| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Lindsay, E M McConnell, S J Hunter, D R McCance, B Sheridan, A B Atkinso. Poor responses to a test dose of subcutaneous octreotide predict the need for adjuvant therapy to achieve 'safe' growth hormone levels. Pituitary. vol 7. issue 3. 2005-12-21. PMID:16328564. |
this study was designed to evaluate whether the acute serum growth hormone (gh) response to a test dose of octreotide in acromegaly predicts longer-term response to the drug at 3 years. |
2005-12-21 |
2023-08-12 |
Not clear |
| Hiroshi Iwai, Hiroyuki Ito, Sari Ri, Takeshi Harada, Noriyuki Hirota, Takaaki Yamauchi, Toshiyuki Miyatake, Yasuhiro Ohno, Norihiko Aok. Type 1 diabetes associated with asymptomatic acromegaly successfully treated with surgery after pregnancy: a case report. Endocrine journal. vol 52. issue 4. 2005-12-14. PMID:16127208. |
although we suspected her of having acromegaly because of high growth hormone (gh) levels (6.9 or 8.5 ng/ml), blood levels of insulin-like growth factor 1 (igf-1) and igf-binding protein-3 (igfbp-3) were within normal range and the circadian rhythm of her blood gh levels was normally maintained. |
2005-12-14 |
2023-08-12 |
Not clear |
| Hiroshi Iwai, Hiroyuki Ito, Sari Ri, Takeshi Harada, Noriyuki Hirota, Takaaki Yamauchi, Toshiyuki Miyatake, Yasuhiro Ohno, Norihiko Aok. Type 1 diabetes associated with asymptomatic acromegaly successfully treated with surgery after pregnancy: a case report. Endocrine journal. vol 52. issue 4. 2005-12-14. PMID:16127208. |
we started a treatment of oral administration of 7.5 mg of bromocriptine per day for the acromegaly from april 28, 2000, because her elevated gh was suspected of causing her diabetes to be poorly controlled. |
2005-12-14 |
2023-08-12 |
Not clear |
| Hiroshi Iwai, Hiroyuki Ito, Sari Ri, Takeshi Harada, Noriyuki Hirota, Takaaki Yamauchi, Toshiyuki Miyatake, Yasuhiro Ohno, Norihiko Aok. Type 1 diabetes associated with asymptomatic acromegaly successfully treated with surgery after pregnancy: a case report. Endocrine journal. vol 52. issue 4. 2005-12-14. PMID:16127208. |
we concluded as follows: to rule out acromegaly in patients with poorly controlled diabetes, 1) measurements of serum gh and igf-1 should be performed, and 2) pituitary mris should be performed if blood levels of gh or igf-1 are high. |
2005-12-14 |
2023-08-12 |
Not clear |
| C Kordon, P Zizzari, M T Bluet-Pajo. A century of GH research revisited: from linear models to network complexity. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114267. |
the history of gh started with the pioneer clinical and anatomical observations of pierre marie, who described the symptoms of acromegaly in 1886. |
2005-11-11 |
2023-08-12 |
Not clear |
| P Jaquet, A Saveanu, A Barlie. New SRIF analogs in the control of human pituitary adenomas: perspectives. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114269. |
although the drugs of reference, octreotide and lanreotide, are widely used in the treatment of acromegaly, their long-term administration allows an effective control of both gh hypersecretion and igf-i levels in about 60% of the patients. |
2005-11-11 |
2023-08-12 |
human |
| J O L Jørgensen, E Vestergaard, L Gormsen, N Jessen, H Nørrelund, J S Christiansen, N Mølle. Metabolic consequences of GH deficiency. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114276. |
patients with active acromegaly are insulin resistant and glucose intolerant, whereas children with gh deficiency are insulin sensitive and may develop fasting hypoglycemia. |
2005-11-11 |
2023-08-12 |
Not clear |
| M C Sheppar. The critical parameters in GH excess. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114283. |
effective biochemical control of gh and igf-i levels in subjects with acromegaly can reduce mortality to that of the general population. |
2005-11-11 |
2023-08-12 |
human |
| M C Sheppar. The critical parameters in GH excess. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114283. |
current approaches to management of acromegaly (surgery, radiotherapy, srif analogues) rely on post-treatment monitoring of gh and igf-i levels. |
2005-11-11 |
2023-08-12 |
human |
| M C Sheppar. The critical parameters in GH excess. Journal of endocrinological investigation. vol 28. issue 5 Suppl. 2005-11-11. PMID:16114283. |
post-operative subjects with acromegaly, with normal igf-i levels but persistently abnormal nadir gh levels after glucose, have an increased risk of disease recurrence. |
2005-11-11 |
2023-08-12 |
human |
| Vanessa Ronconi, Gilberta Giacchetti, Barbara Mariniello, Andrea Camilletti, Franco Mantero, Marco Boscaro, Arianna Vignini, Laura Mazzant. Reduced nitric oxide levels in acromegaly: cardiovascular implications. Blood pressure. vol 14. issue 4. 2005-11-03. PMID:16126556. |
the aim of this study was to evaluate the effect of high levels of growth hormone (gh) and insulin-like growth factor-1 (igf-1) present in acromegaly on no pathway to investigate the role played by this molecule in the cardiovascular changes experienced by these patients. |
2005-11-03 |
2023-08-12 |
Not clear |
| Vanessa Ronconi, Gilberta Giacchetti, Barbara Mariniello, Andrea Camilletti, Franco Mantero, Marco Boscaro, Arianna Vignini, Laura Mazzant. Reduced nitric oxide levels in acromegaly: cardiovascular implications. Blood pressure. vol 14. issue 4. 2005-11-03. PMID:16126556. |
moreover the inverse correlation of no levels with gh, igf-1 and disease duration suggests that reduced levels of platelet no linked to gh excess may contribute to the vascular alterations affecting patients with acromegaly. |
2005-11-03 |
2023-08-12 |
Not clear |
| Jens Otto Lunde Jørgensen, Ulla Feldt-Rasmussen, Jan Frystyk, Jian-Wen Chen, Lars Østergård Kristensen, Claus Hagen, Hans Ørsko. Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist. The Journal of clinical endocrinology and metabolism. vol 90. issue 10. 2005-11-02. PMID:16046586. |
pegvisomant is a gh receptor antagonist that blocks the peripheral actions of gh in acromegaly. |
2005-11-02 |
2023-08-12 |
Not clear |
| Patrizia Tita, Maria Rosaria Ambrosio, Claudia Scollo, Anna Carta, Pietro Gangemi, Marta Bondanelli, Riccardo Vigneri, Ettore C degli Uberti, Vincenzo Pezzin. High prevalence of differentiated thyroid carcinoma in acromegaly. Clinical endocrinology. vol 63. issue 2. 2005-11-01. PMID:16060909. |
acromegaly is a chronic disease caused by increased gh secretion and associated with a greater risk of developing both benign and malignant tumours. |
2005-11-01 |
2023-08-12 |
human |
| Marta Bondanelli, Stefania Bonadonna, Maria Rosaria Ambrosio, Mauro Doga, Monica Gola, Alessandro Onofri, Maria Chiara Zatelli, Andrea Giustina, Ettore C degli Ubert. Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism. Metabolism: clinical and experimental. vol 54. issue 9. 2005-11-01. PMID:16125529. |
chronic growth hormone (gh)/insulin-like growth factor i (igf-i) excess is associated with considerable mortality in acromegaly, but no data are available in pituitary gigantism. |
2005-11-01 |
2023-08-12 |
human |
| Marta Bondanelli, Stefania Bonadonna, Maria Rosaria Ambrosio, Mauro Doga, Monica Gola, Alessandro Onofri, Maria Chiara Zatelli, Andrea Giustina, Ettore C degli Ubert. Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism. Metabolism: clinical and experimental. vol 54. issue 9. 2005-11-01. PMID:16125529. |
six adult male patients with newly diagnosed gigantism due to gh secreting pituitary adenoma were studied and compared with 6 age- and sex-matched patients with acromegaly and 10 healthy subjects. |
2005-11-01 |
2023-08-12 |
human |
| Marta Bondanelli, Stefania Bonadonna, Maria Rosaria Ambrosio, Mauro Doga, Monica Gola, Alessandro Onofri, Maria Chiara Zatelli, Andrea Giustina, Ettore C degli Ubert. Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism. Metabolism: clinical and experimental. vol 54. issue 9. 2005-11-01. PMID:16125529. |
disease duration was significantly longer (p<.05) in patients with gigantism than in patients with acromegaly, whereas gh and igf-i concentrations were comparable. |
2005-11-01 |
2023-08-12 |
human |
| Marta Bondanelli, Stefania Bonadonna, Maria Rosaria Ambrosio, Mauro Doga, Monica Gola, Alessandro Onofri, Maria Chiara Zatelli, Andrea Giustina, Ettore C degli Ubert. Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism. Metabolism: clinical and experimental. vol 54. issue 9. 2005-11-01. PMID:16125529. |
in conclusion, our data suggest that gh/igf-i excess in young adult patients is associated with morphologic and functional cardiac abnormalities that are similar in patients with gigantism and in patients with acromegaly, whereas occurrence of impaired glucose metabolism appears to be higher in patients with acromegaly, although patients with gigantism are exposed to gh excess for a longer period. |
2005-11-01 |
2023-08-12 |
human |
| Ariel L Barka. Biochemical markers of acromegaly: GH vs. IGF-I. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 14 Suppl A. 2005-10-18. PMID:15135787. |
biochemical markers of acromegaly: gh vs. igf-i. |
2005-10-18 |
2023-08-12 |
Not clear |
| Ariel L Barka. Biochemical markers of acromegaly: GH vs. IGF-I. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 14 Suppl A. 2005-10-18. PMID:15135787. |
the development of sensitive and specific growth hormone (gh) and insulin-like growth factor i (igf-i) assays opened a new page in the diagnosis and surveillance of acromegaly. |
2005-10-18 |
2023-08-12 |
Not clear |