| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Kamenicky, Christine Dos Santos, Consuelo Espinosa, Sylvie Salenave, Françoise Galland, Yves Le Bouc, Patrick Maison, Pierre Bougnères, Philippe Chanso. D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly. European journal of endocrinology. vol 161. issue 2. 2009-08-12. PMID:19439509. |
a discrepancy between serum gh and igf1 concentrations is frequent in patients with acromegaly. |
2009-08-12 |
2023-08-12 |
Not clear |
| Peter Kamenicky, Christine Dos Santos, Consuelo Espinosa, Sylvie Salenave, Françoise Galland, Yves Le Bouc, Patrick Maison, Pierre Bougnères, Philippe Chanso. D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly. European journal of endocrinology. vol 161. issue 2. 2009-08-12. PMID:19439509. |
here, we examined whether the exon 3-deleted (d3) gh receptor (ghr) variant, which has been linked to increased responsiveness to gh treatment in short children, influences the gh/igf1 relationship in patients with acromegaly. |
2009-08-12 |
2023-08-12 |
Not clear |
| Tamara Wexler, Lindsay Gunnell, Zehra Omer, Karen Kuhlthau, Catherine Beauregard, Gwenda Graham, Andrea L Utz, Beverly Biller, Lisa Nachtigall, Jay Loeffler, Brooke Swearingen, Anne Klibanski, Karen K Mille. Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly. The Journal of clinical endocrinology and metabolism. vol 94. issue 7. 2009-08-06. PMID:19366847. |
however, it is unknown whether patients with ghd after treatment for acromegaly have a poorer quality of life than those with normal gh levels after cure of acromegaly. |
2009-08-06 |
2023-08-12 |
Not clear |
| N R Biermasz, M J E Wassenaar, A A van der Klaauw, A M Pereira, J W A Smit, F Roelfsema, R Wolterbeek, H M Kroon, M Kloppenburg, J A Romij. Pretreatment insulin-like growth factor-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease. The Journal of clinical endocrinology and metabolism. vol 94. issue 7. 2009-08-06. PMID:19366851. |
the aim of the study was to identify factors influencing the development of osteoarthritis during long-term control of acromegaly, focusing on disease-specific parameters, gh and igf-i concentrations, and duration of disease, adjusted for the well-known determinants of primary osteoarthritis. |
2009-08-06 |
2023-08-12 |
Not clear |
| Sven Gläser, Nele Friedrich, Ralf Ewert, Christoph Schäper, Matthias Nauck, Marcus Dörr, Henry Völzke, Stephan B Felix, Alexander Krebs, Henri Wallaschofski, Beate Koc. Association between serum insulin-like growth factor (IGF) I and IGF binding protein-3 and lung function. The Journal of clinical endocrinology and metabolism. vol 94. issue 7. 2009-08-06. PMID:19401363. |
there is strong evidence that igf-i and igf binding protein 3 (igfbp-3), as central mediators of endocrine and finally metabolic or anabolic effects of gh, were associated with increased lung size in acromegaly or a decrease of respiratory muscle pressures in patients with gh deficiency. |
2009-08-06 |
2023-08-12 |
Not clear |
| Magdalene Andries, Dorte Glintborg, Annette Kvistborg, Claus Hagen, Marianne Anderse. A 12-month randomized crossover study on the effects of lanreotide Autogel and octreotide long-acting repeatable on GH and IGF-l in patients with acromegaly. Clinical endocrinology. vol 68. issue 3. 2009-07-30. PMID:17941902. |
a 12-month randomized crossover study on the effects of lanreotide autogel and octreotide long-acting repeatable on gh and igf-l in patients with acromegaly. |
2009-07-30 |
2023-08-12 |
Not clear |
| Eugenia Resmini, Francesco Minuto, Annamaria Colao, Diego Feron. Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities. Acta diabetologica. vol 46. issue 2. 2009-07-29. PMID:19322513. |
the prevalence of diabetes mellitus and that of igt in acromegaly is reported to range 16-56%, whereas the degree of glucose tolerance seems correlated with circulating growth hormone (gh) levels, age, and disease duration. |
2009-07-29 |
2023-08-12 |
Not clear |
| Eugenia Resmini, Francesco Minuto, Annamaria Colao, Diego Feron. Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities. Acta diabetologica. vol 46. issue 2. 2009-07-29. PMID:19322513. |
however, in acromegaly, increased igf-i levels are unable to counteract the insulin-resistance status determined by gh excess. |
2009-07-29 |
2023-08-12 |
Not clear |
| b' Maria Luisa Granada, Angels Ulied, Felipe F Casanueva, Antonio Pico, Tomas Lucas, Elena Torres, Anna Sanmart\\xc3\\xa. Serum IGF-I measured by four different immunoassays in patients with adult GH deficiency or acromegaly and in a control population. Clinical endocrinology. vol 68. issue 6. 2009-07-23. PMID:17980002.' |
serum igf-i measured by four different immunoassays in patients with adult gh deficiency or acromegaly and in a control population. |
2009-07-23 |
2023-08-12 |
Not clear |
| Alexander A L Jorge, Ivo J P Arnhol. Growth hormone receptor exon 3 isoforms and their implication in growth disorders and treatment. Hormone research. vol 71 Suppl 2. 2009-07-23. PMID:19407498. |
studies that evaluated response to gh treatment determined by these two ghr isoforms in children with gh deficiency, girls with turner syndrome, children born small for gestational age and patients with acromegaly showed that patients carrying the ghrd3 allele demonstrated a greater gh sensitivity than patients homozygous for the ghrfl allele. |
2009-07-23 |
2023-08-12 |
human |
| A Lania, G Mantovani, A Spad. Genetic abnormalities of somatostatin receptors in pituitary tumors. Molecular and cellular endocrinology. vol 286. issue 1-2. 2009-07-17. PMID:17913341. |
as far as polymorphic variants of sst genes are concerned, a possible role of sst5 c1004t and t-461c alleles in influencing gh and igf-i levels in patients with acromegaly has been proposed. |
2009-07-17 |
2023-08-12 |
human |
| Herbert A Schmi. Pasireotide (SOM230): development, mechanism of action and potential applications. Molecular and cellular endocrinology. vol 286. issue 1-2. 2009-07-17. PMID:17977644. |
pasireotide potently suppresses gh, igf-i and acth secretion, indicating potential efficacy in acromegaly and cushing's disease. |
2009-07-17 |
2023-08-12 |
Not clear |
| A Saveanu, P Jaquet, T Brue, A Barlie. Relevance of coexpression of somatostatin and dopamine D2 receptors in pituitary adenomas. Molecular and cellular endocrinology. vol 286. issue 1-2. 2009-07-17. PMID:18241980. |
d2dr and sst2 agonist cotreatment showed limited additivity on gh secretion in acromegaly. |
2009-07-17 |
2023-08-12 |
Not clear |
| Fabio Broglio, Silvia Grottoli, Emanuela Arvat, Ezio Ghig. Endocrine actions of cortistatin: in vivo studies. Molecular and cellular endocrinology. vol 286. issue 1-2. 2009-07-17. PMID:18281148. |
inhibition of gh and insulin secretion in physiological conditions and in acromegaly. |
2009-07-17 |
2023-08-12 |
Not clear |
| F Tanriverdi, H Yapislar, Z Karaca, K Unluhizarci, C Suer, F Kelestimu. Evaluation of cognitive performance by using P300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 19. issue 1. 2009-07-10. PMID:18567522. |
evaluation of cognitive performance by using p300 auditory event related potentials (erps) in patients with growth hormone (gh) deficiency and acromegaly. |
2009-07-10 |
2023-08-12 |
Not clear |
| F Tanriverdi, H Yapislar, Z Karaca, K Unluhizarci, C Suer, F Kelestimu. Evaluation of cognitive performance by using P300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 19. issue 1. 2009-07-10. PMID:18567522. |
impaired cognitive performance has been demonstrated in adults with gh deficiency and acromegaly by using different neuropsychological tests. |
2009-07-10 |
2023-08-12 |
Not clear |
| Antonio Bianchi, Andrea Giustina, Vincenzo Cimino, Roberto Pola, Flavia Angelini, Alfredo Pontecorvi, Laura De Marini. Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly. The Journal of clinical endocrinology and metabolism. vol 94. issue 6. 2009-07-02. PMID:19336510. |
in acromegaly, a discrepancy between what are defined as "normal" levels of gh and igf-i for every given patient is observed in up to 35% of subjects at diagnosis and during the follow-up. |
2009-07-02 |
2023-08-12 |
human |
| Monica Gola, Mauro Doga, Stefania Bonadonna, Gherardo Mazziotti, Pier Paolo Vescovi, Andrea Giustin. Neuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects. Pituitary. vol 9. issue 3. 2009-06-11. PMID:17036195. |
excessive peripheral production of ghrh by a tumor source would therefore be expected to cause somatotroph cell hyperstimulation, increased gh secretion and eventually pituitary acromegaly. |
2009-06-11 |
2023-08-12 |
Not clear |
| Monica Gola, Mauro Doga, Stefania Bonadonna, Gherardo Mazziotti, Pier Paolo Vescovi, Andrea Giustin. Neuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects. Pituitary. vol 9. issue 3. 2009-06-11. PMID:17036195. |
regardless of the cause, gh and igf-1 are invariably elevated and gh levels fail to suppress (<1 microg/l) after an oral glucose load in all forms of acromegaly. |
2009-06-11 |
2023-08-12 |
Not clear |
| Massimo Scacchi, Francesco Cavagnin. Acromegaly. Pituitary. vol 9. issue 4. 2009-06-11. PMID:17077948. |
a random gh level lower than 0.4 microg/l and an igf-i value in the age- and sex-matched normal range makes the diagnosis of acromegaly unlikely. |
2009-06-11 |
2023-08-12 |
Not clear |