| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinying Wang, Qian Wen, Rongsha Chen, Zhichao Gan, Xinwei Huang, Pengfei Wang, Xia Cao, Ninghui Zhao, Zhongshan Yang, Jinyuan Ya. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. Journal of cellular and molecular medicine. 2023-09-05. PMID:37668106. |
in the present study, it was shown that pd mice had significant motor dysfunction, increased iron content, less dopamine neurons and more \xce\xb1-synuclein accumulation in the substantia nigra. |
2023-09-05 |
2023-09-07 |
mouse |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
in parkinson's disease (pd), the activities and levels of mrna and protein of all catecholamine-synthesizing enzymes are decreased, especially in dopamine neurons in the substantia nigra. |
2023-08-28 |
2023-09-07 |
human |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
the death of dopamine neurons in pd in the substantia nigra may be related to (i) inflammatory effect of extra neuronal neuromelanin, (ii) inflammatory cytokines which are produced by activated microglia, (iii) decreased levels of bdnf, and/or (iv) increased levels of apoptosis-related factors. |
2023-08-28 |
2023-09-07 |
human |
| Jiewen Qiu, Lijian Wei, Yilin Su, Yuting Tang, Guoyou Peng, Yimin Hu, Yan He, Hanqun Liu, Wenyuan Guo, Zhuohu Wu, Pingyi Xu, Mingshu M. Lipid Metabolism Disorder in Cerebrospinal Fluid Related to Parkinson's Disease. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626522. |
abnormal accumulation of lipids is found in dopamine neurons and resident microglia in the substantia nigra of patients with parkinson's disease (pd). |
2023-08-26 |
2023-09-07 |
Not clear |
| Amber D Van Laar, Katherine R Webb, Matthew T Keeney, Victor S Van Laar, Alevtina Zharikov, Edward A Burton, Teresa G Hastings, Kelly E Glajch, Warren D Hirst, J Timothy Greenamyre, Emily M Roch. Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy. NPJ Parkinson's disease. vol 9. issue 1. 2023-08-11. PMID:37567894. |
individuals with parkinson's disease (pd) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, \xce\xb1-synuclein accumulation in surviving neurons, and neuroinflammation. |
2023-08-11 |
2023-08-16 |
human |
| Yiming Wang, Yun Xia, Liang Kou, Sijia Yin, Xiaosa Chi, Jingwen Li, Yadi Sun, Jiawei Wu, Qiulu Zhou, Wenkai Zou, Zongjie Jin, Jinsha Huang, Nian Xiong, Tao Wan. Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease. Neurobiology of disease. 2023-07-11. PMID:37433411. |
the primary pathological features include a reduction in the number of dopaminergic neurons in the substantia nigra and decrease in dopamine levels in the nigrostriatal pathway. |
2023-07-11 |
2023-08-14 |
human |
| K N Rose, M Zorlu, X Xue, W Cai, S Lin, M A Schwarzschild, X Chen, S N Gompert. Low-dose carbon monoxide is neuroprotective in rodent models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398030. |
administration of hbi-002 in the asyn model reduced ipsilateral loss of both striatal dopamine and tyrosine hydroxylase (th)-positive neurons in the substantia nigra and reduced asyn aggregates and s129 phosphorylation. |
2023-07-03 |
2023-08-14 |
mouse |
| Olga Kulikova, Dmitry Troshev, Daniil Berezhnoy, Sergey Stvolinsky, Yulia Timoshina, Denis Abaimov, Olga Muzychuk, Alexander Latanov, Tatiana Fedorov. Neuroprotective Efficacy of a Nanomicellar Complex of Carnosine and Lipoic Acid in a Rat Model of Rotenone-Induced Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 12. issue 6. 2023-06-28. PMID:37371945. |
furthermore, it caused an overall increase in brain tissue antioxidant activity, accompanied by a 19% increase in neuron density in the substantia nigra and increased dopamine levels in the striatum relative to animals that only received rotenone. |
2023-06-28 |
2023-08-14 |
rat |
| Yuting Tang, Lijian Wei, Zhuohua Wu, Pingyi Xu, Mingshu M. Parkinson's disease in a patient with GBA and LRRK2 covariants after acute hypoxic insult: a case report. BMC neurology. vol 23. issue 1. 2023-06-10. PMID:37301871. |
as an environmental factor, hypoxic insults may impair dopamine neurons in the substantia nigra and exacerbate pd symptoms. |
2023-06-10 |
2023-08-14 |
Not clear |
| Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
a well-established dopamine replacement therapy for pd is based on dopamine deficiency, primarily due to dopaminergic neuronal loss in the substantia nigra. |
2023-05-17 |
2023-08-14 |
Not clear |
| Kurt M Fraser, Heather J Pribut, Patricia H Janak, Ronald Keifli. From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-15. PMID:37185097. |
from prediction to action: dissociable roles of ventral tegmental area and substantia nigra dopamine neurons in instrumental reinforcement. |
2023-05-15 |
2023-08-14 |
rat |
| Kurt M Fraser, Heather J Pribut, Patricia H Janak, Ronald Keifli. From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-15. PMID:37185097. |
here we examine in detail the mechanisms underlying the ability of ventral tegmental area (vta) and substantia nigra (snc) dopamine neurons to support instrumental learning. |
2023-05-15 |
2023-08-14 |
rat |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-\\xce\\xb11, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. Experimental neurology. 2023-05-13. PMID:37178997. |
while gdnf dose and delivery methods may have contributed to diminished efficacy, one crucial aspect of these clinical studies is that gdnf treatment began ~8\xe2\x80\xafyears after pd diagnosis; a time point representing several years after near 100% depletion of nigrostriatal dopamine markers in striatum and at least 50% in substantia nigra (sn), which represents a time point of initiating gdnf treatment later than reported in some preclinical studies. |
2023-05-13 |
2023-08-14 |
rat |
| Kazutaka Maeda, Ken-Ichi Inoue, Masahiko Takada, Okihide Hikosak. Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085491. |
here we show that amygdala neurons are sensitive to environments and may regulate putative dopamine (da) neurons via an inhibitory projection to the substantia nigra (sn). |
2023-04-21 |
2023-08-14 |
Not clear |
| Haoyang Wang, Kohji Fukunaga, An Cheng, Yifei Wang, Nariko Arimura, Hiroshi Yoshino, Takuya Sasaki, Ichiro Kawahat. Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice. Journal of pharmacological sciences. vol 152. issue 1. 2023-04-14. PMID:37059489. |
consistent with the behavioral tasks, hy-11-9 recovered dopamine neurons from mptp toxicity in the substantia nigra and ventral tegmental areas. |
2023-04-14 |
2023-08-14 |
mouse |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Alexa F Iannitelli, Arielle Segal, Jean-Francoise Pare, Bernard Mulvey, L Cameron Liles, Steven A Sloan, Katharine E McCann, Joseph D Dougherty, Yoland Smith, David Weinshenke. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945637. |
motor symptoms in parkinson's disease (pd) are caused by degeneration of dopamine (da) neurons of the substantia nigra (sn), while early non-motor symptoms such as anxiety and sleep disturbances are likely mediated by dysfunction of locus coeruleus (lc) norepinephrine (ne) neurons. |
2023-03-22 |
2023-08-14 |
mouse |
| Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, Johannes M Dijkstr. The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-20. PMID:36939908. |
the dark pigment neuromelanin (nm) is abundant in cell bodies of dopamine (da) neurons in the substantia nigra (sn) and norepinephrine (ne) neurons in the locus coeruleus (lc) in the human brain. |
2023-03-20 |
2023-08-14 |
human |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-\\xce\\xb11, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909534. |
while gdnf dose and delivery methods may have contributed to diminished efficacy, one crucial aspect of these clinical studies is that gdnf treatment across all studies began \xe2\x88\xbc8 years after pd diagnosis; a time point representing several years after near 100% depletion of nigrostriatal dopamine markers in striatum and at least 50% in substantia nigra (sn), and is later than the timing of gdnf treatment in preclinical studies. |
2023-03-13 |
2023-08-14 |
rat |
| Darya Bazovkina, Nina B Illarionova, Elizabeth A Kulikova, Ekaterina Yu Bazhenova, Nadezhda A Sinyakova, Nikita V Khotskin, Sergey Nikitin, Vasily S Lankin, Elena E Terenina, Oleg V Trapezov, Aleksandr V Kuliko. Studying the brain monoaminergic systems and neurotrophic factors in minipigs with high and low tolerance to the presence of human. Brain, behavior and evolution. 2023-03-13. PMID:36913918. |
in addition, lt minipigs showed increased content of dopamine and its metabolite dopac in the substantia nigra and decreased dopamine level in the striatum as well as reduced content of noradrenaline in the hippocampus. |
2023-03-13 |
2023-08-14 |
human |