| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Trouillas, C Girod, M Lhéritier, B Claustrat, M P Duboi. Morphological and biochemical relationships in 31 human pituitary adenomas with acromegaly. Virchows Archiv. A, Pathological anatomy and histology. vol 389. issue 2. 1981-03-24. PMID:7456323. |
in 22 pure gh cell adenomas and 9 mixed gh cell-prolactin cell adenomas with acromegaly, we compare the morphological and functional data (secretory activity and granular appearance) with gh levels (radioimmunoassays) in the blood and in the tumor. |
1981-03-24 |
2023-08-12 |
human |
| R Luboshitzky, D Barzila. Bromocriptine for an acromegalic patient. Improvement in cardiac function and carpal tunnel syndrome. JAMA. vol 244. issue 16. 1980-12-18. PMID:7420685. |
bromocriptine may correct cardiac dysfunction and carpal tunnel syndrome in acromegaly either by reduction of gh oversecretion or by a direct effect of bromocriptine on dopamine receptors in the heart and peripheral nerve endings. |
1980-12-18 |
2023-08-12 |
Not clear |
| S A Leveston, P E Crye. Endogenous cholinergic modulation of growth-hormone secretion in normal and acromegalic humans. Metabolism: clinical and experimental. vol 29. issue 8. 1980-10-27. PMID:7402075. |
the theoretical possibility that excessive endogenous cholinergic activity might be involved in the pathophysiologic regulation of gh secretion in acromegaly was not, however, supported, since methscopolamine (0.5 mg s.c.), a cholinergic antagonist, did not reduce mean serum gh levels in 3 acromegalic patients. |
1980-10-27 |
2023-08-12 |
human |
| F Manesch. Reappraisal of bromocriptine treatment for acromegaly. Hormone research. vol 12. issue 4. 1980-09-28. PMID:7390405. |
bromocriptine normalises radioimmunoassayble gh levels in a percentage of patients (12%) which is less than those following conventional treatment of acromegaly, surgery (80%) and pituitary irradiation (70%). |
1980-09-28 |
2023-08-12 |
Not clear |
| M Anniko, J Wersäl. Human pituitary tumours in organ culture with correlation to clinical data. Acta oto-laryngologica. vol 89. issue 3-4. 1980-09-28. PMID:7395496. |
the higher the gh concentration was in vitro, the more active was the degree of acromegaly found clinically. |
1980-09-28 |
2023-08-12 |
human |
| R Pelkonen, R Ylikahri, S L Karone. Bomocriptine treatment of patients with acromegaly resistant to conventional therapy. Clinical endocrinology. vol 12. issue 3. 1980-09-26. PMID:6993053. |
eleven patients with active acromegaly resistant to conventional therapy were treated with bromocriptine for 15 (12--22) months by increasing the daily dose stepwise from 5 to 10--60 mg. a satisfactory response was achieved in all but one of the eight patients, in whom the mean diurnal level of serum gh was less than 50 ng/ml, whereas patients with grossly elevated serum gh levels responded poorly. |
1980-09-26 |
2023-08-12 |
Not clear |
| M Trovati, F Massara, F Camanni, G M Molinatti, R Lorenzati, G F Pagan. Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics. Journal of endocrinological investigation. vol 3. issue 2. 1980-09-23. PMID:6104680. |
our data suggest that this somatostatin analog may be potentially useful only when gh suppression is the main therapeutic goal to be reached, as in acromegaly and in severe diabetic retinopathy, but not in metabolic control of mild diabetic patients with a good residual insulin secretion. |
1980-09-23 |
2023-08-12 |
Not clear |
| E E Müller, F Salerno, D Cocchi, V Locatelli, A E Panera. Interaction between the thyrotrophin-releasing hormone-induced growth hormone rise and dopaminergic drugs: studies in pathologic conditions of the animal and man. Clinical endocrinology. vol 11. issue 6. 1980-05-14. PMID:119594. |
we have investigated the gh response to dopaminergic stimuli in two conditions of animals and man, which, like acromegaly, are characterized by a trh-induced gh rise, i.e. |
1980-05-14 |
2023-08-11 |
human |
| E E Müller, F Salerno, D Cocchi, V Locatelli, A E Panera. Interaction between the thyrotrophin-releasing hormone-induced growth hormone rise and dopaminergic drugs: studies in pathologic conditions of the animal and man. Clinical endocrinology. vol 11. issue 6. 1980-05-14. PMID:119594. |
instead, the paradoxical fall of gh after dopaminergic drugs appears to be a prerequisite of acromegaly and may be attributable to receptors for da located on the tumorous tissue. |
1980-05-14 |
2023-08-11 |
human |
| L A Frohman, M Szabo, M Berelowitz, M E Stachur. Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly. The Journal of clinical investigation. vol 65. issue 1. 1980-02-26. PMID:6243140. |
growth hormone (gh)-releasing activity has been detected in extracts of carcinoid and pancreatic islet tumors from three patients with gh-secreting pituitary tumors and acromegaly. |
1980-02-26 |
2023-08-12 |
rat |
| R M Bala, B Bhaumic. Radioimmunoassay of a basic somatomedin: comparison of various assay techniques and somatomedin levels in various sera. The Journal of clinical endocrinology and metabolism. vol 49. issue 5. 1979-12-29. PMID:39945. |
the mean (+/- sem) irsm concentrations in sera from normals and patients with acromegaly, hypopituitarism, gh deficiency before/after treatment, and laron dwarfism were 1.45 +/- 0.17, 5.49 +/- 0.48, 0.19 +/- 0.07, 0.10 +/- 0.02/0.64 +/- 0.45, and 0.25 +/- 0.11 u/ml, respectively, compared to a pooled normal human serum reference standard which was designated to contain 1 irsm u/ml. |
1979-12-29 |
2023-08-11 |
human |
| b' E Carmina, R Lo Coco, P Lanzara, A Jann\\xc3\\xa. Effect of the acute administration of haloperidol and pimozide on plasma GH levels in acromegaly. Acta endocrinologica. vol 91. issue 4. 1979-12-27. PMID:115193.' |
effect of the acute administration of haloperidol and pimozide on plasma gh levels in acromegaly. |
1979-12-27 |
2023-08-11 |
Not clear |
| F Roelfsema, B M Goslings, M Frölich, A J Moolenaar, A P Seters, H Van Sloote. The influence of bromocriptine on serum levels of growth hormone and other pituitary hormones and its metabolic effects in active acromegaly. Clinical endocrinology. vol 11. issue 2. 1979-12-20. PMID:114344. |
the effect of treatment with bromocriptine for 12--18 months on serum gh and metabolic responses was studied in sixteen patients with active acromegaly. |
1979-12-20 |
2023-08-11 |
Not clear |
| R C Eastman, P Gorden, J Rot. Conventional supervoltage irradiation is an effective treatment for acromegaly. The Journal of clinical endocrinology and metabolism. vol 48. issue 6. 1979-08-29. PMID:447799. |
conventional super-voltage irradiation by 5-10 yr produces the same fall in plasma gh as all other forms of treatment for acromegaly, including transphenoidal microsurgery. |
1979-08-29 |
2023-08-11 |
Not clear |
| C Mazzi, R Montanini, L P Riv. [Action of trazodone on the secretion of pituitary hormones. Behavior of prolactin and somatotropin]. Minerva medica. vol 70. issue 13. 1979-07-16. PMID:571582. |
trazpdone on prl and gh was studied in normal subjects and in patients with hypophyseal adenoma coupled with amenorrhoea and galactorrhoea or acromegaly. |
1979-07-16 |
2023-08-11 |
human |
| K Hall, J Brandt, G Enberg, L Fryklun. Immunoreactive somatomedin A in human serum. The Journal of clinical endocrinology and metabolism. vol 48. issue 2. 1979-06-26. PMID:218985. |
in comparison with a serum standard, the mean serum levels in patients with acromegaly or gh deficiency and healthy subjects were 8.7 %/- 0.7 (n = 25), 0.24 +/- 0.02 (n = 25), and 1.15 +/- 0.11 u/ml, respectively. |
1979-06-26 |
2023-08-11 |
human |
| A R Glass, M Schaaf, R C Dimon. Absent growth hormone response to L-tryptophan in acromegaly. The Journal of clinical endocrinology and metabolism. vol 48. issue 4. 1979-06-26. PMID:429511. |
in acromegaly, regulation of gh secretion by dopamine pathways appears to be qualitatively abnormal. |
1979-06-26 |
2023-08-11 |
human |
| A R Glass, M Schaaf, R C Dimon. Absent growth hormone response to L-tryptophan in acromegaly. The Journal of clinical endocrinology and metabolism. vol 48. issue 4. 1979-06-26. PMID:429511. |
to determine whether regulation of gh secretion by serotonin pathways is also abnormal in acromegaly, we administered l-tryptophan (5 g orally), the initial precursor of serotonin, to 10 patients with active acromegaly (9 treated and 1 untreated), 3 patients with cured acromegaly, and 8 normal subjects. |
1979-06-26 |
2023-08-11 |
human |
| A R Glass, M Schaaf, R C Dimon. Absent growth hormone response to L-tryptophan in acromegaly. The Journal of clinical endocrinology and metabolism. vol 48. issue 4. 1979-06-26. PMID:429511. |
in contrast, subjects with active acromegaly did not show an increase in serum gh after l-tryptophan [mean integrated percentage change in serum gh, -25 +/- 25% (se); p = ns]. |
1979-06-26 |
2023-08-11 |
human |
| A R Glass, M Schaaf, R C Dimon. Absent growth hormone response to L-tryptophan in acromegaly. The Journal of clinical endocrinology and metabolism. vol 48. issue 4. 1979-06-26. PMID:429511. |
one patient whose acromegaly had been surgically cured did show a gh rise after l-tryptophan. |
1979-06-26 |
2023-08-11 |
human |