| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaseen Awad-Igbaria, Reem Sakas, Lama Milhem, Tom Fishboom, Aviv Ben-Menashe, Doron Edelman, Alon Shamir, Jean F Soustiel, Eilam Palzu. Mitochondrial Translocator-Protein Ligand Etifoxine Reduces Pain Symptoms and Protects Against Motor Dysfunction Development Following Peripheral Nerve Injury in Rats. Neuropharmacology. 2025-04-06. PMID:40189017. |
peripheral nerve injury enhances mitochondrial translocator protein (tspo) expression in the spinal cord and dorsal root ganglia (drg), which is associated with neuroinflammation and mitochondrial dysfunction contributing to chronic pain development. |
2025-04-06 |
2025-04-09 |
rat |
| Donovan Alexander Argueta, Bryant Avalos, Yugal Goel, Huy Tran, Yannick Fotio, Daniele Piomelli, Nicholas V DiPatrizio, Kalpna Gupt. Neuroprotective, anti-inflammatory and analgesic activity of palmitoylethanolamide in sickle cell mice. Blood advances. 2025-03-14. PMID:40085960. |
increased p38-mitogen activated protein kinase (mapk) activity in the spinal cord and dorsal root ganglia (drg) neurons, and cutaneous mast cell activation, contribute to chronic hyperalgesia in sickle mice. |
2025-03-14 |
2025-03-17 |
mouse |
| Ying Liu, Guo-Xin Zhang, Xue-Min Yao, Wen-Li Wang, Ao-Qing Huang, Hai-Ping Wang, Chun-Yan Zhu, Na Li. [Effect of Yuxuebi Tablets on mice with inflammatory pain based on GPR37-mediated inflammation resolution]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 1. 2025-02-10. PMID:39929659. |
the expression of cd206 and gpr37 significantly decreased in the dorsal root ganglion and dorsal horn of the spinal cord, and il-10 and tgf-β levels in the spinal cord were significantly decreased. |
2025-02-10 |
2025-02-13 |
mouse |
| Ying Liu, Guo-Xin Zhang, Xue-Min Yao, Wen-Li Wang, Ao-Qing Huang, Hai-Ping Wang, Chun-Yan Zhu, Na Li. [Effect of Yuxuebi Tablets on mice with inflammatory pain based on GPR37-mediated inflammation resolution]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 1. 2025-02-10. PMID:39929659. |
compared with those of the model group, the mechanical pain thresholds and hot withdrawal latency of the high-dose group of yuxuebi tablets significantly increased, and the expression of cd68 in the dorsal root ganglion and iba1 in the dorsal horn of the spinal cord significantly decreased. |
2025-02-10 |
2025-02-13 |
mouse |
| Ying Liu, Guo-Xin Zhang, Xue-Min Yao, Wen-Li Wang, Ao-Qing Huang, Hai-Ping Wang, Chun-Yan Zhu, Na Li. [Effect of Yuxuebi Tablets on mice with inflammatory pain based on GPR37-mediated inflammation resolution]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 1. 2025-02-10. PMID:39929659. |
the expression of cd206 and gpr37 in the dorsal root ganglion and dorsal horn of the spinal cord significantly increased, as well as il-10 and tgf-β levels in the spinal cord. |
2025-02-10 |
2025-02-13 |
mouse |
| Juan Wang, Shenghong Li, Jishi Ye, Yafei Yan, Qi Liu, Qiang Jia, Yifan Jia, Long Wan. Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF): A Novel Therapeutic Target for Chemotherapy-Induced Peripheral Neuropathy via Regulation of Integrated Stress Response and Neuroinflammation. Neuropharmacology. 2025-02-05. PMID:39909174. |
utilizing an oxaliplatin-induced cipn mouse model, we investigated manf expression in the dorsal root ganglia (drg) and spinal cord, and evaluated the impacts of aav-mediated manf overexpression on cipn. |
2025-02-05 |
2025-02-08 |
mouse |
| Juan Wang, Shenghong Li, Jishi Ye, Yafei Yan, Qi Liu, Qiang Jia, Yifan Jia, Long Wan. Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF): A Novel Therapeutic Target for Chemotherapy-Induced Peripheral Neuropathy via Regulation of Integrated Stress Response and Neuroinflammation. Neuropharmacology. 2025-02-05. PMID:39909174. |
our findings revealed substantial downregulation of manf expression in both the drg and spinal cord of cipn inflicted mice, with manf majorly localized in neurons as opposed to glial cells. |
2025-02-05 |
2025-02-08 |
mouse |
| Yaseen Awad-Igbaria, Aviv Ben-Menashe, Reem Sakas, Doron Edelman, Tom Fishboom, Alon Shamir, Jean Francois-Soustiel, Eilam Palzu. Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain. Brain : a journal of neurology. 2025-02-04. PMID:39901826. |
here, we found that activating the trpv1 channel in the spinal cord using capsaicin, a trpv1 agonist, results in mechanical and thermal hypersensitivity that were found to be mediated by neuroinflammation, elevated level of apoptosis, and a reduction in transcription of the mitochondrial complexes in the spinal cord and drg. |
2025-02-04 |
2025-02-06 |
Not clear |
| Risa Shinoki, Ryosuke Jikuya, Takuma Nirei, Takeshi Fukazawa, Hiroki Takizawa, Mari Hioki, Sachi Kawaura, Tomoyuki Tatenuma, Go Noguchi, Daiki Ueno, Yusuke Ito, Mitsuru Komeya, Kentaro Muraoka, Hisashi Hasumi, Kazuki Kobayashi, Masahito Takiguchi, Kengo Funakoshi, Kazuhide Makiyama, Naoki Aizawa, Hiroki It. Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction. Scientific reports. vol 15. issue 1. 2025-01-28. PMID:39875474. |
western blotting confirmed crhr1 expression in the dorsal root ganglia (drg) and bladder, but not the spinal cord, of rats. |
2025-01-28 |
2025-01-31 |
rat |
| Risa Shinoki, Ryosuke Jikuya, Takuma Nirei, Takeshi Fukazawa, Hiroki Takizawa, Mari Hioki, Sachi Kawaura, Tomoyuki Tatenuma, Go Noguchi, Daiki Ueno, Yusuke Ito, Mitsuru Komeya, Kentaro Muraoka, Hisashi Hasumi, Kazuki Kobayashi, Masahito Takiguchi, Kengo Funakoshi, Kazuhide Makiyama, Naoki Aizawa, Hiroki It. Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction. Scientific reports. vol 15. issue 1. 2025-01-28. PMID:39875474. |
real-time pcr showed higher crhr2 mrna expression in the spinal cord and drg than in the bladder in both groups. |
2025-01-28 |
2025-01-31 |
rat |
| Fu-Lu Dong, Lina Yu, Pei-Da Feng, Jin-Xuan Ren, Xue-Hui Bai, Jia-Qi Lin, De-Li Cao, Yu-Tao Deng, Yan Zhang, Hui-Hui Shen, Hao Gong, Wen-Xing Sun, Dong-Qiu Chi, Yixiao Mei, Longfei Ma, Ming-Zhe Yin, Meng-Na Li, Peng-Fei Zhang, Nan Hu, Bing-Lin Zhou, Ying Liu, Xuan-Jie Zheng, Yi-Fan Chen, Da Zhong, Yuan-Xiang Tao, Min Yan, Bao-Chun Jian. An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord. Communications biology. vol 8. issue 1. 2025-01-17. PMID:39820760. |
gene reprogramming and tissue remodeling in the dorsal root ganglia (drg) and spinal cord (sc) drive the development and maintenance of neuropathic pain (np). |
2025-01-17 |
2025-01-20 |
mouse |
| Andreea Violeta Grosu, Roxana-Olimpia Gheorghe, Alexandru Filippi, Alexandru Florian Deftu, Manon Isler, Marc Suter, Violeta Ristoi. Dorsal root ganglia CSF1 Journal of the peripheral nervous system : JPNS. 2024-11-24. PMID:39581686. |
dorsal root ganglia csf1 colony-stimulating factor 1 (csf1) is a growth factor secreted by dorsal root ganglia (drg) neurons important for drg macrophages and spinal cord (sc) microglia injury-induced proliferation and activation, specifically released after spared nerve injury (sni). |
2024-11-24 |
2024-11-27 |
mouse |
| Kristine Krajnak, Stacey Waugh, Christopher Warren, Phillip Chapman, Xueyan Xu, Daniel Welcome, Maryann Hammer, Diana Richardson, Renguang Don. Force-induced tissue compression alters circulating hormone levels and biomarkers of peripheral vascular and sensorineural dysfunction in an animal model of hand-arm vibration syndrome. Journal of toxicology and environmental health. Part A. 2024-11-20. PMID:39565925. |
the goal of this study was to use an established rat tail model to determine the mechanisms by which compression of the tail tissues affects (1) the ventral tail artery (vta) and ventral tail nerves (vtn), (2) nerves and sensory receptors in the skin, (3) dorsal root ganglia (drg), and (4) spinal cord. |
2024-11-20 |
2024-11-23 |
rat |
| Rong Chen, Meng Li, Mingxing Din. Optogenetic stimulation of the "Zusanli" acupoint alleviates inflammatory pain through active Wnt/β-Catenin and MAPK signaling pathway in rats. Heliyon. vol 10. issue 21. 2024-11-18. PMID:39553603. |
optogenetic stimulation of gamma-aminobutyric acid (gaba) projections to the "zusanli" acupoints delivered several raav9-gad1-chr2-mcherry particles to the spinal cord horn (scdh) and drg and few raav9-gad1-chr2-mcherry particles to toes, thereby evoking an analgesic effect in complete freund's adjuvant (cfa) rats similar to those of acupuncture. |
2024-11-18 |
2024-11-22 |
rat |
| Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Den. SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. International journal of biological macromolecules. 2024-10-30. PMID:39476923. |
the expression levels of setd2 were significantly decreased in the spinal cord and dorsal root ganglion (drg) of rodents undergoing neuropathic pain induced by sciatic nerve chronic constrictive injury. |
2024-10-30 |
2024-11-02 |
Not clear |
| Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Den. SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. International journal of biological macromolecules. 2024-10-30. PMID:39476923. |
lentiviral shrna-mediated setd2 knockdown and conditional knockout in sensory neurons caused sustained nmdar upregulation in drg and spinal cord, which resulted in heightened neuronal excitability and increased pain hypersensitivity. |
2024-10-30 |
2024-11-02 |
Not clear |
| Marta Alves-Simões, Laura Teege, Cecilia Tomni, Martha Lürkens, Annika Schmidt, Federico Iseppon, Queensta Millet, Samuel Kühs, Istvan Katona, Joachim Weis, Stefan H Heinemann, Christian A Hübner, John Wood, Enrico Leipold, Ingo Kurth, Natja Haa. NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in mice. Pain. 2024-10-09. PMID:39382328. |
nav1.8 and nav1.9, which are encoded by scn10a and scn11a, respectively, are predominantly expressed in pain-sensitive (nociceptive) neurons localized in the dorsal root ganglia (drg) along the spinal cord and in the trigeminal ganglia. |
2024-10-09 |
2024-10-11 |
mouse |
| Adham Farah, Ryan Patel, Piotr Poplawski, Benjamin J Wastie, Mandy Tseng, Allison M Barry, Omar Daifallah, Akash Dubb, Ivan Paul, Hoi Lao Cheng, Faisal Feroz, Yuhe Su, Marva Chan, Hanns Ulrich Zeilhofer, Theodore Price, David L Bennett, Kirsty Bannister, John M Dawe. A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity. Brain : a journal of neurology. 2024-09-20. PMID:39301592. |
our findings point to effects of lgi1 at both the level of the drg and spinal cord, including an important impact of spinal lgi1 on pathological pain. |
2024-09-20 |
2024-09-22 |
mouse |
| Dong-Wook Kang, Sheu-Ran Choi, Hyunjin Shin, Hyeryeong Lee, Jaehong Park, Miae Lee, Miok Bae, Hyun-Woo Ki. Modulation of Brain-derived Neurotrophic Factor Expression by Physical Exercise in Reserpine-induced Pain-depression Dyad in Mice. Experimental neurobiology. vol 33. issue 4. 2024-09-12. PMID:39266473. |
immunofluorescence staining was performed to examine the changes in bdnf expression in the dorsal root ganglion (drg), spinal cord, and hippocampus. |
2024-09-12 |
2024-09-15 |
mouse |
| Taro Koike, Tenga Sato, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yosuke Nakano, Hikaru Iwashita, Yuki Sato, Yukie Hirahara, Masaaki Kitad. CD34 distribution in C-fiber low threshold mechanoreceptors in the mouse dorsal root ganglion and spinal cord. Brain research. 2024-09-10. PMID:39255903. |
cd34 distribution in c-fiber low threshold mechanoreceptors in the mouse dorsal root ganglion and spinal cord. |
2024-09-10 |
2024-09-13 |
mouse |