvers, Lisette C P G M De Groot, Peter Paul De Deyn, Sebastiaan Engelborghs, Renger F Witkamp, Yannick Vermeire. Association between low vitamin D status, serotonin and clinico-bio-behavioral parameters in Alzheimer's disease. Dementia and geriatric cognitive disorders. 2023-10-08. PMID:37806302. |
studies suggest a role of vitamin d in the progression and symptomatology of alzheimer's disease (ad), with few in vitro studies pointing to effects on serotonergic and amyloidogenic turnover. |
2023-10-08 |
2023-10-15 |
Not clear |
| Jing Wang, Yufei Mei, Xiaoqin Zhang, Xiaojie Wei, Yiping Zhang, Dongpi Wang, Jinjin Huang, Keqing Zhu, Guoping Peng, Binggui Su. Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease. Cell reports. vol 42. issue 3. 2023-02-23. PMID:36821438. |
aberrant serotonergic signaling contributes to the hyperexcitability of ca1 pyramidal neurons in a mouse model of alzheimer's disease. |
2023-02-23 |
2023-08-14 |
mouse |
| b' Mirjana Babi\\xc4\\x87 Leko, Matea Nikolac Perkovi\\xc4\\x87, Ena \\xc5\\xa0pani\\xc4\\x87, Dubravka \\xc5\\xa0vob \\xc5\\xa0trac, Nikolina Plei\\xc4\\x87, \\xc5\\xbdeljka Vogrinc, Ivana Gunja\\xc4\\x8da, Dora Be\\xc5\\xbeovan, Gordana Nedi\\xc4\\x87 Erjavec, Nata\\xc5\\xa1a Klepac, Fran Borove\\xc4\\x8dki, Tatijana Zemunik, Nela Pivac, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer\'s Disease. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551873.' |
a decrease in serotonergic transmission throughout the brain is among the earliest pathological changes in alzheimer's disease (ad). |
2022-12-23 |
2023-08-14 |
Not clear |
| Yuki Numagami, Fumi Hoshino, Chiaki Murakami, Masayuki Ebina, Fumio Sakan. Distinct regions of Praja-1 E3 ubiquitin-protein ligase selectively bind to docosahexaenoic acid-containing phosphatidic acid and diacylglycerol kinase δ. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022-12-17. PMID:36528254. |
sert modulates serotonergic system activity and is a therapeutic target for depression, autism, obsessive-compulsive disorder, schizophrenia and alzheimer's disease. |
2022-12-17 |
2023-08-14 |
Not clear |
| Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Baivab Sinha, Bairong Shen, Rohit Sharm. Role of Shankhpushpi (Convolvulus pluricaulis) in Neurological Disorders: An Umbrella Review Covering Evidence from Ethnopharmacology to Clinical Studies. Neuroscience and biobehavioral reviews. 2022-07-25. PMID:35878793. |
network pharmacology results indicate that compounds from c. pluricaulis interact with various proteins, neuro synapses, signaling pathways, and serotonergic synapse which plays a crucial role in neurotransmission, alzheimer's disease, long-term depression, addictions to alcohol, cognitive disorders, psychological conditions, and increasing serotonin concentration in synapses. |
2022-07-25 |
2023-08-14 |
Not clear |
| Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Maurizio Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finse. Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice. Journal of Alzheimer's disease : JAD. 2022-03-28. PMID:35342093. |
modulation of serotonergic signaling by treatment with selective serotonin reuptake inhibitors (ssris) has been suggested to mitigate amyloid-β (aβ) pathology in alzheimer's disease, in addition to exerting an anti-depressant action. |
2022-03-28 |
2023-08-13 |
mouse |
| De-En Han, Zhong-Sheng Yue, Hong-Wei Li, Gai-Zhi Liu, Bang-Rong Cai, Ping Tia. [Anti-depressant components and mechanism of Rehmanniae Radix based on UPLC-Q-Orbitrap HRMS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 4. 2022-03-14. PMID:35285206. |
the key anti-depression targets of rehmanniae radix were concentrated in 24 signaling pathways, including neuroactive ligand-receptor interaction, neurodegenerative disease-multiple diseases pathway, phosphatidylinositol 3-kinase/protein kinase b pathway, serotonergic synapse, and alzheimer's disease. |
2022-03-14 |
2023-08-13 |
Not clear |
| Ana Salomé Correia, Armando Cardoso, Nuno Val. Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson's, and Alzheimer's Diseases, with a Connection with Serotonin. International journal of molecular sciences. vol 22. issue 16. 2021-09-14. PMID:34445231. |
here, we discuss some facts that link major depressive disorder, alzheimer's, and parkinson's to the stress and immune responses, as well as the connection between these responses and serotonergic signaling. |
2021-09-14 |
2023-08-13 |
Not clear |
| Atoossa Fahimi, Mahjabin Noroozi, Ahmad Saleh. Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225963. |
while a handful of neurotransmitter systems including cholinergic, norepinephrinergic, and serotonergic undergo significant degeneration in alzheimer's disease, the cholinergic system has been the prime target for research and therapy. |
2021-07-28 |
2023-08-13 |
Not clear |
| Alok Joshi, Da-Hui Wang, Steven Watterson, Paula L McClean, Chandan K Behera, Trevor Sharp, KongFatt Wong-Li. Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease. Neuropharmacology. vol 174. 2021-07-07. PMID:32380022. |
opportunities for multiscale computational modelling of serotonergic drug effects in alzheimer's disease. |
2021-07-07 |
2023-08-13 |
Not clear |
| Luke Whiley, Katie E Chappell, Ellie D'Hondt, Matthew R Lewis, Beatriz Jiménez, Stuart G Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holme. Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33422142. |
both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of alzheimer's disease (ad). |
2021-06-24 |
2023-08-13 |
Not clear |
| J J van der Zande, M Joling, I G Happach, C Vriend, Ph Scheltens, J Booij, A W Lemstr. Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An NeuroImage. Clinical. vol 25. 2021-01-11. PMID:31790878. |
serotonergic deficits in dementia with lewy bodies with concomitant alzheimer's disease pathology: an to study the influence of concomitant alzheimer's disease (ad) pathology in dementia with lewy bodies (dlb) on dopamine transporter (dat) and serotonin transporter (sert) availability, using |
2021-01-11 |
2023-08-13 |
Not clear |
| b' Dumitru A Iacobas, Sanda Iacobas, Nino Nebieridze, Libor Vel\\xc3\\xad\\xc5\\xa1ek, Jana Vel\\xc3\\xad\\xc5\\xa1kov\\xc3\\xa. Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29973860.' |
se affected all major functional pathways, including apoptosis (61%), alzheimer's disease (47%), cell cycle (59%), long-term potentiation (62%), and depression (55%), as well as synaptic vesicle cycle (62%), glutamatergic (53%), gabaergic (49%), cholinergic (52%), dopaminergic (55%), and serotonergic (49%) neurotransmission. |
2020-10-01 |
2023-08-13 |
rat |
| M Nova Raditya, A M Made Bagus, Ulayatul Kustiati, Hevi Wihadmadyatami, Dwi Liliek Kusindart. Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn. Data in brief. vol 30. 2020-09-28. PMID:32395598. |
the article offers dataset on the expression of serotonergic nerve in the hippocampal area of alzheimer's disease (ad) model. |
2020-09-28 |
2023-08-13 |
rat |
| Masoud Neshan, Arezoo Campbell, Seyed Kazem Malakouti, Mahsa Zareii, Ghasem Ahangar. Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease. Heliyon. vol 6. issue 8. 2020-09-28. PMID:32904297. |
gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |