| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daan van Kruining, Mario Losen, Jonas Dehairs, Johannes V Swinnen, Etienne Waelkens, Maarten Honing, Pilar Martinez-Martine. Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations. Neurobiology of disease. 2025-04-19. PMID:40253012. |
using liquid chromatography-tandem mass spectrometry (lc-ms/ms), we assessed 110 sphingolipid species across four major classes (ceramides (cers), hexosylceramides (hexcers), lactosylceramides (laccers), and sphingomyelins (sms)) at 2, 4, and 6 months in plasma and at 6 months in brain tissue in the cortex, hippocampus, striatum, and cerebellum. |
2025-04-19 |
2025-04-22 |
mouse |
| Benjamin J Buehner, Alejandra O Morcillo-Nieto, Sara E Zsadanyi, Mateus Rozalem Aranha, José Enrique Arriola-Infante, Lídia Vaqué-Alcázar, Javier Arranz, Íñigo Rodríguez-Baz, Lucia Maure Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Nuria Bargalló, Sofía González-Ortiz, Sandra Giménez, Robin de Flores, Paul A Yushkevich, Daniel Alcolea, Olivia Belbin, Alberto Lleó, Maria Carmona-Iragui, Juan Fortea, Alexandre Bejani. Medial temporal lobe atrophy in Down syndrome along the Alzheimer's disease continuum. Brain : a journal of neurology. 2025-04-17. PMID:40243675. |
we identified the entorhinal cortex and posterior hippocampus as the regions showing the earliest loss in down syndrome, starting 13-15 years before alzheimer's disease symptom onset. |
2025-04-17 |
2025-04-19 |
Not clear |
| Paria Hashemi, Mohammad Raman Moloudi, Helia Rahmani, Katayoun Hassanzadeh, Zakaria Vahabzadeh, Esmael Izadpana. Alpha-Pinene Ameliorates Memory Deficits in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease. Neurochemical research. vol 50. issue 3. 2025-04-16. PMID:40237934. |
in addition, apn treatment elevated the gene expression levels of bdnf, trka, trkb, and creb, while significantly decreasing p75 ntr showing a dose-dependent effect in the brain cortex and hippocampus, compared to the 3-np group. |
2025-04-16 |
2025-04-19 |
rat |
| Duan Jiajia, Wang Yiping, Jiang Enyan, Zhu Shouwu, Yang Shuai, Zhang Xiaojian, Jiang Juan, Fang Zhen, Zeng Jia, Wang Jikai, Yan Yang, Li Huiqing, Liu Fe. Maresin-1 alleviates lipid peroxidation-induced ferroptosis after radiation-induced brain injury in mice through the RORα/NRF2 pathway. Experimental neurology. 2025-04-16. PMID:40239796. |
the results showed that maresin-1 could significantly reduce the levels of mda, 4-hne, gssg, and cox2 after ribi; increase the contents of gsh and gpx4; reduce neuronal loss in the cortex and hippocampus; and improve the short-term and long-term neurological functions of mice. |
2025-04-16 |
2025-04-19 |
mouse |
| Märt Rannap, Shinya Ohara, Janis Winterstein, Fabian C Roth, Andreas Draguhn, Alexei V Egoro. Functional and structural organization of medial entorhinal cortex layer VI. iScience. vol 28. issue 4. 2025-04-16. PMID:40235593. |
in addition, neurons in layer vi (lvi) of the medial entorhinal cortex (mec) project back to all hippocampal subregions and contribute to spatial coding and memory. |
2025-04-16 |
2025-04-18 |
Not clear |
| Alexandra Badea, Ali Mahzarnia, Divya Reddy, Zijian Dong, Robert J Anderson, Hae Sol Moon, Jacques A Stout, Janai Williams, Lydianne Hirschler, Emmanuel L Barbier, Christina L William. Neuroimaging Biomarkers of Neuroprotection: Impact of Voluntary versus Enforced Exercise in Alzheimer's Disease Models. bioRxiv : the preprint server for biology. 2025-04-16. PMID:40236037. |
voluntary exercise increased cortical and limbic volumes, particularly in the hippocampus, cingulate, and entorhinal cortex, supporting cognitive and emotional regulation. |
2025-04-16 |
2025-04-18 |
mouse |
| Ziru Deng, Xiang Fei, Siyu Zhang, Min X. A time window for memory consolidation during NREM sleep revealed by cAMP oscillation. Neuron. 2025-04-15. PMID:40233747. |
interestingly, in slow-wave sleep, during which memory consolidation occurs, the camp level in mice was anti-correlated with neural activity and exhibited norepinephrine β1 receptor-dependent infra-slow oscillations that were synchronized across the hippocampus and cortex. |
2025-04-15 |
2025-04-18 |
mouse |
| David Chukwuma Nwikw. Effects of stress on cognitive performance. Progress in brain research. vol 291. 2025-04-13. PMID:40222776. |
the impacts can be short-term or long-term focusing on the working memory, pre-frontal cortex, amygdala, and hippocampus. |
2025-04-13 |
2025-04-16 |
Not clear |
| Yan Jiang, Ajun Wang, Nian Zou, Huimin Dai, Ran Shan, Siyu Ren, Tongcui Jiang, Nan L. Unraveling the crucial role of UPR pathway in rat brain development. Molecular biology reports. vol 52. issue 1. 2025-04-10. PMID:40208490. |
concurrently, in the ca3 region of the hippocampus and the s1tr area of the cerebral cortex, the levels of upr key molecules, grp78 and xbp1s, exhibited an upward trend in accordance with the rats' weekly age. |
2025-04-10 |
2025-04-12 |
rat |
| Jia-Hui Hou, De-Ming Jiang, Min Chu, Li-Yong W. Blood-brain barrier biomarkers modulate the associations of peripheral immunity with Alzheimer's disease. Translational psychiatry. vol 15. issue 1. 2025-04-10. PMID:40210862. |
neu%, lym%, nlr, ccl26, cd40 and matrix metalloproteinase-10 (mmp10) were significantly associated with whole brain, hippocampal volume, middle temporal lobe (mtl) volume, and entorhinal cortex (ec) thickness, the associations of peripheral immune biomarkers with cerebral atrophy degree were mediated by bbb-related biomarkers (proportion: 7-17%; p < 0.05). |
2025-04-10 |
2025-04-14 |
human |
| Ahmed A Morsi, Ezat A Mersal, Marwa Omar Abdel All, Alshaymaa M Abdelmenem, Amal F Dawood, Atheer Alanazi, Norah Mahdi, Mohamed S Sali. ADAM17/ACE2 interaction mediates cadmium-induced brain damage and neuroinflammation in Wistar rats. Cytokine. vol 190. 2025-04-08. PMID:40199064. |
cd resulted in biochemical disturbances in the inflammatory and oxidative stress markers, degenerative histopathological changes in the cerebral cortex and hippocampus, and enhanced adam17 and gfap expression, meanwhile downregulated ace2 expression. |
2025-04-08 |
2025-04-11 |
rat |
| Hirono Shiraki, Eri Segi-Nishida, Kanzo Suzuk. Effect of chronic corticosterone administration on acute stress-mediated gene expression in the cortex and hippocampus of male mice. Biochemical and biophysical research communications. vol 762. 2025-04-08. PMID:40199127. |
we initially found that chronic corticosterone administration altered glucocorticoid signaling-mediated gene expression, such as fk506 binding protein 5 (fkbp5) and glucocorticoid-inducible kinase 1 (sgk1), in the cortex and hippocampus of mice. |
2025-04-08 |
2025-04-11 |
mouse |
| Hirono Shiraki, Eri Segi-Nishida, Kanzo Suzuk. Effect of chronic corticosterone administration on acute stress-mediated gene expression in the cortex and hippocampus of male mice. Biochemical and biophysical research communications. vol 762. 2025-04-08. PMID:40199127. |
in addition, pro-inflammatory cytokines tumor necrosis factor α (tnfa) and interleukin-1β (il1b) mrna expression in the cortex and hippocampus were remarkably enhanced by restraint stress in corticosterone-treated mice, but not in the vehicle group. |
2025-04-08 |
2025-04-11 |
mouse |
| Julie J McInvale, Louisa C Kuper, Evelyn Li, James Bonanno, Daniella Lorman, Ruby Gumenick, Sydney L Vincenti, Lori A Newma. Estradiol effects on astrocytic aquaporin 4 and glutamate transporter 1 expression contribute to shifts in brain dynamics supporting spatial working memory. Behavioural brain research. 2025-04-08. PMID:40199402. |
the current study looked at the effect of 17β-estradiol (e2) on astrocytic glutamate transporter 1 (glt-1) and aquaporin 4 (aqp4) in the prelimbic cortex (prl) and dorsal hippocampus (dhc), areas active in spatial (allocentric) working memory in comparison to dorsolateral striatum (dlstr) which is involved in response or egocentric learning. |
2025-04-08 |
2025-04-11 |
rat |
| Haizhu Zhang, Xiao Han, Zhuoting Zhu, Gengyin Wang, Xinyu Sun, Shuang Li, Yirong Liu, Yuxin Zhang, Linghuan Ga. DCI improves diabetic encephalopathy by modulating the BDNF/NF-κB/GSK-3β pathway. Experimental neurology. 2025-04-05. PMID:40187477. |
the results showed that dci improved learning and memory in db/db mice, reduced nuclear pyknosis and neuronal loss, normalized psd95 and syn protein levels, and modulated inflammatory and apoptosis-related factors in the hippocampus and cortex. |
2025-04-05 |
2025-04-08 |
mouse |
| Ying Lei, Yuxuan Liu, Mingli Wang, Nini Yuan, Yujie Hou, Lingjun Ding, Zhiyong Zhu, Zihan Wu, Chao Li, Mingyuan Zheng, Ruiyi Zhang, Ana Rita Ribeiro Gomes, Yuanfang Xu, Zhaoke Luo, Zhen Liu, Qinwen Chai, Pierre Misery, Yanqing Zhong, Xinxiang Song, Camille Lamy, Wei Cui, Qian Yu, Jiao Fang, Yingjie An, Ye Tian, Yiwen Liu, Xing Sun, Ruiqi Wang, Huanhuan Li, Jingjing Song, Xing Tan, He Wang, Shiwen Wang, Ling Han, Yong Zhang, Shenyu Li, Kexin Wang, Guangling Wang, Wanqiu Zhou, Jianfeng Liu, Cong Yu, Shuzhen Zhang, Liangtang Chang, Dafina Toplanaj, Mengni Chen, Jiabing Liu, Yun Zhao, Biyu Ren, Hanyu Shi, Hui Zhang, Haotian Yan, Jianyun Ma, Lina Wang, Yan Li, Yichen Zuo, Linjie Lu, Liqin Gu, Shuting Li, Yaqian Wang, Yinying He, Shengkang Li, Qi Zhang, Yanbing Lu, Yannong Dou, Yuan Liu, Anqi Zhao, Minyuan Zhang, Xinyan Zhang, Ying Xia, Wei Zhang, Huateng Cao, Zhiyue Lu, Zixian Yu, Xin Li, Xiaofei Wang, Zhifeng Liang, Shengjin Xu, Cirong Liu, Changhong Zheng, Chun Xu, Zhiyong Liu, Chengyu Li, Yan-Gang Sun, Xun Xu, Colette Dehay, Julien Vezoli, Mu-Ming Poo, Jianhua Yao, Longqi Liu, Wu Wei, Henry Kennedy, Zhiming She. Single-cell spatial transcriptome atlas and whole-brain connectivity of the macaque claustrum. Cell. 2025-04-04. PMID:40185102. |
several macaque-specific glutamatergic cell types in ventral vs. dorsal claustral zones selectively co-projected to two functionally related areas-entorhinal cortex and hippocampus vs. motor cortex and putamen, respectively. |
2025-04-04 |
2025-04-08 |
mouse |
| Mehwish Mehreen, Mehak Ali, Huraira Tariq, Aneeqa Noor, Sara Mumtaz, Saima Zafa. Chenodeoxycholic Acid-Mediated neuroprotection via α-synuclein and BDNF Modulation in MPTP-Induced mouse model of Parkinson's disease. Neuroscience. 2025-04-04. PMID:40185387. |
furthermore, the effective defense against mptp-induced dopaminergic degeneration was provided by cdca by improving the morphological and histological features of neurons in the midbrain, hippocampus, cortex and cerebellum. |
2025-04-04 |
2025-04-08 |
mouse |
| Gergely F Turi, Sasa Teng, Xinyue Chen, Emily C Y Lim, Carla Dias, Ruining Hu, Ruizhi Wang, Fenghua Zhen, Yueqing Pen. Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep. eLife. vol 13. 2025-04-03. PMID:40178074. |
for example, hippocampal theta, gamma, and sharp wave oscillations are critical for memory formation and communication between hippocampal subareas and the cortex. |
2025-04-03 |
2025-04-04 |
mouse |
| Shallu Tomer, Lin Pan, Jeffrey Harding, Valerie Rezek, Mitchell Krawczyk, Ethan Cook, Nandita Kedia, Li Wang, Jonathan Le, Heather Martin, Erik Gramajo, Xiang Li, Yewen Zhang, Wenli Mu, Jing Wen, Scott Kitchen, Ye Zhang, Anjie Zhe. A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation. bioRxiv : the preprint server for biology. 2025-03-31. PMID:40161608. |
we observed extensive engraftment of all three types of human glial cells (astrocytes, oligodendroglia, and microglia-like cells) in key cns regions, including the cerebral cortex and hippocampus. |
2025-03-31 |
2025-04-03 |
mouse |
| Anita Avila de Souza, Kelen Cristiane Machado Goularte, Raphaela Cassol Piccoli, Solange Vega Custódio, Julia Eisenhardt de Mello, Melinda Gomes Victor, William Borges Domingues, Lucas Petitemberte de Souza, Laís Dos Santos Gonçalves, Vinicius Farias Campos, Wilson Cunico, Jean Pierre Oses, Francieli Moro Stefanello, Mayara Sandrielly Soares de Aguiar, Roselia Maria Spanevell. 3-(3-(diethylamino)propyl)-2-(4-(methylthio)phenyl)thiazolidin-4-one Attenuates Scopolamine-induced Cognitive Impairment in Rats: Insights Into Neuroprotective Effects. Molecular neurobiology. 2025-03-31. PMID:40164887. |
acetylcholinesterase (ache) activity, oxidative stress, and inflammatory and purinergic parameters were analyzed in the cerebral cortex, hippocampus, cerebrospinal fluid, serum, lymphocytes, and liver. |
2025-03-31 |
2025-04-03 |
rat |