All Relations between spinal cord and drg

Publication Sentence Publish Date Extraction Date Species
Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. this study used an in vivo rat annulus fibrosus (af) injury-driven discogenic pain model to investigate the acute and chronic changes in ivd degeneration and spinal inflammation, as well as sensitization, inflammation, and remodeling in dorsal root ganglion (drg) and spinal cord (sc) dorsal horn. 2024-02-10 2024-02-12 rat
Robert G Stewart, Miriam Camacena, Bryan A Copits, Jon T Sac. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K The Journal of comparative neurology. vol 532. issue 2. 2024-02-09. PMID:38335058. somatosensory neurons have a pseudounipolar morphology and transmit action potentials from peripheral nerve endings through axons that bifurcate to the spinal cord and the cell body within ganglia including the dorsal root ganglia (drg). 2024-02-09 2024-02-12 mouse
Obulapathi Ummadisetty, Akhilesh, Anagha Gadepalli, Deepak Chouhan, Utkarsh Patil, Surya Pratap Singh, Sanjay Singh, Vinod Tiwar. Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation. Molecular neurobiology. 2024-01-26. PMID:38277118. further, molecular biology investigations unveiled heightened oxido-nitrosative stress, coupled with a notable upregulation in the expression of trp channels (trpa1, trpv1, and trpm8), glial cell activation, and neuroinflammation (tnf-α, il-1β) in the sciatic nerve, dorsal root ganglion (drg), and spinal cord of frostbite-injured rats. 2024-01-26 2024-01-28 rat
Heni El Heni, Péter Bátor Kemenesi-Gedei, Laura Pálvölgyi, Ivett Dorina Kozma-Szeredi, Gyöngyi Ki. Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203176. we found a time-dependent change in the expression of oxytocin receptor mrna in l5 dorsal root ganglion neurons, as well as an increase in the level of the receptor protein in the lumbar segment of the spinal cord. 2024-01-11 2024-01-13 rat
Robert G Stewart, Miriam Camacena, Bryan A Copits, Jon T Sac. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K bioRxiv : the preprint server for biology. 2024-01-08. PMID:38187582. somatosensory neurons have a pseudounipolar morphology and transmit action potentials from peripheral nerve endings through axons that bifurcate to the spinal cord and the cell body within ganglia including the dorsal root ganglia (drg). 2024-01-08 2024-01-10 mouse
Obulapathi Ummadisetty, Akhilesh, Anagha Gadepalli, Deepak Chouhan, Vinod Tiwar. Development and validation of clinically Mimicable model of frostbite injury-induced chronic pain. Cellular signalling. 2024-01-04. PMID:38176530. further, molecular analysis indicated that frostbite injury triggered the activation of trp channels (trpa1 and trpm8), microgliosis, and increased neuroinflammation in the dorsal root ganglion (drg) and spinal cord of rats. 2024-01-04 2024-01-07 rat
Akhilesh, Deepak Chouhan, Obulapathi Ummadisetty, Nivedita Verma, Vinod Tiwar. Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling. International immunopharmacology. vol 125. issue Pt A. 2023-12-27. PMID:38149571. notably, bergenin treatment effectively reversed all of these alterations, with the exception of trpm8, in both the drg and spinal cord of neuropathic rats. 2023-12-27 2023-12-29 rat
Urszula Mazur, Ewa Lepiarczyk, Paweł Janikiewicz, Elżbieta Łopieńska-Biernat, Mariusz Krzysztof Majewski, Agnieszka Bossowsk. Distribution and Chemistry of Phoenixin-14, a Newly Discovered Sensory Transmission Molecule in Porcine Afferent Neurons. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068975. to fill the above-mentioned gap and expand our knowledge about the occurrence of pnx in mammalian species other than rodents, this study examined (i) the pattern(s) of pnx occurrence in drg neurons of subsequent neuromeres along the porcine spinal cord, (ii) their intraganglionic distribution and (iii) the pattern(s) of pnx co-occurrence with other biologically active agents. 2023-12-09 2023-12-17 rat
Alejandro Pluma-Pluma, Guadalupe García, Janet Murbartiá. Chronic restraint stress and social transfer of stress produce tactile allodynia mediated by the HMGB1/TNF.Ñó./TNFR1 pathway in female and male rats. Physiology & behavior. 2023-12-02. PMID:38042454. rats under crs or sts enhanced hmgb1 and tnfr1 protein expression in drg and dorsal spinal cord. 2023-12-02 2023-12-10 rat
Ricardo S Harripaul, Elisabetta S Morini, Monica Salani, Emily Logan, Emily Grace Kirchner, Jessica Bolduc, Anil Chekuri, Benjamin Currall, Rachita Yadav, Serkan Erdin, Michael E Talkowski, Dadi Gao, Susan Slaugenhaup. Transcriptome analysis in a humanized mouse model of familial dysautonomia reveals tissue-specific gene expression disruption in the peripheral nervous system. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808686. comparison of fd and control transcriptomes from dorsal root ganglion (drg), trigeminal ganglion (tg), medulla (med), cortex, and spinal cord (sc) showed significantly more differentially expressed genes (degs) in the pns than the cns. 2023-10-09 2023-10-15 mouse
Anagha Gadepalli, Obulapathi Ummadisetty, Akhilesh, Deepak Chouhan, Anmol, Vinod Tiwar. Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats. International immunopharmacology. vol 124. issue Pt B. 2023-10-06. PMID:37801968. further, molecular investigations revealed increased expression of ion channels such as trpa1, trpm8; voltage-gated sodium channels (vgscs) and neuroinflammatory markers in the dorsal root ganglion (drg) and lumbar (l4-l5) spinal cord of neuropathic rats, which was significantly downregulated upon loperamide treatment. 2023-10-06 2023-10-15 rat
Matthew R Sapio, Diana M King, Ellen S Staedtler, Dragan Maric, Jahandar Jahanipour, Natalya A Kurochkina, Allison P Manalo, Andre Ghetti, Andrew J Mannes, Michael J Iadarol. Expression pattern analysis and characterization of the hereditary sensory and autonomic neuropathy 2 A (HSAN2A) gene with no lysine kinase (WNK1) in human dorsal root ganglion. Experimental neurology. 2023-10-04. PMID:37793538. the present study evaluates the transcripts, gene structure, and protein structure of hsn2-containing wnk1 splice variants in drg and spinal cord in order to establish the basal expression patterns of wnk1 and hsn2-containing wnk1 splice variants using multiplex fluorescent situ hybridization. 2023-10-04 2023-10-07 human
Qun Li, Reilley Paige Mathena, Fengying Li, Xinzhong Dong, Yun Guan, Cyrus David Mint. Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762067. here, we used a mouse chronic pain model to test the hypothesis that early exposure to the general anesthetic (ga) isoflurane causes cellular and molecular alterations in dorsal spinal cord (dsc) and dorsal root ganglion (drg) that produces a predisposition to neuropathic pain via an upregulation of the mammalian target of the rapamycin (mtor) signaling pathway. 2023-09-28 2023-10-07 mouse
Scott G Pritzlaff, Johnathan H Goree, Jonathan M Hagedorn, David W Lee, Kenneth B Chapman, Sandy Christiansen, Andrew Dudas, Alexander Escobar, Christopher J Gilligan, Maged Guirguis, Amitabh Gulati, Jessica Jameson, Christopher J Mallard, Melissa Murphy, Kiran V Patel, Raj G Patel, Samir J Sheth, Stephanie Vanterpool, Vinita Singh, Gregory Smith, Natalie H Strand, Chau M Vu, Tolga Suvar, Krishnan Chakravarthy, Leonardo Kapural, Michael S Leong, Timothy R Lubenow, Alaa Abd-Elsayed, Jason E Pope, Dawood Sayed, Timothy R Dee. Pain Education and Knowledge (PEAK) Consensus Guidelines for Neuromodulation: A Proposal for Standardization in Fellowship and Training Programs. Journal of pain research. vol 16. 2023-09-20. PMID:37727682. the american society of pain and neuroscience (aspn) desires to create a consensus of experts to set a minimum standard of competence for neurostimulation procedures, including spinal cord stimulation (scs), dorsal root ganglion stimulation (drg-s), and peripheral nerve stimulation (pns). 2023-09-20 2023-10-07 human
Amanda B Sidwell, Celia McClintock, Katharine I Beča, Susan E Campbell, Beatrice M Girard, Margaret A Vizzar. Repeated variate stress increased voiding frequency and altered TrpV1 and TrpV4 transcript expression in lower urinary tract (LUT) pathways in female mice. Frontiers in urology. vol 2. 2023-09-11. PMID:37692906. quantitative pcr demonstrated significant (p ≤ 0.05) changes in trpv1 and trpv4 mrna expression between control and rvs cohorts in the urothelium, lumbosacral spinal cord, and drg. 2023-09-11 2023-10-07 mouse
Yizhong Peng, Xuanzuo Chen, Zilong Rao, Wei Wu, Huiyin Zuo, Kaibin Chen, Kanglu Li, Hui Lin, Sheng Liu, Yan Xiao, BaiChuan Wang, Daping Quan, Xiangcheng Qing, Ying Bai, Zengwu Sha. Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization. Acta biomaterialia. 2023-08-20. PMID:37598791. besides, ti-cnp-daf relieved mechanical hyperalgesia, reduced cgrp and substance p expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat disc herniation model. 2023-08-20 2023-09-07 rat
Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel, Eilam Palzu. HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. Journal of translational medicine. vol 21. issue 1. 2023-08-15. PMID:37582750. peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (drg) and spinal cord, contributing to neuropathic pain and motor dysfunction. 2023-08-15 2023-09-07 Not clear
Hyelin Ji, Kyung-Ran Kim, Jang-Joon Park, Ju Youn Lee, Yeomoon Sim, Heonsik Choi, Sujeong Ki. Combination gene delivery reduces spinal cord pathology in rats with peripheral neuropathic pain. The journal of pain. 2023-07-13. PMID:37442406. pathological phenomena, such as hyperactivation of sensory neurons and inflammation, are observed in both the dorsal root ganglion (drg) and spinal cord (sc). 2023-07-13 2023-08-14 rat
Sahibpreet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jagg. Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms. Fundamental & clinical pharmacology. 2023-07-04. PMID:37401197. the activation of the ephrin b/ephb system in the dorsal root ganglion and dorsal horn of the spinal cord may be essential in initiating and maintaining neuropathic pain. 2023-07-04 2023-08-14 Not clear
Erick J Rodríguez-Palma, Isabel Velazquez-Lagunas, Ana Belen Salinas-Abarca, Guadalupe C Vidal-Cantú, María J Escoto-Rosales, Gabriela Castañeda-Corral, Alonso Fernández-Guasti, Vinicio Granados-Sot. Spinal alarmin HMGB1 and the activation of TLR4 lead to chronic stress-induced nociceptive hypersensitivity in rodents. European journal of pharmacology. 2023-05-27. PMID:37244377. moreover, chronic stress enhanced hmgb1 and tlr4 protein expression at the dorsal root ganglion, but not at the spinal cord. 2023-05-27 2023-08-14 mouse