All Relations between spinal cord and cerebral cortex

Publication Sentence Publish Date Extraction Date Species
Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Valeria Valsecchi, Giovanna Lombardi, Serenella Anzilotti, Giorgia Andreozzi, Antonia Scognamiglio, Rosa Sparaco, Elisa Perissutti, Beatrice Severino, Michele Gargiulo, Vincenzo Santagada, Giuseppe Pignatar. Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice. ACS pharmacology & translational science. vol 7. issue 7. 2024-07-18. PMID:39022351. the debilitating neurodegenerative disease known as amyotrophic lateral sclerosis (als) is characterized by the progressive loss of motor neurons (mns) in the brain, spinal cord, and motor cortex. 2024-07-18 2024-07-20 mouse
Venkataramanan Srinivasan, Victoria Homer, Darren Barton, Abigail Clutterbuck-James, Siân Jenkins, Claire Potter, Kristian Brock, Ann Logan, Donna Smith, Lars Bruce, Zsuzsanna Nagy, Simon P Bac. A low molecular weight dextran sulphate, ILB®, for the treatment of amyotrophic lateral sclerosis (ALS): An open-label, single-arm, single-centre, phase II trial. PloS one. vol 19. issue 7. 2024-07-11. PMID:38990927. it is a fatal disease with specific loss of motor neurons in the spinal cord, brain stem, and motor cortex leading to progressive paralysis and usually death within five years of diagnosis. 2024-07-11 2024-07-14 Not clear
Natalie E Doody, Nicole J Smith, Elizabeth C Akam, Graham N Askew, Jessica C F Kwok, Ronaldo M Ichiyam. Differential expression of genes in the RhoA/ROCK pathway in the hippocampus and cortex following intermittent hypoxia and high intensity interval training. Journal of neurophysiology. 2024-07-10. PMID:38985935. we investigated whether the rhoa/rock signaling pathway (known to restrict neuroplasticity) is also modulated by ih and hiit in the hippocampus, cortex, and lumbar spinal cord of male wistar rats. 2024-07-10 2024-07-13 rat
Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariott. Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally. European journal of histochemistry : EJH. vol 68. issue 3. 2024-07-04. PMID:38963135. amyotrophic lateral sclerosis (als) is a neurodegenerative disorder involving motor neuron (mn) loss in the motor cortex, brainstem and spinal cord leading to progressive paralysis and death. 2024-07-04 2024-07-10 mouse
Marlene Tahedl, Ee Ling Tan, Jana Kleinerova, Siobhan Delaney, Jennifer C Hengeveld, Mark A Doherty, Russell L Mclaughlin, Pierre-Francois Pradat, Cédric Raoul, Fabrice Ango, Orla Hardiman, Kai Ming Chang, Jasmin Lope, Peter Bed. Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis. Neurology. vol 103. issue 2. 2024-06-20. PMID:38900989. amyotrophic lateral sclerosis (als) is predominantly associated with motor cortex, corticospinal tract (cst), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. 2024-06-20 2024-06-23 Not clear
Justin K Mielke, Mikael Klingeborn, Eric P Schultz, Erin L Markham, Emily D Reese, Parvez Alam, Ian R Mackenzie, Cindy V Ly, Byron Caughey, Neil R Cashman, Moses J Leaven. Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion. Acta neuropathologica. vol 147. issue 1. 2024-06-17. PMID:38884646. here, we report the development of a real-time quaking-induced conversion (rt-quic) seed amplification assay using a recombinant human sod1 substrate to measure sod1 seeding activity in postmortem spinal cord and motor cortex tissue from persons with different als etiologies. 2024-06-17 2024-06-19 human
Justin K Mielke, Mikael Klingeborn, Eric P Schultz, Erin L Markham, Emily D Reese, Parvez Alam, Ian R Mackenzie, Cindy V Ly, Byron Caughey, Neil R Cashman, Moses J Leaven. Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion. Acta neuropathologica. vol 147. issue 1. 2024-06-17. PMID:38884646. our sod1 rt-quic assay detected sod1 seeds in motor cortex and spinal cord dilutions down to 10 2024-06-17 2024-06-19 human
Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvara. Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis. Cells. vol 13. issue 10. 2024-05-24. PMID:38786016. the primary neural circuit affected in amyotrophic lateral sclerosis (als) patients is the corticospinal motor circuit, originating in upper motor neurons (umns) in the cerebral motor cortex which descend to synapse with the lower motor neurons (lmns) in the spinal cord to ultimately innervate the skeletal muscle. 2024-05-24 2024-05-27 human
Mario Manto, Michael Adamaszek, Richard Apps, Erik Carlson, Julian Guarque-Chabrera, Elien Heleven, Shinji Kakei, Kamran Khodakhah, Sheng-Han Kuo, Chi-Ying R Lin, Mati Joshua, Marta Miquel, Hiroshi Mitoma, Noga Larry, Julie Anne Péron, Jasmine Pickford, Dennis J L G Schutter, Manpreet K Singh, Tommy Tan, Hirokazu Tanaka, Peter Tsai, Frank Van Overwalle, Kunihiko Yamashir. Consensus Paper: Cerebellum and Reward. Cerebellum (London, England). 2024-05-20. PMID:38769243. cerebellum is a key-structure for the modulation of motor, cognitive, social and affective functions, contributing to automatic behaviours through interactions with the cerebral cortex, basal ganglia and spinal cord. 2024-05-20 2024-05-27 Not clear
Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzani. Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients: a rare occurrence? Neural regeneration research. vol 20. issue 1. 2024-05-20. PMID:38767482. amyotrophic lateral sclerosis (als) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. 2024-05-20 2024-05-27 human
James R McIntosh, Evan F Joiner, Jacob L Goldberg, Phoebe Greenwald, Alexandra C Dionne, Lynda M Murray, Earl Thuet, Oleg Modik, Evgeny Shelkov, Joseph M Lombardi, Zeeshan M Sardar, Ronald A Lehman, Andrew K Chan, K Daniel Riew, Noam Y Harel, Michael S Virk, Christopher Mandigo, Jason B Carme. Timing-dependent synergies between motor cortex and posterior spinal stimulation in humans. The Journal of physiology. 2024-05-17. PMID:38758005. in 59 individuals undergoing elective cervical spine decompression surgery, the motor cortex was stimulated with scalp electrodes and the spinal cord was stimulated with epidural electrodes, with muscle responses being recorded in arm and leg muscles. 2024-05-17 2024-05-27 rat
Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotte. Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology. 2024-05-04. PMID:38703371. pathogenic variants in the ubqln2 gene cause x-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. 2024-05-04 2024-05-07 Not clear
Sharon Natasha Cox, Claudio Lo Giudice, Anna Lavecchia, Maria Luana Poeta, Matteo Chiara, Ernesto Picardi, Graziano Pesol. Mitochondrial and Nuclear DNA Variants in Amyotrophic Lateral Sclerosis: Enrichment in the Mitochondrial Control Region and Sirtuin Pathway Genes in Spinal Cord Tissue. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672428. amyotrophic lateral sclerosis (als) is a progressive disease with prevalent mitochondrial dysfunctions affecting both upper and lower motor neurons in the motor cortex, brainstem, and spinal cord. 2024-04-27 2024-04-29 human
N Déglo. Gene editing as a therapeutic strategy for spinocerebellar ataxia type-3. Revue neurologique. 2024-04-05. PMID:38580500. clinically, sca3 pathology is characterized by progressive ataxia leading to motor incoordination that may affect balance, gait and speech, and neuropathologically by a progressive degeneration of the spinal cord and cerebellum, as well as the cerebral cortex and basal ganglia. 2024-04-05 2024-04-10 Not clear
LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. 2024-03-19 2024-03-21 human
Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. 2024-03-13 2024-03-16 mouse
Shinji Kubota, Chika Sasaki, Satomi Kikuta, Junichiro Yoshida, Sho Ito, Hiroaki Gomi, Tomomichi Oya, Kazuhiko Sek. Modulation of somatosensory signal transmission in the primate cuneate nucleus during voluntary hand movement. Cell reports. 2024-03-08. PMID:38458194. the attenuation is comparable to the cerebral cortex but more pronounced than in the spinal cord, indicating the cuneate nuclei's role in somatosensory perception modulation during movement. 2024-03-08 2024-03-11 Not clear
Silvia Sapienza, Valentina Tedeschi, Barbara Apicella, Anna Pannaccione, Carmela Russo, Maria Josè Sisalli, Giorgia Magliocca, Stefania Loffredo, Agnese Second. Ultrafine particulate matter pollution and dysfunction of endoplasmic reticulum Ca Ecotoxicology and environmental safety. vol 273. 2024-02-20. PMID:38377779. the present data showed that pm0.1 and np20 exposure induced endoplasmic reticulum (er) stress, as occurred in cortex and spinal cord of als mice carrying g93a mutation in sod1 gene. 2024-02-20 2024-02-23 mouse
Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D'Alessandr. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Frontiers in molecular neuroscience. vol 16. 2024-01-31. PMID:38292023. amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. 2024-01-31 2024-02-02 mouse
Jian Lu, An-Xu He, Zhuo-Ying Jin, Meng Zhang, Zhong-Xin Li, Fan Zhou, Lin Ma, Hong-Ming Jin, Jia-Ying Wang, Xu She. Desloratadine alleviates ALS-like pathology in hSOD1 Acta pharmacologica Sinica. 2024-01-29. PMID:38286832. desloratadine alleviates als-like pathology in hsod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. 2024-01-29 2024-02-01 Not clear