| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Lemke, Regina Carlson, Thomas Flegel, Andrea Volk, Holger Andreas Volk, Andrea Tipold, Jasmin Nicole Nessle. Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia. BMC veterinary research. vol 19. issue 1. 2023-11-25. PMID:37993920. |
if syringomyelia asymmetrically involves the dorsal horn grey matter of the spinal cord, affected dogs show increased signs of dysesthesia and neuropathic pain, like increased itching behaviour. |
2023-11-25 |
2023-11-28 |
Not clear |
| Danielle Diniz Aguiar, J\\xc3\\xbalia Alvarenga Petrocchi, Grazielle Caroline da Silva, Virg\\xc3\\xadnia Soares Lemos, Marina Gomes Miranda E Castor, Andrea de Castro Perez, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romer. Participation of the cannabinoid system and the NO/cGMP/K Neuroscience letters. 2023-10-28. PMID:37898181. |
participation of the cannabinoid system and the no/cgmp/k it has already been shown that serotonin can release endocannabinoids at the spinal cord level, culminating in inhibition of the dorsal horn. |
2023-10-28 |
2023-11-08 |
Not clear |
| John E Gilbert, Tianhe Zhang, Rosana Esteller, Warren M Gril. Network Model of Nociceptive Processing in the Superficial Spinal Dorsal Horn Reveals Mechanisms of Hyperalgesia, Allodynia, and Spinal Cord Stimulation. Journal of neurophysiology. 2023-09-20. PMID:37727912. |
network model of nociceptive processing in the superficial spinal dorsal horn reveals mechanisms of hyperalgesia, allodynia, and spinal cord stimulation. |
2023-09-20 |
2023-10-07 |
Not clear |
| Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for \\xce\\xbc Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. |
by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1\xc2\xa0mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. |
2023-09-07 |
2023-10-07 |
mouse |
| Xiao Fu, Yanhong Zhang, Rui Zhan. Regulatory role of PI3K/Akt/WNK1 signal pathway in mouse model of bone cancer pain. Scientific reports. vol 13. issue 1. 2023-08-31. PMID:37652923. |
the pi3k/akt pathway in the dorsal horn of the mouse spinal cord activates the downstream wnk1 protein, which promotes the release of inflammatory cytokines, which leads to the formation of bcp in mice. |
2023-08-31 |
2023-09-07 |
mouse |
| Li-Guo Dong, Meng-Qi An, Han-Ying Gu, Li-Ge Zhang, Jin-Bao Zhang, Cheng-Jie Li, Cheng-Jie Mao, Fen Wang, Chun-Feng Li. PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons. Acta pharmacologica Sinica. 2023-08-10. PMID:37563446. |
whole-cell recordings from coronal spinal cord slices at l4-l6 revealed that the frequency of spontaneous excitatory postsynaptic currents (sepscs) in dorsal horn neurons was significantly increased, which was reversed by application of a pac1-r antagonist pacap 6-38 (250\xe2\x80\x89nm). |
2023-08-10 |
2023-08-16 |
rat |
| Sahibpreet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jagg. Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms. Fundamental & clinical pharmacology. 2023-07-04. PMID:37401197. |
the activation of the ephrin b/ephb system in the dorsal root ganglion and dorsal horn of the spinal cord may be essential in initiating and maintaining neuropathic pain. |
2023-07-04 |
2023-08-14 |
Not clear |
| Xin Jia, Ziyang Li, Xiafeng Shen, Yu Zhang, Li Zhang, Ling Zhan. High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic post-ischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282487. |
finally, shrna-mediated silencing of chemerin receptor 23 in the spinal cord reversed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammatory polarization of microglia in the dorsal horn of the spinal cord. |
2023-06-07 |
2023-08-14 |
mouse |
| Jie Zheng, Feng Yang, Pu-Wei Yuan, Jing-Jie Fan, Xiao-Hui Zheng, Rui Zhu, Yang-le L. [Effect of electroacupuncture on the expression of Iba-1 in spinal dorsal horn and hippocampus of chronic pain rats with knee osteoarthritis]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 5. 2023-05-29. PMID:37247855. |
to observe the effect of electroacupuncture(ea) on pain-ralated behaviors, morphology of hippocampus, concentrations of inflammatory cytokines and expression of ionized calcium binding adapter molecule 1(iba-1) in dorsal horn of the spinal cord and the hippocampus, and brain-derived neurotrophic factor (bdnf) in hippocampus of rats with knee osteoarthritis (koa), so as to explore the mechanism of ea in improving chronic pain of koa. |
2023-05-29 |
2023-08-14 |
rat |
| Yazead Buhidma, Carl Hobbs, Marzia Malcangio, Susan Dut. Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-04-26. PMID:37100804. |
using the 6-hydroxydopamine (6-ohda) lesioned rat model of pd, we identified reductions in dopaminergic neurons in the periaqueductal grey (pag) and met-enkephalin in the dorsal horn of the spinal cord that were validated in human pd tissue samples. |
2023-04-26 |
2023-08-14 |
human |
| Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Changgeng Pen. Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model. Frontiers in molecular neuroscience. vol 16. 2023-03-20. PMID:36937049. |
ectopic expression of nav1.7 in spinal dorsal horn neurons induced by ngf contributes to neuropathic pain in a mouse spinal cord injury model. |
2023-03-20 |
2023-08-14 |
mouse |
| Fei Yang, Jun-Jie Jing, Si-Yin Fu, Xiu-Zhu Su, Yu-Ling Zhong, Dong-Sheng Chen, Xiao-Zhi Wu, Yi-Qing Zo. Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. Molecular neurobiology. 2023-01-05. PMID:36602702. |
immunohistochemical staining and elisa were used to assess the expression changes of c-fos, iba-1, gfap, mcp-1, and ccr2 in the dorsal horn of the lumbar spinal cord following thalamic hemorrhage, and the involvement of spinal mcp-1 in cpsp was examined by performing intrathecal anti-mcp-1 mab injection to neutralize the spinal extracellular mcp-1. |
2023-01-05 |
2023-08-14 |
rat |
| Jia-Jia Liu, Xuemei Li, Jing Guo, Shuguang Yu, Sha Yan. Role of GRPR in Acupuncture Intervention in the "Itch-scratch Vicious Cycle" Spinal Circuit of Chronic Pruritus. Chinese medicine. vol 18. issue 1. 2023-01-03. PMID:36597164. |
combination the\xc2\xa0latest\xc2\xa0research\xc2\xa0achievements\xc2\xa0of chronic\xc2\xa0itch,\xc2\xa0gastrin-releasing peptide receptor (grpr) in the dorsal horn of the spinal cord may represent\xc2\xa0the first\xc2\xa0molecule\xc2\xa0identified that is dedicated to mediating the itch response and may provide an important therapeutic target for\xc2\xa0the\xc2\xa0treatment of chronic pruritic conditions. |
2023-01-03 |
2023-08-14 |
Not clear |
| Hayate Javed, Aishwarya Mary Johnson, Anil Kumar Challagandla, Bright Starling Emerald, Safa Sheha. Cutaneous Injection of Resiniferatoxin Completely Alleviates and Prevents Nerve-Injury-Induced Neuropathic Pain. Cells. vol 11. issue 24. 2022-12-23. PMID:36552812. |
the results showed that intraplantar injection of rtx (0.002%, 100 \xc2\xb5l) (1) completely reversed the development of chronic thermal and mechanical hypersensitivity; (2) completely prevented the development of nerve-injury-induced thermal and mechanical hypersensitivity when applied one week earlier; (3) caused downregulation of nociceptive pain markers, including trpv1, ib4 and cgrp, and upregulation of vip in the ipsilateral dorsal horn of spinal cord and dorsal root ganglion (drg) immunohistochemically and a significant reduction in the expression of trpv1 mrna and protein in the ipsilateral drg using western blot and qrt-pcr techniques; (4) caused downregulation of pgp 9.5- and cgrp-immunoreactivity in the injected skin; (5) produced significant suppression of c-fos expression, as a neuronal activity marker, in the spinal neurons in response to a second intraplantar rtx injection two weeks later. |
2022-12-23 |
2023-08-14 |
rat |
| Sylvie Cornet, Denis Carr\\xc3\\xa9, Lorenzo Limana, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Steven Evans, Stephane Lezmi, Mikhail Kaliniche. Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model. Scientific reports. vol 12. issue 1. 2022-12-13. PMID:36513684. |
in abobont-a-treated animals cleaved snap25 was absent in the skin and drg, but present in the ipsilateral dorsal horn of the spinal cord. |
2022-12-13 |
2023-08-14 |
Not clear |
| Kelly M Smith, Eileen Nguyen, Sarah E Ros. The delta-opioid receptor bidirectionally modulates itch. The journal of pain. 2022-12-04. PMID:36464136. |
in the spinal cord, dor overlapped with both the npy receptor (npy1r) and kor, suggesting that dor neurons represent a site for convergent itch information in the dorsal horn. |
2022-12-04 |
2023-08-14 |
Not clear |
| Raquel Tonello, Wayne B Anderson, Steve Davidson, Virginie Escriou, Lei Yang, Brian L Schmidt, Wendy L Imlach, Nigel W Bunnet. The contribution of endocytosis to sensitization of nociceptors and synaptic transmission in nociceptive circuits. Pain. 2022-11-15. PMID:36378744. |
mrna encoding dynamin (dnm) 1-3 and adaptor-associated protein kinase 1 (aak1), which mediate clathrin-dependent endocytosis, were localized to primary sensory neurons of dorsal root ganglia of mouse and human and to spinal neurons in the dorsal horn of the mouse spinal cord by rnascope\xc2\xae. |
2022-11-15 |
2023-08-14 |
mouse |
| Yumeng Ding, Liye Hu, Xiaotong Wang, Qingyu Sun, Tingting Hu, Jing Liu, Danmin Shen, Yurui Zhang, Wen Chen, Chao Wei, Meng Liu, Dianxin Liu, Peipei Wang, Chenguang Zhang, Jiannan Zhang, Qian Li, Fei Yan. The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE. Neurobiology of disease. 2022-11-04. PMID:36332813. |
in this study, we demonstrated that spinal dorsal horn astrocytes were activated in the pre-clinical stage of eae mice, and the inhibition of spinal cord astrocyte reactivity effectively alleviates pain symptoms in eae mice. |
2022-11-04 |
2023-08-14 |
mouse |
| Yaohua Chen, Yuping Li, Chunxiang Li, Dan Zhu, Oumei Cheng, Jian Cu. Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-\\xce\\xbaB pathways in astrocytes. Neuroscience letters. 2022-10-25. PMID:36283628. |
immunofluorescence and western blotting were used to analyze the level of tyrosine hydroxylase (th) in the substantia nigra (sn) and the expression of c-fos, gfap, p-ampk, mtor, nf-\xce\xbab, tnf\xce\xb1, and il-6 in the dorsal horn of the spinal cord (dhsc). |
2022-10-25 |
2023-08-14 |
mouse |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
our recent study using minamata disease model rats demonstrated that mehg-mediated neurodegeneration in the sensory nervous system may induce inflammatory microglia production in the dorsal horn of the spinal cord and subsequent somatosensory cortical rewiring, leading to neuropathic pain. |
2022-10-16 |
2023-08-14 |
rat |