| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Sáez-Valero, María L de Ceballos, David H Small, Carmen de Felip. Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide. Neuroscience letters. vol 325. issue 3. 2002-08-14. PMID:12044655. |
previous studies have shown that an abnormal salt-soluble form of g(1) acetylcholinesterase (ache) is increased in the alzheimer's disease (ad) brain. |
2002-08-14 |
2023-08-12 |
rat |
| Lisa R Fodero, Javier Sáez-Valero, Catriona A McLean, Ralph N Martins, Konrad Beyreuther, Colin L Masters, Terry A Robertson, David H Smal. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Journal of neurochemistry. vol 81. issue 3. 2002-07-05. PMID:12065653. |
previous studies have shown that a minor glycoform of acetylcholinesterase (ache) is increased in alzheimer's disease brain and cerebrospinal fluid. |
2002-07-05 |
2023-08-12 |
mouse |
| Lisa R Fodero, Javier Sáez-Valero, Catriona A McLean, Ralph N Martins, Konrad Beyreuther, Colin L Masters, Terry A Robertson, David H Smal. Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Journal of neurochemistry. vol 81. issue 3. 2002-07-05. PMID:12065653. |
the altered ache glycosylation was due to an increase in a minor ache isoform, which did not bind con a, similar to that previously observed to be increased in alzheimer's disease brain and cerebrospinal fluid. |
2002-07-05 |
2023-08-12 |
mouse |
| Lei Yang, Heng-Yi He, Xue-Jun Zhan. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neuroscience research. vol 42. issue 4. 2002-06-25. PMID:11985878. |
acetylcholinesterase (ache) was suggested to be neurotoxic in vivo and in vitro and accelerate assembly of amyloid peptide into alzheimer's fibrils. |
2002-06-25 |
2023-08-12 |
Not clear |
| Jörg Ruof, Thomas Mittendorf, Olaf Pirk, J-Matthias Graf von der Schulenbur. Diffusion of innovations: treatment of Alzheimer's disease in Germany. Health policy (Amsterdam, Netherlands). vol 60. issue 1. 2002-05-07. PMID:11879945. |
systematic barriers seem to slow down the market penetration of innovative acethylcholinesterase (ache) inhibitors in alzheimer's disease. |
2002-05-07 |
2023-08-12 |
Not clear |
| Jörg Ruof, Thomas Mittendorf, Olaf Pirk, J-Matthias Graf von der Schulenbur. Diffusion of innovations: treatment of Alzheimer's disease in Germany. Health policy (Amsterdam, Netherlands). vol 60. issue 1. 2002-05-07. PMID:11879945. |
physicians were asked what they would prescribe if a close relative of theirs had alzheimer's disease) as well as qualitative items examining the physicians' attitudes towards ache inhibitors and the perceived impact on drug budgets. |
2002-05-07 |
2023-08-12 |
Not clear |
| Hans C Dringenberg, Peter Diavolitsi. Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804611. |
inhibitors of ache are used to delay cognitive decline and eeg slowing in patients with alzheimer's disease. |
2002-04-29 |
2023-08-12 |
rat |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| Xiao Qiu Xiao, Hai Yan Zhang, Xi Can Tan. Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. Journal of neuroscience research. vol 67. issue 1. 2002-02-21. PMID:11754078. |
huperzine a, a novel lycopodium alkaloid originally discovered in the chinese herb qian ceng ta (huperzia serrata), is a reversible, potent, and selective acetylcholinesterase (ache) inhibitor and has been extensively used for the treatment of alzheimer's disease (ad) in china. |
2002-02-21 |
2023-08-12 |
rat |
| V N Tales. Acetylcholinesterase in Alzheimer's disease. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589914. |
since the discovery of the cholinergic deficit in alzheimer disease (ad), acetylcholinesterase (ache) has been widely investigated in tissues involved in the disease. |
2001-12-31 |
2023-08-12 |
Not clear |
| S Amici, A Lanari, R Romani, C Antognelli, V Gallai, L Parnett. Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589922. |
at present acetylcholinesterase (ache) inhibitors (acheis) represent the only reliable therapeutic resource for symptomatic treatment of alzheimer disease (ad). |
2001-12-31 |
2023-08-12 |
Not clear |
| Y K Chung, H J Heo, E K Kim, H K Kim, T L Huh, Y Lim, S K Kim, D H Shi. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells. vol 11. issue 2. 2001-12-19. PMID:11355692. |
ache inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of compound currently approved for the treatment of alzheimer's disease (ad). |
2001-12-19 |
2023-08-12 |
Not clear |
| Y K Chung, H J Heo, E K Kim, H K Kim, T L Huh, Y Lim, S K Kim, D H Shi. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells. vol 11. issue 2. 2001-12-19. PMID:11355692. |
this study demonstrated that the ursolic acid of origanum majorana l. appeared to be a potent ache inhibitor in alzheimer's disease. |
2001-12-19 |
2023-08-12 |
Not clear |
| C Brühlmann, F Ooms, P A Carrupt, B Testa, M Catto, F Leonetti, C Altomare, A Carott. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. Journal of medicinal chemistry. vol 44. issue 19. 2001-10-11. PMID:11543689. |
this finding may be of interest in the context of alzheimer's disease because recent observations suggest that mao and ache inhibition might decrease beta-amyloid deposition. |
2001-10-11 |
2023-08-12 |
Not clear |
| K Herholz, B Bauer, K Wienhard, L Kracht, R Mielke, M O Lenz, T Strotmann, W D Heis. In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 12. 2001-08-23. PMID:11458998. |
using a recently developed tracer for positron emission tomography (pet), c-11-labeled n-methyl-4-piperidyl-acetate (c11-mp4a), we measured regional ache activity in 4 non-demented subjects, 4 patients with dementia of alzheimer type (dat) and 1 patient with senile dementia of lewy body type (sdlt), and compared the findings with measurements of blood flow (cbf) and glucose metabolism (cmrglc). |
2001-08-23 |
2023-08-12 |
human |
| P Davidsson, K Blennow, N Andreasen, B Eriksson, L Minthon, C Hess. Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease. Neuroscience letters. vol 300. issue 3. 2001-06-14. PMID:11226635. |
the clinical significance and the effects of pharmacological treatment of patients with alzheimer's disease (ad) were evaluated by measurement of acetylcholinesterase (ache) in the cerebrospinal fluid (csf). |
2001-06-14 |
2023-08-12 |
Not clear |
| H Ogura, T Kosasa, Y Kuriya, Y Yamanish. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods and findings in experimental and clinical pharmacology. vol 22. issue 8. 2001-06-14. PMID:11256231. |
this study was designed to compare the in vitro inhibitory effects on acetylcholinesterase (ache) and butyrylcholinesterase (buche) of donepezil and some other cholinesterase (che) inhibitors which have been developed for the treatment of alzheimer's disease. |
2001-06-14 |
2023-08-12 |
Not clear |
| J Sáez-Valero, D H Smal. Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease. Brain research. vol 889. issue 1-2. 2001-05-17. PMID:11166713. |
our previous studies have shown that a minor isoform of acetylcholinesterase (ache) is increased in the cerebrospinal fluid (csf) of alzheimer's disease (ad) patients. |
2001-05-17 |
2023-08-12 |
Not clear |
| J Sáez-Valero, S S Mok, D H Smal. An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261805. |
the increase in this glycoform of ache is very specific for alzheimer's disease and is not seen in many other neurological diseases including other dementias. |
2001-05-17 |
2023-08-12 |
Not clear |
| N H Greig, E De Micheli, H W Holloway, Q S Yu, T Utsuki, T A Perry, A Brossi, D K Ingram, J Deutsch, D K Lahiri, T T Soncran. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261809. |
phenserine, a phenylcarbamate of physostigmine, is a new potent and highly selective acetylcholinesterase (ache) inhibitor, with a > 50-fold activity versus butyrylcholinesterase (bche), in clinical trials for the treatment of alzheimer's disease (ad). |
2001-05-17 |
2023-08-12 |
rat |