All Relations between microglial cell and spinal cord

Publication Sentence Publish Date Extraction Date Species
Zhilin Ou, Yongquan Cheng, Hao Ma, Kai Chen, Qiong Lin, Jiayu Chen, Ruqin Guo, Zhiping Huang, Qixian Cheng, Nima Alaeiilkhchi, Qingan Zhu, Zucheng Huang, Hui Jian. miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1. Journal of translational medicine. vol 22. issue 1. 2024-07-16. PMID:39010173. mir-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating abca1. 2024-07-16 2024-07-18 Not clear
Ju Gao, Ogoegbunam Okolo, Sandra L Siedlak, Robert P Friedland, Xinglong Wan. Ferritin is closely associated with microglia in amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology. 2024-07-13. PMID:39001793. we also observed an association of ferritin with microglia in cerebral cortical tissue samples of als cases and in the spinal cord tissues of transgenic mice expressing the sod1g93a mutation. 2024-07-13 2024-07-16 mouse
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. pharmacological targeting cgas/sting/nf-κb axis by tryptanthrin induces microglia polarization toward m2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. 2024-07-12 2024-07-14 mouse
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. the m1/m2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury. 2024-07-12 2024-07-14 mouse
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. regulation of shifting microglia polarization from m1 (neurotoxic and proinflammatory type) to m2 (neuroprotective and anti-inflammatory type) after spinal cord injury appears to be crucial. 2024-07-12 2024-07-14 mouse
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. additionally, we found that targeting the cgas/sting/nf-κb pathway with tryptanthrin shifted microglia from the m1 to m2 phenotype after spinal cord injury, inhibited neuronal loss, and promoted tissue repair and functional recovery in a mouse model of spinal cord injury. 2024-07-12 2024-07-14 mouse
Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. taken together, these results suggest that by targeting the cgas/sting/nf-κb axis, tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the m2 phenotype. 2024-07-12 2024-07-14 mouse
Emilia Petillo, Valeria Veneruso, Gianluca Gragnaniello, Lorenzo Brochier, Enrico Frigerio, Giuseppe Perale, Filippo Rossi, Andrea Cardia, Alessandro Orro, Pietro Veglianes. Targeted therapy and deep learning insights into microglia modulation for spinal cord injury. Materials today. Bio. vol 27. 2024-07-08. PMID:38975239. targeted therapy and deep learning insights into microglia modulation for spinal cord injury. 2024-07-08 2024-07-11 Not clear
Alberto Granzotto, Amanda McQuade, Jean Paul Chadarevian, Hayk Davtyan, Stefano L Sensi, Ian Parker, Mathew Blurton-Jones, Ian F Smit. ER and SOCE Ca Cell calcium. vol 123. 2024-07-06. PMID:38970922. er and soce ca the central nervous system (cns) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal cord. 2024-07-06 2024-07-12 Not clear
Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. here, we used high-throughput single-nucleus rna sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes, microglia, and oligodendrocytes in the human spinal cord. 2024-06-27 2024-06-29 mouse
Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. in the human spinal cord, astrocytes, microglia, and oligodendrocytes were each divided into six distinct transcriptomic subclusters. 2024-06-27 2024-06-29 mouse
Yali Chen, Yiyong Wei, Jin Liu, Tao Zhu, Cheng Zhou, Donghang Zhan. Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord. Neural regeneration research. 2024-06-27. PMID:38934400. in the mouse spinal cord, astrocytes, microglia, and oligodendrocytes were divided into five, four, and five distinct transcriptomic subclusters, respectively.the comparative results revealed substantial heterogeneity in all glial cell types between humans and mice. 2024-06-27 2024-06-29 mouse
Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. furthermore, we investigated the colocalization of the aforementioned proteins with neurons, microglia, and astrocyte markers in the spinal cord tissue. 2024-06-26 2024-06-29 mouse
Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. in the in vivo study, we adopted the rat chronic constriction injury model, and the results showed that gb(4 mg/kg) treatment effectively reduced pain sensation in rats and decreased the expressions of iba-1 (a microglia marker), nlrp3 inflammasome, and inflammatory factors, such as interleukin (il)-1β, in the spinal cord 7 days post-surgery. 2024-06-22 2024-06-25 rat
Xintian Ding, Chun Chen, Heng Zhao, Bin Dai, Lei Ye, Tao Song, Shuai Huang, Jia Wang, Tao Yo. Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model. Neural regeneration research. vol 20. issue 3. 2024-06-18. PMID:38886958. journal/nrgr/04.03/01300535-202503000-00030/figure1/v/2024-06-17t092413z/r/image-tiff reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. 2024-06-18 2024-06-21 mouse
Xintian Ding, Chun Chen, Heng Zhao, Bin Dai, Lei Ye, Tao Song, Shuai Huang, Jia Wang, Tao Yo. Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model. Neural regeneration research. vol 20. issue 3. 2024-06-18. PMID:38886958. in this study, shp2 was found to be abundantly expressed in microglia at the site of spinal cord injury. 2024-06-18 2024-06-21 mouse
Faith H Brennan, Emily A Swarts, Kristina A Kigerl, Katherine A Mifflin, Zhen Guan, Benjamin T Noble, Yan Wang, Kristina G Witcher, Jonathan P Godbout, Phillip G Popovic. Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice. Science translational medicine. vol 16. issue 751. 2024-06-12. PMID:38865485. microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice. 2024-06-12 2024-06-15 mouse
Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Youns. Microglia: a promising therapeutic target in spinal cord injury. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819048. microglia: a promising therapeutic target in spinal cord injury. 2024-06-06 2024-06-08 Not clear
Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Youns. Microglia: a promising therapeutic target in spinal cord injury. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819048. in a healthy spinal cord, microglia are accountable for immune surveillance, however, when a spinal cord injury occurs, the microenvironment drastically changes, leading to glial scars and failed axonal regeneration. 2024-06-06 2024-06-08 Not clear
Xiaowei Zha, Guoli Zheng, Thomas Skutella, Karl Kiening, Andreas Unterberg, Alexander Youns. Microglia: a promising therapeutic target in spinal cord injury. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819048. despite a clear understanding of their essential nature and origin, the mechanisms of action and new functions of microglia in spinal cord injury require extensive research. 2024-06-06 2024-06-08 Not clear