| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoaib Khan, Tayyiaba Iqbal, Muhammad Bilal Khan, Rafaqat Hussain, Yousaf Khan, Hany W Darwis. Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile. BMC chemistry. vol 18. issue 1. 2024-11-15. PMID:39522005. |
as a springboard to explore novel potent inhibitors of cholinesterase enzymes (ache and bche) responsible for causing alzheimer disorder, the current study was conducted to synthesize pyrrole derived triazole based schiff base scaffolds by facile synthetic route. |
2024-11-15 |
2024-11-17 |
Not clear |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Hind Al Khashali, Ravel Ray, Ban Darweesh, Caroline Wozniak, Ben Haddad, Stuti Goel, Issah Seidu, Jeneen Khalil, Brooke Lopo, Nayrooz Murshed, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732252. |
we previously reported that the levels of amyloid beta (aβ), at the center of alzheimer's disease pathophysiology, are regulated by acetylcholinesterase (ache) in non-small cell lung cancer (nsclc). |
2024-05-11 |
2024-05-27 |
Not clear |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. |
2024-03-28 |
2024-03-30 |
Not clear |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
despite some limitations being seen in ache inhibitors, ongoing research remains dedicated to finding innovative and more effective treatments for alzheimer's disease. |
2024-03-28 |
2024-03-30 |
Not clear |
| Sabrina Lekmine, Ouided Benslama, Hichem Tahraoui, Mohammad Shamsul Ola, Aicha Laouani, Kenza Kadi, Antonio Ignacio Martín-García, Ahmad Al. Anti-Cholinergic Effects of the Phenolic Extract from the Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543134. |
cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), hold pivotal significance in alzheimer's disease (ad) treatment. |
2024-03-28 |
2024-03-30 |
Not clear |
| Mustafa Kemal Ozalp, Patricia A Vignaux, Ana C Puhl, Thomas R Lane, Fabio Urbina, Sean Ekin. Sequential Contrastive and Deep Learning Models to Identify Selective Butyrylcholinesterase Inhibitors. Journal of chemical information and modeling. 2024-03-27. PMID:38532612. |
butyrylcholinesterase (bche) is a target of interest in late-stage alzheimer's disease (ad) where selective bche inhibitors (bis) may offer symptomatic treatment without the harsh side effects of acetylcholinesterase (ache) inhibitors. |
2024-03-27 |
2024-03-29 |
Not clear |
| Baljit Kaur, Rajbir Kaur, Vivesh, Sudesh Rani, Rajbir Bhatti, Palwinder Sing. Small Peptides Targeting BACE-1, AChE, and A-β Reversing Scopolamine-Induced Memory Impairment: A Multitarget Approach against Alzheimer's Disease. ACS omega. vol 9. issue 11. 2024-03-25. PMID:38524457. |
small peptides targeting bace-1, ache, and a-β reversing scopolamine-induced memory impairment: a multitarget approach against alzheimer's disease. |
2024-03-25 |
2024-03-27 |
Not clear |
| Kübra Nur Arınmış, H Tuba Kıyan, A Alper Öztür. Preparation, Characterization, Antioxidant Activities, and Determination of Anti-Alzheimer Effects of PLGA-Based DDSs Containing Ferulic Acid. ACS omega. vol 9. issue 10. 2024-03-18. PMID:38497027. |
since it has both ache inhibitor and antioxidant properties according to the results of its anti-alzheimer activity, it was concluded that the formulation prepared in this study shows promise in the treatment of both oxidative stress-related diseases and alzheimer's. |
2024-03-18 |
2024-03-20 |
Not clear |
| Varsha Mugundhan, Abirami Arthanari, Parameswari R Parthasarath. Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study. Cureus. vol 16. issue 2. 2024-03-15. PMID:38487137. |
aim this study aims to comprehensively evaluate the effects of ferulic acid (fa) on acetylcholinesterase (ache) enzyme activity and amyloid beta (aβ) peptide plaque formation in an in vitro model of alzheimer's disease (ad). |
2024-03-15 |
2024-03-17 |
Not clear |
| Franziska Pohl, Victoria Lindsay-McGee, Paul Kong Thoo Lin, Patricia Maciel, Andreia Teixeira-Castr. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 microPublication biology. vol 2024. 2024-02-26. PMID:38404918. |
pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a sca3 inhibition of acetylcholinesterase (ache) is a common used treatment option for alzheimer's disease. |
2024-02-26 |
2024-02-28 |
Not clear |
| Panthip Tue-Ngeun, Waleepan Rakitikul, Natechanok Thinkumrob, Supa Hannongbua, Wijitra Meelua, Jitrayut Jitonno. Binding interactions and in silico ADME prediction of isoconessimine derivatives as potent acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 129. 2024-02-24. PMID:38401250. |
in pursuit of new acetylcholinesterase (ache) inhibitors for treating alzheimer's disease (ad), a series of ten previously synthesized isoconessimine compounds (7a-7j) was in silico investigated for their binding interactions with ache and pharmacokinetics based on absorption, distribution, metabolism, and excretion (adme) properties using molecular docking, oniom (our own n-layered integrated molecular orbital and molecular mechanics) method and swissadme tools. |
2024-02-24 |
2024-02-27 |
Not clear |
| Panthip Tue-Ngeun, Waleepan Rakitikul, Natechanok Thinkumrob, Supa Hannongbua, Wijitra Meelua, Jitrayut Jitonno. Binding interactions and in silico ADME prediction of isoconessimine derivatives as potent acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 129. 2024-02-24. PMID:38401250. |
the steric and electronic effects on the aryloxy-substitutional ethyl group as important factors in the ache inhibition were also discussed, which brings a better understanding of alzheimer's disease drug development. |
2024-02-24 |
2024-02-27 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
the present research suggests that taxifolin has a strong ability to bind and inhibit ache and bche and could be used to manage neuron-associated problems; however, further research is required to explore taxifolin's neurological therapeutic potential using animal models of alzheimer's disease. |
2024-02-10 |
2024-02-12 |
Not clear |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
alzheimer's disease (ad) is characterized by cognitive decline, often attributed to the deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (ache) within the biological milieu. |
2024-02-07 |
2024-02-09 |
Not clear |
| Dhairiya Agarwal, Sumit Kumar, Ramesh Ambatwar, Neeru Bhanwala, Lokesh Chandrakar, Gopal Khati. Lead Identification Through In Silico Studies: Targeting Acetylcholinesterase Enzyme Against Alzheimer's Disease. Central nervous system agents in medicinal chemistry. 2024-01-30. PMID:38288823. |
in this work, we aimed to acquire the best potential small molecule for alzheimer's disease (ad) treatment using different models in biovia discovery studio to identify new potential inhibitors of acetylcholinesterase (ache) via in silico studies. |
2024-01-30 |
2024-02-01 |
Not clear |