All Relations between dentate gyrus and molecular layer

Publication Sentence Publish Date Extraction Date Species
Ankangzhi Ma, Yawei Mu, Zixuan Wei, Menghan Sun, Junjie Li, Hanyang Jiang, Cuiqing Zhu, Xianhua Che. SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus. Neuroscience. 2024-07-03. PMID:38960088. in this study, using srsf10 conditional knock-out mice in neural progenitor cells (npcs), we found that dysfunction of srsf10 leads to developmental defects in the dentate gyrus of hippocampus, which manifests as the reduced length and wider suprapyramidal blade and infrapyramidal blade.furthermore, we proved that loss of srsf10 in npcs caused inhibition of the differentiation activity and the abnormal migration of npcs and granule cells, resulting in reduced granule cells and more ectopic granule cells dispersed in the molecular layer and hilus. 2024-07-03 2024-07-10 mouse
Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Ki. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326285. our findings indicated that the volumes of whole bilateral hippocampus, cornus ammonis (ca) 1, molecular layer, left subiculum, ca3, hippocampal tail, right ca4, and granule cell/molecular layers of the dentate gyrus (gc-ml-dg) were significantly smaller in the subclinical depression group than in the control group. 2022-03-25 2023-08-13 human
Ignacio Jure, Eugenia Falomir Lockhart, Alejandro F De Nicola, María Jose Bellini, Florencia Labombard. IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34463925. we also found that sci increased the number of hypertrophic arginase-1 negative microglia concomitant with the decrease of the number of ramified surveillance microglia in the hilus, molecular layer, and subgranular zone of the dentate gyrus. 2021-12-03 2023-08-13 Not clear
Ji-Hye Kwak, Kyungmin Le. Forebrain glutamatergic neuron-specific Ctcf deletion induces reactive microgliosis and astrogliosis with neuronal loss in adult mouse hippocampus. BMB reports. vol 54. issue 6. 2021-07-13. PMID:33612151. although neuronal loss was not observed in ca3, and dentate gyrus (dg) ctcf depletion induced a significant increase in the number of microglia in the stratum oriens of ca3 and reactive microgliosis and astrogliosis in the molecular layer and hilus of the dg in 7.5-10-month-old cko mice. 2021-07-13 2023-08-13 mouse
Andrew J Newell, Sung Hwan Chung, Christine K Wagne. Inhibition of progesterone receptor activity during development increases reelin-immunoreactivity in Cajal-Retzius cells, alters synaptic innervation in neonatal dentate gyrus, and impairs episodic-like memory in adulthood. Hormones and behavior. vol 127. 2021-06-25. PMID:33166560. progesterone receptor (pr) is expressed in cajal-retzius (cr) cells of the dentate gyrus (dg) molecular layer during the postnatal period (p1-28), a critical stage of development for the dentate gyrus and its circuitry. 2021-06-25 2023-08-13 rat
Jon Egaña-Huguet, Itziar Bonilla-Del Río, Sonia M Gómez-Urquijo, Amaia Mimenza, Miquel Saumell-Esnaola, Leire Borrega-Roman, Gontzal García Del Caño, Joan Sallés, Nagore Puente, Inmaculada Gerrikagoitia, Izaskun Elezgarai, Pedro Grande. The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus. Frontiers in neuroanatomy. vol 15. 2021-03-12. PMID:33692673. in the hippocampal dentate gyrus, trpv1 localizes to dendritic spines and dendrites postsynaptic to excitatory synapses in the molecular layer (ml). 2021-03-12 2023-08-13 mouse
Lars Hildebrandt-Einfeldt, Kenrick Yap, Mandy H Paul, Carolin Stoffer, Nadine Zahn, Alexander Drakew, Maximilian Lenz, Andreas Vlachos, Thomas Delle. Crossed Entorhino-Dentate Projections Form and Terminate With Correct Layer-Specificity in Organotypic Slice Cultures of the Mouse Hippocampus. Frontiers in neuroanatomy. vol 15. 2021-03-03. PMID:33643001. the entorhino-dentate projection, i.e., the perforant pathway, terminates in a highly ordered and laminated fashion in the rodent dentate gyrus (dg): fibers arising from the medial entorhinal cortex (mec) terminate in the middle molecular layer, whereas fibers arising from the lateral entorhinal cortex (lec) terminate in the outer molecular layer of the dg. 2021-03-03 2023-08-13 mouse
Nicholas H Russell, Raiford T Black, Nancy N Lee, Adele E Doperalski, Thomas M Reeves, Linda L Phillip. Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury. Brain research. vol 1725. 2020-10-23. PMID:31539545. non-hemorrhagic dentate gyrus showed predominant ho-1 labeling in hilar microglia and in molecular layer astrocytes. 2020-10-23 2023-08-13 rat
Daniel Carey, Hugh Nolan, Rose Anne Kenny, James Meane. Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA). Scientific reports. vol 9. issue 1. 2020-10-16. PMID:31358771. fully-adjusted models revealed that immediate and delayed recall were both associated with cubic fits with respect to volume of subfields ca1, ca2/3, ca4, molecular layer, and granule cell layer of dentate gyrus; moreover, these effects were partly dissociable from quadratic age trends, observed for subiculum, molecular layer, hippocampal tail, and ca1. 2020-10-16 2023-08-13 Not clear
Shweta Prasad, Apurva Shah, Ketaki Swapnil Bhalsing, Keshav J Kumar, Jitender Saini, Madhura Ingalhalikar, Pramod Kumar Pa. Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 5. 2020-07-01. PMID:30888510. significant atrophy of the left subiculum, ca4, granule-cell layer of dentate gyrus, right molecular layer, and hypertrophy of bilateral parasubiculum, right hippocampus-amygdala-transition-area, bilateral hippocampal tail (ht) and widening of right hippocampal fissure was observed in et. 2020-07-01 2023-08-13 Not clear
Natalie M Zahr, Kilian M Pohl, Manojkumar Saranathan, Edith V Sullivan, Adolf Pfefferbau. Hippocampal subfield CA2+3 exhibits accelerated aging in Alcohol Use Disorder: A preliminary study. NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30904825. freesurfer 6.0 hippocampal subfield analysis produced 12 subfields: parasubiculum; presubiculum; subiculum; ca1; ca2+3; ca4; gc-ml-dg (granule cell (gc) and molecular layer (ml) of the dentate gyrus (dg)); molecular layer; hippocampus-amygdala-transition-area (hata); fimbria; hippocampal tail; hippocampal fissure; and whole volume for left and right hippocampi. 2020-01-17 2023-08-13 human
Khushboo Srivastava, Ratnakar Tripathi, Rajnikant Mishr. Age-dependent alterations in expression and co-localization of Pax6 and Ras-GAP in brain of aging mice. Journal of chemical neuroanatomy. vol 92. 2019-10-22. PMID:29787792. the co-localization of pax6 and ras-gap were observed in dentate gyrus (dg) and sub-granular zone (sgz) of hippocampus, in glomerular (glla) and mitral cells (mice) of olfactory lobe, granular cells (grce), purkinje cell (puce) and molecular cell layer (mola) of cerebellum, internal plexiform layer (inpl), molecular layer (mola) of cerebral cortex and in intercalated cells of amygdala (itc), caudate nucleus regions in brain of aging mice. 2019-10-22 2023-08-13 mouse
Kyoung-Sae Na, Eunsoo Won, June Kang, Aram Kim, Sunyoung Choi, Yong-Ku Kim, Min-Soo Lee, Byung-Joo Ha. Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volume. Psychiatry research. Neuroimaging. vol 282. 2019-07-25. PMID:30384146. there were significant interactions between oxtr allele type and diagnosis of mdd on the 7 hippocampal subfield volumes, such as left presubiculum, left subiculum, left molecular, right cornus ammonis 1, right granule cells in the molecular layer of the dentate gyrus, right molecular layer, and right subiculum. 2019-07-25 2023-08-13 Not clear
Agata Mata, Vanessa Gil, Jeús Pérez-Clausell, Miguel Dasilva, Mari Carmen González-Calixto, Eduardo Soriano, José Manuel García-Verdugo, Maria V Sanchez-Vives, José Antonio Del Rí. New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29358640. more relevantly, we describe how subgranular cells express plexind1 and how the absence of sema3e induces a dysregulation of the proliferation of dentate gyrus progenitors leading to the presence of ectopic cells in the molecular layer. 2018-12-11 2023-08-13 mouse
Vanesa Nieto-Estévez, Carlos O Oueslati-Morales, Lingling Li, James Pickel, Aixa V Morales, Carlos Vicario-Abejó. Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis. Stem cells (Dayton, Ohio). vol 34. issue 8. 2017-12-12. PMID:27144663. in both ko mice we found an accumulation of tbr2(+) -intermediate neuronal progenitors, some of which were displaced in the outer granule cell layer (gcl) and the molecular layer (ml) of the dentate gyrus (dg). 2017-12-12 2023-08-13 mouse
B Cao, I C Passos, B Mwangi, H Amaral-Silva, J Tannous, M-J Wu, G B Zunta-Soares, J C Soare. Hippocampal subfield volumes in mood disorders. Molecular psychiatry. vol 22. issue 9. 2017-11-16. PMID:28115740. however, the hippocampus is not a uniform structure and consists of several subfields, such as the cornu ammonis (ca) subfields ca1-4, the dentate gyrus (dg) including a granule cell layer (gcl) and a molecular layer (ml) that continuously crosses adjacent subiculum (sub) and ca fields. 2017-11-16 2023-08-13 human
Jiandong Yu, Bogumila Swietek, Archana Proddutur, Vijayalakshmi Santhakuma. Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiology of disease. vol 89. 2016-12-13. PMID:26804027. in the dentate gyrus, cb1rs regulate synaptic release from accommodating interneurons (ac-ins) with adapting firing characteristics and axonal projections in the molecular layer, but not from fast-spiking basket cells (fs-bcs). 2016-12-13 2023-08-13 rat
Robert Siman, Ryan Cocca, Yina Don. The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy. PloS one. vol 10. issue 11. 2016-06-14. PMID:26540269. focal expression of human tau carrying a p301l mutation but not egfp as a control in layer ii of the lateral entorhinal cortex triggered rapid degeneration of these neurons, loss of lateral perforant pathway synapses in the dentate gyrus outer molecular layer, and activation of neuroinflammatory microglia and astroglia in the two locations. 2016-06-14 2023-08-13 mouse
Carlos Santos-Filho, Camila M de Lima, César A R Fôro, Marcus A de Oliveira, Nara G M Magalhães, Cristovam Guerreiro-Diniz, Daniel G Diniz, Pedro F da C Vasconcelos, Cristovam W P Dini. Visuospatial learning and memory in the Cebus apella and microglial morphology in the molecular layer of the dentate gyrus and CA1 lacunosum molecular layer. Journal of chemical neuroanatomy. vol 61-62. 2015-07-31. PMID:25462387. visuospatial learning and memory in the cebus apella and microglial morphology in the molecular layer of the dentate gyrus and ca1 lacunosum molecular layer. 2015-07-31 2023-08-13 monkey
Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masatoshi Nakamura, Hiroaki Fujii, Masaki And. Intracellular Zn(2+) signaling in the dentate gyrus is required for object recognition memory. Hippocampus. vol 24. issue 11. 2015-07-07. PMID:24978470. znaf-2da injection, which was estimated to chelate intracellular zn(2+) signaling only in the dentate gyrus, affected object recognition memory 1 h after training without affecting intracellular ca(2+) signaling in the dentate molecular layer. 2015-07-07 2023-08-13 rat