| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. Experimental neurology. 2024-09-17. PMID:39288832. |
viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. |
2024-09-17 |
2024-09-20 |
mouse |
| Min Shao, Chen Zhao, Zhijian Pan, Xuanjun Yang, Cheng Gao, Gloria Hio-Cheng Kam, Hefeng Zhou, Simon Ming-Yuen Le. Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo. Chemico-biological interactions. 2024-09-05. PMID:39233265. |
pre-treatment mitigated loss of tyrosine hydroxylase (th)-positive neurons in the substantia nigra and striatal dopaminergic fibers, restoring dopamine levels and ameliorating motor deficits in pd mice. |
2024-09-05 |
2024-09-08 |
mouse |
| Aanchal Verma, Ahsas Goya. Plumbagin's Healing Effect on Motor Impairment in Rotenone-toxified Rodents. Current neurovascular research. 2024-09-04. PMID:39229982. |
parkinson's disease is an illness marked by a gradual mitigation of dopamine neurons within the substantia nigra, which eventually leads to a deficiency of dopamine that further gives rise to mobility as well as cognitive impairments. |
2024-09-04 |
2024-09-06 |
Not clear |
| Rhalena A Thomas, Julien Sirois, Shuming Li, Alexandre Gestin, Ghislaine Deyab, Valerio E C Piscopo, Paula Lépine, Meghna Mathur, Carol X-Q Chen, Vincent Soubannier, Taylor M Goldsmith, Lama Fawaz, Thomas M Durcan, Edward A Fo. CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids. iScience. vol 27. issue 9. 2024-09-03. PMID:39224516. |
among the sorted neurons, we identified subgroups of dopamine neurons: one reminiscent of substantia nigra cells most vulnerable in parkinson's disease. |
2024-09-03 |
2024-09-05 |
human |
| Fanshi Zhang, Zhuofan Ye, Yuanyang Xie, Mei Liu, Li Zhang, Jun Zhang, Zucai X. Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-08-30. PMID:39212870. |
the main pathological change in pd is the degenerative death of dopamine (da) neurons in the midbrain substantia nigra, which causes a significant decrease in the da content of the striatum. |
2024-08-30 |
2024-09-04 |
Not clear |
| Yiting Ni, Qiaowen Tong, Mengying Xu, Jiayi Gu, Hua Y. Gut Microbiota-Induced Modulation of the Central Nervous System Function in Parkinson's Disease Through the Gut-Brain Axis and Short-Chain Fatty Acids. Molecular neurobiology. 2024-08-12. PMID:39134825. |
notably, fecal microbiota transplantation (fmt) from healthy to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse models significantly improved motor function, enhanced dopamine and serotonin levels in the striatum, and increased the number of dopaminergic neurons in the substantia nigra while reducing glial cell activation. |
2024-08-12 |
2024-08-16 |
mouse |
| Satarupa Deb, Anupom Bora. L-theanine, the unique constituent of tea, improves neuronal survivability by curtailing inflammatory responses in MPTP model of Parkinson's disease. Neurochemistry international. 2024-08-11. PMID:39128625. |
the dosage of 100mg/kg of l-theanine also improved striatal dopamine and serotonin level and tyrosine-hydroxylase positive cell count in the substantia nigra. |
2024-08-11 |
2024-08-14 |
mouse |
| Heisuke Mizukami, Makoto Shiraishi, Sakae Hino, Mayumi Kaburagi, Hirofumi Matsumoto, Yuta Hagiwara, Yoshihisa Yaman. Utility of Combining Transcranial Sonography and MIBG Myocardial Scintigraphy to Evaluate Substantia Nigra in Patients with Parkinson's Disease. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928525. |
we investigated iodine-123 metaiodobenzylguanidine (mibg) and tcs during the examination and diagnosis of high-signal-intensity substantia nigra lesion (hsi-snl) incidence in pd patients previously diagnosed with dopamine transporter scintigraphy (dat). |
2024-06-27 |
2024-06-29 |
human |
| Liv Engel, Amy R Wolff, Madelyn Blake, Val L Collins, Sonal Sinha, Benjamin T Saunder. Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning. Current biology : CB. 2024-06-26. PMID:38925117. |
dopamine (da) neurons in the ventral tegmental area (vta) and substantia nigra (snc) are crucial for this process, via engagement of a reciprocally connected network with their striatal targets. |
2024-06-26 |
2024-06-29 |
Not clear |
| Andrew Lian. Assessing gait dysfunction severity in Parkinson's Disease using 2-Stream Spatial-Temporal Neural Network. Journal of biomedical informatics. 2024-06-26. PMID:38925280. |
pd primarily impacts dopaminergic neurons in the brain's substantia nigra, resulting in dopamine deficiency and gait impairments such as bradykinesia and rigidity. |
2024-06-26 |
2024-06-29 |
Not clear |
| Branden J Clark, Mariah J Lelos, Jeanne F Lorin. Advancing Parkinson's disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells. Stem cells (Dayton, Ohio). 2024-06-21. PMID:38902932. |
the motor symptoms of parkinson's disease (pd) are caused by the progressive loss of dopamine neurons from the substantia nigra. |
2024-06-21 |
2024-06-23 |
human |
| Yimiao Jiang, Zengxin Qi, Huixian Zhu, Kangli Shen, Ruiqi Liu, Chenxin Fang, Weiwei Lou, Yifan Jiang, Wangrui Yuan, Xin Cao, Liang Chen, Qianxing Zhuan. Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease. Neural regeneration research. 2024-06-07. PMID:38845220. |
parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. |
2024-06-07 |
2024-06-10 |
Not clear |
| Tae-Yoon Park, Jeha Jeon, Young Cha, Kwang-Soo Ki. Past, present, and future of cell replacement therapy for parkinson's disease: a novel emphasis on host immune responses. Cell research. 2024-05-22. PMID:38777859. |
central to the pathophysiology of pd is the specific degeneration of midbrain dopamine neurons (mdans) in the substantia nigra. |
2024-05-22 |
2024-05-27 |
human |
| Zarghona Imtiaz, Ayaka Kato, Brian H Kopell, Salman E Qasim, Arianna Neal Davis, Lizbeth Nunez Martinez, Matt Heflin, Kaustubh Kulkarni, Amr Morsi, Xiaosi Gu, Ignacio Sae. Human Substantia Nigra Neurons Encode Reward Expectations. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766086. |
dopamine (da) signals originating from substantia nigra (sn) neurons are centrally involved in the regulation of motor and reward processing. |
2024-05-20 |
2024-05-27 |
human |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746104. |
viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. |
2024-05-15 |
2024-05-27 |
mouse |
| Rong Yang, Dai-di Li, Xiao-Xian Li, Xin-Xing Yang, Hui-Ming Gao, Feng Zhan. Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation. International journal of biological macromolecules. vol 269. issue Pt 2. 2024-05-11. PMID:38723817. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder, marked by the degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2024-05-11 |
2024-05-27 |
Not clear |
| Meina He, Xiangming Zhang, Xia Ran, Yan Zhang, Xiaoran Nie, Bo Xiao, Li Lei, Suzhen Zhai, JinMing Zhu, Jingjing Zhang, Rong Li, Zuoji Liu, Yuping Zhu, Zhijun Dai, Zhixu He, Jian Feng, Chunlin Zhan. Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-syn and Clearing ROS in Parkinson's Disease. Advanced materials (Deerfield Beach, Fla.). 2024-05-02. PMID:38696266. |
although evidence indicates that the abnormal accumulation of α-synuclein (α-syn) in dopamine neurons of the substantia nigra is the main pathological feature of parkinson's disease (pd), no compounds that have both α-syn anti-aggregation and α-syn degradation functions have been successful in treating the disease in the clinic. |
2024-05-02 |
2024-05-05 |
mouse |
| Jessica Ahrens, Farida Zaher, Rachel A Rabin, Clifford M Cassidy, Lena Palaniyappa. Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 161. 2024-04-28. PMID:38678736. |
neuromelanin in the substantia nigra (sn) may reflect dopamine auto-oxidation, and can be quantified using neuromelaninsensitive magnetic resonance imaging (neuromelanin-mri) in a non-invasive manner.in this pre-registered systematic review, we assess the current body of evidence related to neuromelanin levels in substance use disorders, using both post-mortem and mri examinations. |
2024-04-28 |
2024-05-01 |
Not clear |
| Ratna Dini Haryuni, Takamasa Nukui, Jin-Lan Piao, Takashi Shirakura, Chieko Matsui, Tomoyuki Sugimoto, Kousuke Baba, Shunya Nakane, Yuji Nakatsuj. Elevated Serum Xanthine Oxidase and Its Correlation with Antioxidant Status in Patients with Parkinson's Disease. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672506. |
parkinson's disease (pd) is a neurodegenerative movement disorder associated with a loss of dopamine neurons in the substantia nigra. |
2024-04-27 |
2024-04-29 |
Not clear |
| Katerina Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose B Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda M Halliday, Alexandra B Nelson, Elyssa B Margolis, Ken Nakamur. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645054. |
parkinson's disease (pd) is characterized by the death of substantia nigra (snc) dopamine (da) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. |
2024-04-22 |
2024-04-24 |
mouse |