| Danielle Diniz Aguiar, J\\xc3\\xbalia Alvarenga Petrocchi, Grazielle Caroline da Silva, Virg\\xc3\\xadnia Soares Lemos, Marina Gomes Miranda E Castor, Andrea de Castro Perez, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romer. Participation of the cannabinoid system and the NO/cGMP/K Neuroscience letters. 2023-10-28. PMID:37898181.
||participation of the cannabinoid system and the no/cgmp/k it has already been shown that serotonin can release endocannabinoids at the spinal cord level, culminating in inhibition of the dorsal horn.
| Elaine M Jennings, Bright N Okine, Weredeselam M Olango, Michelle Roche, David P Fin. Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25988529.
||given the well-documented role of the endocannabinoid system in stress and pain, we investigated associated alterations in endocannabinoid signalling in the dorsal horn of the spinal cord and amygdala.
| Friederike Knerlich-Lukoschus, Malte Noack, Beata von der Ropp-Brenner, Ralph Lucius, Hubertus Maximilian Mehdorn, Janka Held-Feind. Spinal cord injuries induce changes in CB1 cannabinoid receptor and C-C chemokine expression in brain areas underlying circuitry of chronic pain conditions. Journal of neurotrauma. vol 28. issue 4. 2011-08-11. PMID:21265596.
||due to their involvement in neuro-modulatory processes, the endogenous cannabinoid system and chemokine network, which were shown to interact which each other, are potential key elements in the cascades underlying central neuropathic pain development after spinal cord injury (sci).
| W P Farquhar-Smith, M Egertov\\xc3\\xa1, E J Bradbury, S B McMahon, A S Rice, M R Elphic. Cannabinoid CB(1) receptor expression in rat spinal cord. Molecular and cellular neurosciences. vol 15. issue 6. 2000-08-30. PMID:10860578.
||while evidence implicates the endogenous cannabinoid system as a novel analgesic target at a spinal level, detailed analysis of the distribution of the cannabinoid receptor cb(1) in spinal cord has not been reported.
| R G Pertwe. Pharmacology of cannabinoid receptor ligands. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469884.
||the discovery of this endogenous cannabinoid system has been paralleled by a renewed interest in possible therapeutic applications of cannabinoids, for example in the management of pain and in the suppression of muscle spasticity/spasm associated with multiple sclerosis or spinal cord injury.