| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie An, Inna Astapova, Guofang Zhang, Andrew L Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J Muehlbauer, Tabitha George, Joseph Brozinick, Mark A Herman, Christopher B Newgar. Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345566. |
the drop in free coa levels, needed for the 2-ketoglutarate dehydrogenase reaction, as well as a decrease in transcripts encoding the anaplerotic enzymes pyruvate carboxylase, glutamate dehydrogenase, and aspartate transaminase likely contributed to these effects. |
2024-09-30 |
2024-10-02 |
rat |
| Qiuyu Lan, Ana Cristina De Aguiar Saldanha Pinheiro, Giacomo Braschi, Gianfranco Picone, Pietro Rocculi, Luca Lagh. Integrated metabolomics analysis of chill-stored rose shrimp (Parapenaeus longirostris) treated with different pressure levels of high hydrostatic pressure by Journal of food science. 2024-08-04. PMID:39098810. |
metabolic pathway analysis revealed several pathways underlying spoilage, including pyruvate metabolism, valine, leucine, and isoleucine biosynthesis, purine metabolism, methane metabolism, glycine, serine, and threonine metabolism, citrate cycle (tca cycle), glycolysis/gluconeogenesis, alanine, aspartate, and glutamate metabolism, sulfur metabolism, pantothenate and coa biosynthesis, glutathione metabolism, and glyoxylate and dicarboxylate metabolism. |
2024-08-04 |
2024-08-07 |
Not clear |
| Jiedan Liao, Wenshuo Hu, Weijun Wang, Xinyan Wang, Shu Yu, Xinni Niu, Wenhui Zhu, Bolun Zhou, Yiwan Song, Weijun Zeng, Zhimin Lu, Jinding Che. Plasma metabonomics of classical swine fever virus-infected pigs. Frontiers in veterinary science. vol 10. 2023-12-22. PMID:38130437. |
thirteen metabolic pathways changed significantly in csfv-infected pigs, including tricarboxylic acid cycle, inositol phosphate metabolism, glycine, serine and threonine metabolism,lysine degradation, alanine, aspartate and glutamic acid metabolism, pantothenate and coa biosynthesis, β-alanine metabolism, lysine degradation, arginine and proline metabolism, glycerolipid metabolism, phenylalanine metabolism, arachidonic acid metabolism, linoleic acid metabolism. |
2023-12-22 |
2023-12-24 |
Not clear |
| Maria-Armineh Tossounian, Stefan Denchev Hristov, Jonathan Alexis Semelak, Bess Yi Kun Yu, Maria Baczynska, Yuhan Zhao, Dario Ariel Estrin, Madia Trujillo, Valeriy Filonenko, Jerome Gouge, Ivan Gou. A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298313. |
site-directed mutagenesis and coa-based affinity purifications showed that arginine 58 mutation to glutamate (r58e) and threonine 94 mutation to aspartate (t94d) prevent hnme1 from binding to coa. |
2023-06-11 |
2023-08-14 |
human |
| John E Crona. How an overlooked gene in coenzyme a synthesis solved an enzyme mechanism predicament. Molecular microbiology. 2023-05-04. PMID:37140060. |
the first committed step in the coa synthetic pathway is synthesis of β-alanine from aspartate. |
2023-05-04 |
2023-08-14 |
Not clear |
| Sehwan Jeong, Young Guk Kim, Sungjun Kim, Kyobum Ki. Enhanced anticancer efficacy of primed natural killer cells Biomaterials science. 2022-09-01. PMID:36048163. |
for the protection of encapsulated cargo il-15 while maintaining its bioactivity under physiological conditions, we utilized a coacervate (coa) consisting of a cationic methoxy polyethylene glycol-poly(ethylene arginyl aspartate diglyceride) (mpeg-pead) polymer, anionic counterpart heparin, and cargo il-15. |
2022-09-01 |
2023-08-14 |
Not clear |
| Renu Yadav, Rashmi Saini, Arindam Adhikary, Sanjeev Kuma. Unravelling cross priming induced heat stress, combinatorial heat and drought stress response in contrasting chickpea varieties. Plant physiology and biochemistry : PPB. vol 180. 2022-04-10. PMID:35398655. |
additionally, the differential metabolic pathways involved in heat tolerance were alanine, aspartate, and glutamate metabolism, pantothenate coa biosynthesis, fructose and mannose metabolism and pentose phosphate pathway in pdg4 variety. |
2022-04-10 |
2023-08-13 |
Not clear |
| J B Delaye, D Lanznaster, C Veyrat-Durebex, A Fontaine, G Bacle, A Lefevre, R Hergesheimer, J C Lecron, P Vourc'h, C R Andres, F Maillot, P Corcia, P Emond, H Blasc. Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:33021723. |
at 16 weeks, metabolomics analyses revealed a clear discrimination (cv-anova = 0.0086) according to the treatment and the most discriminant pathways, including sphingolipid metabolism, butanoate metabolism, pantothenate and coa biosynthesis, and the metabolism of amino acids like tyrosine, arginine, proline, glycine, serine, alanine, aspartate, and glutamate. |
2021-07-30 |
2023-08-13 |
mouse |
| Uiseon Park, Min Suk Lee, Jin Jeon, Sangmin Lee, Mintai P Hwang, Yadong Wang, Hee Seok Yang, Kyobum Ki. Coacervate-mediated exogenous growth factor delivery for scarless skin regeneration. Acta biomaterialia. vol 90. 2020-05-12. PMID:30936036. |
this study presents an exogenous gf delivery platform developed using coacervates (coa), a tertiary complex of poly(ethylene argininyl aspartate diglyceride) (pead) polycation, heparin, and cargo gfs (i.e., transforming growth factor beta 3 (tgf-β3) and interleukin 10 (il-10)). |
2020-05-12 |
2023-08-13 |
rat |
| Sharanbasappa Shrimant Karade, Shilpika Pandey, Ahmadullah Ansari, Swetarka Das, Sarita Tripathi, Ashish Arora, Sidharth Chopra, J Venkatesh Pratap, Arunava Dasgupt. Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress. Biochimica et biophysica acta. Proteins and proteomics. vol 1867. issue 3. 2019-08-07. PMID:30342240. |
sequence analysis classifies rv3272 as a family iii coa transferase with the classical two domain structure and conserved aspartate residue (d175). |
2019-08-07 |
2023-08-13 |
Not clear |
| Sammy Pontrelli, Riley C B Fricke, Shao Thing Teoh, Walter A Laviña, Sastia Prama Putri, Sorel Fitz-Gibbon, Matthew Chung, Matteo Pellegrini, Eiichiro Fukusaki, James C Lia. Metabolic repair through emergence of new pathways in Escherichia coli. Nature chemical biology. vol 14. issue 11. 2019-05-07. PMID:30327558. |
here, we use a Δpand (encoding for aspartate 1-decarboxylase) strain of e. coli that is unable to produce the β-alanine required for coa biosynthesis to demonstrate that metabolic systems can overcome pathway damage by extensively rerouting metabolic pathways and modifying existing enzymes for unnatural functions. |
2019-05-07 |
2023-08-13 |
Not clear |
| Hongshan Li, Hao Ying, Airong Hu, Yaoren Hu, Dezhou L. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Biological & pharmaceutical bulletin. vol 40. issue 5. 2018-02-12. PMID:28458350. |
we found that liver tissues showed significant hepatic steatosis and vacuolar degeneration with significantly higher triglyceride (tg), free fatty acid (ffa) and malonyl coa, serum alanine aminotransferase (alt), aspartate aminotransferase (ast) and gamma-glutamyl transferase (ggt) activities in model group versus normal control group (p<0.01). |
2018-02-12 |
2023-08-13 |
rat |
| Pooja Gopal, Michelle Yee, Jickky Sarathy, Jian Liang Low, Jansy P Sarathy, Firat Kaya, Véronique Dartois, Martin Gengenbacher, Thomas Dic. Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis. ACS infectious diseases. vol 2. issue 9. 2018-01-29. PMID:27759369. |
rather than finding mutations in the proposed candidate targets fatty acid synthase i and ribosomal protein s1, we found resistance conferring mutations in two pathways: missense mutations in aspartate decarboxylase pand, involved in the synthesis of the essential acyl carrier coenzyme a (coa), and frameshift mutations in the vitro nonessential polyketide synthase genes mas and ppsa-e, involved in the synthesis of the virulence factor phthiocerol dimycocerosate (pdim). |
2018-01-29 |
2023-08-13 |
Not clear |
| Chaiyos Sirithanakorn, Sarawut Jitrapakdee, Paul V Attwoo. Investigation of the Roles of Allosteric Domain Arginine, Aspartate, and Glutamate Residues of Rhizobium etli Pyruvate Carboxylase in Relation to Its Activation by Acetyl CoA. Biochemistry. vol 55. issue 30. 2017-05-09. PMID:27379711. |
investigation of the roles of allosteric domain arginine, aspartate, and glutamate residues of rhizobium etli pyruvate carboxylase in relation to its activation by acetyl coa. |
2017-05-09 |
2023-08-13 |
Not clear |
| Jason Carere, Sarah E McKenna, Matthew S Kimber, Stephen Y K Sea. Characterization of an aldolase-dehydrogenase complex from the cholesterol degradation pathway of Mycobacterium tuberculosis. Biochemistry. vol 52. issue 20. 2014-02-04. PMID:23614353. |
substitution of serine 41 in hsag with isoleucine or aspartate resulted in about 35-fold increase in km for coa but only 4-fold increase in km dephospho-coa, suggesting that this residue interacts with the 3'-ribose phosphate of coa. |
2014-02-04 |
2023-08-12 |
Not clear |
| Shiv Shankhar Kaundu. An aspartate to glycine change in the carboxyl transferase domain of acetyl CoA carboxylase and non-target-site mechanism(s) confer resistance to ACCase inhibitor herbicides in a Lolium multiflorum population. Pest management science. vol 66. issue 11. 2011-02-22. PMID:20648527. |
an aspartate to glycine change in the carboxyl transferase domain of acetyl coa carboxylase and non-target-site mechanism(s) confer resistance to accase inhibitor herbicides in a lolium multiflorum population. |
2011-02-22 |
2023-08-12 |
Not clear |
| Mariel C Gerrard Wheeler, Cintia L Arias, Marcos A Tronconi, Verónica G Maurino, Carlos S Andreo, María F Drincovitc. Arabidopsis thaliana NADP-malic enzyme isoforms: high degree of identity but clearly distinct properties. Plant molecular biology. vol 67. issue 3. 2008-08-19. PMID:18288573. |
the results obtained show that arg115 is involved in fumarate activation, while the amino-terminal part is critical for aspartate and coa activation, as well as for the reverse reaction. |
2008-08-19 |
2023-08-12 |
Not clear |
| Marie E Gibbs, Hilary G E Lloyd, Thomas Santa, Leif Hert. Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence. Journal of neuroscience research. vol 85. issue 15. 2008-01-22. PMID:17455305. |
dab-mediated memory inhibition was successfully challenged by administration at 0 or 20 min posttraining of acetate (an astrocyte-specific acetyl coa precursor) together with aspartate, substituting for pyruvate carboxylation, or of glutamine at 0-2.5 or 30 min posttraining. |
2008-01-22 |
2023-08-12 |
chicken |
| Sarawut Jitrapakdee, Abdussalam Adina-Zada, Paul G Besant, Kathy H Surinya, W Wallace Cleland, John C Wallace, Paul V Attwoo. Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA. The international journal of biochemistry & cell biology. vol 39. issue 6. 2007-09-25. PMID:17478118. |
pyc1 and pyc2 display different allosteric properties with respect to acetyl coa activation and aspartate inhibition, with pyc1 showing a higher degree of cooperativity than pyc2, even in the absence of aspartate. |
2007-09-25 |
2023-08-12 |
Not clear |
| Torun M Melø, Ursula Sonnewald, Monique Touret, Astrid Nehli. Cortical glutamate metabolism is enhanced in a genetic model of absence epilepsy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 12. 2006-12-28. PMID:16538229. |
neuronal mitochondrial metabolism was also enhanced as detected by elevated amounts of n-acetylaspartate and nicotinamide adenine dinucleotide as well as increased incorporation of label from [2-(13)c]acetyl coa into glutamate, glutamine, and aspartate. |
2006-12-28 |
2023-08-12 |
rat |