| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Masoumeh Kourosh Kourosh-Arami, Alireza Komaki, Masoumeh Gholam. The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem. Protein and peptide letters. 2023-11-27. PMID:38008945. |
hypocretin is involved in both arousal and addiction, and brainstem areas such as the locus coeruleus (lc), paragigantocellularis (pgi), and dorsal raphe (dr) contribute to these functions. |
2023-11-27 |
2023-11-28 |
Not clear |
| Simon Levinson, Michelle Miller, Ahmed Iftekhar, Monica Justo, Daniel Arriola, Wenxin Wei, Saman Hazany, Josue M Avecillas-Chasin, Taylor P Kuhn, Andreas Horn, Ausaf A Bar. A structural connectivity atlas of limbic brainstem nuclei. Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555163. |
several brainstem nuclei have been identified as the primary central nervous system (cns) source of important monoaminergic ascending fibers including the noradrenergic locus coeruleus, serotonergic dorsal raphe nucleus, and dopaminergic ventral tegmental area. |
2023-08-09 |
2023-08-16 |
Not clear |
| Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588734. |
fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. |
2023-01-02 |
2023-08-14 |
Not clear |
| Marc Schneeberger, Nicola L Brice, Kyle Pellegrino, Luca Parolari, Jordan T Shaked, Keith J Page, François Marchildon, Douglas W Barrows, Thomas S Carroll, Thomas Tolpiko, Victoria M Mulligan, Robert Newman, Kevin Doyle, Roland Bürli, Daniel F Barker, Angela Glen, María José Ortuño, Alexander R Nectow, Nicolas Renier, Paul Cohen, Mark Carlton, Nathaniel Heintz, Jeffrey M Friedma. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nature metabolism. 2022-11-21. PMID:36411386. |
food intake and body weight are tightly regulated by neurons within specific brain regions, including the brainstem, where acute activation of dorsal raphe nucleus (drn) glutamatergic neurons expressing the glutamate transporter vglut3 (drn |
2022-11-21 |
2023-08-14 |
Not clear |
| Dominique F Leitner, Evgeny Kanshin, Manor Askenazi, Arline Faustin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Thomas Wisniewski, Orrin Devinsk. Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy. Brain communications. vol 4. issue 4. 2022-08-05. PMID:35928051. |
to understand the potential role of brainstem nuclei in sudden unexpected death in epilepsy, we evaluated molecular signalling pathways using localized proteomics in microdissected midbrain dorsal raphe and medial medullary raphe serotonergic nuclei, as well as the ventrolateral medulla in brain tissue from epilepsy patients who died of sudden unexpected death in epilepsy and other causes in diverse epilepsy syndromes and non-epilepsy control cases ( |
2022-08-05 |
2023-08-14 |
Not clear |
| Tatiana Bezdudnaya, Moin Vahora, David Giacobbo, Vitaliy Marchenk. Anatomical Basis of Interactions Between Locomotor and Respiratory Systems. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555670. |
in the brainstem, the double-labeled neurons were seen in the following structures: 1) midbrain - in all parts of periaqueductal gray substance (pag), dorsal raphe (dr) and deep mesncephalic (dme) nuclei; 2) pons - in kölliker-fuse and parabrachial nuclei (pb/kf), in areas of noradrenergic groups of cells (locus coeruleus and a5) and sub-coeruleus areas, in oral and caudal pontine nuclei (pno and pnc); 3) medulla - in all parts of raphe (obscurus, magnus and pallidus), gigantocellular reticular (gi), internal reticular (irt), and lateral paragigantocellular (lpgi) nuclei, in para-fascial/retrotrapezoid area (pf/rtn), and in bötzinger and pre-bötzinger complexes (bc and pbc). |
2022-05-13 |
2023-08-13 |
rat |
| Rafael Barrientos, Alberto Alatorre, Aldo Oviedo-Chávez, Alfonso Delgado, Nielsine Nielsen, Enrique Querejet. Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats. Experimental brain research. 2022-03-02. PMID:35234992. |
it also receives aminergic information from several brain stem nuclei, including serotonergic fibers originated in the dorsal raphe nucleus. |
2022-03-02 |
2023-08-13 |
rat |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguch. Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes. Frontiers in physiology. vol 12. 2022-02-03. PMID:35111079. |
serotonergic neurons in the central nervous system, including the dorsal raphe (dr) and median raphe (mr) nuclei, are spatially clustered in the brainstem and provide ascending innervation to the entire forebrain and midbrain. |
2022-02-03 |
2023-08-13 |
chicken |
| Ali Seifinejad, Anne Vassalli, Mehdi Taft. Neurobiology of cataplexy. Sleep medicine reviews. vol 60. 2021-11-30. PMID:34607185. |
the neurocircuits of cataplexy, originally confined to the brainstem as those of rem sleep atonia, now include the hypothalamus, dorsal raphe (dr), amygdala and frontal cortex, and its neurochemistry originally focused on catecholamines and acetylcholine now extend to hypocretin (hcrt) and other neuromodulators. |
2021-11-30 |
2023-08-13 |
Not clear |
| Conor Fearon, Andrew J Lees, John J McKinley, Allan McCarthy, Shane Smyth, Michael Farrell, Timothy Lync. On the Emergence of Tremor in Prodromal Parkinson's Disease. Journal of Parkinson's disease. vol 11. issue 1. 2021-11-12. PMID:33325397. |
the hypothalamic paraventricular nucleus (pvn) plays a central role in autonomic control including bowel/bladder function, cardiovascular homeostasis and yawning and innervates multiple brainstem nuclei involved in autonomic functions (including brainstem reticular formation, locus ceruleus, dorsal raphe nucleus and motor nucleus of the vagus). |
2021-11-12 |
2023-08-13 |
Not clear |
| Max L Mehlman, Jennifer L Marcroft, Jeffrey S Taub. Anatomical projections to the dorsal tegmental nucleus and abducens nucleus arise from separate cell populations in the nucleus prepositus hypoglossi, but overlapping cell populations in the medial vestibular nucleus. The Journal of comparative neurology. vol 529. issue 10. 2021-09-30. PMID:33511641. |
we also examined labeling patterns in other structures located in the brainstem and posterior cortex and observed (1) complex patterns of interhemispheric connectivity between the left and right dtn, (2) projections from the supragenual nucleus, interpeduncular nucleus, and retrosplenial cortex to the dtn, (3) projections from the lateral superior olive to the abn, and (4) a unique population of cerebrospinal fluid-contacting neurons in the dorsal raphe nucleus. |
2021-09-30 |
2023-08-13 |
rat |
| Vito S Hernández, Mario A Zetter, Enrique C Guerra, Ileana Hernández-Araiza, Nikita Karuzin, Oscar R Hernández-Pérez, Lee E Eiden, Limei Zhan. ACE2 expression in rat brain: Implications for COVID-19 associated neurological manifestations. Experimental neurology. vol 345. 2021-09-16. PMID:34400158. |
we found discrete neuronal groups immunopositive for ace2 in brainstem respiratory rhythm generating centers, including the pontine nucleus, the parafascicular/retrotrapezoid nucleus, the parabrachial nucleus, the bötzinger, and pre-bötzinger complexes and the nucleus of tractus solitarius; in the arousal-related pontine reticular nucleus and gigantocellular reticular nuclei; in brainstem aminergic nuclei, including substantia nigra, ventral tegmental area, dorsal raphe, and locus coeruleus; in the epithalamic habenula, hypothalamic paraventricular and supramammillary nuclei; and in the hippocampus. |
2021-09-16 |
2023-08-13 |
rat |
| Chao-Chao Yu, Chuan He, Yan-Jun Du, Shan Gao, Yuan-Fang Lin, Shu-Qin Wang, Li Wang, Jia Wang, Xue-Song Wang, Tao Jiang, Li-Hong Kon. Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging. Neural regeneration research. vol 16. issue 5. 2021-06-23. PMID:33229729. |
preventive electroacupuncture alleviated memory impairment, decreased tau hyperphosphorylation, and reduced glycogen synthase kinase-3β protein and mrna expression levels in the brainstem dorsal raphe nucleus, where intracellular neurofibrillary tangle lesions first occur. |
2021-06-23 |
2023-08-13 |
rat |
| Xiaoxi Ji, Hui Wang, Minwei Zhu, Yingjie He, Hong Zhang, Xiaoguang Chen, Wenpeng Gao, Yili F. Brainstem atrophy in the early stage of Alzheimer's disease: a voxel-based morphometry study. Brain imaging and behavior. vol 15. issue 1. 2021-04-27. PMID:31898091. |
postmortem studies on patients with alzheimer's disease (ad) have confirmed that the dorsal raphe nucleus (drn) in the brainstem is the first brain structure affected in the earliest stage of ad. |
2021-04-27 |
2023-08-13 |
human |
| Benjamin W Okaty, Nikita Sturrock, Yasmin Escobedo Lozoya, YoonJeung Chang, Rebecca A Senft, Krissy A Lyon, Olga V Alekseyenko, Susan M Dymeck. A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe eLife. vol 9. 2021-02-16. PMID:32568072. |
a single-cell transcriptomic and anatomic atlas of mouse dorsal raphe among the brainstem raphe nuclei, the dorsal raphe nucleus (dr) contains the greatest number of |
2021-02-16 |
2023-08-13 |
mouse |
| László Ákos Kovács, Josef Andreas Schiessl, Anna Elisabeth Nafz, Valér Csernus, Balázs Gaszne. Both Basal and Acute Restraint Stress-Induced c-Fos Expression Is Influenced by Age in the Extended Amygdala and Brainstem Stress Centers in Male Rats. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30186150. |
we hypothesized that the function of the hpa axis (i.e., ppvn c-fos and blood corticosterone (cort) level), the neuronal activity of nine stress-related limbic areas (i.e., magnocellular pvn (mpvn), medial (mea), central (cea), basolateral nuclei of the amygdala, the oval (ovbnst), dorsolateral (dlbnst), dorsomedial (dmbnst), ventral and fusiform (fubnst) divisions of the bed nucleus of the stria terminalis (bnst)), and two brainstem stress centers such as the centrally projecting edinger-westphal nucleus (cpew) and dorsal raphe nucleus (dr) show age dependency in their c-fos response. |
2020-10-01 |
2023-08-13 |
rat |
| Steven F Maie. Behavioral control blunts reactions to contemporaneous and future adverse events: medial prefrontal cortex plasticity and a corticostriatal network. Neurobiology of stress. vol 1. 2020-09-30. PMID:25506602. |
once control is detected, other mpfc neurons that project to stress-responsive brainstem (dorsal raphe nucleus, drn) and limbic (amygdala) structures exert top-down inhibitory control over the activation of these structures that is produced by the adverse event. |
2020-09-30 |
2023-08-13 |
Not clear |
| Leighton R Barnden, Zack Y Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhut. Intra brainstem connectivity is impaired in chronic fatigue syndrome. NeuroImage. Clinical. vol 24. 2020-09-22. PMID:31671321. |
we selected limited brainstem reticular activation system (ras) regions-of-interest (rois) based on previous structural mri findings in a different me/cfs cohort (bilateral rostral medulla and midbrain cuneiform nucleus), the dorsal raphe nucleus, and two subcortical rois (hippocampus subiculum and thalamus intralaminar nucleus) reported to have rich brainstem connections. |
2020-09-22 |
2023-08-13 |
Not clear |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
tph2 expression in the dorsal raphe nucleus (drn) and caudal raphe nucleus (crn) of brainstem, and tph2 and th expression in ventral tegmental areas (vtn) of the midbrain were determined by qpcr. |
2020-03-13 |
2023-08-13 |
Not clear |