| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica Ardon, Lily Nguyen, Rui Chen, Jeffrey Rogers, Tim Stout, Sara Thomasy, Ala Moshir. Onset and Progression of Disease in Nonhuman Primates With PDE6C Cone Disorder. Investigative ophthalmology & visual science. vol 65. issue 14. 2024-12-06. PMID:39641747. |
the purposes of this study are to characterize the phenotype in pde6c macaques in detail to determine the onset of the cone phenotype, the degree to which the phenotype progresses, if heterozygote animals have an intermediate phenotype, and if rod photoreceptor function declines over time. |
2024-12-06 |
2024-12-08 |
Not clear |
| Wallace B Thoreson, Asia L Sladek, Cody L Barta, Lou E Townsen. Rod inputs arrive at horizontal cell somas in mouse retina solely via rod-cone coupling. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554062. |
rod and cone photoreceptor cells selectively contact different compartments of axon-bearing retinal horizontal cells in the retina. |
2024-11-18 |
2024-11-22 |
mouse |
| Kuanxiang Sun, Junyao Chen, Yudi Fan, Jinrui Cai, Xiaoyan Jiang, Wenjing Liu, Xianjun Zh. Lack of retinal degeneration in a Dram2 knockout mouse model. Vision research. vol 226. 2024-11-09. PMID:39520804. |
cone-rod dystrophy is characterised by primary cone involvement, or sometimes simultaneous cone and rod loss, thus leading to decreased visual acuity, colour vision deficits, photophobia, and decreased sensitivity of the central visual field. |
2024-11-09 |
2024-11-17 |
mouse |
| Edward V Famigliett. Mammalian Retinal Bipolar Cells: Morphological Identification and Systematic Classification in Rabbit Retina. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345639. |
the present detailed study of more than 800 bipolar cells in ten golgi-impregnated rabbit retinas indicates that there are 14-16 types of cone bipolar cell and one type of rod bipolar cell in rabbit retina. |
2024-09-30 |
2024-10-02 |
mouse |
| Soo-Young Kim, Christine Haewon Park, Bo-Hyun Moon, Gail K Seabol. Murine Retina Outer Plexiform Layer Development and Transcriptome Analysis of Pre-Synapses in Photoreceptors. Life (Basel, Switzerland). vol 14. issue 9. 2024-09-28. PMID:39337887. |
the transcription factor neural retina leucine zipper (nrl) determines the rod vs. cone photoreceptor cell fate and is critical for rod differentiation. |
2024-09-28 |
2024-10-01 |
Not clear |
| Breyanna L Cavanaugh, Michelle L Milstein, R Casey Boucher, Sharon X Tan, Mario W Hanna, Adam Seidel, Rikard Frederiksen, Thomas L Saunders, Alapakkam P Sampath, Kenneth P Mitton, Dao-Qi Zhang, Andrew F X Goldber. A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration. Human molecular genetics. 2024-09-04. PMID:39231530. |
peripherin-2 (prph2) is a photoreceptor-specific tetraspanin protein that structures the disk rim membranes of rod and cone outer segment (os) organelles, and is required for os morphogenesis. |
2024-09-04 |
2024-09-08 |
mouse |
| Breyanna L Cavanaugh, Michelle L Milstein, R Casey Boucher, Sharon X Tan, Mario W Hanna, Adam Seidel, Rikard Frederiksen, Thomas L Saunders, Alapakkam P Sampath, Kenneth P Mitton, Dao-Qi Zhang, Andrew F X Goldber. A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration. Human molecular genetics. 2024-09-04. PMID:39231530. |
young (p21) prph2y285x/wt mice developed near-normal photoreceptor numbers; however, os membrane architecture was disrupted, os protein levels were reduced, and in vivo and ex vivo electroretinography (erg) analyses found that rod and cone photoreceptor function were each severely reduced. |
2024-09-04 |
2024-09-08 |
mouse |
| Breyanna L Cavanaugh, Michelle L Milstein, R Casey Boucher, Sharon X Tan, Mario W Hanna, Adam Seidel, Rikard Frederiksen, Thomas L Saunders, Alapakkam P Sampath, Kenneth P Mitton, Dao-Qi Zhang, Andrew F X Goldber. A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration. Human molecular genetics. 2024-09-04. PMID:39231530. |
altogether, the current studies validate a new mouse model for investigating prph2 disease pathophysiology, and demonstrate that rod and cone photoreceptor function and structure are each directly and substantially impaired by the y285x mutation. |
2024-09-04 |
2024-09-08 |
mouse |
| S Supanji, A B I Perdamaian, D K Paramita, R I Jeni. An uncommon case of retinitis pigmentosa patients based on clinical and genetic study. The Medical journal of Malaysia. vol 79. issue Suppl 4. 2024-08-31. PMID:39215425. |
a genetics analysis was conducted in case 1, finding various mutations associated with ird mutation at the cone protein-encoded gene that concentrated at the central and rod protein-encoded gene concentrated at the peripheral retina. |
2024-08-31 |
2024-09-04 |
Not clear |
| Ping Song, Dhwani Parsana, Rupesh Singh, Lana M Pollock, Bela Anand-Apte, Brian D Perkin. Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39209978. |
surprisingly, light-induced photoreceptor ablation induced müller glia proliferation in irf8 mutants and cone and rod photoreceptor regeneration. |
2024-08-29 |
2024-09-04 |
zebrafish |
| Jingjin Xu, Chengtian Zhao, Yunsi Kan. The Formation and Renewal of Photoreceptor Outer Segments. Cells. vol 13. issue 16. 2024-08-28. PMID:39195247. |
in the retina, rod and cone photoreceptor neurons are the initial sites where vision forms. |
2024-08-28 |
2024-08-30 |
Not clear |
| Jessica Fernandes Scortecci, Fabian A Garces, Jai K Mahto, Laurie L Molday, Filip Van Petegem, Robert S Molda. Structural and Functional Characterization of the Nucleotide-binding Domains of ABCA4 and their Role in Stargardt Disease. The Journal of biological chemistry. 2024-08-11. PMID:39128720. |
abca4 is an atp-binding cassette (abc) transporter that prevents the buildup of toxic retinoid compounds by facilitating the transport of n-retinylidene-phosphatidylethanolamine across membranes of rod and cone photoreceptor cells. |
2024-08-11 |
2024-08-14 |
Not clear |
| Wesley Maddox, Gregory J Ordemann, Juan de la Rosa Vázquez, Angie Huang, Christof Gault, Serena R Wisner, Kate Randall, Daiki Futagi, Nihal A Salem, R Dayne Mayfield, Boris V Zemelman, Steven DeVries, Mrinalini Hoon, Amy Le. A non-conducting role of the Ca bioRxiv : the preprint server for biology. 2024-08-09. PMID:38106079. |
a non-conducting role of the ca in congenital stationary night blindness type 2 (csnb2), a disorder involving the cav1.4 (l-type) ca2+ channel, visual impairment is mild considering that cav1.4 mediates synaptic release from rod and cone photoreceptors. |
2024-08-09 |
2024-08-12 |
mouse |
| Almaqdad Alsalloum, Kristina Shefer, Pavel Bogdanov, Natalia Mingaleva, Alexander Kim, Sofya Feoktistova, Olga Mityaeva, Pavel Volchko. Establishment of a human induced pluripotent stem cell line (ABi004-A) carrying a compound heterozygous mutation in the KCNV2 gene. Stem cell research. vol 80. 2024-07-31. PMID:39083856. |
pathogenic variants in the kcnv2 gene can cause a rare retinal dystrophy that can be inherited recessively, known as cone dystrophy with supernormal rod response (cdsrr). |
2024-07-31 |
2024-08-03 |
human |
| Fenglan Wang, Wenhui Zhong, Jun Zhan. Investigating Retinal Circuits and Molecular Localization by Pre-Embedding Immunoelectron Microscopy. Journal of visualized experiments : JoVE. issue 209. 2024-07-29. PMID:39072644. |
to better investigate retinal circuits and cross-talk, such as the link between cone and rod pathways, and precise molecular localization (neurotransmitters or neuropeptides), such as the presence of substance p-like immunoreactivity in the mouse retina, we employed a pre-embedding immunoelectron microscopy (immuno-em) method to explore synaptic connections and organization. |
2024-07-29 |
2024-08-02 |
mouse |
| Logan Ganzen, Shubhash Chandra Yadav, Mingxiao Wei, Hong Ma, Scott Nawy, Richard H Krame. Retinoic acid-dependent loss of synaptic output from bipolar cells impairs visual information processing in inherited retinal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-07-26. PMID:39060177. |
in retinitis pigmentosa (rp), rod and cone photoreceptors degenerate, depriving downstream neurons of light-sensitive input, leading to vision impairment or blindness. |
2024-07-26 |
2024-07-29 |
mouse |
| Hung-Ju Chiang, Yuko Nishiwaki, Wei-Chieh Chiang, Ichiro Masa. Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Disease models & mechanisms. vol 17. issue 7. 2024-07-16. PMID:38813692. |
in mak mutants, both cone and rod photoreceptors completely lacked outer segments and underwent apoptosis. |
2024-07-16 |
2024-07-18 |
mouse |
| Héloïse Rach, Ulker Kilic-Huck, Pierre A Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgi. The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1. Journal of sleep research. 2024-07-12. PMID:38993053. |
cone, rod and retinal ganglion cells electrical activity were recorded with flash-electroretinography in non-dilated eye of 31 patients with idiopathic hypersomnia (women 84%, 26.6 ± 5.9 years), 19 patients with narcolepsy type 1 (women 63%, 36.6 ± 12.7 years) and 43 controls (women 58%, 30.6 ± 9.3 years). |
2024-07-12 |
2024-07-14 |
Not clear |
| Héloïse Rach, Ulker Kilic-Huck, Pierre A Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgi. The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1. Journal of sleep research. 2024-07-12. PMID:38993053. |
reduced cone a-wave amplitude (p = 0.039) and prolonged cone (p = 0.022) and rod b-wave (p = 0.009) latencies were observed in patients with narcolepsy type 1 as compared with controls, while prolonged photopic negative response-wave latency (retinal ganglion cells activity) was observed in patients with idiopathic hypersomnia as compared with controls (p = 0.033). |
2024-07-12 |
2024-07-14 |
Not clear |
| Héloïse Rach, Ulker Kilic-Huck, Pierre A Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgi. The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1. Journal of sleep research. 2024-07-12. PMID:38993053. |
the rod and cone b-wave latency clearly distinguished narcolepsy type 1 from idiopathic hypersomnia and controls (area under the curve > 0.70), and the photopic negative response-wave latency distinguished idiopathic hypersomnia and narcolepsy type 1 from controls with an area under the curve > 0.68. |
2024-07-12 |
2024-07-14 |
Not clear |