| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Xue, Xiao-Hui Li, Hong-Qun Ding, Xin Qian, Meng-Yu Zhang, Kai Chen, Zi-Wei Wei, Ying Li, Jun-Hai Jia, Wei-Ning Zhan. Pyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments. Metabolic brain disease. vol 40. issue 1. 2024-12-19. PMID:39699742. |
cannabinoid receptor interacting protein 1 (cnrip1) and cannabinoid receptor-1 (cb1r), which regulate memory, cognitive and motor activity, were detected in the prefrontal cortex (pfc) and hippocampus of the offspring rats, and the cell proliferation in the hippocampal dentate gyrus (dg) was also observed. |
2024-12-19 |
2024-12-21 |
rat |
| Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Victor Silva Dias, Camila Pereira Medeiros, Fernanda Wickert, Nadja Schroder, Marcia Giovernardi, Renata Padilha Guede. Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring. Neuropharmacology. vol 262. 2024-10-25. PMID:39447736. |
behavioral tests assessed anxiety-like manifestations and social behavior, while neuroinflammatory and endocannabinoid markers were evaluated in the hypothalamus, prefrontal cortex (pfc) and hippocampus, as well as the biochemical profile in the plasma. |
2024-10-25 |
2024-10-28 |
rat |
| Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Victor Silva Dias, Camila Pereira Medeiros, Fernanda Wickert, Nadja Schroder, Marcia Giovernardi, Renata Padilha Guede. Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring. Neuropharmacology. vol 262. 2024-10-25. PMID:39447736. |
cbd treatment attenuated maternal obesity-induced anxiety-like and social behavioral alterations, restoring exacerbated astrocytic and microglial markers in the hypothalamus, pfc and hippocampus of the offspring, as well as endocannabinoid levels in the pfc, with notable sex differences. |
2024-10-25 |
2024-10-28 |
rat |
| Sierra J Stringfield, Erin K Kirschmann, Mary M Torregross. Working memory performance predicts, but does not reduce, cocaine- and cannabinoid-seeking in adult male rats. The international journal of neuropsychopharmacology. 2024-10-07. PMID:39373213. |
we investigated whether working memory training could elevate bdnf levels in the prefrontal cortex and if this training would predict or protect against cocaine or cannabinoid seeking. |
2024-10-07 |
2024-10-09 |
rat |
| İsmail Mücahit Alptekin, Funda Pınar Çakıroğlu, Tuba Reçber, Emirhan Nemutl. Inulin may prevent the high-fat diet induced-obesity via suppressing endocannabinoid system in the prefrontal cortex in Wistar rats. International journal of food sciences and nutrition. 2024-10-04. PMID:39363521. |
inulin may prevent the high-fat diet induced-obesity via suppressing endocannabinoid system in the prefrontal cortex in wistar rats. |
2024-10-04 |
2024-10-07 |
rat |
| İsmail Mücahit Alptekin, Funda Pınar Çakıroğlu, Tuba Reçber, Emirhan Nemutl. Inulin may prevent the high-fat diet induced-obesity via suppressing endocannabinoid system in the prefrontal cortex in Wistar rats. International journal of food sciences and nutrition. 2024-10-04. PMID:39363521. |
although there is evidence that the endocannabinoid system has metabolic effects in the prefrontal cortex, studies investigating the effects of inulin on the endocannabinoid system are limited. |
2024-10-04 |
2024-10-07 |
rat |
| İsmail Mücahit Alptekin, Funda Pınar Çakıroğlu, Tuba Reçber, Emirhan Nemutl. Inulin may prevent the high-fat diet induced-obesity via suppressing endocannabinoid system in the prefrontal cortex in Wistar rats. International journal of food sciences and nutrition. 2024-10-04. PMID:39363521. |
this study investigated the impact of inulin on obesity through the endocannabinoid system in the prefrontal cortex. |
2024-10-04 |
2024-10-07 |
rat |
| Tong Zhang, JiaGuang Sun, Qiang Jiao, ShuaiChen Li, XiangBo Meng, JingPu Shi, Bo Wan. Cannabinoid type 2 receptor deficiency leads to Aβ-induced cognitive impairment through promoting microglial sensitivity to Aβ in the prefrontal cortex in mice. IBRO neuroscience reports. vol 17. 2024-09-19. PMID:39297128. |
cannabinoid type 2 receptor deficiency leads to aβ-induced cognitive impairment through promoting microglial sensitivity to aβ in the prefrontal cortex in mice. |
2024-09-19 |
2024-09-21 |
mouse |
| Marieka V DeVuono, Mina G Nashed, Mohammed H Sarikahya, Andrea Kocsis, Kendrick Lee, Sebastian R Vanin, Roger Hudson, Eryn P Lonnee, Walter J Rushlow, Daniel B Hardy, Steven R Laviolett. Prenatal tetrahydrocannabinol and cannabidiol exposure produce sex-specific pathophysiological phenotypes in the adolescent prefrontal cortex and hippocampus. Neurobiology of disease. 2024-07-03. PMID:38960101. |
these phenotypes were associated with sex and treatment-specific neuronal and gene transcriptional alterations in the prefrontal cortex, and ventral hippocampus, regions where the endocannabinoid system is implicated in affective and cognitive development. |
2024-07-03 |
2024-07-10 |
rat |
| Justyna Socha, Pawel Grochecki, Marta Marszalek-Grabska, Aleksandra Skrok, Irena Smaga, Tymoteusz Slowik, Wojciech Prazmo, Robert Kotlinski, Malgorzata Filip, Jolanta H Kotlinsk. Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928357. |
however, cbd was able to prevent the reinstatement of oxy-induced cpp only in adolescent males and this outcome was associated with an increased cannabinoid 1 receptor (cb1r) and a decreased mu opioid receptor (mor) expression in the prefrontal cortex (pfc). |
2024-06-27 |
2024-06-29 |
rat |
| Sierra J Stringfield, Erin K Kirschmann, Mary M Torregross. Working memory performance predicts, but does not reduce, cocaine- and cannabinoid-seeking in adult male rats. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853853. |
we investigated whether working memory training could elevate bdnf levels in the prefrontal cortex and if this training would predict or protect against cocaine or cannabinoid seeking. |
2024-06-10 |
2024-06-14 |
rat |
| Keerthana Deepti Karunakaran, Michael Pascale, Nisan Ozana, Kevin Potter, Gladys N Pachas, A Eden Evins, Jodi M Gilma. Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-07. PMID:38714786. |
cannabinoid 1 receptors, the main target of Δ9-tetrahydrocannabinol (thc), the primary intoxicating cannabinoid in cannabis, are densely localized within prefrontal cortex; therefore, prefrontal brain regions are key locations to examine brain changes that characterize acute intoxication. |
2024-05-07 |
2024-05-27 |
human |
| Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Vitória Luiza de Camargo Milczarski, Victor Silva Dias, Camila Scheid, Josias de Oliveira Merib, Marcia Giovernardi, Renata Padilha Guede. Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring. Brain, behavior, and immunity. 2024-04-12. PMID:38608740. |
overall, the findings of this study provide insight into the signaling pathways for the therapeutic benefits of cbd on neuroinflammation and neurochemical imbalances caused by perinatal maternal obesity in the pfc and the hippocampus, which translates into the behavioral manifestations, highlighting the sexual dimorphism encompassing both the transgenerational effect of obesity and the endocannabinoid system. |
2024-04-12 |
2024-04-15 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
prefrontal cortex (pfc) maturation during adolescence is characterized by structural and functional changes, which involve the remodeling of gaba and glutamatergic synapses, as well as changes in the endocannabinoid system. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
yet, the way pfc endocannabinoid signaling interacts with local gaba and glutamatergic function to impact its processing of afferent transmission during the adolescent transition to adulthood remains unknown. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
here we combined pfc local field potential recordings with local manipulations of 2-ag and anandamide levels to assess how pfc endocannabinoid signaling is recruited to modulate ventral hippocampal and basolateral amygdalar inputs in vivo in adolescent and adult male rats. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
we found that the pfc endocannabinoid signaling does not fully emerge until late-adolescence/young adulthood. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
collectively, these results indicate a protracted recruitment of pfc endocannabinoid signaling, which becomes online in late adolescence/young adulthood as revealed by its impact on hippocampal and amygdalar-evoked local field potential responses and trace fear memory behavior. |
2024-03-12 |
2024-03-14 |
rat |
| Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joc. Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology. 2024-02-24. PMID:38401791. |
repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the flinders sensitive line (fsl) rat model of depression. |
2024-02-24 |
2024-02-27 |
rat |
| Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joc. Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology. 2024-02-24. PMID:38401791. |
the pfc was analyzed by a) western blotting to assess markers of synaptic plasticity and cannabinoid signaling in synaptosome and cytosolic fractions; b) mass spectrometry-based lipidomics to investigate endocannabinoid levels (ecb). |
2024-02-24 |
2024-02-27 |
rat |