| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Kuldeep Sachdeva, Chris N Goulbourne, Martin J Berg, James Peddy, Philip H Stavrides, Anna Pensalfini, Monika Pawlik, Lauren Whyte, Basavaraj S Balapal, Subbanna Shivakumar, Cynthia Bleiwas, John F Smiley, Paul M Mathews, Ralph A Nixo. Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345644. |
we additionally demonstrate pathological consequences of appl1 overexpression, including functional changes in hippocampal long-term potentiation (ltp) and long-term depression (ltd), as well as degeneration of the large projection cholinergic neurons of the basal forebrain and impairment of hippocampal-dependent memory. |
2024-09-30 |
2024-10-02 |
mouse |
| Ze-Ka Chen, Luis Quintanilla, Yijing Su, Ryan N Sheehy, Jeremy M Simon, Yan-Jia Luo, Ya-Dong Li, Zhe Chen, Brent Asrican, Dalton S Tart, W Todd Farmer, Guo-Li Ming, Hongjun Song, Juan Son. Septo-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 40. 2024-09-23. PMID:39312657. |
cholinergic neurons in the basal forebrain play a crucial role in regulating adult hippocampal neurogenesis (ahn). |
2024-09-23 |
2024-09-26 |
Not clear |
| Sarah Steffens, Hilla Mäkinen, Tarja Stenberg, Henna-Kaisa Wigre. Microglial morphology aligns with vigilance stage-specific neuronal oscillations in a brain region-dependent manner. Glia. 2024-09-20. PMID:39301843. |
using iba1 immunostaining to identify microglia, we quantified morphological changes in microglia at different timepoints in multiple brain regions (cortex, hippocampus, basal forebrain, hindbrain, and cerebellum) in b6 male mice using semi-automated 3d structural analysis. |
2024-09-20 |
2024-09-22 |
mouse |
| Hao Li, Ying Li, Ting Wang, Shen Li, Heli Liu, Shuyi Ning, Wei Shen, Zhe Zhao, Haitao W. Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain. Neuroscience bulletin. 2024-09-14. PMID:39277552. |
we provide detailed descriptions of oxtr expression patterns in key brain regions, including the cortex, basal forebrain, hippocampus, and amygdaloid complex, with a focus on the precise localization of oxtr |
2024-09-14 |
2024-09-18 |
mouse |
| Yoshihiro Chadani, Ryoko Fujito, Naohiro Kimura, Ryo Kawai, Tetsuo Kashibayashi, Ryuichi Takahashi, Hideki Kanemoto, Kazunari Ishii, Kenji Tagai, Shunichiro Shinagawa, Manabu Ikeda, Hiroaki Kazu. Neural basis of false recognition in Alzheimer's disease and dementia with lewy bodies. Scientific reports. vol 14. issue 1. 2024-09-12. PMID:39266605. |
the number of false recognitions significantly negatively correlated with rgmv in the bilateral hippocampus, left parahippocampal gyrus, bilateral amygdala, and bilateral entorhinal cortex in patients with ad (p < 0.05, family-wise error [few] corrected) and in the bilateral hippocampus, left parahippocampal gyrus, right inferior frontal gyrus, right middle frontal gyrus, right basal forebrain, right insula, left medial and lateral orbital gyri, and left fusiform in those with dlb (p < 0.05, fwe corrected). |
2024-09-12 |
2024-09-15 |
Not clear |
| Lindsey Avery Fitzsimons, Mohammad Atif-Sheikh, Jayden Lovely, Madison Mueth, Makaela Rice, Kevin Kotredes, Gareth Howell, Benjamin J Harriso. CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211110. |
basal forebrain cholinergic neurons project to the hippocampus and cortex, are critical for learning and memory, and are central to the pathogenesis of alzheimer's disease (ad). |
2024-08-30 |
2024-09-04 |
Not clear |
| Youngnam Kang, Hiroki Toyoda, Mitsuru Sait. Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 18. 2024-07-12. PMID:38994328. |
on the other hand, a large number of epidemiological studies have shown that tooth loss or masticatory dysfunction is a risk factor for dementia including ad, and numerous studies using experimental animals have also shown that masticatory dysfunction causes brain degeneration in the basal forebrain, hippocampus, and cerebral cortex similar to those observed in human ad, and that learning and memory functions are impaired accordingly. |
2024-07-12 |
2024-07-14 |
human |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Fulton T Crews, Victoria Macht, Ryan P Vetren. Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD. Advances in drug and alcohol research. vol 4. 2024-03-25. PMID:38524847. |
hmgb1 rest induction reduces cholinergic neurons in basal forebrain and cholinergic innervation of hippocampus. |
2024-03-25 |
2024-03-27 |
human |
| Florian Lammers-Lietz, Friedrich Borchers, Insa Feinkohl, Stefan Hetzer, Cicek Kanar, Frank Konietschke, Gunnar Lachmann, Claudia Chien, Claudia Spies, Georg Winterer, Laszlo Zaborszky, Norman Zacharias, Friedemann Pau. An exploratory research report on brain mineralization in postoperative delirium and cognitive decline. The European journal of neuroscience. 2024-02-21. PMID:38379517. |
we measured relative swi intensities in the basal ganglia, hippocampus and posterior basal forebrain cholinergic system (pbfcs). |
2024-02-21 |
2024-02-23 |
Not clear |
| Ruben Carvalho, Alisa N Lukoyanova, João Casalta-Lopes, Nikolay V Lukoyanov, Joana Isabel Soare. Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy. AIMS neuroscience. vol 10. issue 4. 2024-01-08. PMID:38188006. |
however, little is known about the involvement of the basal forebrain gabaergic neurons in epilepsy; despite this, they largely project to the temporal lobe and are crucial for the regulation of the hippocampal circuitry. |
2024-01-08 |
2024-01-10 |
rat |
| Samual J Crowley, Prabesh Kanel, Stiven Roytman, Nicolaas I Bohnen, Benjamin M Hampstea. Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson's disease. Brain : a journal of neurology. 2023-12-18. PMID:38109781. |
the basal forebrain integrity metrics fully mediated the relationship between hippocampal acetylcholine and delayed memory and partially mediated the relationship between lateral capsular and lateral perisylvian acetylcholine and delayed memory. |
2023-12-18 |
2023-12-21 |
Not clear |
| C Bañuelos, J R Kittleson, K H LaNasa, C S Galiano, S M Roth, E J Perez, J M Long, M T Roberts, S Fong, P R Rap. Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-10-05. PMID:37798131. |
basal forebrain (bf) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. |
2023-10-05 |
2023-10-07 |
monkey |
| C Bañuelos, J R Kittleson, K H LaNasa, C S Galiano, S M Roth, E J Perez, J M Long, M T Roberts, S Fong, P R Rap. Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-10-05. PMID:37798131. |
although a long history of research on neurocognitive aging has focused on the role of the cholinergic basal forebrain system, intermingled gabaergic cells are numerically as prominent and well-positioned to regulate the activity of their cortical projection targets, including the hippocampus and prefrontal cortex. |
2023-10-05 |
2023-10-07 |
monkey |
| Craig Poskanzer, Mariam Al. Switching between external and internal attention in hippocampal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-22. PMID:37607818. |
pharmacological, computational, and animal studies have identified input from the cholinergic basal forebrain as important for biasing the hippocampus towards processing external information, whereas complementary research suggests the dorsal attention network (dan) may aid in allocating attentional resources towards accessing internal information. |
2023-08-22 |
2023-09-07 |
human |
| Craig Poskanzer, Mariam Al. Switching between external and internal attention in hippocampal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-22. PMID:37607818. |
we therefore tested the hypothesis that the basal forebrain and dan drive the hippocampus towards external and internal attention, respectively. |
2023-08-22 |
2023-09-07 |
human |
| Craig Poskanzer, Mariam Al. Switching between external and internal attention in hippocampal networks. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-08-22. PMID:37607818. |
together, these results provide evidence that the basal forebrain and dan may modulate the hippocampus to switch between external and internal attention. |
2023-08-22 |
2023-09-07 |
human |
| Cheng Zhou, Linbo Wang, Wei Cheng, JinChao Lv, Xiaoujun Guan, Tao Guo, Jingjing Wu, Wei Zhang, Ting Gao, Xiaocao Liu, Xueqin Bai, Haoting Wu, Zhengye Cao, Luyan Gu, Jingwen Chen, Jiaqi Wen, Peiyu Huang, Xiaojun Xu, Baorong Zhang, Jianfeng Feng, Minming Zhan. Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-07-13. PMID:37443179. |
the integrity of substantia nigra (sn), locus coeruleus (lc), amygdala, hippocampus, entorhinal cortex, and basal forebrain were assessed using diffusion and neuromelanin-sensitive mri. |
2023-07-13 |
2023-08-14 |
Not clear |
| Julia Schumacher, Prabesh Kanel, Martin Dyrba, Alexander Storch, Nicolaas I Bohnen, Stefan Teipel, Michel J Groth. Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease. Brain : a journal of neurology. 2023-07-05. PMID:37403733. |
the combined models for the prediction of cognitive scores showed that both cholinergic markers (posterior basal forebrain volume and cortical pmp pet signal) were independently related to multi-domain cognitive deficits, and were more important predictors for all cognitive scores, including memory scores, than hippocampal volume. |
2023-07-05 |
2023-08-14 |
human |
| Cigdem Ulasoglu-Yildiz, Zerrin Yildirim, Catherine E Myers, Mark A Gluck, Hakan Gurvi. Altered learning and transfer abilities in Korsakoff's syndrome depending on task complexity. Applied neuropsychology. Adult. 2023-05-27. PMID:37243624. |
learning the stimulus-response associations and transferring the just-learned associations to novel combinations were previously tested by specific tasks in memory-impaired patients with hippocampal, basal forebrain, and basal ganglia damage. |
2023-05-27 |
2023-08-14 |
Not clear |