| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinxin Wang, Jiajun Ju, Yafei Xie, Lihua Han. Emerging roles of the G-protein-coupled receptor 37 in neurological diseases and pain. Neuroscience. 2024-09-07. PMID:39244010. |
as a member of the g protein-coupled receptor family, gpr37 features a seven-transmembrane helix structure and is widely expressed in various brain regions, including the substantia nigra and striatum. |
2024-09-07 |
2024-09-10 |
Not clear |
| Xiang Zuo, Hui-Juan Bai, Qi-Li Zhao, Shu-Hui Zhang, Xin Zhao, Xi-Zeng Fen. 17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice. Molecular neurobiology. 2024-09-02. PMID:39222261. |
this exacerbated neuronal apoptosis, ultimately intensifying dopaminergic neuronal degeneration and death in the substantia nigra and striatum of pd mice. |
2024-09-02 |
2024-09-04 |
mouse |
| M A Elfoul. Improved Mathematical Models of Parkinson's Disease with Hopf Bifurcation and Huntington's Disease with Chaos. Acta biotheoretica. vol 72. issue 3. 2024-09-02. PMID:39223402. |
a decrease of gaba in the striatum or delayed excitation of the substantia nigra from the subthalamus may be a major cause of parkinson's disease. |
2024-09-02 |
2024-09-05 |
Not clear |
| Fanshi Zhang, Zhuofan Ye, Yuanyang Xie, Mei Liu, Li Zhang, Jun Zhang, Zucai X. Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-08-30. PMID:39212870. |
the main pathological change in pd is the degenerative death of dopamine (da) neurons in the midbrain substantia nigra, which causes a significant decrease in the da content of the striatum. |
2024-08-30 |
2024-09-04 |
Not clear |
| Daniel Wolf, Maurilyn Ayon-Olivas, Michael Sendtne. BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200225. |
bdnf is necessary for neuronal and functional maintenance in the striatum and the substantia nigra, both structures involved in the pathogenesis of parkinson's disease (pd). |
2024-08-29 |
2024-09-01 |
Not clear |
| Alfonso Mata-Bermudez, Ricardo Trejo-Chávez, Marina Martínez-Vargas, Adán Pérez-Arredondo, Maria de Los Ángeles Martínez-Cardenas, Araceli Diaz-Ruiz, Camilo Rios, Luz Navarr. Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders. Frontiers in neuroscience. vol 18. 2024-08-23. PMID:39176379. |
we describe the changes that occur in the clinical picture of post-tbi patients, such as alterations in mood and anxiety associated with dat activity in the striatum, the relationship between post-tbi major depressive disorders (mdd) with lower availability of the da receptors d2r and d3r in the caudate and thalamus, as well as a decrease in the volume of the substantia nigra (sn) associated with anxiety symptoms. |
2024-08-23 |
2024-08-25 |
Not clear |
| Yiting Ni, Qiaowen Tong, Mengying Xu, Jiayi Gu, Hua Y. Gut Microbiota-Induced Modulation of the Central Nervous System Function in Parkinson's Disease Through the Gut-Brain Axis and Short-Chain Fatty Acids. Molecular neurobiology. 2024-08-12. PMID:39134825. |
notably, fecal microbiota transplantation (fmt) from healthy to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse models significantly improved motor function, enhanced dopamine and serotonin levels in the striatum, and increased the number of dopaminergic neurons in the substantia nigra while reducing glial cell activation. |
2024-08-12 |
2024-08-16 |
mouse |
| Jin Hee Kim, Jin Se Kim, In Gyoung Ju, Eugene Huh, Yujin Choi, Seungmin Lee, Jun-Young Cho, Boyoung Y Park, Myung Sook O. Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson's Disease-Related Pathology in Mice. Biomolecules & therapeutics. 2024-08-02. PMID:39092515. |
moreover, 6-shogaol-only or co-treatment with 6-shogaol and l-dopa protected dopaminergic neurons in the striatum and reduced neuroinflammation in the striatum and substantia nigra. |
2024-08-02 |
2024-08-05 |
mouse |
| Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Deha. Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-08-01. PMID:39090150. |
we characterised the pattern of dopaminergic loss in the striatum and the substantia nigra, the regional distribution of α-synuclein immunoreactivity in several brain structures, and its pathological status (i.e., s129 phosphorylation), the accumulation of heavy metals in nigral sections and occurrence of lysosomal dysfunction. |
2024-08-01 |
2024-08-05 |
Not clear |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Kai Wang, Chao Han, Jinwei Yang, Wenhao Xu, Lei Wang, Huaiyu Li, Yu Wan. Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway. PloS one. vol 19. issue 7. 2024-07-23. PMID:39042624. |
motor deficits were assessed via pole test, hang test, gait analysis, and open field test, while dopaminergic neuron damage was evaluated through immunofluorescence, nissl staining, and western blot analysis of tyrosine hydroxylase (th) in the substantia nigra and striatum. |
2024-07-23 |
2024-07-26 |
mouse |
| Da Gao, Qing-Lian Li, Qi-Zhang Wang, Chun-Xiao Wu, Xiao-Qian Hao, Xiao-Ling Wang, Meng-Zhu Li, Li-Jun Zhao, Mei-Ling Zh. Moxibustion improves motor function by down-regulating SNX5 and inhibiting ferroptosis in neurons of corpus striatum in mice with Parkinson's disease. Zhen ci yan jiu = Acupuncture research. vol 49. issue 7. 2024-07-18. PMID:39020492. |
to explore the effect of moxibustion on the expression of sorting nexin 5 (snx5), glutathione peroxidase (gpx4) and ferritin heavy chain (fth1) in the corpus striatum in mice with parkinson's disease (pd), so as to explore its mechanisms underlying improvement of pd by ameliorating ferroptosis in the substantia nigra striatum. |
2024-07-18 |
2024-07-20 |
mouse |
| Jinhan Nam, Christopher T Richie, Brandon K Harvey, Merja H Voutilaine. Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-07-17. PMID:39019902. |
aav-hcdnf resulted in the expression of hcdnf in the striatum (str) and substantia nigra (sn), and no toxic effects on the nigrostriatal pathway were observed. |
2024-07-17 |
2024-07-20 |
mouse |
| Sandipan Pati, Shruti Agashe, Ammar Kheder, Kristen Riley, Jay Gavvala, Robert McGovern, Surya Suresh, Ganne Chaitanya, Stephen Thompso. Stereoelectroencephalography of the Deep Brain: Basal Ganglia and Thalami. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 41. issue 5. 2024-06-27. PMID:38935656. |
the basal ganglia, comprising the subthalamic nucleus, globus pallidus, substantia nigra, and striatum, have gained recognition for their involvement in both focal and generalized epilepsy. |
2024-06-27 |
2024-06-30 |
Not clear |
| Lina Ding, Long Wang, Jiaxin Yang, Cuicui Jiang, Xifeng Sun, Huite Huang, Xiuyuan Zhan, Feilong Liu, Qunlin Zhan. (+)-Borneol Protects Dopaminergic Neuronal Loss in Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease Mice: A Study of Dopamine Level using In Vivo Brain Microdialysis. ACS chemical neuroscience. 2024-05-15. PMID:38747405. |
it is worth noting that the enhanced level of da by (+)-borneol was enabled by the reduction in loss of tyrosine hydroxylase-immunoreactive dopaminergic neurons in the substantia nigra and striatum and promotion of reserpine- or nomifensine-induced da release in pd mice. |
2024-05-15 |
2024-05-27 |
mouse |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Ing Chee Wee, Alina Arulsamy, Frances Corrigan, Lyndsey Collins-Prain. Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson's Disease Risk. Molecules (Basel, Switzerland). vol 29. issue 7. 2024-04-13. PMID:38611750. |
at 12 months post-injury, astrocyte reactivity (gfap) and microglial levels (iba1) were assessed in the striatum (str), substantia nigra (sn), and prefrontal cortex (pfc) using immunohistochemistry. |
2024-04-13 |
2024-04-15 |
rat |
| Isabel Soto, Robert McManus, Walter Navarrete-Barahona, Ella A Kasanga, Kirby Doshier, Vicki A Nejtek, Michael F Salvator. Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. Experimental neurology. 2024-04-05. PMID:38580154. |
young adult pink1 ko rats exhibited hyperkinetic behavior associated with elevated da and th in the substantia nigra (sn), which decreased therein, but not striatum, in the aged ko rats. |
2024-04-05 |
2024-04-10 |
human |
| Hoang Kieu Chi Ngo, Hoang Le, Samuel J Ayer, Grace F Crotty, Michael A Schwarzschild, Rachit Baksh. Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons. Research square. 2024-04-02. PMID:38562908. |
lps treatment caused a greater increase in the activated astrocyte marker glial fibrillary acidic protein (gfap) in the striatum and substantia nigra of lrrk2 g2019s mice than in those of wt mice. |
2024-04-02 |
2024-04-04 |
mouse |
| Hadeer O Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustaf. Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway. Neuropharmacology. 2024-03-17. PMID:38494124. |
nrf2 content significantly decreased with the accumulation of α-synuclein and tau proteins in both the substantia nigra and striatum. |
2024-03-17 |
2024-03-20 |
Not clear |