| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitriy A Lanshakov, Ekaterina V Sukhareva, Veta V Bulygina, Anna A Khozyainova, Tatiana S Gerashchenko, Evgeny V Denisov, Tatyana S Kalinin. Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN). Scientific reports. vol 14. issue 1. 2024-09-19. PMID:39300279. |
we detected a massive shift in neuropeptide crh, trh,cga, tshb, uts2b, tac4, lep and neuropeptide receptor hcrtr1, sstr5, bdkrb2, crhr2 signaling, as well as glutamate grin3b, grm2 and gaba gpr156, acetylcholine chrm4,chrne, adrenergic adra2b receptors expression. |
2024-09-19 |
2024-09-22 |
rat |
| Tamás Körtési, Gábor Nagy-Grócz, László Vécse. The role of kynurenines in migraine-related neuroimmune pathways. The journal of headache and pain. vol 25. issue 1. 2024-08-07. PMID:39107712. |
the kynurenine system is collectively known as the kynurenine pathway (kp), which can act on multiple receptors, such as glutamate receptors, aryl hydrocarbon receptors (ahrs), g protein-coupled receptors 35 (gpr35), and α-7 nicotinic acetylcholine (α7 nach) receptors. |
2024-08-07 |
2024-08-09 |
Not clear |
| Ahmed Nebli, Christian Schiffer, Meiqi Niu, Nicola Palomero-Gallagher, Katrin Amunts, Timo Dickschei. Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain. Neuroinformatics. 2024-07-08. PMID:38976151. |
specifically, we utilize conditional generative adversarial networks (cgans) to predict the density distributions of the m2 receptor of acetylcholine and the kainate receptor for glutamate in the macaque monkey's primary visual (v1) and motor cortex (m1), based on light microscopic scans of cell-body stained sections. |
2024-07-08 |
2024-07-11 |
human |
| Gandhi Rádis-Baptista, Katsuhiro Konn. Spider and Wasp Acylpolyamines: Venom Components and Versatile Pharmacological Leads, Probes, and Insecticidal Agents. Toxins. vol 16. issue 6. 2024-06-26. PMID:38922129. |
acylpolyamines are venom components exclusively from spiders and a species of solitary wasp, which cause inhibition chiefly of iono-tropic glutamate receptors (ampa, nmda, and ka iglurs) and nicotinic acetylcholine receptors (nachrs). |
2024-06-26 |
2024-06-29 |
human |
| Daniela L Uliana, Joao Roberto F Lisboa, Felipe V Gomes, Anthony A Grac. The excitatory-inhibitory balance as a target for the development of novel drugs to treat schizophrenia. Biochemical pharmacology. 2024-05-23. PMID:38782077. |
compounds targeting the glycine site at glutamate nmda receptors and muscarinic acetylcholine receptors on pv interneurons that can increase pv interneuron drive, as well as drugs that increase the postsynaptic action of gaba, such as positive allosteric modulators of α5-gaba-a receptors, and decrease glutamatergic output, such as mglur2/3 agonists, represent promising approaches. |
2024-05-23 |
2024-05-27 |
Not clear |
| Gao-Lin Qiu, Li-Jun Peng, Peng Wang, Zhi-Lai Yang, Ji-Qian Zhang, Hu Liu, Xiao-Na Zhu, Jin Rao, Xue-Sheng Li. Zoological research. vol 45. issue 3. 2024-05-20. PMID:38766749. |
here, we measured the dynamics of five neurotransmitters, including γ-aminobutyric acid, glutamate, norepinephrine, acetylcholine, and dopamine, in the medial prefrontal cortex and primary visual cortex of c57bl/6 mice through |
2024-05-20 |
2024-05-27 |
mouse |
| Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R Harrington, Claude M Wischik, Grażyna Niewiadomska, Gernot Riede. Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors. Brain research bulletin. 2024-04-27. PMID:38677558. |
interference of cholinesterase inhibition with hmtm was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of hmtm at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate release and mitochondrial activity. |
2024-04-27 |
2024-04-30 |
mouse |
| Alyssa D Huff, Marlusa Karlen-Amarante, Luiz M Oliveira, Jan-Marino Ramire. Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production. eLife. vol 12. 2024-04-24. PMID:38655918. |
pico is characterized by interneurons co-expressing transporters for glutamate (vglut2) and acetylcholine (chat). |
2024-04-24 |
2024-04-28 |
mouse |
| Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zha. New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists. Neuropsychiatric disease and treatment. vol 20. 2024-03-25. PMID:38525480. |
according to recent research, several receptors, including 5-hydroxytryptamine, glutamate, γ-aminobutyric acid, acetylcholine receptors and norepinephrine, play a role in the development of schizophrenia. |
2024-03-25 |
2024-03-27 |
Not clear |
| Daisuke Tsuboi, Taku Nagai, Junichiro Yoshimoto, Kozo Kaibuch. Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling. Frontiers in molecular neuroscience. vol 17. 2024-03-22. PMID:38516040. |
neuromodulators such as dopamine and acetylcholine control cognition and emotion by regulating the excitatory/inhibitory balance initiated by glutamate and gaba. |
2024-03-22 |
2024-03-24 |
Not clear |
| Linhong Jiang, Zhenyang Yu, Yanbin Zhao, Daqiang Yi. Obesogenic potentials of environmental artificial sweeteners with disturbances on both lipid metabolism and neural responses. The Science of the total environment. 2024-02-10. PMID:38340820. |
moreover, they also interfered neurotransmitters including serotonin (5-ht), dopamine (da) and acetylcholine (ach), with influences in gsα (e.g., via expressions of gsα-1, ser-7), glutamate (e.g., mgl-1), and cgmp-dependent signaling pathways (e.g., egl-4). |
2024-02-10 |
2024-02-14 |
caenorhabditis_elegans |
| b' Milo\\xc5\\xa1 Markovi\\xc4\\x87, Nata\\xc5\\xa1a Petronijevi\\xc4\\x87, Milena Sta\\xc5\\xa1evi\\xc4\\x87, Ivana Sta\\xc5\\xa1evi\\xc4\\x87 Karli\\xc4\\x8di\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Slavica Risti\\xc4\\x87, Mina Stojkovi\\xc4\\x87, Nata\\xc5\\xa1a Mili\\xc4\\x87, Tatjana Nikoli\\xc4\\x8. Decreased Plasma Levels of Kynurenine and Kynurenic Acid in Previously Treated and First-Episode Antipsychotic-Naive Schizophrenia Patients. Cells. vol 12. issue 24. 2023-12-22. PMID:38132134.' |
tryptophan (trp) catabolites exert neuroactive effects, with the plethora of evidence suggesting that kynurenic acid (kyna), a catabolite of the kynurenine pathway (kp), acts as the regulator of glutamate and acetylcholine in the brain, contributing to the schizophrenia pathophysiology. |
2023-12-22 |
2023-12-24 |
Not clear |
| Alyssa Huff, Marlusa Karlen-Amarante, Luiz Marcelo Oliveira, Jan Marino Ramire. Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in swallow pattern generation. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808787. |
pico is characterized by interneurons co-expressing transporters for glutamate (vglut2) and acetylcholine (chat). |
2023-10-09 |
2023-10-15 |
mouse |
| Hany H Arab, Ahmed H Eid, Rania Yahia, Shuruq E Alsufyani, Ahmed M Ashour, Azza A K El-Sheikh, Hany W Darwish, Muhammed A Saad, Muhammad Y Al-Shorbagy, Marwa A Masou. Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats. Pharmaceuticals (Basel, Switzerland). vol 16. issue 9. 2023-09-28. PMID:37765022. |
notably, it significantly diminished hippocampal glutamate content and enhanced acetylcholine and gaba neurotransmitters. |
2023-09-28 |
2023-10-07 |
rat |
| Jessica Hotard Chancey, Christoph Kellendonk, Jonathan A Javitch, David M Lovinge. Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693570. |
acetylcholine (ach), released from cholinergic interneurons (chis), regulates striatal function by modulating msn and interneuron excitability, dopamine and glutamate release, and synaptic plasticity. |
2023-09-11 |
2023-10-07 |
mouse |
| Hany H Arab, Ahmed H Eid, Shuruq E Alsufyani, Ahmed M Ashour, Azza A K El-Sheikh, Hany W Darwish, Gehan S Georg. Neuroprotective Impact of Linagliptin against Cadmium-Induced Cognitive Impairment and Neuropathological Aberrations: Targeting SIRT1/Nrf2 Axis, Apoptosis, and Autophagy. Pharmaceuticals (Basel, Switzerland). vol 16. issue 8. 2023-08-26. PMID:37630980. |
meanwhile, it enhanced hippocampal acetylcholine and gaba and diminished the glutamate spike. |
2023-08-26 |
2023-09-07 |
rat |
| Yong Peng, Hong Jin, Ya-Hui Xue, Quan Chen, Shun-Yu Yao, Miao-Qiao Du, Shu Li. Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600514. |
the pathophysiological basis of ad involves abnormal deposition of beta-amyloid protein (aβ), abnormal tau protein phosphorylation, decreased activity of acetylcholine content, glutamate toxicity, autophagy, inflammatory reactions, mitochondria-targeting, and multi-targets. |
2023-08-21 |
2023-09-07 |
Not clear |
| Lynne Chantranupong, Celia C Beron, Joshua A Zimmer, Michelle J Wen, Wengang Wang, Bernardo L Sabatin. Dopamine and glutamate regulate striatal acetylcholine in decision-making. Nature. 2023-08-09. PMID:37557915. |
dopamine and glutamate regulate striatal acetylcholine in decision-making. |
2023-08-09 |
2023-08-16 |
Not clear |
| Dora Steel, Kimberley M Reid, Antonio Pisani, Ellen J Hess, Susan Fox, Manju A Kuria. Advances in targeting neurotransmitter systems in dystonia. International review of neurobiology. vol 169. 2023-07-23. PMID:37482394. |
in this chapter we discuss the physiology of key neurotransmitters, including dopamine, noradrenaline, serotonin (5-hydroxytryptamine), acetylcholine, gaba, glutamate, adenosine and cannabinoids, and their role in dystonia. |
2023-07-23 |
2023-08-14 |
Not clear |
| Mauro Congiu, Sarah Mondoloni, Ioannis S Zouridis, Lisa Schmors, Salvatore Lecca, Arnaud L Lalive, Kyllian Ginggen, Fei Deng, Philipp Berens, Rosa Chiara Paolicelli, Yulong Li, Andrea Burgalossi, Manuel Mamel. Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning. Molecular psychiatry. 2023-07-06. PMID:37414924. |
while glutamate, gaba, and serotonin release in lhb remain stable across associative learning, we observe enhanced acetylcholine signaling developing throughout conditioning. |
2023-07-06 |
2023-08-14 |
mouse |