| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang Li, Osama F Elabi, Tim Fieblinger, M Angela Cenc. Structural-functional properties of direct-pathway striatal neurons at early and chronic stages of dopamine denervation. The European journal of neuroscience. 2023-10-25. PMID:37876330. |
the dendritic arbour of striatal projection neurons (spns) is the primary anatomical site where dopamine and glutamate inputs to the basal ganglia functionally interact to control movement. |
2023-10-25 |
2023-11-08 |
mouse |
| Marika Alborghetti, Edoardo Bianchini, Lanfranco De Carolis, Silvia Galli, Francesco E Pontieri, Domiziana Rinald. Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488838. |
besides, safinamide may interfere with neurodegenerative mechanisms, counteracting excessive glutamate overdrive in basal ganglia motor circuit and reducing death from excitotoxicity. |
2023-07-25 |
2023-08-14 |
Not clear |
| Mykyta M Chernov, Christina B Swan, James C Leite. In Search of a Feedback Signal for Closed-Loop Deep Brain Stimulation: Stimulation of the Subthalamic Nucleus Reveals Altered Glutamate Dynamics in the Globus Pallidus in Anesthetized, 6-Hydroxydopamine-Treated Rats. Biosensors. vol 13. issue 4. 2023-05-16. PMID:37185555. |
we tested the hypotheses that dbs releases glutamate in selected basal ganglia nuclei and that the creation of 6-hydroxydopamine (6-ohda)-induced nigrostriatal lesions alters glutamate release during dbs in those basal ganglia nuclei. |
2023-05-16 |
2023-08-14 |
rat |
| Mark P Epping-Jordan, Fran\\xc3\\xa7oise Girard, Anne-Sophie Bessis, Vincent Mutel, Christelle Bol\\xc3\\xa9a, Francis Derouet, Abdelhak Bessif, Brice Mingard, St\\xc3\\xa9phanie Barbier, Justine S Paradis, Jean-Philippe Rocher, Robert L\\xc3\\xbctjens, Mikhail Kalinichev, Sonia Pol. Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson's Disease. Cells. vol 12. issue 7. 2023-04-13. PMID:37048075. |
excessive glutamate activity in the basal ganglia resulting from degeneration of the nigrostriatal dopamine pathway has been implicated in the motor symptoms, nms and dyskinesias in pd patients. |
2023-04-13 |
2023-08-14 |
Not clear |
| M\\xc3\\xa9lanie Bourque, Marc Morissette, Fran\\xc3\\xa7ois Conquet, Delphine Charvin, Th\\xc3\\xa9r\\xc3\\xa8se Di Paol. Foliglurax, a positive allosteric modulator of the metabotrophic glutamate receptor 4, protects dopaminergic neurons in MPTP-lesioned male mice. Brain research. 2023-03-27. PMID:36972837. |
overactivity of the corticostriatal glutamatergic pathway is documented in parkinson's disease (pd) and stimulation of presynaptic metabotropic glutamate 4 (mglu4) receptors on these striatal afferents inhibits glutamate release normalizing neuronal activity in the basal ganglia. |
2023-03-27 |
2023-08-14 |
mouse |
| Kate Merritt, Robert A McCutcheon, Andr\\xc3\\xa9 Aleman, Sarah Ashley, Katherine Beck, Wolfgang Block, Oswald J N Bloemen, Faith Borgan, Christiana Boules, Juan R Bustillo, Aristides A Capizzano, Jennifer M Coughlin, Anthony David, Camilo de la Fuente-Sandoval, Arsime Demjaha, Kara Dempster, Kim Q Do, Fei Du, Peter Falkai, Beata Gali\\xc5\\x84ska-Skok, J\\xc3\\xbcrgen Gallinat, Charles Gasparovic, Cedric E Ginestet, Naoki Goto, Ariel Graff-Guerrero, Beng-Choon Ho, Oliver Howes, Sameer Jauhar, Peter Jeon, Tadafumi Kato, Charles A Kaufmann, Lawrence S Kegeles, Matcheri S Keshavan, Sang-Young Kim, Bridget King, Hiroshi Kunugi, J Lauriello, Pablo Le\\xc3\\xb3n-Ortiz, Edith Liemburg, Meghan E Mcilwain, Gemma Modinos, Elias Mouchlianitis, Jun Nakamura, Igor Nenadic, Dost \\xc3\\x96ng\\xc3\\xbcr, Miho Ota, Lena Palaniyappan, Christos Pantelis, Tulsi Patel, Eric Plitman, Sotirios Posporelis, Scot E Purdon, J\\xc3\\xbcrgen R Reichenbach, Perry F Renshaw, Francisco Reyes-Madrigal, Bruce R Russell, Akira Sawa, Martin Schaefer, Dikoma C Shungu, Stefan Smesny, Jeffrey A Stanley, James Stone, Agata Szulc, Reggie Taylor, Katharine N Thakkar, Jean Th\\xc3\\xa9berge, Philip G Tibbo, Th\\xc3\\xa9r\\xc3\\xa8se van Amelsvoort, Jerzy Walecki, Peter C Williamson, Stephen J Wood, Lijing Xin, Hidenori Yamasue, Philip McGuire, Alice Egerto. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis. Molecular psychiatry. 2023-02-22. PMID:36806762. |
studies in younger, more symptomatic patients were associated with greater variability in the basal ganglia (bg glutamate with age: z\xe2\x80\x89=\xe2\x80\x89-0.03, p\xe2\x80\x89=\xe2\x80\x890.003, symptoms: z\xe2\x80\x89=\xe2\x80\x890.007, p\xe2\x80\x89=\xe2\x80\x890.02) and temporal lobe (glutamate with age: z\xe2\x80\x89=\xe2\x80\x89-0.03, p\xe2\x80\x89=\xe2\x80\x890.02), while studies with older, more symptomatic patients associated with greater variability in mfc (glutamate with age: z\xe2\x80\x89=\xe2\x80\x890.01, p\xe2\x80\x89=\xe2\x80\x890.02, glutamine with symptoms: z\xe2\x80\x89=\xe2\x80\x890.01, p\xe2\x80\x89=\xe2\x80\x890.02). |
2023-02-22 |
2023-08-14 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Marc Morissette, M\\xc3\\xa9lanie Bourque, Marie-\\xc3\\x88ve Tremblay, Th\\xc3\\xa9r\\xc3\\xa8se Di Paol. Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys. Cells. vol 11. issue 4. 2022-02-25. PMID:35203338. |
in conclusion, these results showed increased inflammatory markers in the basal ganglia associated with lid and revealed that mpep inhibition of glutamate activity reduced lid and levels of inflammatory markers. |
2022-02-25 |
2023-08-13 |
monkey |
| Robert Lalonde, Catherine Straziell. The mouse at the popcorn stage of development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-01-26. PMID:35080044. |
based mostly on results found in adult mice and rats, there may also be a role for cortico-subcortical systems that include the cerebellum and basal ganglia requiring the influence of biogenic amines, glutamate, and endocannabinoids. |
2022-01-26 |
2023-08-13 |
mouse |
| Jonathan W Dickerson, P Jeffrey Con. Therapeutic potential of targeting metabotropic glutamate receptors for Parkinson's disease. Neurodegenerative disease management. vol 2. issue 2. 2021-10-21. PMID:23526920. |
in this article, we will review the role of metabotropic glutamate receptors within the basal ganglia and discuss the potential for modulation of metabotropic glutamate receptors as a treatment for pd. |
2021-10-21 |
2023-08-12 |
Not clear |
| Annalisa Pinna, Marcello Serra, Jacopo Marongiu, Micaela Morell. Pharmacological interactions between adenosine A Parkinsonism & related disorders. vol 80 Suppl 1. 2021-10-11. PMID:33349579. |
the other principal neurotransmitters/neuromodulators known to control basal ganglia functions and, in particular, motor functions, are gaba, glutamate, serotonin (5-ht), noradrenaline, acetylcholine, adenosine and endocannabinoids. |
2021-10-11 |
2023-08-13 |
Not clear |
| Xiangchuan Chen, Diana J Beltran, Valeriya D Tsygankova, Bobbi J Woolwine, Trusharth Patel, Wendy Baer, Jennifer C Felger, Andrew H Miller, Ebrahim Haroo. Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34482366. |
we measured markers of glial dysfunction and distress including glutamate (glu) and myo-inositol in the left basal ganglia using magnetic resonance spectroscopy (mrs); metrics of local activity coherence (regional homogeneity, reho) and functional connectivity from resting-state functional mri measures; and anhedonia from the inventory for depressive symptoms-self report version (ids-sr). |
2021-10-11 |
2023-08-13 |
human |
| Amber M Muehlmann, Sebastian Maletz, Michael A King, Mark H Lewi. Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32461129. |
in the current study, we tested whether a drug cocktail (dopamine d2 receptor antagonist + adenosine a2a receptor agonist + glutamate mglu5 positive allosteric modulator) designed to activate the indirect basal ganglia pathway would reduce repetitive behavior in c58 mice after both acute and sub-chronic administration. |
2021-10-05 |
2023-08-13 |
mouse |
| Robert A McCutcheon, Kate Merritt, Oliver D Howe. Dopamine and glutamate in individuals at high risk for psychosis: a meta-analysis of in vivo imaging findings and their variability compared to controls. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 3. 2021-09-23. PMID:34505389. |
there were no significant differences between high-risk individuals and controls in striatal presynaptic dopaminergic function, striatal d2/d3 receptor availability, prefrontal cortex glutamate or glx, hippocampal glutamate or glx, or basal ganglia glx. |
2021-09-23 |
2023-08-13 |
Not clear |
| James J Prisciandaro, William Mellick, Lindsay M Squeglia, Sara Hix, Lauren Arnold, Bryan K Tollive. Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. Addiction biology. 2021-08-14. PMID:34390300. |
primary analyses revealed that (1) gabapentin was well tolerated and adherence and retention were high, (2) gabapentin increased dorsal anterior cingulate cortex (dacc) and right basal ganglia (rbg) glutamate levels and (3) gabapentin increased activation to visual cannabis cues in the posterior midcingulate cortex (pmcc, a region involved in response inhibition to rewarding stimuli). |
2021-08-14 |
2023-08-13 |
human |
| Rosalinda C Roberts, Lesley A McCollum, Kirsten E Schoonover, Samuel J Mabry, Joy K Roche, Adrienne C Laht. Ultrastructural evidence for glutamatergic dysregulation in schizophrenia. Schizophrenia research. 2021-08-01. PMID:32014360. |
following a brief summary of glutamate circuitry and how synapses are identified at the electron microscopic (em) level, we will review em pathology in the cortex and basal ganglia. |
2021-08-01 |
2023-08-13 |
human |
| Javier Pagonabarraga, Michele Tinazzi, Carla Caccia, Wolfgang H Jos. The role of glutamatergic neurotransmission in the motor and non-motor symptoms in Parkinson's disease: Clinical cases and a review of the literature. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 90. 2021-07-26. PMID:34275546. |
glutamate is the major excitatory neurotransmitter in the central nervous system and, as such, many brain regions, including the basal ganglia, are rich in glutamatergic neurons. |
2021-07-26 |
2023-08-13 |
Not clear |
| Mohammed E Choudhury, Yuka Kigami, Junya Tanak. Dual Roles of Microglia in the Basal Ganglia in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 8. 2021-05-25. PMID:33918947. |
on the other hand, microglia are also activated in the basal ganglia outputs (the substantia nigra pars reticulata and the globus pallidus) in response to excess glutamate released from hyperactive subthalamic nuclei-derived synapses. |
2021-05-25 |
2023-08-13 |
Not clear |
| Farhan Augustine, Shreenath Rajendran, Harvey S Singe. Cortical endogenous opioids and their role in facilitating repetitive behaviors in deer mice. Behavioural brain research. vol 379. 2021-04-30. PMID:31676208. |
in this study, we pursue the mechanism of repetitive behaviors by performing stereological analyses and liquid chromatography/ mass spectrometry (lc-ms/ms) measurements of glutamate (glut), gaba, 3,4-dihydroxyphenylacetic acid (dopac), dopamine (da), leu-enkephalin (leu-enk), and dynorphin-a (dyn-a) in frontal cortex (fc), prefrontal cortex (pfc), and basal ganglia. |
2021-04-30 |
2023-08-13 |
mouse |
| Zahra Jafari, Bryan E Kolb, Majid H Mohajeran. Auditory Dysfunction in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 4. 2021-04-27. PMID:32052894. |
improvement in auditory responses following dopaminergic therapies also indicates the presence of similar neurotransmitters (i.e., glutamate and dopamine) in the auditory system and basal ganglia. |
2021-04-27 |
2023-08-13 |
Not clear |