| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivi M Heine, Stephanie Doove. Neuroglia in autism spectrum disorders. Handbook of clinical neurology. vol 210. 2025-03-27. PMID:40148051. |
in asd, astrocytes show altered glutamate metabolism, directly influencing neuronal network activity, while microglia display impaired synaptic pruning, an essential developmental process for the refinement of neuronal connections. |
2025-03-27 |
2025-03-30 |
Not clear |
| Bethania Mongi-Bragato, Marianela Adela Sánchez, María Paula Avalos, María Julieta Boezio, Andrea Susana Guzman, Diana Rigoni, Eduardo Marcelo Perassi, Carlos Ruben Mas, Mariano Bisbal, Flavia Andrea Bollati, Liliana Marina Cancel. Activation of nuclear factor-kappa B in the nucleus accumbens core is necessary for chronic stress-induced glutamate and neuro-immune alterations that facilitate cocaine self-administration. Brain, behavior, and immunity. 2025-03-26. PMID:40139275. |
we previously demonstrated that chronic stress induced reactive microglia and increased tnf-α expression in the nucleus accumbens core (nacore), both alterations strongly linked with impaired glutamate homeostasis and the facilitation of cocaine self-administration. |
2025-03-26 |
2025-03-30 |
human |
| Bethania Mongi-Bragato, Marianela Adela Sánchez, María Paula Avalos, María Julieta Boezio, Andrea Susana Guzman, Diana Rigoni, Eduardo Marcelo Perassi, Carlos Ruben Mas, Mariano Bisbal, Flavia Andrea Bollati, Liliana Marina Cancel. Activation of nuclear factor-kappa B in the nucleus accumbens core is necessary for chronic stress-induced glutamate and neuro-immune alterations that facilitate cocaine self-administration. Brain, behavior, and immunity. 2025-03-26. PMID:40139275. |
the nuclear factor kappa-b (nf-κb) is a critical regulator of many immune- and addiction-related genes, such as the gene coding for glutamate transporter (glt-1), and it is considered a master regulator of inflammation, reported to be a key driver of microglia activation in psychiatric diseases. |
2025-03-26 |
2025-03-30 |
human |
| Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masu. Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis. Neuropathology : official journal of the Japanese Society of Neuropathology. 2025-03-11. PMID:40065552. |
cultured microglia treated with soluble iron over-released glutamate and tnf-α via aconitase 1 and tace, respectively. |
2025-03-11 |
2025-03-13 |
human |
| Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masu. Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis. Neuropathology : official journal of the Japanese Society of Neuropathology. 2025-03-11. PMID:40065552. |
cultured microglia treated with tnf-α over-released glutamate via gac. |
2025-03-11 |
2025-03-13 |
human |
| Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masu. Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis. Neuropathology : official journal of the Japanese Society of Neuropathology. 2025-03-11. PMID:40065552. |
these observations provide in vivo and in vitro evidence that microglia and astrocytes are glutamate suppliers in response to soluble iron overload and oxidative stress, respectively, in sporadic als. |
2025-03-11 |
2025-03-13 |
human |
| Filiz Onat, My Andersson, Nihan Çarça. The Role of Glial Cells in the Pathophysiology of Epilepsy. Cells. vol 14. issue 2. 2025-01-24. PMID:39851521. |
microglia, the innate immune cells of the cns, contribute to neuroinflammation, glutamate excitotoxicity, and the balance between excitatory and inhibitory neurotransmission, underscoring their dual role in seizure promotion and protection. |
2025-01-24 |
2025-01-27 |
Not clear |
| Oumeima Achour, Yosr Z Haffani, Sihem Mbarek, Oumayma Hammami, Monssef Feki, Ayachi Zemmel, Serge Picaud, Nourhène Boudhrioua, Rafika Ben Chaouacha-Cheki. Hydroxytyrosol-rich Olive Mill Wastewater, A Potential Protector Against Dyslipidemia, Diabetes and Diabetic Retinopathy in Psammomys obesus. Chemistry & biodiversity. 2025-01-02. PMID:39746854. |
its long-term administration attenuates retinal glial reactivity, microglia number, changes in glutamate homeostasis and synaptic function in diabetic animals with retinopathy. |
2025-01-02 |
2025-01-05 |
human |
| Huidong Li, Faqin Li, Zhaoyi Chen, Erwen Wu, Xiaoxi Dai, Danni Li, Haojie An, Shiyi Zeng, Chunyan Wang, Li Yang, Cheng Lon. Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala: association with enhanced cued fear expression. Neural regeneration research. vol 20. issue 11. 2024-12-23. PMID:39715097. |
further, loss of cyld in glutamatergic neurons resulted in enhanced neuronal activation, impaired excitatory synaptic transmission, and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male mice. |
2024-12-23 |
2024-12-26 |
mouse |
| Pelin Saglam-Metiner, Sena Yanasik, Yusuf Caglar Odabasi, Jennifer Modamio, Moritz Negwer, Cigir Biray-Avci, Ayse Guler, Ali Erturk, Ender Yildirim, Ozlem Yesil-Celikta. ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation. Communications biology. vol 7. issue 1. 2024-12-05. PMID:39639082. |
besides, midazolam administration stimulated expression of cd40 and cd203c+ reactivated mast cell proliferation and compromised bbb permeability and decreased teer values with higher barrier disruption, whereas increased populations of cd11b+ microglia, higher expressions of gfap/dlg4/gjb1 and gaba-a-/nmdar1- identities, as well as glutamate related neurotoxicity and il1b, ifng, ifna1, il6 genes mediated proinflammation, resulting in increased apoptotic zones are observed in cerebral organoids. |
2024-12-05 |
2024-12-08 |
human |
| Zizheng Suo, Ting Xiao, Yinyin Qu, Yuxiang Zheng, Wenjie Xu, Bowen Zhou, Jing Yang, Jie Yu, Hui Zheng, Cheng N. Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment. Aging cell. 2024-11-14. PMID:39540334. |
reactive microglia also aggravated astrocyte and oligodendrocyte cytotoxicity through the pgd2/dp and complement pathways, altering glutamate level and synaptic function via the "tripartite synapses" model, and affecting neuronal myelination. |
2024-11-14 |
2024-11-17 |
mouse |
| Cheng-Yi Chang, Chih-Cheng Wu, Chung-Yuh Tzeng, Jian-Ri Li, Yu-Fang Chen, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Chun-Jung Che. NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation. Journal of neuroinflammation. vol 21. issue 1. 2024-11-08. PMID:39511597. |
in microglia, jev infection induced glutamate release and activated post-receptor nmda signaling, leading to activation of ca |
2024-11-08 |
2024-11-16 |
mouse |
| Roberta Amoriello, Clara Ballerin. Immunofluorescence Staining of Murine Spinal Cord Sections to Evaluate Microglial Activation and Astrogliosis. Methods in molecular biology (Clifton, N.J.). vol 2857. 2024-09-30. PMID:39348064. |
aging impacts microglia and astrocytes by promoting the production of pro-inflammatory cytokines, impairing microglial phagocytosis and motility and astrocyte glutamate uptake. |
2024-09-30 |
2024-10-02 |
mouse |
| Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christi. The effect of traumatic brain injury on learning and memory: A synaptic focus. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-09-24. PMID:39316552. |
this hypothesis is based on the plausible roles of cb1 receptors in regulating inhibitory tone, influencing astrocytes and microglia, and modulating glutamate release. |
2024-09-24 |
2024-09-27 |
Not clear |
| Yue Sun, Wentao Sun, Jiawei Liu, Baiwen Zhang, Lei Zheng, Wei Zo. The dual role of microglia in intracerebral hemorrhage. Behavioural brain research. 2024-08-11. PMID:39128628. |
the damage in cerebral hemorrhage is embodied in the following aspects: releasing inflammatory factors and inflammatory mediators, triggering programmed cell death, producing glutamate induced excitotoxicity, and destroying blood-brain barrier; the protective effect is reflected in the phagocytosis and clearance of harmful substances by microglia, and the secretion of anti-inflammatory and neurotrophic factors. |
2024-08-11 |
2024-08-14 |
Not clear |
| Angélica Coyoy-Salgado, Julia Segura-Uribe, Hermelinda Salgado-Ceballos, Tzayaka Castillo-Mendieta, Stephanie Sánchez-Torres, Ximena Freyermuth-Trujillo, Carlos Orozco-Barrios, Sandra Orozco-Suarez, Iris Feria-Romero, Rodolfo Pinto-Almazán, Gabriela Moralí de la Brena, Christian Guerra-Araiz. Evaluating Sex Steroid Hormone Neuroprotection in Spinal Cord Injury in Animal Models: Is It Promising in the Clinic? Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062051. |
as neuroprotection has been associated with signaling pathways, the effects of these hormones are observed on astrocytes and microglia, modulating the inflammatory response, cerebral blood flow, and metabolism, mediating glutamate excitotoxicity, and their antioxidant effects. |
2024-07-27 |
2024-07-29 |
Not clear |
| Chang Li, Yi Cai, Yongmin Chen, Jingyi Tong, Youbin Li, Dong Liu, Yun Wang, Zhiping Li, Yan Wang, Qifu L. ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR. Redox biology. vol 75. 2024-07-09. PMID:38981367. |
further, abcg2 overexpression significantly suppressed the oxidative stress and apoptosis induced by glutamate, kainic acid (ka), and lipopolysaccharide (lps) in neuronal and microglia cells. |
2024-07-09 |
2024-07-12 |
mouse |
| Yuning Mai, Zhen Cheng, Ze Wang, Tao Hu, Yuanyuan Zhang, Xiya Yuan, Xing Xu, Yu Fan, Feifei Ge, Pengbo Shi, Jun Wang, Xin Yang, Xiaowei Gua. Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 7. 2024-07-09. PMID:38981852. |
in vitro, the m1-like bv2 microglia cell medium, containing high levels of interleukin 1α and tumor necrosis factor α, elevated a1-like polarization of astrocytes, which weakened their capacity for glutamate clearance. |
2024-07-09 |
2024-07-12 |
mouse |
| Neha S Rawani, Allen W Chan, Serdar M Dursun, Glen B Bake. The Underlying Neurobiological Mechanisms of Psychosis: Focus on Neurotransmission Dysregulation, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929148. |
in the current review, it is reported how several of these factors, namely dysregulation of neurotransmitters [dopamine, serotonin, glutamate, and γ-aminobutyric acid (gaba)], neuroinflammation, glia (microglia, astrocytes, and oligodendrocytes), the hypothalamic-pituitary-adrenal axis, the gut microbiome, oxidative stress, and mitochondrial dysfunction contribute to psychosis and interact with one another. |
2024-06-27 |
2024-06-29 |
Not clear |
| Temitope Adeoye, Syed I Shah, Ghanim Ulla. Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer's Disease. Aging and disease. 2024-06-24. PMID:38913039. |
co-expression networks highlighted the extended involvement of astrocytes and microglia in biological processes beyond neuroinflammation, such as calcium homeostasis, glutamate regulation, lipid metabolism, vesicle-mediated transport, and tor signaling. |
2024-06-24 |
2024-06-26 |
Not clear |