| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tristan Hurzeler, Joshua Watt, Warren Logge, Ellen Towers, Anastasia Suraev, Nicholas Lintzeris, Paul Haber, Kirsten C Morle. Neuroimaging studies of cannabidiol and potential neurobiological mechanisms relevant for alcohol use disorders: a systematic review. Journal of cannabis research. vol 6. issue 1. 2024-03-21. PMID:38509580. |
the results suggest that cbd modulates γ-aminobutyric acid and glutamate signaling in the basal ganglia and dorso-medial prefrontal cortex. |
2024-03-21 |
2024-03-23 |
human |
| Jin-Bao Zhang, Fen Wang, Yu-Ting Tang, Meng-Zhu Pang, Dan Li, Chun-Feng Li. Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling. ACS chemical neuroscience. 2024-01-26. PMID:38277219. |
nmda receptors are ion-gated glutamate receptors with high calcium permeability, and their glun2d subunits are prominently distributed in the basal ganglia and brainstem nuclei. |
2024-01-26 |
2024-01-29 |
rat |
| Priya P Shejul, Gaurav M Dosh. Glutamate Receptors and C-ABL Inhibitors: A New Therapeutic Approach for Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2024-01-26. PMID:38273763. |
furthermore, glutamate receptors have also been proposed as potential therapeutic targets for the treatment of pd since they facilitate and regulate synaptic neurotransmission throughout the basal ganglia motor system. |
2024-01-26 |
2024-01-28 |
Not clear |
| Y Schneider, C Gauer, M Andert, A Hoffmann, M J Riemenschneider, W Krebs, N Chalmers, C Lötzsch, U J Naumann, W Xiang, V Rothhammer, R Beckervordersandforth, J C M Schlachetzki, J Winkle. Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy. Acta neuropathologica communications. vol 12. issue 1. 2024-01-03. PMID:38167307. |
notably, msa mice exhibited a decreased expression of the glutamate transporter 1 and glutamate aspartate transporter in the basal ganglia, but not the motor cortex. |
2024-01-03 |
2024-01-06 |
mouse |
| Oliver D Howes, Bernard R Bukala, Katherine Bec. Schizophrenia: from neurochemistry to circuits, symptoms and treatments. Nature reviews. Neurology. 2023-12-19. PMID:38110704. |
this evidence demonstrates regionally specific neurotransmitter alterations, including higher glutamate and dopamine measures in the basal ganglia, and lower glutamate, dopamine and γ-aminobutyric acid (gaba) levels in cortical regions, particularly the frontal cortex, relative to healthy individuals. |
2023-12-19 |
2023-12-21 |
Not clear |
| Chang Li, Osama F Elabi, Tim Fieblinger, M Angela Cenc. Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation. The European journal of neuroscience. 2023-10-25. PMID:37876330. |
the dendritic arbour of striatal projection neurons (spns) is the primary anatomical site where dopamine and glutamate inputs to the basal ganglia functionally interact to control movement. |
2023-10-25 |
2023-11-08 |
mouse |
| Marika Alborghetti, Edoardo Bianchini, Lanfranco De Carolis, Silvia Galli, Francesco E Pontieri, Domiziana Rinald. Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488838. |
besides, safinamide may interfere with neurodegenerative mechanisms, counteracting excessive glutamate overdrive in basal ganglia motor circuit and reducing death from excitotoxicity. |
2023-07-25 |
2023-08-14 |
Not clear |
| Mykyta M Chernov, Christina B Swan, James C Leite. In Search of a Feedback Signal for Closed-Loop Deep Brain Stimulation: Stimulation of the Subthalamic Nucleus Reveals Altered Glutamate Dynamics in the Globus Pallidus in Anesthetized, 6-Hydroxydopamine-Treated Rats. Biosensors. vol 13. issue 4. 2023-05-16. PMID:37185555. |
we tested the hypotheses that dbs releases glutamate in selected basal ganglia nuclei and that the creation of 6-hydroxydopamine (6-ohda)-induced nigrostriatal lesions alters glutamate release during dbs in those basal ganglia nuclei. |
2023-05-16 |
2023-08-14 |
rat |
| Mark P Epping-Jordan, Françoise Girard, Anne-Sophie Bessis, Vincent Mutel, Christelle Boléa, Francis Derouet, Abdelhak Bessif, Brice Mingard, Stéphanie Barbier, Justine S Paradis, Jean-Philippe Rocher, Robert Lütjens, Mikhail Kalinichev, Sonia Pol. Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease. Cells. vol 12. issue 7. 2023-04-13. PMID:37048075. |
excessive glutamate activity in the basal ganglia resulting from degeneration of the nigrostriatal dopamine pathway has been implicated in the motor symptoms, nms and dyskinesias in pd patients. |
2023-04-13 |
2023-08-14 |
Not clear |
| Mélanie Bourque, Marc Morissette, François Conquet, Delphine Charvin, Thérèse Di Paol. Foliglurax, a positive allosteric modulator of the metabotrophic glutamate receptor 4, protects dopaminergic neurons in MPTP-lesioned male mice. Brain research. 2023-03-27. PMID:36972837. |
overactivity of the corticostriatal glutamatergic pathway is documented in parkinson's disease (pd) and stimulation of presynaptic metabotropic glutamate 4 (mglu4) receptors on these striatal afferents inhibits glutamate release normalizing neuronal activity in the basal ganglia. |
2023-03-27 |
2023-08-14 |
mouse |
| Kate Merritt, Robert A McCutcheon, André Aleman, Sarah Ashley, Katherine Beck, Wolfgang Block, Oswald J N Bloemen, Faith Borgan, Christiana Boules, Juan R Bustillo, Aristides A Capizzano, Jennifer M Coughlin, Anthony David, Camilo de la Fuente-Sandoval, Arsime Demjaha, Kara Dempster, Kim Q Do, Fei Du, Peter Falkai, Beata Galińska-Skok, Jürgen Gallinat, Charles Gasparovic, Cedric E Ginestet, Naoki Goto, Ariel Graff-Guerrero, Beng-Choon Ho, Oliver Howes, Sameer Jauhar, Peter Jeon, Tadafumi Kato, Charles A Kaufmann, Lawrence S Kegeles, Matcheri S Keshavan, Sang-Young Kim, Bridget King, Hiroshi Kunugi, J Lauriello, Pablo León-Ortiz, Edith Liemburg, Meghan E Mcilwain, Gemma Modinos, Elias Mouchlianitis, Jun Nakamura, Igor Nenadic, Dost Öngür, Miho Ota, Lena Palaniyappan, Christos Pantelis, Tulsi Patel, Eric Plitman, Sotirios Posporelis, Scot E Purdon, Jürgen R Reichenbach, Perry F Renshaw, Francisco Reyes-Madrigal, Bruce R Russell, Akira Sawa, Martin Schaefer, Dikoma C Shungu, Stefan Smesny, Jeffrey A Stanley, James Stone, Agata Szulc, Reggie Taylor, Katharine N Thakkar, Jean Théberge, Philip G Tibbo, Thérèse van Amelsvoort, Jerzy Walecki, Peter C Williamson, Stephen J Wood, Lijing Xin, Hidenori Yamasue, Philip McGuire, Alice Egerto. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis. Molecular psychiatry. 2023-02-22. PMID:36806762. |
studies in younger, more symptomatic patients were associated with greater variability in the basal ganglia (bg glutamate with age: z = -0.03, p = 0.003, symptoms: z = 0.007, p = 0.02) and temporal lobe (glutamate with age: z = -0.03, p = 0.02), while studies with older, more symptomatic patients associated with greater variability in mfc (glutamate with age: z = 0.01, p = 0.02, glutamine with symptoms: z = 0.01, p = 0.02). |
2023-02-22 |
2023-08-14 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Marc Morissette, Mélanie Bourque, Marie-Ève Tremblay, Thérèse Di Paol. Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys. Cells. vol 11. issue 4. 2022-02-25. PMID:35203338. |
in conclusion, these results showed increased inflammatory markers in the basal ganglia associated with lid and revealed that mpep inhibition of glutamate activity reduced lid and levels of inflammatory markers. |
2022-02-25 |
2023-08-13 |
monkey |
| Robert Lalonde, Catherine Straziell. The mouse at the popcorn stage of development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-01-26. PMID:35080044. |
based mostly on results found in adult mice and rats, there may also be a role for cortico-subcortical systems that include the cerebellum and basal ganglia requiring the influence of biogenic amines, glutamate, and endocannabinoids. |
2022-01-26 |
2023-08-13 |
mouse |
| Jonathan W Dickerson, P Jeffrey Con. Therapeutic potential of targeting metabotropic glutamate receptors for Parkinson's disease. Neurodegenerative disease management. vol 2. issue 2. 2021-10-21. PMID:23526920. |
in this article, we will review the role of metabotropic glutamate receptors within the basal ganglia and discuss the potential for modulation of metabotropic glutamate receptors as a treatment for pd. |
2021-10-21 |
2023-08-12 |
Not clear |
| Annalisa Pinna, Marcello Serra, Jacopo Marongiu, Micaela Morell. Pharmacological interactions between adenosine A Parkinsonism & related disorders. vol 80 Suppl 1. 2021-10-11. PMID:33349579. |
the other principal neurotransmitters/neuromodulators known to control basal ganglia functions and, in particular, motor functions, are gaba, glutamate, serotonin (5-ht), noradrenaline, acetylcholine, adenosine and endocannabinoids. |
2021-10-11 |
2023-08-13 |
Not clear |
| Xiangchuan Chen, Diana J Beltran, Valeriya D Tsygankova, Bobbi J Woolwine, Trusharth Patel, Wendy Baer, Jennifer C Felger, Andrew H Miller, Ebrahim Haroo. Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34482366. |
we measured markers of glial dysfunction and distress including glutamate (glu) and myo-inositol in the left basal ganglia using magnetic resonance spectroscopy (mrs); metrics of local activity coherence (regional homogeneity, reho) and functional connectivity from resting-state functional mri measures; and anhedonia from the inventory for depressive symptoms-self report version (ids-sr). |
2021-10-11 |
2023-08-13 |
human |
| Amber M Muehlmann, Sebastian Maletz, Michael A King, Mark H Lewi. Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32461129. |
in the current study, we tested whether a drug cocktail (dopamine d2 receptor antagonist + adenosine a2a receptor agonist + glutamate mglu5 positive allosteric modulator) designed to activate the indirect basal ganglia pathway would reduce repetitive behavior in c58 mice after both acute and sub-chronic administration. |
2021-10-05 |
2023-08-13 |
mouse |
| Robert A McCutcheon, Kate Merritt, Oliver D Howe. Dopamine and glutamate in individuals at high risk for psychosis: a meta-analysis of in vivo imaging findings and their variability compared to controls. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 3. 2021-09-23. PMID:34505389. |
there were no significant differences between high-risk individuals and controls in striatal presynaptic dopaminergic function, striatal d2/d3 receptor availability, prefrontal cortex glutamate or glx, hippocampal glutamate or glx, or basal ganglia glx. |
2021-09-23 |
2023-08-13 |
Not clear |
| James J Prisciandaro, William Mellick, Lindsay M Squeglia, Sara Hix, Lauren Arnold, Bryan K Tollive. Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. Addiction biology. 2021-08-14. PMID:34390300. |
primary analyses revealed that (1) gabapentin was well tolerated and adherence and retention were high, (2) gabapentin increased dorsal anterior cingulate cortex (dacc) and right basal ganglia (rbg) glutamate levels and (3) gabapentin increased activation to visual cannabis cues in the posterior midcingulate cortex (pmcc, a region involved in response inhibition to rewarding stimuli). |
2021-08-14 |
2023-08-13 |
human |