| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan M Meyer, Ken Kramer, Scott Vuocolo, Inder Kaul, Andrew C Mille. From Theory to Therapy: Unlocking the Potential of Muscarinic Receptor Activation in Schizophrenia With the Dual M1/M4 Muscarinic Receptor Agonist Xanomeline and Trospium Chloride and Insights From Clinical Trials. The international journal of neuropsychopharmacology. 2025-03-08. PMID:40056428. |
this has prompted the search for novel mechanisms with improved efficacy and tolerability based on evidence supporting involvement of other neurotransmitter systems in schizophrenia pathophysiology, including acetylcholine, gamma-aminobutyric acid, and glutamate. |
2025-03-08 |
2025-03-11 |
Not clear |
| Panshi Liu, Donghui Song, Xinping Deng, Yuanqi Shang, Qiu Ge, Ze Wang, Hui Zhan. The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN). Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025-03-06. PMID:40050146. |
subthreshold itbs led to changes in the baseline coupling between ben and several neurotransmitter receptor/transporter maps, primarily involving serotonin (5-ht), cannabinoid (cb), acetylcholine (ach), and glutamate (glu). |
2025-03-06 |
2025-03-09 |
human |
| Isabella Berardelli, Elena Rogante, Federico Formica, Riccardo Iannazzo, Attilio Valerio Mammoliti, Raffaele Riccioni, Skender Veizi, Roger S McIntyre, Maurizio Pompil. The efficacy of vortioxetine in the acute treatment of major depressive disorder: A systematic review and meta-analysis. Journal of psychopharmacology (Oxford, England). 2025-02-01. PMID:39891526. |
among the available pharmacological treatments for acute major depressive disorder (mdd), vortioxetine, a serotonin transporter inhibitor (sert), has been widely used for its multimodal action on serotonin neurotransmission, which produces essential changes also on glutamate, gamma amino butyric acid (gaba), norepinephrine, acetylcholine, and dopamine. |
2025-02-01 |
2025-02-04 |
Not clear |
| Ankur Gaur, Yash Pal Singh, Rajiv Sharma, Neeraj Bainsa. Deoxyvasicinone hybrids in the management of Alzheimer's disease: Recent advances on manmade derivatives, pharmacological activities, and structure-activity relationship. Archiv der Pharmazie. vol 358. issue 1. 2024-12-28. PMID:39731272. |
although the exact pathophysiological causes of ad remain unclear, its pathogenesis is primarily driven by several distinct biochemical alterations: (i) the accumulation of toxic aβ plaques, (ii) the hyperphosphorylation of tau proteins, (iii) oxidative stress resulting in cell death, and (iv) an imbalance between the two main neurotransmitters, glutamate and acetylcholine (ach). |
2024-12-28 |
2024-12-30 |
Not clear |
| Judy Cheng, Ellen T Koch, Daniel Ramandi, James P Mackay, Timothy P O'Leary, William Rees-Jones, Lynn A Raymon. Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease. Neurobiology of disease. 2024-12-24. PMID:39716682. |
d2 receptors are also expressed on glutamatergic cortical terminals, cholinergic interneurons, and dopaminergic terminals from substantia nigra where they suppress release of glutamate, acetylcholine and dopamine, respectively, and these cell types may contribute to early striatal dysfunction in hd. |
2024-12-24 |
2024-12-26 |
mouse |
| Siddhant Tripathi, Yashika Sharma, Dileep Kuma. Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment. Protein and peptide letters. 2024-12-24. PMID:39716791. |
memantine moderates the toxic effects of excessive glutamate activity by blocking nmda receptors, which decreases neurotoxicity in ad, while acetylcholine esterase inhibitors function by blocking cholinergic receptors (muscarinic and nicotinic), preventing the breakdown of acetylcholine, thereby enhancing cholinergic transmission, thus improving cognitive functions in mild to moderate stages of ad. |
2024-12-24 |
2024-12-26 |
Not clear |
| Zhuxiao Tang, Yahui Ye, Kaichuang Yang, Xi Guo, Xin Gao, Cheng Wu, Jingyu Wang, Deqing Pen. Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury. Journal of cellular and molecular medicine. vol 28. issue 22. 2024-11-26. PMID:39588835. |
four weeks after transplantation, the expression of neuron-specific enolase (nse) in rat anti-human nuclear monoclonal antibody (mab1281)-positive cells was detected by immunostaining in spinal cord tissue sections of the two groups to assess the differentiation of cbmmsc to neuron-like cells in the nerve conduits after transplantation; the number of brdu-positive cells was detected to assess the neuronal regeneration of the localized spinal cord injury of the two groups; and the length of axons was observed with laser confocal photography was used to observe the length of axons; he staining was used to observe the scarring and cavities in the spinal cord sections of the two groups; immunofluorescence was used to detect neuron-like markers (nestin, nse, nf200, gfap) in the two groups, and the od values were determined by the image processing and analysis system (ipaas); and western blot was used to detect the neurotransmitters of motor fibres, acetylcholinesterase (chat), sensory fibres, and sensory fibres, as well as the neurotransmission of motor fibres, acetylcholine production-limiting enzyme (chat) and sensory fibre neurotransmitter glutamate synthase (gogat); motor function was assessed by bbb score; somatosensory evoked potentials (seps) and motor evoked potentials (meps) were detected by body surface electrode assay in the two groups, and the neurophysiological recovery effect was evaluated. |
2024-11-26 |
2024-11-28 |
rat |
| Dmitriy A Lanshakov, Ekaterina V Sukhareva, Veta V Bulygina, Anna A Khozyainova, Tatiana S Gerashchenko, Evgeny V Denisov, Tatyana S Kalinin. Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN). Scientific reports. vol 14. issue 1. 2024-09-19. PMID:39300279. |
we detected a massive shift in neuropeptide crh, trh,cga, tshb, uts2b, tac4, lep and neuropeptide receptor hcrtr1, sstr5, bdkrb2, crhr2 signaling, as well as glutamate grin3b, grm2 and gaba gpr156, acetylcholine chrm4,chrne, adrenergic adra2b receptors expression. |
2024-09-19 |
2024-09-22 |
rat |
| Tamás Körtési, Gábor Nagy-Grócz, László Vécse. The role of kynurenines in migraine-related neuroimmune pathways. The journal of headache and pain. vol 25. issue 1. 2024-08-07. PMID:39107712. |
the kynurenine system is collectively known as the kynurenine pathway (kp), which can act on multiple receptors, such as glutamate receptors, aryl hydrocarbon receptors (ahrs), g protein-coupled receptors 35 (gpr35), and α-7 nicotinic acetylcholine (α7 nach) receptors. |
2024-08-07 |
2024-08-09 |
Not clear |
| Ahmed Nebli, Christian Schiffer, Meiqi Niu, Nicola Palomero-Gallagher, Katrin Amunts, Timo Dickschei. Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain. Neuroinformatics. 2024-07-08. PMID:38976151. |
specifically, we utilize conditional generative adversarial networks (cgans) to predict the density distributions of the m2 receptor of acetylcholine and the kainate receptor for glutamate in the macaque monkey's primary visual (v1) and motor cortex (m1), based on light microscopic scans of cell-body stained sections. |
2024-07-08 |
2024-07-11 |
human |
| Gandhi Rádis-Baptista, Katsuhiro Konn. Spider and Wasp Acylpolyamines: Venom Components and Versatile Pharmacological Leads, Probes, and Insecticidal Agents. Toxins. vol 16. issue 6. 2024-06-26. PMID:38922129. |
acylpolyamines are venom components exclusively from spiders and a species of solitary wasp, which cause inhibition chiefly of iono-tropic glutamate receptors (ampa, nmda, and ka iglurs) and nicotinic acetylcholine receptors (nachrs). |
2024-06-26 |
2024-06-29 |
human |
| Daniela L Uliana, Joao Roberto F Lisboa, Felipe V Gomes, Anthony A Grac. The excitatory-inhibitory balance as a target for the development of novel drugs to treat schizophrenia. Biochemical pharmacology. 2024-05-23. PMID:38782077. |
compounds targeting the glycine site at glutamate nmda receptors and muscarinic acetylcholine receptors on pv interneurons that can increase pv interneuron drive, as well as drugs that increase the postsynaptic action of gaba, such as positive allosteric modulators of α5-gaba-a receptors, and decrease glutamatergic output, such as mglur2/3 agonists, represent promising approaches. |
2024-05-23 |
2024-05-27 |
Not clear |
| Gao-Lin Qiu, Li-Jun Peng, Peng Wang, Zhi-Lai Yang, Ji-Qian Zhang, Hu Liu, Xiao-Na Zhu, Jin Rao, Xue-Sheng Li. Zoological research. vol 45. issue 3. 2024-05-20. PMID:38766749. |
here, we measured the dynamics of five neurotransmitters, including γ-aminobutyric acid, glutamate, norepinephrine, acetylcholine, and dopamine, in the medial prefrontal cortex and primary visual cortex of c57bl/6 mice through |
2024-05-20 |
2024-05-27 |
mouse |
| Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R Harrington, Claude M Wischik, Grażyna Niewiadomska, Gernot Riede. Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors. Brain research bulletin. 2024-04-27. PMID:38677558. |
interference of cholinesterase inhibition with hmtm was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of hmtm at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate release and mitochondrial activity. |
2024-04-27 |
2024-04-30 |
mouse |
| Alyssa D Huff, Marlusa Karlen-Amarante, Luiz M Oliveira, Jan-Marino Ramire. Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production. eLife. vol 12. 2024-04-24. PMID:38655918. |
pico is characterized by interneurons co-expressing transporters for glutamate (vglut2) and acetylcholine (chat). |
2024-04-24 |
2024-04-28 |
mouse |
| Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zha. New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists. Neuropsychiatric disease and treatment. vol 20. 2024-03-25. PMID:38525480. |
according to recent research, several receptors, including 5-hydroxytryptamine, glutamate, γ-aminobutyric acid, acetylcholine receptors and norepinephrine, play a role in the development of schizophrenia. |
2024-03-25 |
2024-03-27 |
Not clear |
| Daisuke Tsuboi, Taku Nagai, Junichiro Yoshimoto, Kozo Kaibuch. Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling. Frontiers in molecular neuroscience. vol 17. 2024-03-22. PMID:38516040. |
neuromodulators such as dopamine and acetylcholine control cognition and emotion by regulating the excitatory/inhibitory balance initiated by glutamate and gaba. |
2024-03-22 |
2024-03-24 |
Not clear |
| Linhong Jiang, Zhenyang Yu, Yanbin Zhao, Daqiang Yi. Obesogenic potentials of environmental artificial sweeteners with disturbances on both lipid metabolism and neural responses. The Science of the total environment. 2024-02-10. PMID:38340820. |
moreover, they also interfered neurotransmitters including serotonin (5-ht), dopamine (da) and acetylcholine (ach), with influences in gsα (e.g., via expressions of gsα-1, ser-7), glutamate (e.g., mgl-1), and cgmp-dependent signaling pathways (e.g., egl-4). |
2024-02-10 |
2024-02-14 |
caenorhabditis_elegans |
| b' Milo\\xc5\\xa1 Markovi\\xc4\\x87, Nata\\xc5\\xa1a Petronijevi\\xc4\\x87, Milena Sta\\xc5\\xa1evi\\xc4\\x87, Ivana Sta\\xc5\\xa1evi\\xc4\\x87 Karli\\xc4\\x8di\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Slavica Risti\\xc4\\x87, Mina Stojkovi\\xc4\\x87, Nata\\xc5\\xa1a Mili\\xc4\\x87, Tatjana Nikoli\\xc4\\x8. Decreased Plasma Levels of Kynurenine and Kynurenic Acid in Previously Treated and First-Episode Antipsychotic-Naive Schizophrenia Patients. Cells. vol 12. issue 24. 2023-12-22. PMID:38132134.' |
tryptophan (trp) catabolites exert neuroactive effects, with the plethora of evidence suggesting that kynurenic acid (kyna), a catabolite of the kynurenine pathway (kp), acts as the regulator of glutamate and acetylcholine in the brain, contributing to the schizophrenia pathophysiology. |
2023-12-22 |
2023-12-24 |
Not clear |
| Alyssa Huff, Marlusa Karlen-Amarante, Luiz Marcelo Oliveira, Jan Marino Ramire. Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in swallow pattern generation. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808787. |
pico is characterized by interneurons co-expressing transporters for glutamate (vglut2) and acetylcholine (chat). |
2023-10-09 |
2023-10-15 |
mouse |