| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Amoriello, Clara Ballerin. Immunofluorescence Staining of Murine Spinal Cord Sections to Evaluate Microglial Activation and Astrogliosis. Methods in molecular biology (Clifton, N.J.). vol 2857. 2024-09-30. PMID:39348064. |
aging impacts microglia and astrocytes by promoting the production of pro-inflammatory cytokines, impairing microglial phagocytosis and motility and astrocyte glutamate uptake. |
2024-09-30 |
2024-10-02 |
mouse |
| Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christi. The effect of traumatic brain injury on learning and memory: A synaptic focus. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-09-24. PMID:39316552. |
this hypothesis is based on the plausible roles of cb1 receptors in regulating inhibitory tone, influencing astrocytes and microglia, and modulating glutamate release. |
2024-09-24 |
2024-09-27 |
Not clear |
| Yue Sun, Wentao Sun, Jiawei Liu, Baiwen Zhang, Lei Zheng, Wei Zo. The dual role of microglia in intracerebral hemorrhage. Behavioural brain research. 2024-08-11. PMID:39128628. |
the damage in cerebral hemorrhage is embodied in the following aspects: releasing inflammatory factors and inflammatory mediators, triggering programmed cell death, producing glutamate induced excitotoxicity, and destroying blood-brain barrier; the protective effect is reflected in the phagocytosis and clearance of harmful substances by microglia, and the secretion of anti-inflammatory and neurotrophic factors. |
2024-08-11 |
2024-08-14 |
Not clear |
| Angélica Coyoy-Salgado, Julia Segura-Uribe, Hermelinda Salgado-Ceballos, Tzayaka Castillo-Mendieta, Stephanie Sánchez-Torres, Ximena Freyermuth-Trujillo, Carlos Orozco-Barrios, Sandra Orozco-Suarez, Iris Feria-Romero, Rodolfo Pinto-Almazán, Gabriela Moralí de la Brena, Christian Guerra-Araiz. Evaluating Sex Steroid Hormone Neuroprotection in Spinal Cord Injury in Animal Models: Is It Promising in the Clinic? Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062051. |
as neuroprotection has been associated with signaling pathways, the effects of these hormones are observed on astrocytes and microglia, modulating the inflammatory response, cerebral blood flow, and metabolism, mediating glutamate excitotoxicity, and their antioxidant effects. |
2024-07-27 |
2024-07-29 |
Not clear |
| Chang Li, Yi Cai, Yongmin Chen, Jingyi Tong, Youbin Li, Dong Liu, Yun Wang, Zhiping Li, Yan Wang, Qifu L. ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR. Redox biology. vol 75. 2024-07-09. PMID:38981367. |
further, abcg2 overexpression significantly suppressed the oxidative stress and apoptosis induced by glutamate, kainic acid (ka), and lipopolysaccharide (lps) in neuronal and microglia cells. |
2024-07-09 |
2024-07-12 |
mouse |
| Yuning Mai, Zhen Cheng, Ze Wang, Tao Hu, Yuanyuan Zhang, Xiya Yuan, Xing Xu, Yu Fan, Feifei Ge, Pengbo Shi, Jun Wang, Xin Yang, Xiaowei Gua. Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 7. 2024-07-09. PMID:38981852. |
in vitro, the m1-like bv2 microglia cell medium, containing high levels of interleukin 1α and tumor necrosis factor α, elevated a1-like polarization of astrocytes, which weakened their capacity for glutamate clearance. |
2024-07-09 |
2024-07-12 |
mouse |
| Neha S Rawani, Allen W Chan, Serdar M Dursun, Glen B Bake. The Underlying Neurobiological Mechanisms of Psychosis: Focus on Neurotransmission Dysregulation, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929148. |
in the current review, it is reported how several of these factors, namely dysregulation of neurotransmitters [dopamine, serotonin, glutamate, and γ-aminobutyric acid (gaba)], neuroinflammation, glia (microglia, astrocytes, and oligodendrocytes), the hypothalamic-pituitary-adrenal axis, the gut microbiome, oxidative stress, and mitochondrial dysfunction contribute to psychosis and interact with one another. |
2024-06-27 |
2024-06-29 |
Not clear |
| Temitope Adeoye, Syed I Shah, Ghanim Ulla. Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer's Disease. Aging and disease. 2024-06-24. PMID:38913039. |
co-expression networks highlighted the extended involvement of astrocytes and microglia in biological processes beyond neuroinflammation, such as calcium homeostasis, glutamate regulation, lipid metabolism, vesicle-mediated transport, and tor signaling. |
2024-06-24 |
2024-06-26 |
Not clear |
| Er Chen, Zhi-Qiang Zhang, An-Cong Xu, Fan Huang, Yan-Xuan He, Xi-Chong Yu, Guo-Xin H. INFLUENCES OF HEAT STRESS ON GLUTAMATE TRANSMISSION-DEPENDENT EXPRESSION LEVELS OF IL-1β and IL-18 IN BV-2 MICROGLIAL CELLS. Shock (Augusta, Ga.). vol 62. issue 1. 2024-06-20. PMID:38668801. |
conclusion: the findings confirmed that microglia could be involved in hs primarily through glutamate metabolisms, influencing the expression levels and release of il-1β and il-18. |
2024-06-20 |
2024-06-22 |
Not clear |
| Carlos Cruchaga, Joseph Bradley, Daniel Western, Ciyang Wang, Eder Lucio Da Fonseca, Achal Neupane, Jiji Kurup, NIcholas Ray, Melissa Jean-Francois, Priyanka Gorijala, Kristy Bergmann, John Budde, Eden Martin, Margaret Pericak-Vance, Michael Cuccaro, Brian Kunkle, John Morris, David Holtzman, Richard Perrin, Adam Naj, Jonathan Haines, Gerard Schellenberg, Victoria Fernandez, Christiane Reitz, Gary Beecham, Alzheimer's Disease Genetics Consortium, Charles F And Joanne Knight Alzheimer's Disease Research Ce Adr. Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square. 2024-06-17. PMID:38883718. |
by integrating gene-based analysis, eqtl, pqtl and functional annotations, we nominate four novel genes that are involved in microglia activation, glutamate production, and signaling pathways. |
2024-06-17 |
2024-06-19 |
Not clear |
| Ana Bagues, Jiaxin Hu, Ishraq Alshanqiti, Man-Kyo Chun. Neurobiological mechanisms of botulinum neurotoxin-induced analgesia for neuropathic pain. Pharmacology & therapeutics. 2024-05-23. PMID:38782121. |
although peripheral administration of bont leads to changes in the central nervous system (e.g., decreased phosphorylation of glutamate receptors in second-order neurons, reduced activation of microglia, contralateral localization, and cortical reorganization), whether such changes are secondary to changes in primary afferents or directly mediated by trans-synaptic, transcytotic, or the hematogenous transport of bont is controversial. |
2024-05-23 |
2024-05-27 |
Not clear |
| Temitope Adeoye, Syed I Shah, Ghanim Ulla. Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559218. |
co-expression networks highlighted the extended involvement of astrocytes and microglia in biological processes beyond neuroinflammation, such as calcium homeostasis, glutamate regulation, lipid metabolism, vesicle-mediated transport, and tor signaling. |
2024-04-01 |
2024-04-04 |
Not clear |
| Meishan Lu, Jiachen Shi, Xue Li, Yanjun Liu, Yuanfa Li. Long-term intake of thermo-induced oxidized oil results in anxiety-like and depression-like behaviors: involvement of microglia and astrocytes. Food & function. 2024-03-27. PMID:38533894. |
tioo primarily induced these two emotional disorders by affecting the differentiation of microglia, the level of inflammatory factors, the activation of astrocytes, and glutamate circulation in brain tissue. |
2024-03-27 |
2024-03-29 |
mouse |
| Yangzhi Xie, Liang Chen, Jiacheng Chen, Yan Luo, Zhe Peng, Hao Zhang, Zhao Pan, Yongjun Che. Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in Microglia by Alleviating Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. Journal of integrative neuroscience. vol 23. issue 2. 2024-02-29. PMID:38419440. |
metabotropic glutamate receptor 8 suppresses m1 polarization in microglia by alleviating endoplasmic reticulum stress and mitochondrial dysfunction. |
2024-02-29 |
2024-03-02 |
Not clear |
| Priscila G C Almeida, João Victor Nani, Jean Pierre Oses, Elisa Brietzke, Mirian A F Hayash. Neuroinflammation and glial cell activation in mental disorders. Brain, behavior, & immunity - health. vol 2. 2024-02-20. PMID:38377429. |
in this context, microglial dysfunction has recently emerged as a possible pivotal player, as during the neuroinflammatory response, microglia can be over-activated, and excessive production of pro-inflammatory cytokines, which can modify the kynurenine and glutamate signaling, is reported. |
2024-02-20 |
2024-02-23 |
Not clear |
| Jit Chatterjee, Joshua P Koleske, Astoria Chao, Andrew D Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T Kummer, David H Gutman. Brain injury drives optic glioma formation through neuron-glia signaling. Acta neuropathologica communications. vol 12. issue 1. 2024-02-02. PMID:38308315. |
we further elucidate the underlying molecular and cellular mechanisms, whereby glutamate released from damaged neurons stimulates il-1β release by oligodendrocytes to induce microglia expression of ccl5, a growth factor critical for nf1-opg formation. |
2024-02-02 |
2024-02-05 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
ripk1 activation in mecp2-deficient microglia promotes inflammation and glutamate release in rtt. |
2024-01-30 |
2024-02-02 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
ripk1 inhibition in mecp2-deficient microglia reduced oxidative stress, cytokines production and induction of slc7a11, slc38a1, and gls, which mediate the release of glutamate. |
2024-01-30 |
2024-02-02 |
mouse |
| Ze Cao, Xia Min, Xingxing Xie, Maoqing Huang, Yingying Liu, Weimin Sun, Guifang Xu, Miao He, Kaiwen He, Ying Li, Junying Yua. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 6. 2024-01-30. PMID:38289948. |
mecp2-deficient microglia release high levels of glutamate to impair glutamate-mediated excitatory neurotransmission and promote increased levels of glua1 and glua2/3 proteins in vivo, which was reduced upon ripk1 inhibition. |
2024-01-30 |
2024-02-02 |
mouse |
| Jiang-Ping Wei, Zi-Xuan Zhao, Jing Zeng, Fang-Hong Shang, Lei Hua, Yong Yang, Xiao-Mei Zhan. [Yigong Powder regulates CXCL12/CXCR4 signaling to reduce glutamate release and prevent cognitive decline in mouse model of aging]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 23. 2024-01-11. PMID:38212005. |
furthermore, yigong powder decreased the average fluorescence intensity of cxcl12 and cxcr4, reduced cxcr4-positive astrocytes and microglia, down-regulated the protein levels of p-erk/erk and tnfr1, and lowered the level of glutamate in the brain tissue. |
2024-01-11 |
2024-01-14 |
mouse |