| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Amrutha, Chandran S Abhinand, Shubham Sukerndeo Upadhyay, Ravishankar Parvaje, Thottethodi Subrahmanya Keshava Prasad, Prashant Kumar Mod. Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease. Scientific reports. vol 15. issue 1. 2025-03-08. PMID:40057579. |
pathway analysis highlighted the enrichment of camp, mtor, mapk, and pi3k-akt signaling pathways along with cholinergic, dopaminergic, serotonergic, glutamatergic synapse, and apoptosis. |
2025-03-08 |
2025-03-12 |
human |
| Junia Lara de Deus, Juliana Marino Maia, Renato Nery Soriano, Mateus R Amorim, Luiz G S Branc. Psychedelics in neuroinflammation: Mechanisms and therapeutic potential. Progress in neuro-psychopharmacology & biological psychiatry. 2025-02-01. PMID:39892847. |
beyond the serotonergic system, other neurotransmitter systems-including the glutamatergic, dopaminergic, noradrenergic, gamma-aminobutyric acid (gabaergic), and cholinergic systems-also play significant roles in mediating the effects of psychedelics. |
2025-02-01 |
2025-02-04 |
Not clear |
| Hui Li, Jinyu Chen, Chenyin Dong, Xiaoxia Chen, Yulun Gu, Yongqi Jiang, Jingwen Cui, Haibo Che. Behavioral and molecular neurotoxicity of thermally degraded polystyrene in Caenorhabditis elegans. Journal of hazardous materials. vol 487. 2025-01-19. PMID:39827801. |
in transgenic nematodes, t-ps exposure significantly impacted fluorescence intensity and the percentage of worms exhibiting neurodegeneration in serotonergic, cholinergic, dopaminergic, and γ-aminobutyric acid (gaba) neurons. |
2025-01-19 |
2025-01-23 |
caenorhabditis_elegans |
| Maximiliano Abarca, Humberto Pizarro, M Leonor Bustamante, Gustav Rohde, Marcelo Arancibi. Genetic and neurobiological aspects of psychosis in major neurocognitive disorder. Medwave. vol 25. issue 1. 2025-01-08. PMID:39772397. |
on the other hand, alterations of the cholinergic, serotonergic, dopaminergic, and gabaergic neurotransmitter systems and the excitatory-inhibitory balance have been described in dementia. |
2025-01-08 |
2025-01-13 |
Not clear |
| Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajd. Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder. Molecules (Basel, Switzerland). vol 29. issue 22. 2024-11-27. PMID:39598660. |
while the etiology and pathophysiology of autism spectrum disorder are still not fully understood, recent studies have suggested that wide alterations in the gabaergic, glutamatergic, cholinergic, and serotonergic systems play a key role in its development and progression. |
2024-11-27 |
2024-11-29 |
Not clear |
| Bandral Sunil Kumar, Basavana Gowda Hosur Dinesh, Sandra Ross Olakkengil Shajan, Nandini Markuli Sadashivappa, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Panneerselvam Theivendren, Parasuraman Pavada. Alzheimer's Disease Protein Targets: Comprehensive Review and Future Directions. Current pharmaceutical design. 2024-10-21. PMID:39428938. |
the text also examines subcortical nuclei participation, such as the noradrenergic locus coeruleus, serotonergic dorsal raphe, and cholinergic basal nucleus. |
2024-10-21 |
2024-10-23 |
Not clear |
| Tzayaka Castillo-Mendieta, Guadalupe Bautista-Poblet, Angélica Coyoy-Salgado, Emily L Castillo-García, Rodolfo Pinto-Almazán, Claudia Erika Fuentes-Venado, Teresa Neri-Gómez, Christian Guerra-Araiz. Effect of Chronic Tibolone Administration on Memory and Choline Acetyltransferase and Tryptophan Hydroxylase Content in Aging Mice. Brain sciences. vol 14. issue 9. 2024-09-28. PMID:39335399. |
these results show that long-term tib administration improves memory without affecting locomotor activity and modulates cholinergic but not serotonergic systems in the hippocampus of aged male mice. |
2024-09-28 |
2024-10-01 |
mouse |
| Alexey P Bolshakov, Konstantin Gerasimov, Yulia V Dobryakov. Alzheimer's Disease: An Attempt of Total Recall. Journal of Alzheimer's disease : JAD. 2024-09-13. PMID:39269841. |
we have detailed the degenerative changes that occur in several neuronal populations, including the cholinergic neurons in the nucleus basalis of meynert, the histaminergic neurons in the tuberomammillary nucleus, the serotonergic neurons in the raphe nuclei, and the noradrenergic neurons in the locus coeruleus. |
2024-09-13 |
2024-09-16 |
human |
| Jinquan Li, Yanjun Liu, Chuhui Yin, Yan Zeng, Yufei Me. Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity. Ageing research reviews. 2024-09-01. PMID:39218080. |
therefore, in this narrative review, we discuss the role of aβ-induced altered intrinsic neuronal properties as well as structural and functional remodeling of glutamatergic, gabaergic, cholinergic, noradrenergic, serotonergic circuits in hippocampal hyperactivity. |
2024-09-01 |
2024-09-04 |
Not clear |
| Ângel Inácio, Laura Aguiar, Raquel Carrilho, Patrícia Pires, Joana Ferreira, Luís Coelho, Mário Rui Mascarenhas, Luís Sardinha, Tiago Bilhim, João Pisco, Manuel Bicho, Maria Clara Bich. Genetic Contribution of the Adrenergic, Cholinergic, and Serotonergic Systems to Leiomyoma Development and Treatment. International journal of molecular and cellular medicine. vol 12. issue 4. 2024-07-16. PMID:39006196. |
we aim to study the contribution of genes of the adrenergic (adbr2 - rs1042713, nm_000024.6:c.46g>a, np_000015.2:p. gly16arg), cholinergic (chrna5 - rs16969968, nm_000745.3:c.1192g>a, np_000736.2:p.asp398asn), and serotonergic systems (slc6a4 - 5-httvntr-intron2, htr2a - rs6313, nm_000621.5:c.102c>t, np_ 001365853 .1: p. ser 34=) to gynecological tumorigenesis and their treatment by embolization. |
2024-07-16 |
2024-07-18 |
Not clear |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Raina Ardasheva, Veselin Popov, Viktor Yotov, Natalia Prissadova, Mina Pencheva, Iva Slavova, Valentin Turiyski, Athanas Kraste. Accelerated Electron Ionization-Induced Changes in the Myenteric Plexus of the Rat Stomach. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928511. |
this study aims to investigate the effects of accelerated electron radiation on some pivotal neurotransmitter circuits (cholinergic and serotonergic) of rats' myenteric plexus. |
2024-06-27 |
2024-06-29 |
rat |
| Boxuan Li, Shizhe Deng, Hailun Jiang, Weiming Zhu, Bifang Zhuo, Yuzheng Du, Zhihong Men. The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review. Frontiers in neuroscience. vol 18. 2024-03-19. PMID:38500484. |
here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (gabaergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. |
2024-03-19 |
2024-03-21 |
Not clear |
| Helamã Moraes Dos Santos, Amanda Gollo Bertollo, Maiqueli Eduarda Dama Mingoti, Roberta Eduarda Grolli, Kelli Maria Kreuz, Zuleide Maria Ignáci. Dementia and depression: Biological connections with amyloid β protein. Basic & clinical pharmacology & toxicology. 2024-03-09. PMID:38459754. |
small extracellular senile plaques composed of filamentous aggregates of amyloid β (aβ) protein tend to bind to neuronal receptors, affecting cholinergic, serotonergic, dopaminergic and noradrenergic neurotransmission, leading to neuroinflammation, among other pathophysiologic processes and subsequent neuronal death, followed by dementia. |
2024-03-09 |
2024-03-11 |
Not clear |
| Tosin A Olasehinde, Oyinlola O Olaoku. The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255283. |
some of the molecular and biochemical mechanisms of apigenin include activation of the erk/creb/bdnf signalling pathway; modulation of neurotransmitter levels and monoaminergic, cholinergic, dopaminergic and serotonergic systems; inhibition of pro-inflammatory cytokine production; and attenuation of oxidative neuronal damage. |
2024-01-23 |
2024-01-25 |
mouse |
| Adam Wojtas, Krystyna Gołembiowsk. Molecular and Medical Aspects of Psychedelics. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203411. |
the data show a significant effect of nbomes on glutamatergic, dopaminergic, serotonergic, and cholinergic neurotransmission in the frontal cortex, striatum, and nucleus accumbens. |
2024-01-11 |
2024-01-13 |
rat |
| Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharm. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend. Neuroscience and biobehavioral reviews. 2023-11-04. PMID:37925093. |
network pharmacology analysis reveals that these compounds protect against long-term depression, aging-associated diseases, alzheimer's disease, and other addictions through interactions with cholinergic, dopaminergic, and serotonergic proteins, validated in animal studies only. |
2023-11-04 |
2023-11-08 |
Not clear |
| Sara Mostafalou, Mohammad Abdollah. The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides. Archives of toxicology. 2023-10-03. PMID:37787774. |
apart from inhibiting the cholinesterase enzyme, op compounds are believed to cause other pathological mechanisms at both the extracellular level (cholinergic, serotonergic, dopaminergic, glutamatergic, and gabaergic synapses) and the intracellular level (oxidative stress, mitochondrial dysfunction, inflammation, autophagy, and apoptosis) that contribute to these disorders. |
2023-10-03 |
2023-10-07 |
human |
| Joseph V Martin, Pradip K Sarka. Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters? Frontiers in endocrinology. vol 14. 2023-09-13. PMID:37701902. |
furthermore, thyronines bind specifically to other defined neurotransmitter receptors, including gabaergic, catecholaminergic, glutamatergic, serotonergic and cholinergic systems. |
2023-09-13 |
2023-10-07 |
Not clear |
| Noor Ali, Rohab Sohail, Syeda Rabab Jaffer, Sadia Siddique, Berfin Kaya, Inioluwa Atowoju, Alizay Imran, Whitney Wright, Spandana Pamulapati, Faiza Choudhry, Anum Akbar, Uzzam Ahmed Khawaj. The Role of Estrogen Therapy as a Protective Factor for Alzheimer's Disease and Dementia in Postmenopausal Women: A Comprehensive Review of the Literature. Cureus. vol 15. issue 8. 2023-09-08. PMID:37680393. |
estrogen prevents dementia by augmenting hippocampal and prefrontal cortex function, reducing neuroinflammation, preventing degradation of estrogen receptors, decreasing oxidative damage to the brain, and increasing cholinergic and serotonergic function. |
2023-09-08 |
2023-10-07 |
Not clear |