| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie An, Inna Astapova, Guofang Zhang, Andrew L Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J Muehlbauer, Tabitha George, Joseph Brozinick, Mark A Herman, Christopher B Newgar. Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345566. |
the drop in free coa levels, needed for the 2-ketoglutarate dehydrogenase reaction, as well as a decrease in transcripts encoding the anaplerotic enzymes pyruvate carboxylase, glutamate dehydrogenase, and aspartate transaminase likely contributed to these effects. |
2024-09-30 |
2024-10-02 |
rat |
| Qiuyu Lan, Ana Cristina De Aguiar Saldanha Pinheiro, Giacomo Braschi, Gianfranco Picone, Pietro Rocculi, Luca Lagh. Integrated metabolomics analysis of chill-stored rose shrimp (Parapenaeus longirostris) treated with different pressure levels of high hydrostatic pressure by Journal of food science. 2024-08-04. PMID:39098810. |
metabolic pathway analysis revealed several pathways underlying spoilage, including pyruvate metabolism, valine, leucine, and isoleucine biosynthesis, purine metabolism, methane metabolism, glycine, serine, and threonine metabolism, citrate cycle (tca cycle), glycolysis/gluconeogenesis, alanine, aspartate, and glutamate metabolism, sulfur metabolism, pantothenate and coa biosynthesis, glutathione metabolism, and glyoxylate and dicarboxylate metabolism. |
2024-08-04 |
2024-08-07 |
Not clear |
| Maria-Armineh Tossounian, Stefan Denchev Hristov, Jonathan Alexis Semelak, Bess Yi Kun Yu, Maria Baczynska, Yuhan Zhao, Dario Ariel Estrin, Madia Trujillo, Valeriy Filonenko, Jerome Gouge, Ivan Gou. A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298313. |
site-directed mutagenesis and coa-based affinity purifications showed that arginine 58 mutation to glutamate (r58e) and threonine 94 mutation to aspartate (t94d) prevent hnme1 from binding to coa. |
2023-06-11 |
2023-08-14 |
human |
| Yang Liao, Jiyong Bian, Shiyu Miao, Siqi Xu, Rui Li, Ruiping Liu, Huijuan Liu, Jiuhui Q. Regulation of denitrification performance and microbial topology by lights: Insight into wavelength effects towards microbiota. Water research. vol 232. 2023-02-06. PMID:36746030. |
as revealed by metabolomics, pantothenate and coa biosynthesis, glutamate metabolism and alkaloid biosynthesis presented high impact values. |
2023-02-06 |
2023-08-14 |
Not clear |
| Meijuan Xu, Hui Gao, Zhenfeng Ma, Jin Han, Keyi Zheng, Minglong Shao, Zhiming Ra. Development of a 2-pyrrolidone biosynthetic pathway in Corynebacterium glutamicum by engineering an acetyl-CoA balance route. Amino acids. 2022-10-12. PMID:36224443. |
here, we established a 2-pyrrolidone biosynthesis pathway in corynebacterium glutamicum, by expressing glutamate decarboxylase (gad) mutant and β-alanine coa transferase (act) which activates spontaneous dehydration cyclization of gaba to form 2-pyrrolidone. |
2022-10-12 |
2023-08-14 |
Not clear |
| Renu Yadav, Rashmi Saini, Arindam Adhikary, Sanjeev Kuma. Unravelling cross priming induced heat stress, combinatorial heat and drought stress response in contrasting chickpea varieties. Plant physiology and biochemistry : PPB. vol 180. 2022-04-10. PMID:35398655. |
additionally, the differential metabolic pathways involved in heat tolerance were alanine, aspartate, and glutamate metabolism, pantothenate coa biosynthesis, fructose and mannose metabolism and pentose phosphate pathway in pdg4 variety. |
2022-04-10 |
2023-08-13 |
Not clear |
| Qian Jia, Yuan Ni, Shengnan Min, Liang Ming, Yiwen Qian, Xueyan Cen, Jialian Wang, Xuehong Ton. The ontogenesis of catabolic abilities and energy metabolism during endogenous nutritional periods of tongue sole, Cynoglossus semilaevis. Journal of fish biology. vol 99. issue 5. 2021-11-19. PMID:34392536. |
meanwhile, specific enzymes including pyruvate kinase (pk), glutamic oxalo acetic transaminase (got) and glutamate dehydrogenase (gdh), and hydroxyacyl coa dehydrogenase (hoad) as well as their ratios were assayed to evaluate the abilities to use energy substrates of carbohydrates, amino acids and fatty acids, respectively, for energy production. |
2021-11-19 |
2023-08-13 |
Not clear |
| J B Delaye, D Lanznaster, C Veyrat-Durebex, A Fontaine, G Bacle, A Lefevre, R Hergesheimer, J C Lecron, P Vourc'h, C R Andres, F Maillot, P Corcia, P Emond, H Blasc. Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:33021723. |
at 16 weeks, metabolomics analyses revealed a clear discrimination (cv-anova = 0.0086) according to the treatment and the most discriminant pathways, including sphingolipid metabolism, butanoate metabolism, pantothenate and coa biosynthesis, and the metabolism of amino acids like tyrosine, arginine, proline, glycine, serine, alanine, aspartate, and glutamate. |
2021-07-30 |
2023-08-13 |
mouse |
| Solange D Sousa, Luigi Lucini, Paolo Ajmone-Marsan, Maurício F van Tilburg, Arlindo A Mour. Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams. Molecular reproduction and development. vol 87. issue 4. 2021-05-20. PMID:32202367. |
meaningful pathways associated with agf metabolites included glycine, serine and threonine metabolism; pantothenate and coa biosynthesis; galactose metabolism; glutamate metabolism and phenylalanine metabolism, and so forth. |
2021-05-20 |
2023-08-13 |
human |
| Bushra Amin, Katarena I Ford, Renã A S Robinso. Quantitative proteomics to study aging in rabbit liver. Mechanisms of ageing and development. vol 187. 2021-02-05. PMID:32126221. |
seven proteins were differentially-expressed at all ages and include fatty acid binding protein, aldehyde dehydrogenase, enoyl-coa hydratase, 3-hydroxyacyl coa dehydrogenase, apolipoprotein c3, peroxisomal sarcosine oxidase, adhesion g-protein coupled receptor, and glutamate ionotropic receptor kinate. |
2021-02-05 |
2023-08-13 |
rabbit |
| Christos Chinopoulos, Thomas N Seyfrie. Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis. ASN neuro. vol 10. 2019-10-07. PMID:30909720. |
production of high-energy phosphates would be supported by glutaminolysis-a hallmark of gbm metabolism-through the sequential conversion of glutamine → glutamate → alpha-ketoglutarate → succinyl coa → succinate. |
2019-10-07 |
2023-08-13 |
Not clear |
| Zachary Bloomgarde. Diabetes and branched-chain amino acids: What is the link? Journal of diabetes. vol 10. issue 5. 2018-09-19. PMID:29369529. |
[figure: see text] the metabolism of bcaa involves two processes: (i) a reversible process catalysed by a branched-chain aminotransferase (bcat), either cytosolic or mitochondrial, requiring pyridoxal to function as an amino group carrier, by which the bcaa with 2-ketoglutarate produce a branched-chain keto acid plus glutamate; and (ii) the irreversible mitochondrial process catalysed by branched-chain keto acid dehydrogenase (bckdh) leading to formation of acetyl-coenzyme a (coa), propionyl-coa, and 2-methylbutyryl-coa from leucine, valine, and isoleucine, respectively, which enter the tricarboxylic acid (krebs) cycle as acetyl-coa, propionyl-coa, and 2-methylbutyryl-coa, respectively, leading to atp formation. |
2018-09-19 |
2023-08-13 |
Not clear |
| Paavo Korge, Guillaume Calmettes, James N Weis. Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD(+) ratio. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27068062. |
if malate and glutamate were provided before rather than after piericidin or rotenone, ros generation was markedly reduced due to time-dependent efflux of coa. |
2018-01-09 |
2023-08-13 |
Not clear |
| Chaiyos Sirithanakorn, Sarawut Jitrapakdee, Paul V Attwoo. Investigation of the Roles of Allosteric Domain Arginine, Aspartate, and Glutamate Residues of Rhizobium etli Pyruvate Carboxylase in Relation to Its Activation by Acetyl CoA. Biochemistry. vol 55. issue 30. 2017-05-09. PMID:27379711. |
investigation of the roles of allosteric domain arginine, aspartate, and glutamate residues of rhizobium etli pyruvate carboxylase in relation to its activation by acetyl coa. |
2017-05-09 |
2023-08-13 |
Not clear |
| Jesse R Murphy, Elwood A Mullins, T Joseph Kappoc. Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase. Frontiers in chemistry. vol 4. 2016-05-31. PMID:27242998. |
a structure of the active mutant aarc-n347a bound to coa revealed both solvent replacement of the missing contact and displacement of the adjacent glu294, indicating that asn347 both polarizes and orients the essential glutamate. |
2016-05-31 |
2023-08-13 |
Not clear |
| Arpád Dobolyi, Attila G Bagó, Aniko Gál, Mária J Molnár, Miklós Palkovits, Vera Adam-Vizi, Christos Chinopoulo. Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain. Journal of bioenergetics and biomembranes. vol 47. issue 1-2. 2015-10-26. PMID:25370487. |
the absence of sucla2 and suclg2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the gaba shunt and ketone body metabolism which do not require succinyl coa ligase activity, and glutamate dehydrogenase 1, an enzyme exhibiting exquisite sensitivity to inhibition by gtp. |
2015-10-26 |
2023-08-13 |
human |
| Rodrigo Torres, Benson Lan, Yama Latif, Nicholas Chim, Celia W Gouldin. Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta crystallographica. Section D, Biological crystallography. vol 70. issue Pt 4. 2015-03-30. PMID:24699651. |
ripa belongs to the family i coa transferases, which share structural homology, a conserved catalytic glutamate which forms a covalent coa-thioester intermediate and a flexible loop adjacent to the active site known as the g(v/i)g loop. |
2015-03-30 |
2023-08-13 |
human |
| Marina Blazquez, Aitor Carretero, James K Ellis, Toby J Athersuch, Rachel Cavill, Timothy M D Ebbels, Hector C Keun, José V Castell, Agustín Lahoz, Roque Bor. A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR). Journal of proteome research. vol 12. issue 6. 2013-12-23. PMID:23641669. |
a combination of adenoviral transfections for ccaat/enhancer-binding protein β (c/ebpβ), hepatocyte nuclear factor 4α (hnf4α), and constitutive androstane receptor (car) decreased intracellular glutamate, succinate, leucine, and valine levels in hepg2 cells, suggestive of a switch to catabolism to increase lipogenic acetyl coa and increased anaplerosis to replenish the tricarboxylic acid cycle. |
2013-12-23 |
2023-08-12 |
human |
| A P Farrell, J A Johansen, R K Suare. Effects of exercise-training on cardiac performance and muscle enzymes in rainbow trout,Oncorhynchus mykiss. Fish physiology and biochemistry. vol 9. issue 4. 2013-11-13. PMID:24213727. |
maximal activities of citrate synthase (cs), b-hydroxyacyl coa dehydrogenase (hoad), glutamate dehydrogenase (gdh) and carnitine palmitoyl transferase (cpt) were measured in cardiac and skeletal muscles. |
2013-11-13 |
2023-08-12 |
Not clear |
| Gengxiang Zhao, Norma M Allewell, Mendel Tuchman, Dashuang Sh. Structure of the complex of Neisseria gonorrhoeae N-acetyl-L-glutamate synthase with a bound bisubstrate analog. Biochemical and biophysical research communications. vol 430. issue 4. 2013-08-06. PMID:23261468. |
n-acetyl-l-glutamate synthase catalyzes the conversion of accoa and glutamate to coa and n-acetyl-l-glutamate (nag), the first step of the arginine biosynthetic pathway in lower organisms. |
2013-08-06 |
2023-08-12 |
Not clear |