| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niraj Kumar Singh, Pranjul Singh, Prachi Varshney, Ashini Singh, Bharat Bhusha. Multimodal action of phosphodiesterase 5 inhibitors against neurodegenerative disorders: An update review. Journal of biochemical and molecular toxicology. vol 38. issue 11. 2024-10-19. PMID:39425458. |
phosphodiesterase type 5 (pde5) is an enzyme primarily found in the smooth muscle of the corpus cavernosum and also highly expressed in the substantia nigra, cerebellum, caudate, hippocampal regions and cerebellar purkinje cells, responsible for selectively breaking down cyclic guanosine monophosphate (cgmp) into 5'-gmp and regulate intracellular cgmp levels. |
2024-10-19 |
2024-10-21 |
Not clear |
| Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Jarek Wegiel, Eulalia Badmaev, Wayne P Silverman, Mony de Leon, Barry Reisberg, Thomas Wisniewsk. Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or β-Amyloidosis. Journal of neuropathology and experimental neurology. vol 76. issue 6. 2017-07-31. PMID:28505333. |
the study revealed the absence of significant neuronal loss in 7 regions and topographically selective reduction of neuronal reserve over 77 years in 8 brain structures including the entorhinal cortex (ec) (-33.3%), the second layer of the ec (-54%), cornu ammonis sector 1 (ca1) (-28.5%), amygdala, (-45.8%), thalamus (-40.5%), caudate nucleus (-35%), purkinje cells (-48.3%), and neurons in the dentate nucleus (40.1%). |
2017-07-31 |
2023-08-13 |
human |
| Y Honjo, Y Shirakashi, Y Kawamoto, I Akiguch. Anti-DARPP32 antibody-immunopositive inclusions in the brain of patients with multiple system atrophy. Clinical neuropathology. vol 27. issue 5. 2008-10-21. PMID:18808062. |
neurons in the caudate, globus pallidus, substantia nigra, hypothalamus, neocortex layers ii and iii, and cerebellar purkinje cells were all immunopositive for darpp32 in the normal control brains, and the immunostaining patterns were very similar to those observed in patients with msa. |
2008-10-21 |
2023-08-12 |
human |
| Margie Castillo-Meléndez, Jo Ann Chow, David W Walke. Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusion. Pediatric research. vol 55. issue 5. 2004-11-08. PMID:14764919. |
pyknotic cell numbers were significantly increased in hippocampal ca1 and ca3, parietal cortex, caudate nucleus, putamen, and cerebellar purkinje cells after uco. |
2004-11-08 |
2023-08-12 |
Not clear |
| C Dirk Keene, Xilma R Ortiz-Gonzalez, Yuehua Jiang, David A Largaespada, Catherine M Verfaillie, Walter C Lo. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell transplantation. vol 12. issue 3. 2004-04-13. PMID:12797375. |
more specifically, donor-derived neurons contributed to each of the cellular layers of the cortex; the pyramidal and granule cell layers, as well as the hilus, of the hippocampus; purkinje and granule cell layers in the cerebellum; and gabaergic cells in the caudate and putamen. |
2004-04-13 |
2023-08-12 |
mouse |
| Masaki Yoshida, Tetsumori Yamashima, Liang Zhao, Katsuhiro Tsuchiya, Yukihiko Kohda, Anton B Tonchev, Masayuki Matsuda, Eiki Kominam. Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition. Acta neuropathologica. vol 104. issue 3. 2002-10-17. PMID:12172912. |
pyramidal neurons of the hippocampus, purkinje cells in the cerebellum, and neurons in the caudate nucleus, outer putamen and cortical iii, v layers, are known to be vulnerable to ischemia. |
2002-10-17 |
2023-08-12 |
monkey |
| G K Wenning, F Tison, Y Ben Shlomo, S E Daniel, N P Quin. Multiple system atrophy: a review of 203 pathologically proven cases. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 2. 1997-07-17. PMID:9087971. |
the main pathological change comprised cell loss and gliosis in the putamen, caudate nucleus, external pallidum, substantia nigra, locus ceruleus, inferior olives, pontine nuclei, cerebellar purkinje cells, and intermediolateral cell columns of the spinal cord. |
1997-07-17 |
2023-08-12 |
Not clear |
| S P Knight, M M Richardson, A P Osmand, A Stakkestad, N T Potte. Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues. Journal of the neurological sciences. vol 146. issue 1. 1997-06-19. PMID:9077491. |
prominently staining regions included layers ii, iii, v, and vi of cerebral cortex, ca1-4 of the hippocampus, caudate nucleus, putamen, globus pallidus, amygdala, thalamus, red nucleus, pons, purkinje cells, and deep cerebellar nuclei. |
1997-06-19 |
2023-08-12 |
mouse |
| I Ferrer, M Olivé, R Rivera, A Pou, B Narberhaus, A Ugart. Hereditary spastic paraparesis with dementia, amyotrophy and peripheral neuropathy. A neuropathological study. Neuropathology and applied neurobiology. vol 21. issue 3. 1995-11-27. PMID:7477734. |
neuropathological findings correlate with neurological deficits, although neuron loss in the caudate and putamen, substantia nigra, and loss of purkinje cells were clinically silent. |
1995-11-27 |
2023-08-12 |
Not clear |
| K Yoshida, S Ikeda, K Kawaguchi, N Yanagisaw. Adult GM1 gangliosidosis: immunohistochemical and ultrastructural findings in an autopsy case. Neurology. vol 44. issue 12. 1995-01-11. PMID:7991129. |
neuronal loss and intracytoplasmic storage were most prominent in the caudate nucleus and putamen and, to a lesser degree, in the amygdala, globus pallidus, and purkinje cells in the cerebellum. |
1995-01-11 |
2023-08-12 |
Not clear |
| P Mailleux, K Takazawa, C Erneux, J J Vanderhaeghe. Distribution of the neurons containing inositol 1,4,5-trisphosphate 3-kinase and its messenger RNA in the developing rat brain. The Journal of comparative neurology. vol 327. issue 4. 1993-03-30. PMID:8382709. |
the enzyme mrna could be detected first at postnatal day 0, (birth, p0) in the perikarya of the cerebellar purkinje cells, followed at p4 by the hippocampal ca1 pyramidal cells and granule cells of the dentate gyrus and finally, at p9, by a majority of the neurons in the cortical layers ii-iii and v, especially in the frontal cortex and cingulate cortex; claustrum; caudate, putamen, accumbens, olfactory tubercle and calleja islets; anterior olfactory nucleus; taenia tecta; piriform piriform cortex; dorsolateral septum; bed nucleus stria terminalis; amygdala; hippocampal ca2-4 sectors and subiculum. |
1993-03-30 |
2023-08-12 |
rat |
| T Inagaki, H Ishino, H Senoh, C Naora, M Iijima, T Sasaki, A Hikij. [A case of bilateral necrosis of the basal ganglia after hypotensive shocks]. No to shinkei = Brain and nerve. vol 41. issue 5. 1989-11-28. PMID:2803820. |
1) laminar necrosis of the deep layers of the cerebral cortex, 2) bilateral necrosis of the hippocampal sommer sector, 3) bilateral necrosis of the caudate nucleus, putamen and pallidum with neuronal loss and infiltration of fat granule cells, 4) sparing of the internal capsules, 5) bilateral necrosis of the reticular zone of the substantia nigra, 6) foci of fresh necrosis and loss of purkinje cells in the cerebellum. |
1989-11-28 |
2023-08-11 |
Not clear |
| D S Snyder, S Simonis, B G Uzman, J N Whitake. Rat neural tissue cathepsin D: ultrastructural immunocytochemistry. Journal of neurocytology. vol 14. issue 4. 1986-01-08. PMID:3906045. |
immunoreactive cathepsin d was present in lysosomes and pleomorphic dense bodies of neurons in the anterior horn of spinal cord, cerebellar purkinje and granule cell layers, caudate nucleus and trigeminal ganglion. |
1986-01-08 |
2023-08-11 |
rat |
| D G Kirch, M R Palmer, M Egan, R Freedma. Electrophysiological interactions between haloperidol and reduced haloperidol, and dopamine, norepinephrine and phencyclidine in rat brain. Neuropharmacology. vol 24. issue 5. 1985-08-26. PMID:2862598. |
haloperidol antagonized dopaminergic inhibition of caudate neurons and inhibition of cerebellar purkinje neurons induced by noradrenaline, whereas reduced haloperidol was an ineffective antagonist. |
1985-08-26 |
2023-08-11 |
rat |
| b' R N Auer, Y Olsson, B K Siesj\\xc3\\xb. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study. Diabetes. vol 33. issue 11. 1984-12-21. PMID:6500189.' |
the cerebral cortex, hippocampus, caudate nucleus, spinal cord, and, to a lesser extent, cerebellar purkinje cells were affected. |
1984-12-21 |
2023-08-12 |
rat |
| D L Montgomery, R W Stort. Hereditary striatonigral and cerebello-olivary degeneration of the Kerry Blue Terrier. II. Ultrastructural lesions in the caudate nucleus and cerebellar cortex. Journal of neuropathology and experimental neurology. vol 43. issue 3. 1984-07-06. PMID:6726284. |
in the cerebellar cortex, the lesions involved principally purkinje cells and progressed through a pattern of degeneration comparable to that involving intrinsic neurons of the caudate nucleus. |
1984-07-06 |
2023-08-12 |
Not clear |
| N Yoshimura, H Kud. Mitochondrial abnormalities in Menkes' kinky hair disease (MKHD). Electron-microscopic study of the brain from an autopsy case. Acta neuropathologica. vol 59. issue 4. 1983-08-26. PMID:6868958. |
these abnormalities of mitochondria were present in decreasing severity in the following: purkinje cells, neurons of the molecular and granule cell layers of the cerebellum, and neurons of the cerebral cortex, globus pallidus, lateral nuclei of the thalamus, caudate nucleus, and the myelinated axons in the white matter. |
1983-08-26 |
2023-08-12 |
mouse |
| J N Whitaker, L C Terry, W O Whetsel. Immunocytochemical localization of cathepsin D in rat neural tissue. Brain research. vol 216. issue 1. 1981-10-14. PMID:7020877. |
cd was also readily detected in brain stem sensory neurons, pyramidal cells of the hippocampus, inferior olive and purkinje cells, but was absent or present in very small quantities in the granule cells of the cerebellar cortex, the more superficial layers of the neocortex, and smaller neurons of the caudate nucleus. |
1981-10-14 |
2023-08-12 |
rat |
| V S Zelenskaia, G M Gruzde. [Different forms of potentials discharged by caudate nucleus neurons]. Neirofiziologiia = Neurophysiology. vol 9. issue 2. 1977-06-30. PMID:870840. |
the observations are discussed with regard to the origin of diverse forms of the potentials in the caudate nucleus neurons and compared to those made on the cerebellar purkinje cells. |
1977-06-30 |
2023-08-11 |
Not clear |
| G G Yarbroug. Ouabain antagonism of noradrenaline inhibitions of cerebellar Purkinje cells and dopamine inhibitions of caudate neurones. Neuropharmacology. vol 15. issue 6. 1976-09-01. PMID:945485. |
ouabain antagonism of noradrenaline inhibitions of cerebellar purkinje cells and dopamine inhibitions of caudate neurones. |
1976-09-01 |
2023-08-11 |
Not clear |