All Relations between prefrontal cortex and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Marieka V DeVuono, Mina G Nashed, Mohammed H Sarikahya, Andrea Kocsis, Kendrick Lee, Sebastian R Vanin, Roger Hudson, Eryn P Lonnee, Walter J Rushlow, Daniel B Hardy, Steven R Laviolett. Prenatal tetrahydrocannabinol and cannabidiol exposure produce sex-specific pathophysiological phenotypes in the adolescent prefrontal cortex and hippocampus. Neurobiology of disease. 2024-07-03. PMID:38960101. these phenotypes were associated with sex and treatment-specific neuronal and gene transcriptional alterations in the prefrontal cortex, and ventral hippocampus, regions where the endocannabinoid system is implicated in affective and cognitive development. 2024-07-03 2024-07-10 rat
Justyna Socha, Pawel Grochecki, Marta Marszalek-Grabska, Aleksandra Skrok, Irena Smaga, Tymoteusz Slowik, Wojciech Prazmo, Robert Kotlinski, Malgorzata Filip, Jolanta H Kotlinsk. Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928357. however, cbd was able to prevent the reinstatement of oxy-induced cpp only in adolescent males and this outcome was associated with an increased cannabinoid 1 receptor (cb1r) and a decreased mu opioid receptor (mor) expression in the prefrontal cortex (pfc). 2024-06-27 2024-06-29 rat
Sierra J Stringfield, Erin K Kirschmann, Mary M Torregross. Working memory performance predicts, but does not reduce, cocaine- and cannabinoid-seeking in adult male rats. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853853. we investigated whether working memory training could elevate bdnf levels in the prefrontal cortex and if this training would predict or protect against cocaine or cannabinoid seeking. 2024-06-10 2024-06-14 rat
Keerthana Deepti Karunakaran, Michael Pascale, Nisan Ozana, Kevin Potter, Gladys N Pachas, A Eden Evins, Jodi M Gilma. Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-07. PMID:38714786. cannabinoid 1 receptors, the main target of Δ9-tetrahydrocannabinol (thc), the primary intoxicating cannabinoid in cannabis, are densely localized within prefrontal cortex; therefore, prefrontal brain regions are key locations to examine brain changes that characterize acute intoxication. 2024-05-07 2024-05-27 human
Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Vitória Luiza de Camargo Milczarski, Victor Silva Dias, Camila Scheid, Josias de Oliveira Merib, Marcia Giovernardi, Renata Padilha Guede. Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring. Brain, behavior, and immunity. 2024-04-12. PMID:38608740. overall, the findings of this study provide insight into the signaling pathways for the therapeutic benefits of cbd on neuroinflammation and neurochemical imbalances caused by perinatal maternal obesity in the pfc and the hippocampus, which translates into the behavioral manifestations, highlighting the sexual dimorphism encompassing both the transgenerational effect of obesity and the endocannabinoid system. 2024-04-12 2024-04-15 rat
Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. prefrontal cortex (pfc) maturation during adolescence is characterized by structural and functional changes, which involve the remodeling of gaba and glutamatergic synapses, as well as changes in the endocannabinoid system. 2024-03-12 2024-03-14 rat
Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. yet, the way pfc endocannabinoid signaling interacts with local gaba and glutamatergic function to impact its processing of afferent transmission during the adolescent transition to adulthood remains unknown. 2024-03-12 2024-03-14 rat
Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. here we combined pfc local field potential recordings with local manipulations of 2-ag and anandamide levels to assess how pfc endocannabinoid signaling is recruited to modulate ventral hippocampal and basolateral amygdalar inputs in vivo in adolescent and adult male rats. 2024-03-12 2024-03-14 rat
Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. we found that the pfc endocannabinoid signaling does not fully emerge until late-adolescence/young adulthood. 2024-03-12 2024-03-14 rat
Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. collectively, these results indicate a protracted recruitment of pfc endocannabinoid signaling, which becomes online in late adolescence/young adulthood as revealed by its impact on hippocampal and amygdalar-evoked local field potential responses and trace fear memory behavior. 2024-03-12 2024-03-14 rat
Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joc. Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology. 2024-02-24. PMID:38401791. repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the flinders sensitive line (fsl) rat model of depression. 2024-02-24 2024-02-27 rat
Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joc. Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology. 2024-02-24. PMID:38401791. the pfc was analyzed by a) western blotting to assess markers of synaptic plasticity and cannabinoid signaling in synaptosome and cytosolic fractions; b) mass spectrometry-based lipidomics to investigate endocannabinoid levels (ecb). 2024-02-24 2024-02-27 rat
Laura Rullo, Loredana Maria Losapio, Camilla Morosini, Francesca Mottarlini, Sara Schiavi, Valeria Buzzelli, Fabrizio Ascone, Roberto Ciccocioppo, Liana Fattore, Lucia Caffino, Fabio Fumagalli, Patrizia Romualdi, Viviana Trezza, Sanzio Candelett. Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats. Frontiers in cellular neuroscience. vol 17. 2024-01-04. PMID:38174157. outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats. 2024-01-04 2024-01-06 rat
Mohammed H Sarikahya, Samantha L Cousineau, Marta De Felice, Hanna J Szkudlarek, Karen K W Wong, Marieka V DeVuono, Kendrick Lee, Mar Rodríguez-Ruiz, Dana Gummerson, Emma Proud, Tsun Hay Jason Ng, Roger Hudson, Tony Jung, Daniel B Hardy, Ken K-C Yeung, Susanne Schmid, Walter Rushlow, Steven R Laviolett. Prenatal THC exposure induces long-term, sex-dependent cognitive dysfunction associated with lipidomic and neuronal pathology in the prefrontal cortex-hippocampal network. Molecular psychiatry. 2023-07-31. PMID:37525013. the endocannabinoid system (ecs), which relies on polyunsaturated fatty acids (pufas) to function, plays a crucial role in regulating prefrontal cortical (pfc) and hippocampal network-dependent behaviors essential for cognition and memory. 2023-07-31 2023-08-14 Not clear
Cristina Izquierdo-Luengo, Marc Ten-Blanco, María Ponce-Renilla, Ramiro Perezzan, Inmaculada Pereda-Pérez, Fernando Berrender. Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225721. a transitory decrease in the expression of gad67 and cb2 cannabinoid receptors in the prefrontal cortex was also found in male mice exposed to jwh-018. 2023-05-24 2023-08-14 mouse
Michał Szulc, Radosław Kujawski, Amanda Pacholak, Marta Poprawska, Kamila Czora-Poczwardowska, Bogna Geppert, Przemysław Ł Mikołajcza. Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049542. in the prefrontal cortex, hippocampus, and striatum, the cannabinoid (cb1r and cb2r) and dopaminergic (drd1, drd2, drd4, drd5) receptors' mrna level changes were analyzed using the quantitative rt-pcr method. 2023-04-13 2023-08-14 rat
Johanna S Qvist, Maria Scherma, Nitya Jayaram-Lindström, Walter Fratta, Denise B Kandel, Eric R Kandel, Paola Fadda, Philippe A Mela. Synaptoproteomic Analysis of the Prefrontal Cortex Reveals Spatio-Temporal Changes in SYNGAP1 Following Cannabinoid Exposure in Rat Adolescence. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614142. synaptoproteomic analysis of the prefrontal cortex reveals spatio-temporal changes in syngap1 following cannabinoid exposure in rat adolescence. 2023-01-08 2023-08-14 rat
Johanna S Qvist, Maria Scherma, Nitya Jayaram-Lindström, Walter Fratta, Denise B Kandel, Eric R Kandel, Paola Fadda, Philippe A Mela. Synaptoproteomic Analysis of the Prefrontal Cortex Reveals Spatio-Temporal Changes in SYNGAP1 Following Cannabinoid Exposure in Rat Adolescence. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614142. to understand these changes, we exposed mid-adolescent male rats to a synthetic cannabinoid (win 55,212-2 mesylate; win) and, following drug abstinence through late adolescence, we subjected the synaptosomal fractions of the prefrontal cortex (pfc) to proteomic analyses. 2023-01-08 2023-08-14 rat
Kate Zara Peters, Fabien Nanei. The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period. Frontiers in neural circuits. vol 16. 2022-11-17. PMID:36389180. the role of dopamine and endocannabinoid systems in prefrontal cortex development: adolescence as a critical period. 2022-11-17 2023-08-14 Not clear
Kate Zara Peters, Fabien Nanei. The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period. Frontiers in neural circuits. vol 16. 2022-11-17. PMID:36389180. in this review, we highlight recent advances in our understanding of the maturation of the dopamine system and the endocannabinoid system in the prefrontal cortex during adolescence. 2022-11-17 2023-08-14 Not clear