| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fred Williams, Steven Hunter, Lisa Bradley, Harvinder S Chahal, Helen L Storr, Scott A Akker, Ajith V Kumar, Stephen M Orme, Jane Evanson, Noina Abid, Patrick J Morrison, Márta Korbonits, A Brew Atkinso. Clinical experience in the screening and management of a large kindred with familial isolated pituitary adenoma due to an aryl hydrocarbon receptor interacting protein (AIP) mutation. The Journal of clinical endocrinology and metabolism. vol 99. issue 4. 2014-06-03. PMID:24423289. |
germline aip mutations usually cause young-onset acromegaly with low penetrance in a subset of familial isolated pituitary adenoma families. |
2014-06-03 |
2023-08-12 |
Not clear |
| H Nishizawa, H Fukuoka, G Iguchi, N Inoshita, S Yamada, Y Takahash. AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 121. issue 5. 2013-12-31. PMID:23674160. |
aip mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. |
2013-12-31 |
2023-08-12 |
Not clear |
| H Nishizawa, H Fukuoka, G Iguchi, N Inoshita, S Yamada, Y Takahash. AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 121. issue 5. 2013-12-31. PMID:23674160. |
the clinical characteristics of acromegaly associated with aip mutations are reportedly macroadenomas with tumor extension and invasion, lower decreases in gh and igf-i and less tumor shrinkage with ssa treatment, and sparsely granulated somatotroph cell type, which are comparable with those observed in panch. |
2013-12-31 |
2023-08-12 |
Not clear |
| Rhodri M L Morgan, Laura C Hernández-Ramírez, Giampaolo Trivellin, Lihong Zhou, S Mark Roe, Márta Korbonits, Chrisostomos Prodromo. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300914. |
mutations of the aryl hydrocarbon receptor interacting protein (aip) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. |
2013-06-24 |
2023-08-12 |
Not clear |
| Federica Guaraldi, Valentina Corazzini, Gary L Gallia, Silvia Grottoli, Karen Stals, Nadezhda Dalantaeva, Lawrence A Frohman, Márta Korbonits, Roberto Salvator. Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. Pituitary. vol 15 Suppl 1. 2013-05-07. PMID:22527616. |
we present the case of a patient who was diagnosed with acromegaly due to the aip mutation c.241c>t (p.r81x) at the age of 34 years, and treated by transsphenoidal surgery. |
2013-05-07 |
2023-08-12 |
Not clear |
| Carmen Fajardo-Montañana, Adrian F Daly, Pedro Riesgo-Suárez, José Gómez-Vela, María A Tichomirowa, Rosa Camara-Gómez, Albert Becker. [AIP mutations in familial and sporadic pituitary adenomas: local experience and review of the literature]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. vol 56. issue 7. 2010-03-04. PMID:19883897. |
mutations of the gene aip (aryl hydrocarbon receptor-interacting protein) may account for 15% of fipa families (50% of familial acromegaly), and as such the genetic causes continue to be studied. |
2010-03-04 |
2023-08-12 |
Not clear |
| Rebecca DiGiovanni, Stefano Serra, Shereen Ezzat, Sylvia L As. AIP Mutations are not identified in patients with sporadic pituitary adenomas. Endocrine pathology. vol 18. issue 2. 2008-03-25. PMID:17916996. |
recently, mutations in the aryl hydrocarbon receptor-interacting protein (aip) were identified as germline events leading to pituitary tumor predisposition in finnish and italian families with familial growth hormone-secreting pituitary adenomas and acromegaly. |
2008-03-25 |
2023-08-12 |
human |
| Sosipatros A Boikos, Constantine A Strataki. Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis. Human molecular genetics. vol 16 Spec No 1. 2007-11-08. PMID:17613552. |
the genetic causes of common pituitary tumors remain for the most part unknown; progress has been limited to the elucidation of the molecular etiology of four genetic syndromes predisposing to pituitary neoplasias: mccune-albright syndrome, multiple endocrine neoplasia type 1, carney complex and, most recently, familial acromegaly and prolactinomas and other tumors caused by mutations in the gnas, menin, prkar1a, aip, and p27 (cdkn1b) genes, respectively. |
2007-11-08 |
2023-08-12 |
human |
| Marianthi Georgitsi, Anniina Raitila, Auli Karhu, Karoliina Tuppurainen, Markus J Mäkinen, Outi Vierimaa, Ralf Paschke, Wolfgang Saeger, Rob B van der Luijt, Timo Sane, Mercedes Robledo, Ernesto De Menis, Robert J Weil, Anna Wasik, Grzegorz Zielinski, Olga Lucewicz, Jan Lubinski, Virpi Launonen, Pia Vahteristo, Lauri A Aaltone. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 10. 2007-04-24. PMID:17360484. |
a total of 460 patients were investigated by aip sequencing: young acromegaly patients, unselected acromegaly patients, unselected pituitary adenoma patients, and endocrine neoplasia-predisposition patients who were negative for men1 mutations. |
2007-04-24 |
2023-08-12 |
Not clear |