| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ankangzhi Ma, Yawei Mu, Zixuan Wei, Menghan Sun, Junjie Li, Hanyang Jiang, Cuiqing Zhu, Xianhua Che. SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus. Neuroscience. 2024-07-03. PMID:38960088. |
in this study, using srsf10 conditional knock-out mice in neural progenitor cells (npcs), we found that dysfunction of srsf10 leads to developmental defects in the dentate gyrus of hippocampus, which manifests as the reduced length and wider suprapyramidal blade and infrapyramidal blade.furthermore, we proved that loss of srsf10 in npcs caused inhibition of the differentiation activity and the abnormal migration of npcs and granule cells, resulting in reduced granule cells and more ectopic granule cells dispersed in the molecular layer and hilus. |
2024-07-03 |
2024-07-10 |
mouse |
| Danielle Guez-Barber, Lorianna M Colon, Dana Raphael, Max A Wragan, Sanghee Yun, Amelia J Eisc. Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice. Neuroscience letters. 2023-03-10. PMID:36898652. |
to address this knowledge gap, iba1+ cells in the dg (which are enriched in the hilus and molecular layer) in female and male c57bl/6j mice were analyzed for their number (via stereology) and density (via stereology and via sampling). |
2023-03-10 |
2023-08-14 |
mouse |
| Ignacio Jure, Eugenia Falomir Lockhart, Alejandro F De Nicola, María Jose Bellini, Florencia Labombard. IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34463925. |
we also found that sci increased the number of hypertrophic arginase-1 negative microglia concomitant with the decrease of the number of ramified surveillance microglia in the hilus, molecular layer, and subgranular zone of the dentate gyrus. |
2021-12-03 |
2023-08-13 |
Not clear |
| Ignacio Jure, Eugenia Falomir Lockhart, Alejandro F De Nicola, María Jose Bellini, Florencia Labombard. IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34463925. |
in the hilus and molecular layer, igf1 gene therapy recovered the number of surveillance microglia coincident with a reduction of hypertrophic microglia cell number. |
2021-12-03 |
2023-08-13 |
Not clear |
| Lyles R Clark, Sanghee Yun, Nana K Acquah, Priya L Kumar, Hannah E Metheny, Rikley C C Paixao, Akivas S Cohen, Amelia J Eisc. Mild Traumatic Brain Injury Induces Transient, Sequential Increases in Proliferation, Neuroblasts/Immature Neurons, and Cell Survival: A Time Course Study in the Male Mouse Dentate Gyrus. Frontiers in neuroscience. vol 14. 2021-01-26. PMID:33488351. |
proliferating cells, neuroblasts/immature neurons, and surviving cells were quantified via stereology in dg subregions (subgranular zone [sgz], outer granule cell layer [ogcl], molecular layer, and hilus) at short-term (3 days post-injury, dpi), intermediate (7 dpi), and long-term (31 dpi) time points. |
2021-01-26 |
2023-08-13 |
mouse |
| Erica L Littlejohn, Danielle Scott, Kathryn E Saatma. Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32276671. |
igf1 overexpression increased the number of gcl neurons born acutely after trauma that survived 6 weeks to maturity (neun+brdu+), and enhanced their outward migration into the gcl while significantly reducing the proportion localized ectopically to the hilus and molecular layer. |
2021-01-15 |
2023-08-13 |
mouse |
| Gisela H Maia, Joana I Soares, Sérgio G Almeida, Juliana M Leite, Helena X Baptista, Alisa N Lukoyanova, Cátia S Brazete, Nikolai V Lukoyano. Altered serotonin innervation in the rat epileptic brain. Brain research bulletin. vol 152. 2020-08-14. PMID:31301378. |
the areal density of the small-sized varicosities was decreased in the dg (hilus and molecular layer), il cortex (layers ii/iii) and ms, while that of the larger-sized varicosities was increased. |
2020-08-14 |
2023-08-13 |
rat |
| Joana I Soares, Maria C Valente, Pedro A Andrade, Gisela H Maia, Nikolai V Lukoyano. Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy. The Journal of comparative neurology. vol 525. issue 12. 2018-04-25. PMID:28472854. |
it was found that the density of cholinergic fiber varicosities was higher in epileptic rats versus control rats in the inner and outer zones of the dentate molecular layer, but it was reduced in the dentate hilus. |
2018-04-25 |
2023-08-13 |
rat |
| Joana I Soares, Maria C Valente, Pedro A Andrade, Gisela H Maia, Nikolai V Lukoyano. Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy. The Journal of comparative neurology. vol 525. issue 12. 2018-04-25. PMID:28472854. |
these results revealed previously unknown details of structural reorganization of the septohippocampal cholinergic system in experimental epilepsy, involving fiber sprouting into the dentate molecular layer and a parallel fiber retraction from the dentate hilus. |
2018-04-25 |
2023-08-13 |
rat |
| Ignacio Jure, Luciana Pietranera, Alejandro F De Nicola, Florencia Labombard. Spinal Cord Injury Impairs Neurogenesis and Induces Glial Reactivity in the Hippocampus. Neurochemical research. vol 42. issue 8. 2018-04-19. PMID:28290135. |
furthermore, the density of reactive microglia increased in the hilus whereas astrogliosis developed in the molecular layer after moderate sci. |
2018-04-19 |
2023-08-13 |
rat |
| Paul S Buckmaster, Emily Abrams, Xiling We. Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy. The Journal of comparative neurology. vol 525. issue 11. 2018-03-19. PMID:28425097. |
seizure frequency was not significantly correlated with the generation of hilar ectopic granule cells, the number of mossy cells, the extent of mossy fiber sprouting, the extent of astrogliosis, or the number of gabaergic interneurons in the molecular layer or hilus. |
2018-03-19 |
2023-08-13 |
mouse |
| Raquel Romay-Tallon, Tania Rivera-Baltanas, Lisa E Kalynchuk, Hector J Carunch. Differential effects of corticosterone on the colocalization of reelin and neuronal nitric oxide synthase in the adult hippocampus in wild type and heterozygous reeler mice. Brain research. vol 1594. 2015-08-04. PMID:25451109. |
there is a main effect of cort in the density of both reelin+ and nnos+ cells in the dentate subgranular zone and hilus, and in reelin+ cells in the molecular layer and ca3 stratum radiatum; and a main effect of genotype on the co-localization of both markers in the dentate subgranular zone, and in the density of reelin+ cell sin the stratum lacunosum moleculare. |
2015-08-04 |
2023-08-13 |
mouse |
| Hidenori Ito, Rika Morishita, Ikuko Iwamoto, Koh-ichi Nagat. Establishment of an in vivo electroporation method into postnatal newborn neurons in the dentate gyrus. Hippocampus. vol 24. issue 12. 2015-07-22. PMID:24979187. |
consequently, gfp-positive cells in dg were observed to extend branched dendrites and long axons into the molecular layer and the hilus, respectively, 21 days after electrporation. |
2015-07-22 |
2023-08-13 |
mouse |
| Zhaoliang Liang, Fei Gao, Fajun Wang, Xiaochen Wang, Xinyu Song, Kejing Liu, Ren-Zhi Zha. Status epilepticus increases mature granule cells in the molecular layer of the dentate gyrus in rats. Neural regeneration research. vol 8. issue 7. 2014-09-10. PMID:25206705. |
immunostaining showed that many doublecortin-positive cells were present in the molecular layer and the hilus 7 days after the induction of status epilepticus. |
2014-09-10 |
2023-08-13 |
rat |
| Zhaoliang Liang, Lin Zhang, Xiaochen Wang, Fei Gao, Xiaona Wang, Shuo Zhou, Shuyan Yu, Ren-Zhi Zha. Distribution and neurochemical features of neuronal nitric oxide synthase-expressing interneurons in the rat dentate gyrus. Brain research. vol 1505. 2013-09-10. PMID:23419891. |
within the dg, nnos-positive cells were found to reside in all three layers of dg; percentages of distribution in the molecular layer, granule cell layer and the hilus are 25.4%, 9.4% and 65.2%, respectively. |
2013-09-10 |
2023-08-12 |
rat |
| Oualid Sbai, Michel Khrestchatisky, Monique Esclapez, Lotfi Ferha. Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells. Hippocampus. vol 22. issue 3. 2012-07-23. PMID:21240918. |
we showed that da immunoreactivity was decreased in the inner molecular layer (iml) and in the hilus (h) of the dg, at latent stage, when spinogenesis and morphogenesis occur. |
2012-07-23 |
2023-08-12 |
rat |
| Charles E Ribak, Lee A Shapiro, Zachary D Perez, Igor Spigelma. Microglia-associated granule cell death in the normal adult dentate gyrus. Brain structure & function. vol 214. issue 1. 2010-03-30. PMID:19936784. |
previous studies showed that the microglial cells in the dentate gyrus have a heterogeneous morphology with multipolar cells in the hilus and fusiform cells apposed to the granule cell layer both at the hilar and at the molecular layer borders. |
2010-03-30 |
2023-08-12 |
Not clear |
| Reiko Nagashima, Chie Sugiyama, Yuka Gotoh, Masanori Yoneyama, Nobuyuki Kuramoto, Takahiro Taira, Hiroyoshi Ariga, Kiyokazu Ogit. Altered expression of DJ-1 in the hippocampal cells following in vivo and in vitro neuronal damage induced by trimethyltin. Neuroscience letters. vol 440. issue 3. 2008-11-05. PMID:18572315. |
an intraperitoneal injection of tmt at the dose of 2.8 mg/kg produced dj-1 up-regulation in the ca1 pyramidal cell layer, ca3 stratum lucidum, dentate molecular layer, and dentate hilus, but not in the dentate granule cell layer, on day 3-5 post-treatment. |
2008-11-05 |
2023-08-12 |
mouse |
| Nadine I Holter, Nadine Zuber, Claus Bruehl, Andreas Draguh. Functional maturation of developing interneurons in the molecular layer of mouse dentate gyrus. Brain research. vol 1186. 2008-03-04. PMID:17996219. |
many gabaergic interneurons migrate from the dentate molecular layer towards their final position in the hilus during the first two postnatal weeks. |
2008-03-04 |
2023-08-12 |
mouse |
| Yury M Morozov, Albert E Ayoub, Pasko Raki. Translocation of synaptically connected interneurons across the dentate gyrus of the early postnatal rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 19. 2006-05-31. PMID:16687493. |
we observed dynamic morphogenetic transformation of the cck(+) interneurons, from a horizontal bipolar shape situated in the molecular layer, through a transitional triangular and then vertical bipolar form that they acquire while traversing the granular layer to finally assume an adult-like pyramidal-shaped morphology on entering the hilus. |
2006-05-31 |
2023-08-12 |
rat |