| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Samir Haj-Dahmane, Roh-Yu She. Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 44. 2015-01-06. PMID:25355210. |
alpha 1-adrenergic receptors (α1-ars) control the activity of dorsal raphe nucleus (drn) serotonin (5-ht) neurons and play crucial role in the regulation of arousal and stress homoeostasis. |
2015-01-06 |
2023-08-13 |
rat |
| Xavier López-Gil, Francesc Artigas, Albert Adel. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Current pharmaceutical design. vol 16. issue 5. 2010-06-25. PMID:19909228. |
atypical antipsychotic drugs might further act upon 5-ht(2a), 5-ht(1a) and alpha(1)-adrenoceptors present in pyramidal cells (including those projecting to the dorsal raphe nucleus), which would directly inhibit an excessive excitability of these cells. |
2010-06-25 |
2023-08-12 |
rat |
| Ramez Ghanbari, Mostafa El Mansari, Mohammed Shahid, Pierre Blie. Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19116183. |
this study electrophysiologically characterized the in vivo effects of asenapine at dorsal raphe nucleus (drn) and hippocampus serotonin-1a (5-ht(1a)), ventral tegmental area d(2), locus coeruleus 5-ht(2a,) and alpha(2)-adrenergic receptors in anesthetized rats. |
2009-05-20 |
2023-08-12 |
rat |
| Keisuke Kawai, Shuji Murakami, Emiko Senba, Takeharu Yamanaka, Yuya Fujiwara, Chikako Arimura, Takehiro Nozaki, Masato Takii, Chiharu Kub. Changes in estrogen receptors alpha and beta expression in the brain of mice exposed prenatally to bisphenol A. Regulatory toxicology and pharmacology : RTP. vol 47. issue 2. 2007-04-03. PMID:17222491. |
newborn male offspring (bis-a mice) were evaluated for the immunoreactivity of ers alpha and beta, serotonin, and serotonin transporter positive cells in the dorsal raphe nucleus (drn). |
2007-04-03 |
2023-08-12 |
mouse |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
in the presence of the alpha(1)-adrenoceptor agonist phenylephrine (1microm) all spontaneously active neurones recorded in the median and dorsal raphe nuclei fired slowly (<5hz) and regularly. |
2006-04-24 |
2023-08-12 |
rat |
| Sarah J Judge, Sarah E Gartsid. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochemistry international. vol 48. issue 2. 2006-04-24. PMID:16256247. |
here, using in vitro extracellular single unit electrophysiology we examined the responses of individual neurones in the rat median raphe nucleus and dorsal raphe nucleus to alpha(1)-adrenoceptor and 5-ht(1a) receptor activation and made comparisons between the two nuclei. |
2006-04-24 |
2023-08-12 |
rat |
| T Bandoh, M Hayashi, K Ino, S Takada, D Ushizawa, K Hosh. Acute effect of milnacipran on the relationship between the locus coeruleus noradrenergic and dorsal raphe serotonergic neuronal transmitters. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 6. 2005-01-13. PMID:15589386. |
these results may suggest that an increase of na in the locus coeruleus with the treatment of yohimbine after milnacipran results from negative feedback following the blockade of alpha(2)-adrenoceptors achieved with yohimbine, and that way100635 but not nan-190 recovered milnacipran-induced decrease of 5-hiaa in the dorsal raphe nucleus to control levels by preventing the activation for the presynaptic 5-ht(1a) autoreceptor. |
2005-01-13 |
2023-08-12 |
Not clear |
| Heidi E W Day, Benjamin N Greenwood, Sayamwong E Hammack, Linda R Watkins, Monika Fleshner, Steven F Maier, Serge Campea. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. The Journal of comparative neurology. vol 474. issue 3. 2004-07-14. PMID:15174080. |
differential expression of 5ht-1a, alpha 1b adrenergic, crf-r1, and crf-r2 receptor mrna in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. |
2004-07-14 |
2023-08-12 |
rat |
| Olga L Pudovkina, Thomas I F H Cremers, Ben H C Westerin. Regulation of the release of serotonin in the dorsal raphe nucleus by alpha1 and alpha2 adrenoceptors. Synapse (New York, N.Y.). vol 50. issue 1. 2003-12-12. PMID:12872296. |
to investigate the modulation of serotonin release in the dorsal raphe nucleus (drn) by alpha(1) and alpha(2) adrenoceptors, dual-probe microdialysis was performed in conscious rats. |
2003-12-12 |
2023-08-12 |
rat |
| Olga L Pudovkina, Thomas I F H Cremers, Ben H C Westerin. The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual-probe microdialysis. European journal of pharmacology. vol 445. issue 1-2. 2003-01-17. PMID:12065192. |
the inhibition of locus coeruleus activity by the infusion of the alpha(2)-adrenoceptor agonist clonidine (100 microm) decreased the release of noradrenaline to 20% in the locus coeruleus and 30% in the dorsal raphe, whilst the release of 5-ht decreased to 80% of control in the two brain areas. |
2003-01-17 |
2023-08-12 |
rat |
| R S Bitner, A L Nikke. Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat. Brain research. vol 938. issue 1-2. 2002-08-08. PMID:12031534. |
using an antibody against the alpha 7 nachr subunit, immunohistochemical staining was observed in rat dorsal raphe nucleus (drn) and locus coeruleus (lc), serotonergic and noradrenergic brainstem nuclei, respectively. |
2002-08-08 |
2023-08-12 |
rat |
| H Lu, H Ozawa, M Nishi, T Ito, M Kawat. Serotonergic neurones in the dorsal raphe nucleus that project into the medial preoptic area contain oestrogen receptor beta. Journal of neuroendocrinology. vol 13. issue 10. 2001-12-05. PMID:11679052. |
the present study used immunohistochemistry, in situ hybridization and retrograde transport analysis to investigate whether serotonin neurones in the dorsal raphe nucleus (drn) of females projecting into the mpa contained oestrogen receptor alpha or beta. |
2001-12-05 |
2023-08-12 |
rat |
| H Nakamoto, Y Soeda, S Takami, M Minami, M Sato. Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA. Brain research. Molecular brain research. vol 76. issue 1. 2000-04-24. PMID:10719219. |
calcitonin receptor mrna was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation. |
2000-04-24 |
2023-08-12 |
mouse |
| C Peyron, P H Luppi, P Fort, C Rampon, M Jouve. Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus. The Journal of comparative neurology. vol 364. issue 3. 1997-03-07. PMID:8820873. |
a large body of data suggests that the activation of alpha 1 receptors by a tonic noradrenergic input might be responsible for the tonic discharge of the serotonergic neurons of the dorsal raphe nucleus (drn). |
1997-03-07 |
2023-08-12 |
rat |
| S Oleskevich, J T William. Cocaine prolongs norepinephrine synaptic potentials in rat dorsal raphe. Journal of neurophysiology. vol 73. issue 2. 1995-06-26. PMID:7760127. |
these results suggest that cocaine enhances the excitatory action of ne in the dorsal raphe by a prolongation of the alpha 1-adrenoceptor-mediated sepsp. |
1995-06-26 |
2023-08-12 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Alpha 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1357604. |
in addition, alpha 2-adrenoceptor antagonist, idazoxan, increased the 5-htp accumulation in both the hippocampus and the dorsal raphe nucleus. |
1992-11-06 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Alpha 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1357604. |
administration of alpha 2-adrenoceptor agonist, clonidine, produced a reduction of the in vivo 5-htp accumulation in both the rat hippocampus and dorsal raphe nucleus. |
1992-11-06 |
2023-08-11 |
rat |
| D A Smith, D W Gallage. Electrophysiological and biochemical characterization of the development of alpha 1-adrenergic and 5-HT1 receptors associated with dorsal raphe neurons. Brain research. Developmental brain research. vol 46. issue 2. 1989-07-07. PMID:2541945. |
electrophysiological and quantitative autoradiographic receptor binding approaches were used to characterize the postnatal development of alpha 1-adrenergic and serotonergic receptors in the midbrain dorsal raphe nucleus (drn) in rats. |
1989-07-07 |
2023-08-11 |
rat |
| D A Smith, D W Gallage. Electrophysiological and biochemical characterization of the development of alpha 1-adrenergic and 5-HT1 receptors associated with dorsal raphe neurons. Brain research. Developmental brain research. vol 46. issue 2. 1989-07-07. PMID:2541945. |
electrophysiological and biochemical characterization of the development of alpha 1-adrenergic and 5-ht1 receptors associated with dorsal raphe neurons. |
1989-07-07 |
2023-08-11 |
rat |