| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aldo R Tejeda-Martínez, Ana R Ramos-Molina, Patricia A Brand-Rubalcava, Mario E Flores-Sot. Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review. Medicine. vol 103. issue 28. 2024-07-12. PMID:38996114. |
disorders such as anxiety, depression, schizophrenia, epilepsy, sexual disorders, and eating disorders, have been closely linked to variations in 5-ht concentrations and modifications in brain structures, including the raphe nuclei (rn), prefrontal cortex, basal ganglia, hippocampus, and hypothalamus, among others. |
2024-07-12 |
2024-07-15 |
Not clear |
| Kristoffer Højgaard, Erik Kaadt, Birgitte Hviid Mumm, Vitor Silva Pereira, Betina Elfvin. Dysregulation of circadian clock gene expression patterns in a treatment-resistant animal model of depression. Journal of neurochemistry. 2024-07-06. PMID:38970299. |
in the hippocampus, 10 ccgs were affected by acth treatment, whereas in the adrenal glands, 5 ccgs were affected and in the prefrontal cortex, hypothalamus and liver 4 ccgs were regulated. |
2024-07-06 |
2024-07-12 |
rat |
| Christina Thomou, Markus Nussbaumer, Eleni Grammenou, Chrysoula Komini, Angeliki-Maria Vlaikou, Maria P Papageorgiou, Michaela D Filio. Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice. Molecular neurobiology. 2024-05-18. PMID:38761326. |
we also investigated eh-induced effects at the protein and mrna levels in adult male hab mice in the hypothalamus, the prefrontal cortex, and the hippocampus by examining the same mitochondrial/energy pathways and mitochondrial dynamics mechanisms (fission, fusion, biogenesis, and mitophagy) in all three brain regions.eh exerts anxiolytic effects in adult hab but not nab male mice and does not affect hab or nab maternal behavior, although basal hab vs. nab maternal behaviors differ. |
2024-05-18 |
2024-05-27 |
mouse |
| Yehong Fang, Yunkai Sun, Yi Liu, Tieqiao Liu, Wei Hao, Yanhui Lia. Neurobiological mechanisms and related clinical treatment of addiction: a review. Psychoradiology. vol 2. issue 4. 2024-04-26. PMID:38665277. |
the changes in the orbitofrontal cortex, dorsolateral prefrontal cortex, amygdala, and hypothalamus emotional system in the withdrawal/negative affect stage involve increases in negative emotional states, dysphoric-like effects, and stress-like responses. |
2024-04-26 |
2024-04-28 |
Not clear |
| Deniz Önal, Hilal Korkmaz, Gizem Önal, Bilge Pehlivanoğl. Body Weight Modulates the Impact of Oxytocin on Chronic Cold-Immobilization Stress Response. Peptides. 2024-03-31. PMID:38555975. |
while oxtr expression levels in the prefrontal cortex did not vary according to the body weight and oxytocin application, oxtr levels in the hypothalamus were higher in the hfd- and/or oxytocin-treated animals. |
2024-03-31 |
2024-04-03 |
rat |
| Jorge Miguel Amaya, Hetty C M Sips, Eva M G Viho, Jan Kroon, Onno C Meije. Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain. Frontiers in endocrinology. vol 14. 2024-02-02. PMID:38303978. |
after chronic treatment with corticosterone, dihydrotestosterone, a combination of both, and corticosterone in combination with the ar antagonist enzalutamide, we compared the expression of glucocorticoid receptor (nr3c1, also abbreviated gr) target genes in brain regions where ar and gr are co-expressed, namely: prefrontal cortex, hypothalamus, hippocampus, ventral tegmental area and substantia nigra. |
2024-02-02 |
2024-02-04 |
mouse |
| Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. |
the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. |
2024-01-11 |
2024-01-13 |
rat |
| Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Nadine Parker, Kevin O'Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Høegh, Trine Lagerberg, Weiqiu Cheng, Tyler Seibert, Srdjan Djurovic, Anders Dale, Hang Zhou, Howard Edenberg, Joel Gelernter, Olav Smeland, Guy Hindley, Ole Andreasse. Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals. Research square. 2024-01-10. PMID:38196616. |
loci were mapped to genes enriched for brain regions relevant for aud (striatum, hypothalamus, and prefrontal cortex) and potential drug targets (gabaergic, dopaminergic and serotonergic neurons). |
2024-01-10 |
2024-01-13 |
Not clear |
| Agnes Hazi, Esmaeil Ebrahimie, Elizabeth A Levay, Manijeh Mohammadi-Dehcheshmeh, Matt Zelko, Antonina Govic, Helen Nasse. Crosstalk between short- and long-term calorie restriction transcriptomic signatures with anxiety-like behavior, aging, and neurodegeneration: implications for drug repurposing. Frontiers in behavioral neuroscience. vol 17. 2023-12-14. PMID:38094940. |
we investigated the effects of short- and long-term cr on behavior as well as transcriptome profiles in the hypothalamus, amygdala, prefrontal cortex, pituitary, and adrenal glands of hooded wistar and long evans male rats. |
2023-12-14 |
2023-12-17 |
rat |
| Pang-Ning Teng, Waleed Barakat, Sophie M Tran, Zoe M Tran, Nicholas W Bateman, Kelly A Conrads, Katlin N Wilson, Julie Oliver, Glenn Gist, Brian L Hood, Ming Zhou, G Larry Maxwell, Lorenzo Leggio, Thomas P Conrads, Mary R Le. Brain proteomic atlas of alcohol use disorder in adult males. Translational psychiatry. vol 13. issue 1. 2023-10-13. PMID:37833300. |
we performed a quantitative proteomic analysis using a liquid chromatography-tandem mass spectrometry (lc-ms/ms) analysis of human postmortem tissue from brain regions that play key roles in the development and maintenance of aud, the amygdala (amg), hippocampus (hipp), hypothalamus (hyp), nucleus accumbens (nac), prefrontal cortex (pfc) and ventral tegmental area (vta). |
2023-10-13 |
2023-10-15 |
human |
| Zubeyde Ercan, Ozgur Bulmus, Emine Kacar, Ihsan Serhatlioglu, Gokhan Zorlu, Haluk Kelestimu. Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats. Journal of molecular neuroscience : MN. 2023-10-04. PMID:37794307. |
brain-derived neurotrophic factor (bdnf), dopamine receptors, and serotonin receptor (htr2a) gene expression in the prefrontal cortex, corpus striatum, and hypothalamus were decreased by crs. |
2023-10-04 |
2023-10-07 |
rat |
| Raoni Conceição Dos-Santos, Brook L W Sweeten, Claire E Stelly, Jeffrey G Taske. The Neuroendocrine Impact of Acute Stress on Synaptic Plasticity. Endocrinology. 2023-10-03. PMID:37788632. |
we describe the synaptic plasticity that occurs in four stress-associated brain structures, the hypothalamus, hippocampus, amygdala, and prefrontal cortex, in response to single or short-term stress exposure. |
2023-10-03 |
2023-10-07 |
Not clear |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
this, study, then, was designed to analyze the long-term effects of early postnatal exposure to cmi on the expression of 5-ht1a, 5-ht2a, and 5-ht3 receptors, as well as bdnf and gr in the following brain regions: pfc, amygdala, hippocampus, and hypothalamus, which could be related to alterations in memory and learning, as evaluated using the novel object recognition (nor) and morris water maze (mwm). |
2023-09-15 |
2023-10-07 |
rat |
| Ofelia Limón-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jiménez, Marco Cerbón, Herlinda Bonilla-Jaim. Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats. Behavioural brain research. 2023-09-15. PMID:37714467. |
expression of the 5-ht1a receptor increased in the hippocampus, amygdala, and hypothalamus, but decreased in the pfc, while the 5-ht2a and bdnf receptors decreased their expression in the pfc, amygdala, and hippocampus. |
2023-09-15 |
2023-10-07 |
rat |
| Andreia Amaro, Diana Sousa, Mariana Sá-Rocha, Marcos Divino Ferreira-Junior, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, Cátia Barra, Tamaeh Monteiro-Alfredo, Rodrigo Mello Gomes, Paulo Cezar de Freitas Mathias, Filipa I Baptista, Paulo Matafom. Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes. Nutrients. vol 15. issue 16. 2023-08-26. PMID:37630771. |
neurodevelopmental tests were conducted at infancy, whereas behavioural tests to assess locomotion, anxiety, and memory were performed at adolescence, together with molecular analysis of the hippocampus, hypothalamus, and prefrontal cortex. |
2023-08-26 |
2023-09-07 |
Not clear |
| Payman Raise-Abdullahi, Morvarid Meamar, Abbas Ali Vafaei, Maryam Alizadeh, Masoomeh Dadkhah, Sakineh Shafia, Mohadeseh Ghalandari-Shamami, Ramtin Naderian, Seyed Afshin Samaei, Ali Rashidy-Pou. Hypothalamus and Post-Traumatic Stress Disorder: A Review. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37508942. |
linked to the prefrontal cortex and limbic structures, especially the amygdala and hippocampus, the hypothalamus acts as a central hub, integrating physiological aspects of the stress response. |
2023-07-29 |
2023-08-14 |
Not clear |
| Emine Kacar, Ozgur Bulmus, Zubeyde Ercan, Ilay Buran Kavuran, Gokhan Zorlu, Fatih Tan, Ihsan Serhatlioglu, Haluk Kelestimu. Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300694. |
treadmill exercise caused a significant decrease in ef, ml, il, mf, if, iii, el, pei, ir1, mft, ift, irt sexual behavior parameters and kisspeptin and kiss1r gene expression in the hypothalamus, hippocampus, prefrontal cortex and corpus striatum in e group compared to c group (p<0.05), and a significant increase in ml, il, iii, el sexual behavior parameters (p<0.05). |
2023-06-11 |
2023-08-14 |
rat |
| Emine Kacar, Ozgur Bulmus, Zubeyde Ercan, Ilay Buran Kavuran, Gokhan Zorlu, Fatih Tan, Ihsan Serhatlioglu, Haluk Kelestimu. Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300694. |
based on this effect, we believe that it is caused by an increase in kisspeptin and kiss1r expression in the hypothalamus, hippocampus, prefrontal cortex and corpus striatum. |
2023-06-11 |
2023-08-14 |
rat |
| Zala Slabe, Rawien A Balesar, Ronald W H Verwer, Joop J Van Heerikhuize, Gwyneth A Pechler, Maja Zorović, Witte J G Hoogendijk, Dick F Swaa. Alterations in pituitary adenylate cyclase-activating polypeptide in major depressive disorder, bipolar disorder, and comorbid depression in Alzheimer's disease in the human hypothalamus and prefrontal cortex. Psychological medicine. 2023-05-25. PMID:37226771. |
alterations in pituitary adenylate cyclase-activating polypeptide in major depressive disorder, bipolar disorder, and comorbid depression in alzheimer's disease in the human hypothalamus and prefrontal cortex. |
2023-05-25 |
2023-08-14 |
human |
| Yaling Liu, Anna Li, Chloe Bair-Marshall, Helen Xu, Hyun Jung Jee, Elaine Zhu, Mengqi Sun, Qiaosheng Zhang, Arthur Lefevre, Zhe Sage Chen, Valery Grinevich, Robert C Froemke, Jing Wan. Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain. Neuron. 2023-04-06. PMID:37023755. |
here, we examined how oxytocin (ot) signaling from the hypothalamus regulates nociceptive coding in the pfc. |
2023-04-06 |
2023-08-14 |
rat |