| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary M Gemzik, Amy L Griffi. Medial septal theta stimulation enhances spatial working memory performance in rats. Learning & memory (Cold Spring Harbor, N.Y.). vol 32. issue 4. 2025-04-10. PMID:40210434. |
spatial working memory (swm) relies on the integrity of the medial septum area (msa) and its ability to drive theta (4-12 hz) oscillations in the hippocampus. |
2025-04-10 |
2025-04-14 |
rat |
| Ekaterine E Kipiani, Maia A Burjanadze, Manana G Dashniani, Nino C Chkhikvishvili, Temur L Naneishvili, Mariam R Chighladze, Barbare G Nozadze, Gela V Beseli. Medial septum deep brain stimulation enhances memory and hippocampal neurogenesis in the D-galactose induced rat model of aging: behavioral and immunohistochemical study. Experimental brain research. vol 243. issue 4. 2025-03-18. PMID:40100345. |
in present study we tested the hypothesis that medial septum (ms) dbs enhances memory function by modulating the hippocampal neurogenesis in the d-galactose (d-gal) induced rat model of aging. |
2025-03-18 |
2025-03-21 |
rat |
| Mariam Chighladze, Khatuna Rusadze, Maia Burjanadze, Manana Dashniani, Lali Kruashvil. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751552. |
in the present study, we evaluated the effect of medial septum (ms) deep brain stimulation (dbs) on okadaic acid (oa) induced impairment of spatial working memory and neuropathological changes in the hippocampus in rats. |
2025-01-03 |
2025-01-05 |
rat |
| Mohammed Zacky Ariffin, Si Yun Ng, Hamzah Nadia, Darrel Koh, Natasha Loh, Naomi Michiko, Sanjay Khann. Neurokinin1 - cholinergic receptor mechanisms in the medial Septum-Dorsal hippocampus axis mediates experimental neuropathic pain. Neurobiology of pain (Cambridge, Mass.). vol 16. 2024-09-03. PMID:39224764. |
the neurokinin-1 receptors (nk1rs) in the forebrain medial septum (ms) region are localized exclusively on cholinergic neurons that partly project to the hippocampus and the cingulate cortex (cg), regions implicated in nociception. |
2024-09-03 |
2024-09-05 |
rat |
| Eric Fagerli, Charles W Jackson, Iris Escobar, Fernando J Ferrier, Efrain J Perez Lao, Isabel Saul, Jorge Gomez, Kunjan R Dave, Oliver Bracko, Miguel A Perez-Pinzo. Resveratrol Mitigates Cognitive Impairments and Cholinergic Cell Loss in the Medial Septum in a Mouse Model of Gradual Cerebral Hypoperfusion. Antioxidants (Basel, Switzerland). vol 13. issue 8. 2024-08-29. PMID:39199230. |
despite these deficits, no hippocampal pathology was observed; however, cholinergic cell loss in the medial septum was significantly increased after gbccas. |
2024-08-29 |
2024-09-01 |
mouse |
| Alyssa Kniffin, Miranda Targum, Aryan Patel, Debra A Bangasser, Vinay Parik. Alterations in hippocampal cholinergic dynamics following CRF infusions into the medial septum of male and female rats. Neurochemistry international. 2024-04-11. PMID:38604443. |
alterations in hippocampal cholinergic dynamics following crf infusions into the medial septum of male and female rats. |
2024-04-11 |
2024-04-14 |
rat |
| Qiao Ye, Gocylen Gast, Erik George Wilfley, Hanh Huynh, Chelsea Hays, Todd C Holmes, Xiangmin X. Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-19. PMID:38503494. |
input-mapped brain regions include hippocampal subregions (ca1, ca2, ca3), medial septum and diagonal band (ms-db), retrosplenial cortex (rsc), sub, post subiculum (postsub), visual cortex (vis), auditory cortex (aud), somatosensory cortex (ss), entorhinal cortex (ec), thalamus, perirhinal cortex (prh), ectorhinal cortex (ect) and temporal association cortex (tea). |
2024-03-19 |
2024-03-23 |
mouse |
| Lidia I Madrid, Katelyn Hafey, Saurabh Bandhavkar, Gabriela O Bodea, Javier Jimenez-Martin, Michael Milne, Tara L Walker, Geoffrey J Faulkner, Elizabeth J Coulson, Dhanisha J Jhaver. Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis. Development (Cambridge, England). 2023-12-08. PMID:38063486. |
using a targeted ablation approach, we also show that medial septum (ms) and the diagonal band of broca (dbb) cholinergic neurons support both the survival and morphological maturation of adult-born neurons in the mouse hippocampus. |
2023-12-08 |
2023-12-17 |
mouse |
| Mu-Hsuan Chen, Hsiao-Chun Lin, Tzu Chao, Viola Szu-Yuan Lee, Chia-Lung Hou, Tsyr-Jiuan Wang, Jeng-Rung Che. Hyaluronic Acid Conjugated with 17β-Estradiol Effectively Alleviates Estropause-Induced Cognitive Deficits in Rats. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958552. |
our study revealed an 11% rise in choline acetyltransferase (chat) expression in both the medial septal nucleus (ms nucleus) and the hippocampus, along with a 14-18% increase in dendritic spine density in hippocampal pyramidal neurons, following ha-e2 treatment in ohe rats. |
2023-11-14 |
2023-11-20 |
rat |
| Guy Cheron, Laurence Ris, Ana Maria Ceboll. Nucleus incertus provides eye velocity and position signals to the vestibulo-ocular cerebellum: a new perspective of the brainstem-cerebellum-hippocampus network. Frontiers in systems neuroscience. vol 17. 2023-06-12. PMID:37304152. |
faced with these forgotten cerebellar projections of the nic, the present perspective discusses the possibility that, in addition to the already described pathways linking the cerebellum and the hippocampus via the medial septum, these nic signals related to the vestibulo-ocular reflex and gaze holding could participate in the hippocampal control of navigation. |
2023-06-12 |
2023-08-14 |
Not clear |
| Junzi Chen, Yu Wang, Cong Chen, Qingyang Zhang, Shuang Wang, Yi Wang, Jiajia Fang, Ying Wan. Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282477. |
in a mouse model of chronic temporal lobe epilepsy induced by kainic acid, the number of medial septum cholinergic neurons was reduced and acetylcholine release was reduced in the hippocampus. |
2023-06-07 |
2023-08-14 |
mouse |
| Junzi Chen, Yu Wang, Cong Chen, Qingyang Zhang, Shuang Wang, Yi Wang, Jiajia Fang, Ying Wan. Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282477. |
furthermore, selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice, and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid- and kindling-induced epilepsy models. |
2023-06-07 |
2023-08-14 |
mouse |
| Junzi Chen, Yu Wang, Cong Chen, Qingyang Zhang, Shuang Wang, Yi Wang, Jiajia Fang, Ying Wan. Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282477. |
these results suggest that activation of medial septum cholinergic neurons reduces cognitive deficits in temporal lobe epilepsy by increasing acetylcholine release via projections to the hippocampus. |
2023-06-07 |
2023-08-14 |
mouse |
| Yuta Madokoro, Daisuke Kato, Yo Tsuda, Itsumi Arakawa, Kengo Suzuki, Toyohiro Sato, Masayuki Mizuno, Yuto Uchida, Kosei Ojika, Noriyuki Matsukaw. Direct Enhancement Effect of Hippocampal Cholinergic Neurostimulating Peptide on Cholinergic Activity in the Hippocampus. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240261. |
the cholinergic efferent network from the medial septal nucleus to the hippocampus is crucial for learning and memory. |
2023-05-27 |
2023-08-14 |
mouse |
| Isis Gil-Miravet, Ángel Núñez-Molina, Mónica Navarro-Sánchez, Esther Castillo-Gómez, Francisco Ros-Bernal, Andrew L Gundlach, Francisco E Olucha-Bordona. Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity. Brain structure & function. 2023-05-12. PMID:37173580. |
activity in the hippocampus and entorhinal cortex can be driven from the medial septum (ms), and the ni projects to all these centers, where a prominent pattern of activity is theta rhythm, which is related to spatial memory processing. |
2023-05-12 |
2023-08-14 |
rat |
| Alyssa Kniffin, Debra A Bangasser, Vinay Parik. Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications. The European journal of neuroscience. 2023-04-29. PMID:37118907. |
the medial septum cholinergic neurons extensively innervate the hippocampus. |
2023-04-29 |
2023-08-14 |
Not clear |
| Yuh-Tarng Chen, Rachel Arano, Jun Guo, Uzair Saleem, Ying Li, Wei X. Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior. Frontiers in synaptic neuroscience. vol 15. 2023-04-24. PMID:37091878. |
therefore, this study reveals a specific long-range inhibitory synaptic output from the hippocampus to the medial septum in the regulation of animal locomotion. |
2023-04-24 |
2023-08-14 |
mouse |
| Nima Salimi-Nezhad, Stephan Missault, Anaïs Notario Reinoso, Atefe Hassani, Mahmood Amiri, Georgios A Keliri. The impact of selective and non-selective medial septum stimulation on hippocampal neuronal oscillations: A study based on modeling and experiments. Neurobiology of disease. 2023-02-23. PMID:36822547. |
the medial septum (ms) in the forebrain provides major cholinergic input to the hpc and has been shown to play a significant role in generating oscillations in hippocampal neurons. |
2023-02-23 |
2023-08-14 |
rat |
| Lu Yin, Jinming Zhang, Hongwei Ma, Xinxin Zhang, Zhongmin Fan, Yongheng Yang, Mengyun Li, Jing Han, Xijing Zhan. Selective activation of cholinergic neurotransmission from the medial septal nucleus to hippocampal pyramidal neurones improves sepsis-induced cognitive deficits in mice. British journal of anaesthesia. 2023-02-22. PMID:36813621. |
we assessed real-time alterations of acetylcholine neurotransmission from the medial septal nucleus to the hippocampus, and explored whether sepsis-induced cognitive deficits can be relieved by activating upstream cholinergic projections. |
2023-02-22 |
2023-08-14 |
mouse |
| Francisco Velasquez, Conor Dickson, Michelle L Kloc, Carmel A Schneur, Jeremy M Barry, Gregory L Holme. Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures. Neurobiology of disease. 2023-01-31. PMID:36720444. |
we used optogenetic stimulation of the medial septum to induce physiological 7 hz theta oscillations in the hippocampus during the critical period of spatial cognition following early-life seizures. |
2023-01-31 |
2023-08-14 |
human |