| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ot Prat, Luigi Petrucco, Vilim Štih, Ruben Portugue. Comparing the representation of a simple visual stimulus across the cerebellar network. eNeuro. 2024-07-03. PMID:38960706. |
its function is supported by the convergence of fibers from granule cells (gcs) and inferior olive neurons (ions) onto purkinje cells (pcs). |
2024-07-03 |
2024-07-10 |
zebrafish |
| Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller, Reza Shadmeh. The olivary input to the cerebellum dissociates sensory events from movement plans. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 17. 2024-04-17. PMID:38630714. |
neurons in the inferior olive are thought to anatomically organize the purkinje cells (p-cells) of the cerebellum into computational modules, but what is computed by each module? |
2024-04-17 |
2024-04-20 |
human |
| Josefine Öhman, Elias Sjölin, Maurizio Cundari, Fredrik Johansson, Mike Gilbert, Henk-Jan Boele, Pär Svensson, Anders Rasmusse. The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells. Cerebellum (London, England). 2024-03-12. PMID:38467957. |
climbing fibers, connecting the inferior olive and purkinje cells, form the nervous system's strongest neural connection. |
2024-03-12 |
2024-03-14 |
Not clear |
| Sebastián Loyola, Tycho M Hoogland, Hugo Hoedemaker, Vincenzo Romano, Mario Negrello, Chris I De Zeeu. How inhibitory and excitatory inputs gate output of the inferior olive. eLife. vol 12. 2023-08-01. PMID:37526175. |
the inferior olive provides the climbing fibers to purkinje cells in the cerebellar cortex, where they elicit all-or-none complex spikes and control major forms of plasticity. |
2023-08-01 |
2023-08-14 |
mouse |
| Yuanjun Luo, Yuhan Chao, Richard Nana Abankwah Owusu-Mensah, Jingyun Zhang, Tatsumi Hirata, Izumi Sugihar. Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography. Scientific reports. vol 13. issue 1. 2023-05-02. PMID:37130860. |
the olivocerebellar projection is organized into an intricate topographical connection from the inferior olive (io) subdivisions to the longitudinally-striped compartments of cerebellar purkinje cells (pcs), to play an essential role in cerebellar coordination and learning. |
2023-05-02 |
2023-08-14 |
mouse |
| Suk-King Lai, Kenneth Lap-Kei Wu, Chun-Wai Ma, Ka-Pak Ng, Xiao-Qian Hu, Kin Wai Tam, Wing-Ho Yung, Yu Tian Wang, Tak Pan Wong, Daisy Kwok-Yan Shum, Ying-Shing Cha. Timely insertion of AMPA receptor in developing vestibular circuits is required for manifestation of righting reflexes and effective navigation. Progress in neurobiology. 2023-01-07. PMID:36608782. |
this was accompanied by delayed pruning of the inferior olive inputs to purkinje cells and permanent reduction in their plasticity. |
2023-01-07 |
2023-08-14 |
Not clear |
| Kimberly Luttik, Victor Olmos, Ashley Owens, Aryaan Khan, Joy Yun, Terri Driessen, Janghoo Li. Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex. Cells. vol 11. issue 17. 2022-09-09. PMID:36078042. |
the neurodegenerative disease spinocerebellar ataxia type 1 (sca1) is known to lead to the progressive degeneration of specific neuronal populations, including cerebellar purkinje cells (pcs), brainstem cranial nerve nuclei and inferior olive nuclei, and spinocerebellar tracts. |
2022-09-09 |
2023-08-14 |
mouse |
| Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Emilia Puig Lombardi, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, Thierry Billette de Villemeur, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, Vincent Cantagre. Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation. American journal of human genetics. 2022-04-07. PMID:35390279. |
we also show that loss of function of prdm13 in zebrafish leads to a reduction in purkinje cells numbers and a complete absence of the inferior olive nuclei. |
2022-04-07 |
2023-08-13 |
mouse |
| Weipang Chang, Andrea Pedroni, Reinhard W Köster, Stefania Giacomello, Konstantinos Ampatzi. Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34526620. |
compared with the purkinje cells in the corpus cerebelli, the valvular purkinje cells receive weak and occasional input from the inferior olive and are not active during locomotion. |
2021-11-26 |
2023-08-13 |
zebrafish |
| Takayuki Michikawa, Takamasa Yoshida, Satoshi Kuroki, Takahiro Ishikawa, Shinji Kakei, Ryo Kimizuka, Atsushi Saito, Hideo Yokota, Akinobu Shimizu, Shigeyoshi Itohara, Atsushi Miyawak. Distributed sensory coding by cerebellar complex spikes in units of cortical segments. Cell reports. vol 37. issue 6. 2021-11-10. PMID:34758322. |
climbing fibers from the inferior olive transmit sensory signals to purkinje cells, but how the signals are represented in the cerebellar cortex remains elusive. |
2021-11-10 |
2023-08-13 |
mouse |
| Akshay Markanday, Joachim Bellet, Marie E Bellet, Junya Inoue, Ziad M Hafed, Peter Thie. Using deep neural networks to detect complex spikes of cerebellar Purkinje cells. Journal of neurophysiology. vol 123. issue 6. 2021-07-19. PMID:32374226. |
one of the most powerful excitatory synapses in the brain is formed by cerebellar climbing fibers, originating from neurons in the inferior olive, that wrap around the proximal dendrites of cerebellar purkinje cells. |
2021-07-19 |
2023-08-13 |
human |
| Stephen G Lisberge. The Rules of Cerebellar Learning: Around the Ito Hypothesis. Neuroscience. vol 462. 2021-05-14. PMID:32866603. |
(3) recurrent feedback from purkinje cells to the inferior olive, through interneurons in the cerebellar nucleus, limits the magnitude of fast, early learning in the cerebellar cortex. |
2021-05-14 |
2023-08-13 |
monkey |
| David J Herzfeld, Nathan J Hall, Marios Tringides, Stephen G Lisberge. Principles of operation of a cerebellar learning circuit. eLife. vol 9. 2021-03-16. PMID:32352914. |
the four principles are: (1) early, fast, acquisition driven by climbing fiber inputs to the cerebellar cortex, with poor retention; (2) learned responses of purkinje cells guide transfer of learning from the cerebellar cortex to the deep cerebellar nucleus, with excellent retention; (3) functionally different neural signals are subject to learning in the cerebellar cortex versus the deep cerebellar nuclei; and (4) negative feedback from the cerebellum to the inferior olive reduces the magnitude of the teaching signal in climbing fibers and limits learning. |
2021-03-16 |
2023-08-13 |
human |
| Josef Turecek, Wade G Regeh. Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters. eLife. vol 9. 2021-03-08. PMID:33259288. |
the inferior olive (io) is composed of electrically-coupled neurons that make climbing fiber synapses onto purkinje cells. |
2021-03-08 |
2023-08-13 |
mouse |
| Hirofumi Fujita, Takashi Kodama, Sascha du La. Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. eLife. vol 9. 2021-02-23. PMID:32639229. |
each fastigial cell type is connected with a specific set of purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. |
2021-02-23 |
2023-08-13 |
mouse |
| T. Knöpfel, I. Vranesic, C. Staub, B. H. Gähwile. Climbing Fibre Responses in Olivo-cerebellar Slice Cultures. II. Dynamics of Cytosolic Calcium in Purkinje Cells. The European journal of neuroscience. vol 3. issue 4. 2019-11-20. PMID:12106192. |
the generation of climbing fibre responses in cerebellar purkinje cells has been analysed in co-cultured slices of rat cerebellum and inferior olive. |
2019-11-20 |
2023-08-12 |
rat |
| I. Torres-Aleman, S. Pons, F. F. Santos-Benit. Survival of Purkinje Cells in Cerebellar Cultures is Increased by Insulin-like Growth Factor I. The European journal of neuroscience. vol 4. issue 9. 2019-11-20. PMID:12106309. |
recently, we have described the existence of an igf-i-containing pathway in afferents of purkinje neurons arising from the inferior olive. |
2019-11-20 |
2023-08-12 |
rat |
| J. A. Armengol, A. López-Romá. Left Unilateral Inferior Pedunculotomy Prevents Neuronal Death During Postnatal Development of the Remaining Left Inferior Olivary Complex in the Rat. The European journal of neuroscience. vol 4. issue 7. 2019-11-20. PMID:12106327. |
it is concluded that the increase of available purkinje cells during early postnatal development of the olivocerebellar projection prevents neuronal death in the remaining inferior olivary complex following pedunculotomy. |
2019-11-20 |
2023-08-12 |
rat |
| Julian Cheron, Guy Chero. Beta-gamma burst stimulations of the inferior olive induce high-frequency oscillations in the deep cerebellar nuclei. The European journal of neuroscience. vol 48. issue 8. 2019-11-14. PMID:29460990. |
as the inhibition of the deep cerebellar nuclei is related to inhibitory inputs from purkinje cells, we speculate that the oscillation represents the unmasking of the synchronous activation of another subtype of deep cerebellar neuronal subtype, devoid of gaba receptors and under the direct control of the climbing fibres from the inferior olive. |
2019-11-14 |
2023-08-13 |
mouse |
| Guy Cheron, Javier Márquez-Ruiz, Julian Cheron, Cynthia Prigogine, Claudia Ammann, Robert Lukowski, Peter Ruth, Bernard Da. Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD. Scientific reports. vol 8. issue 1. 2019-09-27. PMID:29523816. |
purkinje cell bkchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents ltd. purkinje cells (pc) control deep cerebellar nuclei (dcn), which in turn inhibit inferior olive nucleus, closing a positive feedback loop via climbing fibers. |
2019-09-27 |
2023-08-13 |
mouse |