All Relations between cerebellum and molecular layer

Publication Sentence Publish Date Extraction Date Species
Jennifer L Fessler, Megan A Stiles, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherr. The Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model. Cerebellum (London, England). 2024-06-08. PMID:38850484. to test whether w246g elovl4 altered neuronal generation or survival in the cerebellum, we compared the numbers of purkinje cells, unipolar brush cells, molecular layer interneurons, granule and displaced granule cells in the cerebellum of wildtype, heterozygous, and homozygous sca34-ki rats at four months of age, when motor impairment is already present. 2024-06-08 2024-06-11 human
Liam P Hallada, Abbas Shirinifard, David J Soleck. Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585827. leveraging advanced imaging techniques, specific probes for cell recognition, and analytical methods to dissect adhesion dynamics, our findings reveal: 1) jam-c cis or trans mutants result in reduced adhesion formation between cgns and cerebellar glia, 2) these mutants exhibit delayed recruitment of pard3 at the adhesion sites, and 3) cgns with jam-c mutations experience postponed sorting and entry into the cerebellar molecular layer (ml). 2024-04-08 2024-04-10 Not clear
Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R William. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells. eLife. vol 12. 2024-03-27. PMID:38536959. kit is enriched in molecular layer interneurons (mlis) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar kit ligand is selectively expressed by a target of their inhibition, purkinje cells (pcs). 2024-03-27 2024-03-30 mouse
Maxime Beau, David J Herzfeld, Francisco Naveros, Marie E Hemelt, Federico D'Agostino, Marlies Oostland, Alvaro Sánchez-López, Young Yoon Chung, Michael Maibach, Hannah N Stabb, M Gabriela Martínez Lopera, Agoston Lajko, Marie Zedler, Shogo Ohmae, Nathan J Hall, Beverley A Clark, Dana Cohen, Stephen G Lisberger, Dimitar Kostadinov, Court Hull, Michael Häusser, Javier F Medin. A deep-learning strategy to identify cell types across species from high-density extracellular recordings. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352514. we combine optogenetic activation and pharmacology using the cerebellum as a testbed to generate a curated ground-truth library of electrophysiological properties for purkinje cells, molecular layer interneurons, golgi cells, and mossy fibers. 2024-02-14 2024-02-16 Not clear
Owen Y Chao, Salil Saurav Pathak, Hao Zhang, George J Augustine, Jason M Christie, Chikako Kikuchi, Hiroki Taniguchi, Yi-Mei Yan. Social memory deficit caused by dysregulation of the cerebellar vermis. Nature communications. vol 14. issue 1. 2023-09-26. PMID:37752149. we selectively increased the excitability of molecular layer interneurons (mlis) to suppress purkinje cell firing in the mouse cerebellar vermis. 2023-09-26 2023-10-07 mouse
Kathryn Lynn Carzoli, Georgios Kogias, Jessica Fawcett-Patel, Siqiong June Li. Cerebellar interneurons control fear memory consolidation via learning-induced HCN plasticity. Cell reports. vol 42. issue 9. 2023-09-01. PMID:37656617. in the cerebellum, we find that silencing molecular layer interneurons completely abolishes fear memory, revealing their critical role in memory consolidation. 2023-09-01 2023-09-07 Not clear
Roberta Maria Lorenzi, Alice Geminiani, Yann Zerlaut, Marialaura De Grazia, Alain Destexhe, Claudia A M Gandini Wheeler-Kingshott, Fulvia Palesi, Claudia Casellato, Egidio D'Angel. A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics. PLoS computational biology. vol 19. issue 9. 2023-09-01. PMID:37656758. here we have designed and simulated a multi-layer mf of the cerebellar microcircuit (including granule cells, golgi cells, molecular layer interneurons, and purkinje cells) and validated it against experimental data and the corresponding spiking neural network (snn) microcircuit model. 2023-09-01 2023-09-07 mouse
Federico Trigo, Shin-Ya Kawaguch. Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons. eLife. vol 12. 2023-08-11. PMID:37565643. analogue signaling of somatodendritic synaptic activity to axon enhances gaba release in young cerebellar molecular layer interneurons. 2023-08-11 2023-08-16 rat
Masashi Nishikawa, Tohru Matsuki, Nanako Hamada, Atsuo Nakayama, Hidenori Ito, Koh-Ichi Nagat. Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development. Medical molecular morphology. 2023-07-04. PMID:37402055. in cerebellum, wac was detected in the nucleus of purkinje cells and granule cells, and possibly interneurons in the molecular layer. 2023-07-04 2023-08-14 mouse
Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al Qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A M Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M C van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxen. Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1. Neuron. 2023-06-15. PMID:37321222. using in vivo two-photon imaging in behaving spinocerebellar ataxia type 1 (sca1) mice, wherein purkinje neurons (pns) degenerate, we identify an inhibitory circuit element (molecular layer interneurons [mlins]) that becomes prematurely hyperexcitable, compromising sensorimotor signals in the cerebellum at early stages. 2023-06-15 2023-08-14 mouse
Yang Liu, Li-Xin Cao, Wei-Yao Wang, Yong-Rui Piao, Jun-Ya Wang, Chun-Ping Chu, Yan-Hua Bing, De-Lai Qi. GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell Frontiers in molecular neuroscience. vol 16. 2023-04-24. PMID:37089690. in the cerebellar cortex, glp-1 receptor is abundantly expressed in the molecular layer, purkinje cell (pc) layer and granular layer, indicating that glp-1 may modulate the cerebellar neuronal activity. 2023-04-24 2023-08-14 mouse
Bastien Le Guellec, Laura C Gomez, Gerardo Malagon, Thibault Collin, Alain Mart. Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum. The Journal of general physiology. vol 155. issue 5. 2023-04-03. PMID:37010482. however, when studying miniature glutamatergic currents at cerebellar synapses between parallel fibers and molecular layer interneurons, we found that these currents were sometimes organized in bursts of events occurring at high frequency (about 30 hz). 2023-04-03 2023-08-14 Not clear
Sarmad Hayder Weli Weli, Ahmad Yahyazade. Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide. Journal of chemical neuroanatomy. vol 130. 2023-03-29. PMID:36989922. in addition, the mean volumes of molecular layer, granular layer, white matter, and cerebellum were significantly decreased in the sk group compared to the control group (p < 0.05). 2023-03-29 2023-08-14 rat
Sarmad Hayder Weli Weli, Ahmad Yahyazade. Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide. Journal of chemical neuroanatomy. vol 130. 2023-03-29. PMID:36989922. in the sk + gb group, the total number purkinje cell, and granular cells, as well as the mean volumes of molecular layer, granular layer, white matter, and cerebellum were significantly increased than the sk group (p < 0.05). 2023-03-29 2023-08-14 rat
Moritoshi Hirono, Masanori Nakat. Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells. Scientific reports. vol 13. issue 1. 2023-02-08. PMID:36750743. we found that ghrelin enhanced gabaergic transmission between molecular layer interneurons (mlis) and pcs using electrophysiological recordings in mouse cerebellar slices. 2023-02-08 2023-08-14 mouse
Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo Murayama, Hideki Mochizuk. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-01-27. PMID:36703300. severe neuronal loss in the substantia nigra and prominent loss of purkinje cells, atrophy of the molecular layer, and proliferation of bergmann glia in the cerebellum were common features. 2023-01-27 2023-08-14 Not clear
Audrey Bonnan, Ke Zhang, Michael A Gaffield, Jason M Christi. Expression of a form of cerebellar motor memory requires learned alterations to the activity of inhibitory molecular layer interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-14. PMID:36639897. expression of a form of cerebellar motor memory requires learned alterations to the activity of inhibitory molecular layer interneurons. 2023-01-14 2023-08-14 mouse
Hunter E Halverson, Jinsook Kim, Andrei Khilkevich, Michael D Mauk, George J Augustin. Feedback inhibition underlies new computational functions of cerebellar interneurons. eLife. vol 11. 2022-12-08. PMID:36480240. the function of a feedback inhibitory circuit between cerebellar purkinje cells and molecular layer interneurons (mlis) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and 2022-12-08 2023-08-14 Not clear
Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, José Ávila-Mendoza, Carlos G Martínez-Moreno, Carlos Arámburo, Maricela Lun. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232848. histological analysis showed that hypoxia provoked a significant modification in the size and organization of cerebellar layers; however, gh administration restored the width of external granular layer (egl) and molecular layer (ml) and improved the purkinje and granular neurons survival. 2022-10-14 2023-08-14 chicken
Sharon Baughman Shively, Nancy A Edwards, Tobey J MacDonald, Kory R Johnson, Natalia M Diaz-Rodriguez, Marsha J Merrill, Alexander O Vortmeye. Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients. Journal of neuropathology and experimental neurology. 2022-08-18. PMID:35980299. multiple, microscopic, vhl-deficient precursors, termed developmentally arrested structural elements (dases), consistently involve the cerebellar molecular layer in vhl patients, indicating the tumor site of origin. 2022-08-18 2023-08-14 mouse