| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer L Fessler, Megan A Stiles, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherr. The Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model. Cerebellum (London, England). 2024-06-08. PMID:38850484. |
to test whether w246g elovl4 altered neuronal generation or survival in the cerebellum, we compared the numbers of purkinje cells, unipolar brush cells, molecular layer interneurons, granule and displaced granule cells in the cerebellum of wildtype, heterozygous, and homozygous sca34-ki rats at four months of age, when motor impairment is already present. |
2024-06-08 |
2024-06-11 |
human |
| Kaylie Robinson, Mathias Delhaye, Ann Marie Crai. Mapping proteomic composition of excitatory postsynaptic sites in the cerebellar cortex. Frontiers in molecular neuroscience. vol 17. 2024-05-24. PMID:38783902. |
for example, ampa receptors were most concentrated at synapses on molecular layer interneurons and at climbing fiber synapses, shank1 was most concentrated at parallel fiber synapses on purkinje cells, and shank2 at both climbing fiber and parallel fiber synapses on purkinje cells but little on molecular layer interneurons. |
2024-05-24 |
2024-05-27 |
Not clear |
| Elizabeth P Lackey, Luis Moreira, Aliya Norton, Marie E Hemelt, Tomas Osorno, Tri M Nguyen, Evan Z Macosko, Wei-Chung Allen Lee, Court A Hull, Wade G Regeh. Specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar Purkinje cells. Neuron. 2024-05-01. PMID:38692278. |
specialized connectivity of molecular layer interneuron subtypes leads to disinhibition and synchronous inhibition of cerebellar purkinje cells. |
2024-05-01 |
2024-05-04 |
Not clear |
| Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R William. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells. eLife. vol 12. 2024-03-27. PMID:38536959. |
kit is enriched in molecular layer interneurons (mlis) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar kit ligand is selectively expressed by a target of their inhibition, purkinje cells (pcs). |
2024-03-27 |
2024-03-30 |
mouse |
| Shiori Kamiya, Tetsuya Kobayashi, Kazuhiko Sawad. Tracking of Internal Granular Progenitors Responding to Valproic Acid in the Cerebellar Cortex of Infant Ferrets. Cells. vol 13. issue 4. 2024-02-23. PMID:38391920. |
no edu- or brdu-labeling was found in purkinje cells and molecular layer interneurons. |
2024-02-23 |
2024-02-25 |
Not clear |
| Maxime Beau, David J Herzfeld, Francisco Naveros, Marie E Hemelt, Federico D'Agostino, Marlies Oostland, Alvaro Sánchez-López, Young Yoon Chung, Michael Maibach, Hannah N Stabb, M Gabriela Martínez Lopera, Agoston Lajko, Marie Zedler, Shogo Ohmae, Nathan J Hall, Beverley A Clark, Dana Cohen, Stephen G Lisberger, Dimitar Kostadinov, Court Hull, Michael Häusser, Javier F Medin. A deep-learning strategy to identify cell types across species from high-density extracellular recordings. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352514. |
we combine optogenetic activation and pharmacology using the cerebellum as a testbed to generate a curated ground-truth library of electrophysiological properties for purkinje cells, molecular layer interneurons, golgi cells, and mossy fibers. |
2024-02-14 |
2024-02-16 |
Not clear |
| Chris I De Zeeuw, Julius Koppen, George G Bregman, Marit Runge, Devika Narai. Heterogeneous encoding of temporal stimuli in the cerebellar cortex. Nature communications. vol 14. issue 1. 2023-11-21. PMID:37989740. |
recently, similar local connectivity motifs have been discovered among purkinje and molecular layer interneurons of the cerebellar cortex, however, task-related activity in these neurons has often been associated with relatively simple facilitation and suppression dynamics. |
2023-11-21 |
2023-11-29 |
Not clear |
| Gonzalo Monjarás-Romo, Lilian Zavala-Romero, Maria Fernanda Tejada-Pineda, Juan Marcos Meraz-Soto, Daniel Ballesteros-Herrera, Jesús Cienfuegos-Meza, Roberto Javier Alcaráz-Félix, Sergio Moreno-Jiméne. Lhermitte-Duclos Disease: A Case Series. Cureus. vol 15. issue 8. 2023-10-02. PMID:37779805. |
the histopathological report showed that large ganglion cells had replaced the granular layer, purkinje cells had degenerated, the molecular layer had become hyper-myelinated, and synaptophysin and chromogranin were positive. |
2023-10-02 |
2023-10-07 |
Not clear |
| Roberta Maria Lorenzi, Alice Geminiani, Yann Zerlaut, Marialaura De Grazia, Alain Destexhe, Claudia A M Gandini Wheeler-Kingshott, Fulvia Palesi, Claudia Casellato, Egidio D'Angel. A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics. PLoS computational biology. vol 19. issue 9. 2023-09-01. PMID:37656758. |
here we have designed and simulated a multi-layer mf of the cerebellar microcircuit (including granule cells, golgi cells, molecular layer interneurons, and purkinje cells) and validated it against experimental data and the corresponding spiking neural network (snn) microcircuit model. |
2023-09-01 |
2023-09-07 |
mouse |
| Masashi Nishikawa, Tohru Matsuki, Nanako Hamada, Atsuo Nakayama, Hidenori Ito, Koh-Ichi Nagat. Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development. Medical molecular morphology. 2023-07-04. PMID:37402055. |
in cerebellum, wac was detected in the nucleus of purkinje cells and granule cells, and possibly interneurons in the molecular layer. |
2023-07-04 |
2023-08-14 |
mouse |
| Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al Qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A M Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M C van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxen. Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1. Neuron. 2023-06-15. PMID:37321222. |
using in vivo two-photon imaging in behaving spinocerebellar ataxia type 1 (sca1) mice, wherein purkinje neurons (pns) degenerate, we identify an inhibitory circuit element (molecular layer interneurons [mlins]) that becomes prematurely hyperexcitable, compromising sensorimotor signals in the cerebellum at early stages. |
2023-06-15 |
2023-08-14 |
mouse |
| Ashvini Amol Kolhe, Asha Shenoy, Shubhra Tayal, Naina Atul Goe. Lhermitte-Duclos disease: A series of six cases. Journal of neurosciences in rural practice. vol 14. issue 1. 2023-03-09. PMID:36891111. |
histomorphology showed thickening and vacuolation of the molecular layer, loss of purkinje cells, and replacement of granular cell layer by large dysplastic ganglion cells. |
2023-03-09 |
2023-08-14 |
Not clear |
| Reem Ibrahim Abd El-Hay, Shireen A Mazroa, E El-Mohandes, Moustafa A. The possible protective role of melatonin versus garlic on monosodium Glutamate-induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscope study. Ultrastructural pathology. 2023-02-21. PMID:36803391. |
msg group demonstrated congested blood vessels, vacuolations in the molecular layer, and purkinje cells appeared irregular with nuclear degeneration. |
2023-02-21 |
2023-08-14 |
rat |
| Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo Murayama, Hideki Mochizuk. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-01-27. PMID:36703300. |
severe neuronal loss in the substantia nigra and prominent loss of purkinje cells, atrophy of the molecular layer, and proliferation of bergmann glia in the cerebellum were common features. |
2023-01-27 |
2023-08-14 |
Not clear |
| Hunter E Halverson, Jinsook Kim, Andrei Khilkevich, Michael D Mauk, George J Augustin. Feedback inhibition underlies new computational functions of cerebellar interneurons. eLife. vol 11. 2022-12-08. PMID:36480240. |
the function of a feedback inhibitory circuit between cerebellar purkinje cells and molecular layer interneurons (mlis) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and |
2022-12-08 |
2023-08-14 |
Not clear |
| Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, José Ávila-Mendoza, Carlos G Martínez-Moreno, Carlos Arámburo, Maricela Lun. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232848. |
histological analysis showed that hypoxia provoked a significant modification in the size and organization of cerebellar layers; however, gh administration restored the width of external granular layer (egl) and molecular layer (ml) and improved the purkinje and granular neurons survival. |
2022-10-14 |
2023-08-14 |
chicken |
| I O Imosem. Aquoeus Extracts of Daucus Carota (Linn) Protected the Postnatal Developing Cerebellum of Wistar Rats Against Arsenic-Induced Oxidative Stress. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 36. issue 2. 2022-08-10. PMID:35947743. |
histologically, the cerebellar cortex of the as pups showed persistent external granular layer (egl) on postnatal day 21, reduced thickness of the molecular layer (ml) on postnatal day 28, pyknotic and depleted purkinje cells compared with the control and other treated rats. |
2022-08-10 |
2023-08-14 |
rat |
| Wen Li, Lei Chen, Jonathan T Fleming, Emily Brignola, Kirill Zavalin, Andre H Lagrange, Tonia S Rex, Shane A Heiney, Gregory J Wojaczynski, Javier F Medina, Chin Chian. Dendritic inhibition by Shh signaling-dependent stellate cell pool is critical for motor learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-19. PMID:35589396. |
the molecular layer interneurons (mli), consisting of basket cells (bcs) and stellate cells (scs), provide dendritic and somatic inhibitory synapses onto purkinje cells, respectively. |
2022-05-19 |
2023-08-13 |
Not clear |
| Yasmin Fidler, Jose Rosa Gome. Effects of a Single Dose of X-Ray Irradiation on MMP-9 Expression and Morphology of the Cerebellum Cortex of Adult Rats. Cerebellum (London, England). 2022-03-09. PMID:35262839. |
mmp-9 expression was significantly increased on 4, 9, and 14 days, being detected around the purkinje cells and in parallel fibres at the molecular layer. |
2022-03-09 |
2023-08-13 |
rat |
| Koichi Okamoto, Masakuni Amari, Tomoyuki Iwai, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatam. An autopsy case of amyloid angiopathy-related cerebellar hemorrhage. Neuropathology : official journal of the Japanese Society of Neuropathology. 2022-01-10. PMID:35001426. |
in the cerebellum, abundant caa-involved vessels were observed in the subarachnoid space and molecular layer and to a lesser extent in the purkinje and granule layers. |
2022-01-10 |
2023-08-13 |
Not clear |