All Relations between nucleus accumbens and prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Gabriele Floris, Konrad R Dabrowski, Mary Tresa Zanda, Stephanie E Daw. Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38854027. psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. 2024-06-10 2024-06-14 human
Isabel C Duarte, Ana Dionísio, Joana Oliveira, Marco Simões, Rita Correia, Joana A Dias, Salomé Caldeira, João Redondo, Miguel Castelo-Branc. Neural underpinnings of ethical decisions in life and death dilemmas in naïve and expert firefighters. Scientific reports. vol 14. issue 1. 2024-06-08. PMID:38851794. these realistic life-saving dilemmas activate the same core reward and affective processing network, in particular the ventromedial prefrontal cortex, nucleus accumbens and amygdala, irrespective of prior expertise, thereby supporting general domain theories of ethical decision-making. 2024-06-08 2024-06-11 Not clear
Richard Quansah Amissah, Hakan Kayir, Malik Asfandyaar Talhat, Ahmad Hassan, Yu Gu, Ron Johnson, Karolina Urban, Jibran Y Khokha. The Journal of pharmacology and experimental therapeutics. 2024-06-06. PMID:38844363. sprague-dawley rats (6 males, 7 females) were implanted with electrodes in the prefrontal cortex (pfc), dorsal hippocampus (dhipp), cingulate cortex (cg), and nucleus accumbens (nac). 2024-06-06 2024-06-10 rat
Xue-Fen Zhang, Yi-Dan Li, Yue Li, Ying Li, Dan Xu, Lin-Lin Bi, Hai-Bo X. Ventral subiculum promotes wakefulness through several pathways in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-11. PMID:38734818. in addition, optogenetic stimulation of vsub glutamatergic terminals and retrograde-targeted chemogenetic activation of vsub glutamatergic neurons revealed that vsub promoted arousal by innervating the lateral hypothalamus (lh), nucleus accumbens (nac) shell, and prefrontal cortex (pfc). 2024-05-11 2024-05-27 mouse
Hao Li, Mina A Jacob, Mengfei Cai, Roy P C Kessels, David G Norris, Marco Duering, Frank-Erik de Leeuw, Anil M Tuladha. Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease. Brain : a journal of neurology. 2024-05-06. PMID:38709856. we reconstructed five tracts connecting ventral tegmental area (vta) and the dorsolateral prefrontal cortex (dlpfc), ventral lateral pfc (vlpfc), medial orbitofrontal cortex (mofc), anterior cingulate cortex (acc) and nucleus accumbens (nac) within meso-cortical and meso-limbic pathways using diffusion weighted imaging. 2024-05-06 2024-05-27 human
Jérôme Jeanblanc, Romain Bordy, Grégory Fouquet, Virginie Jeanblanc, Mickaël Naassil. Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats. Brain : a journal of neurology. 2024-05-04. PMID:38703387. transcripts from the dopaminergic system were quantified in the nucleus accumbens and prefrontal cortex. 2024-05-04 2024-05-07 rat
Jérôme Jeanblanc, Romain Bordy, Grégory Fouquet, Virginie Jeanblanc, Mickaël Naassil. Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats. Brain : a journal of neurology. 2024-05-04. PMID:38703387. in rats that self-administered ethanol but not in those self-administering saccharin, dopamine d2 receptor mrna were increased in both the nucleus accumbens and the prefrontal cortex by psilocybin, while d1r mrna was increased only in the prefrontal cortex. 2024-05-04 2024-05-07 rat
Maysam Fadaei-Kenarsary, Khadijeh Esmaeilpour, Mohammad Shabani, Vahid Sheiban. Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments. Addiction & health. vol 16. issue 1. 2024-04-23. PMID:38651025. the brain's lateral paragigantocellularis (lpgi), nucleus accumbens (nac), caudate-putamen (cpu), prefrontal cortex (pfc), and hippocampus, can be affected by ms. dopamine receptor subtype genes, alcohol biomarker minor allele, and preproenkephalin mrna may be affected by alcohol or substance use disorders. 2024-04-23 2024-04-26 Not clear
Matthew P Gunn, Gregory M Rose, Alexis E Whitton, Diego A Pizzagalli, David G Gilber. Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2024-04-16. PMID:38624067. we hypothesized that high rsfc between brain areas with high densities of nicotinic receptors (insula, anterior cingulate cortex [acc], hippocampus, thalamus) and areas involved in reward-seeking (nucleus accumbens [nacc], prefrontal cortex [pfc]) would predict nicotine-enhanced reward sensitivity and smoking progression. 2024-04-16 2024-04-18 Not clear
Florian Schoukroun, Katia Befort, Romain Bourd. The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-03. PMID:38570645. similar to addictive drugs, such foods activate the brain's reward circuit, involving mesolimbic dopaminergic projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) and the prefrontal cortex. 2024-04-03 2024-04-06 rat
Cherish E Ardinger, Christopher C Lapish, David N Linsenbard. Repeated Binge Alcohol Drinking Leads to Reductions in Corticostriatal Theta Coherence in Female but not Male Mice. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496601. to further our understanding of how repeated alcohol (ethanol; etoh) consumption impacts the corticostriatal circuit, extracellular electrophysiological recordings (local field potentials; lfps) were gathered from the nucleus accumbens (nac) and prefrontal cortex (pfc) of c57bl/6j mice voluntarily consuming etoh or water using a 'drinking-in-the-dark' (did) procedure. 2024-03-18 2024-03-20 mouse
Kaili Du, Qianwen Shi, Xiuya Zhou, Lifei Zhang, Hongliang Su, Chao Zhang, Zhiwen Wei, Ting Liu, Li Wang, Xiaohui Wang, Bin Cong, Keming Yu. Melatonin attenuates fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice. Physiology & behavior. 2024-03-16. PMID:38492912. the accompanying changes in the expression of brain and muscle arnt-like (bmal1), tyrosine hydroxylase (th), and monoamine oxidase a (mao-a) in relevant brain regions including the suprachiasmatic nucleus (scn), nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus (hip) were investigated by western blot assays to dissect the mechanism by which melatonin modulates fentanyl - induced behavioral sensitization and circadian rhythm disorders. 2024-03-16 2024-03-19 mouse
Mohit Kumar, Chitralekha Gusain, Babita Bhatt, Roshan Lal, Mahendra Bishno. Sex-specific effects of sucrose withdrawal on anxiety-like behavior and neuroimmune response. Neuropharmacology. 2024-02-25. PMID:38403263. sucrose bingeing and subsequent withdrawal showed elevated protein levels of pro-inflammatory cytokines/chemokines/growth factors in the prefrontal cortex (il-1β, il-6, tnfα, ifn-γ, il-10, ccl5, vegf) and nucleus accumbens (il-1β, il-6, il-10, vegf) of male mice as compared to their water controls. 2024-02-25 2024-02-28 mouse
Alicia C Wells, Shahrdad Lotfipou. Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits. Advances in drug and alcohol research. vol 3. 2024-02-23. PMID:38389806. due to the large percentage of women utilizing nicotine products during pregnancy in the united states and globally, this review seeks to centralize pre-clinical and clinical studies focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (pne) such as alterations to the hypothalamic-pituitary-adrenal (hpa) axis and brain regions such as the prefrontal cortex (pfc), ventral tegmental area (vta), nucleus accumbens (na), hippocampus, and caudate as well as changes to nachr and cholinergic receptor signaling, long-term drug seeking behavior following pne, and other related developmental disorders. 2024-02-23 2024-02-25 Not clear
Anna C Cichocki, Richard E Zinbarg, Michelle G Craske, Iris K-Y Chat, Katherine S Young, Susan Y Bookheimer, Robin Nussloc. Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex. Psychiatry research. Neuroimaging. vol 339. 2024-02-15. PMID:38359709. using structural mri, gray matter volumes were extracted for emotion generation (amygdala, nucleus accumbens) and regulation (orbitofrontal, ventrolateral, and dorsolateral prefrontal cortex) regions, often implicated in depression and anxiety. 2024-02-15 2024-02-18 Not clear
R Heijkoop, J F Lalanza, M Solanas, A Álvarez-Monell, A Subias-Gusils, R M Escorihuela, E M S Snoere. Changes in reward-induced neural activity upon Cafeteria Diet consumption. Physiology & behavior. 2024-02-02. PMID:38307359. to this end, rats were exposed to a 6-week diet with either standard chow, or ad libitum daily access to caf diet, 30% restricted but daily access to caf diet, or one-day-a-week (intermittent) ad libitum access to caf diet, after which c-fos expression in the nucleus accumbens (nac), prefrontal cortex (pfc), and ventral tegmental area (vta) following consumption of a caf reward of choice was examined. 2024-02-02 2024-02-05 rat
Julie D White, Melyssa S Minto, Caryn Willis, Bryan C Quach, Shizhong Han, Ran Tao, Amy Deep-Soboslay, Lea Zillich, Shaunna L Clark, Edwin J C G van den Oord, Thomas M Hyde, R Dayne Mayfield, Bradley T Webb, Eric O Johnson, Joel E Kleinman, Laura J Bierut, Dana B Hancoc. Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex. medRxiv : the preprint server for health sciences. 2024-01-31. PMID:38293028. here, we interrogate aud-associated dna methylation (dnam) changes within and across addiction-relevant brain regions: the nucleus accumbens (nac) and dorsolateral prefrontal cortex (dlpfc). 2024-01-31 2024-02-02 Not clear
A Khayat, R Yak. Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system. Translational psychiatry. vol 14. issue 1. 2024-01-19. PMID:38242878. our study demonstrates that enhancing the gabaergic inputs from the rmtg to the vta can mitigate cocaine-induced molecular changes in key regions, namely the vta, nucleus accumbens (nac), and prefrontal cortex (pfc). 2024-01-19 2024-01-22 Not clear
Jyoti Lodha, Emily R Brocato, McKenzie Nash, Madison M Marcus, A Chris Pais, Alex B Pais, Michael F Miles, Jennifer Theresa Wolstenholm. Adolescent social housing protects against adult emotional and cognitive deficits and alters the PFC and NAc transcriptome in male and female C57BL/6J mice. Frontiers in neuroscience. vol 17. 2023-12-22. PMID:38130694. the study goal is to implement a novel neighbor housing environment to identify the effects of adolescent neighbor housing and/or binge ethanol drinking on (1) a battery of emotional and cognitive tasks (2) adult ethanol drinking behavior, and (3) the nucleus accumbens and prefrontal cortex transcriptome. 2023-12-22 2023-12-24 mouse
Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. specifically, jwh-133 administration was found to upregulate Δ-fosb expression in the nucleus accumbens (nac), elevate cx3cl1 levels in both the ventral tegmental area and prefrontal cortex (pfc), and concurrently reduce il-1β expression in the pfc and nac among cocaine-treated animals. 2023-12-12 2023-12-17 mouse