| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zong, Ren-Li Cao, Yuan-Bin Li, Wu-Qiong Hou, Sen-Sen Li, Li-Ting Xu, Fang-Ting Zhou, Feng Huang, Na Lin, Xiao-Hui Su, Zhen Wang, Yan-Li Gu, Hui Xiong, Chao Wang, Yun Su. [Mongolian medicine Naru-3 reduces neuroinflammation in maintenance stage of neuropathic pain by inhibiting astrocyte activation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 11. 2024-07-23. PMID:39041159. |
nr-3 may relieve the pain in the maintenance stage of np by blocking the matrix metalloproteinase 2(mmp2)/interleukin-1β(il-1β) pathway in the astrocytes of the dorsal root ganglion(drg) and spinal cord. |
2024-07-23 |
2024-07-25 |
mouse |
| Anutosh Roy, Gisela Segond von Banchet, Fátima Gimeno-Ferrer, Christian König, Annett Eitner, Andrea Ebersberger, Matthias Ebbinghaus, Johannes Leuchtweis, Hans-Georg Schaibl. Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000275. |
downregulation of egfr in drg neurons in acute arthritis may limit nociception, but pronounced delayed activation of egfr in the spinal cord may be involved in chronic inflammatory pain. |
2024-07-13 |
2024-07-15 |
mouse |
| Yongjiang Wu, Yanfei Wang, Yunchi Lu, Junguo Yan, Hongjun Zhao, Riyun Yang, Jingying Pa. Research advances in huntingtin-associated protein 1 and its application prospects in diseases. Frontiers in neuroscience. vol 18. 2024-07-08. PMID:38975245. |
besides brain, hap1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. |
2024-07-08 |
2024-07-11 |
Not clear |
| Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sanyal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim, Victoria E Abrair. The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States. bioRxiv : the preprint server for biology. 2024-05-13. PMID:38712022. |
activity within the drg, spinal cord, and dcn have all been implicated in mediating allodynia, yet the dcn remains understudied at the cellular, circuit, and functional levels compared to the other two. |
2024-05-13 |
2024-05-27 |
mouse |
| Le Niu, Chun-Jiang Zuo, Yong-Ling Zhang, Cui-Xia Ma, Xiang-Wen Zhou, Shi-Ru Sun, Xue-Xue Tang, Guo-Quan Huang, Si-Cheng Zha. Oxidative stress mediated decrement of spinal endomorphin-2 contributes to lumbar disc herniation sciatica in rats. Neurochemistry international. vol 177. 2024-05-12. PMID:38729355. |
in addition, mor expression in drg and spinal cord remained unchanged in ldhs rats. |
2024-05-12 |
2024-05-27 |
rat |
| Shota Yamamoto, Tomomi Hashidate-Yoshida, Yuki Yoshinari, Takao Shimizu, Hideo Shindo. Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain. iScience. vol 27. issue 4. 2024-05-08. PMID:38715939. |
we show that pni transiently increases platelet-activating factor (paf) levels, a potent inflammatory phospholipid mediator, in the dorsal root ganglia (drg) and spinal cord. |
2024-05-08 |
2024-05-27 |
mouse |
| Matthew R Sapio, Ellen S Staedtler, Diana M King, Dragan Maric, Jahandar Jahanipour, Andre Ghetti, Kenneth A Jacobson, Andrew J Mannes, Michael J Iadarol. Analgesic candidate adenosine A3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia. Pain. 2024-05-01. PMID:38691673. |
analgesic candidate adenosine a3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia. |
2024-05-01 |
2024-05-04 |
mouse |
| Yu-Fei Han, Xi Con. Comparison of the efficacy of spinal cord stimulation and dorsal root ganglion stimulation in the treatment of painful diabetic peripheral neuropathy: a prospective, cohort-controlled study. Frontiers in neurology. vol 15. 2024-04-26. PMID:38660091. |
the aim of this study was to compare the clinical outcomes of spinal cord stimulation (scs) and dorsal root ganglion stimulation (drg-s) in the treatment of painful diabetic peripheral neuropathy (pdpn). |
2024-04-26 |
2024-04-28 |
Not clear |
| Qiang Zhang, Ran Ding, Yuanjie Li, Dan Qiao, Jiamin Kang, Linyue Zong, Yun Li, Yuan Yuan, Yang Jiao, Chunyan Wang, Yonghao Yu, Linlin Zhang, Yize L. Euchromatin histone-lysine N-methyltransferase 2 regulates the expression of potassium-sodium-activated channel subfamily T member 1 in primary sensory neurons and contributes to remifentanil-induced pain sensitivity. Brain research bulletin. 2024-04-26. PMID:38670469. |
these results suggest that g9a contributes to the development of rih by epigenetically silencing slo2.2 in drg neurons, leading to decreased central sensitization in the spinal cord. |
2024-04-26 |
2024-04-29 |
Not clear |
| Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Ta. NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. EMBO reports. 2024-04-09. PMID:38594391. |
here, we show that systemic paclitaxel administration upregulates the expression of neurotrophin-3 (nt3) mrna and nt3 protein in the neurons of dorsal root ganglia (drg), but not in the spinal cord. |
2024-04-09 |
2024-04-12 |
mouse |
| Zhucheng Lin, Xuan Luo, Jason R Wickman, Deepa Reddy, Richa Pande, Yuzhen Tian, Vivian Triana, Jingyun Lee, Cristina M Furdui, Desmond Pink, Ahmet Sacan, Seena K Aji. Inflammatory pain resolution by mouse serum-derived small extracellular vesicles. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405813. |
chipcytometry of spinal cord and dorsal root ganglion (drg) from sev treated mice showed that prophylactic sev treatment reduced the number of natural killer (nk) and nkt cells in spinal cord and increased cd206+ anti-inflammatory macrophages in (drg) after cfa injection. |
2024-02-26 |
2024-02-28 |
mouse |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
this study used an in vivo rat annulus fibrosus (af) injury-driven discogenic pain model to investigate the acute and chronic changes in ivd degeneration and spinal inflammation, as well as sensitization, inflammation, and remodeling in dorsal root ganglion (drg) and spinal cord (sc) dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |
| Robert G Stewart, Miriam Camacena, Bryan A Copits, Jon T Sac. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K The Journal of comparative neurology. vol 532. issue 2. 2024-02-09. PMID:38335058. |
somatosensory neurons have a pseudounipolar morphology and transmit action potentials from peripheral nerve endings through axons that bifurcate to the spinal cord and the cell body within ganglia including the dorsal root ganglia (drg). |
2024-02-09 |
2024-02-12 |
mouse |
| Obulapathi Ummadisetty, Akhilesh, Anagha Gadepalli, Deepak Chouhan, Utkarsh Patil, Surya Pratap Singh, Sanjay Singh, Vinod Tiwar. Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation. Molecular neurobiology. 2024-01-26. PMID:38277118. |
further, molecular biology investigations unveiled heightened oxido-nitrosative stress, coupled with a notable upregulation in the expression of trp channels (trpa1, trpv1, and trpm8), glial cell activation, and neuroinflammation (tnf-α, il-1β) in the sciatic nerve, dorsal root ganglion (drg), and spinal cord of frostbite-injured rats. |
2024-01-26 |
2024-01-28 |
rat |
| Heni El Heni, Péter Bátor Kemenesi-Gedei, Laura Pálvölgyi, Ivett Dorina Kozma-Szeredi, Gyöngyi Ki. Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203176. |
we found a time-dependent change in the expression of oxytocin receptor mrna in l5 dorsal root ganglion neurons, as well as an increase in the level of the receptor protein in the lumbar segment of the spinal cord. |
2024-01-11 |
2024-01-13 |
rat |
| Robert G Stewart, Miriam Camacena, Bryan A Copits, Jon T Sac. Distinct cellular expression and subcellular localization of Kv2 voltage-gated K bioRxiv : the preprint server for biology. 2024-01-08. PMID:38187582. |
somatosensory neurons have a pseudounipolar morphology and transmit action potentials from peripheral nerve endings through axons that bifurcate to the spinal cord and the cell body within ganglia including the dorsal root ganglia (drg). |
2024-01-08 |
2024-01-10 |
mouse |
| Obulapathi Ummadisetty, Akhilesh, Anagha Gadepalli, Deepak Chouhan, Vinod Tiwar. Development and validation of clinically Mimicable model of frostbite injury-induced chronic pain. Cellular signalling. 2024-01-04. PMID:38176530. |
further, molecular analysis indicated that frostbite injury triggered the activation of trp channels (trpa1 and trpm8), microgliosis, and increased neuroinflammation in the dorsal root ganglion (drg) and spinal cord of rats. |
2024-01-04 |
2024-01-07 |
rat |
| Akhilesh, Deepak Chouhan, Obulapathi Ummadisetty, Nivedita Verma, Vinod Tiwar. Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling. International immunopharmacology. vol 125. issue Pt A. 2023-12-27. PMID:38149571. |
notably, bergenin treatment effectively reversed all of these alterations, with the exception of trpm8, in both the drg and spinal cord of neuropathic rats. |
2023-12-27 |
2023-12-29 |
rat |
| Urszula Mazur, Ewa Lepiarczyk, Paweł Janikiewicz, Elżbieta Łopieńska-Biernat, Mariusz Krzysztof Majewski, Agnieszka Bossowsk. Distribution and Chemistry of Phoenixin-14, a Newly Discovered Sensory Transmission Molecule in Porcine Afferent Neurons. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38068975. |
to fill the above-mentioned gap and expand our knowledge about the occurrence of pnx in mammalian species other than rodents, this study examined (i) the pattern(s) of pnx occurrence in drg neurons of subsequent neuromeres along the porcine spinal cord, (ii) their intraganglionic distribution and (iii) the pattern(s) of pnx co-occurrence with other biologically active agents. |
2023-12-09 |
2023-12-17 |
rat |
| Alejandro Pluma-Pluma, Guadalupe García, Janet Murbartiá. Chronic restraint stress and social transfer of stress produce tactile allodynia mediated by the HMGB1/TNF.Ñó./TNFR1 pathway in female and male rats. Physiology & behavior. 2023-12-02. PMID:38042454. |
rats under crs or sts enhanced hmgb1 and tnfr1 protein expression in drg and dorsal spinal cord. |
2023-12-02 |
2023-12-10 |
rat |