| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Xia, Cheng Yu, Jin Liu, Jiezhao Lin, Jiao Lyu, Xin Wang, Lixin Zh. DANCR Knockdown Alleviates Neuroinflammation and Functional Recovery after Spinal Cord Injury via Regulating the ACTN4 / STAT3 Axis. Archives of biochemistry and biophysics. 2025-01-11. PMID:39798643. |
polarization of microglia following spinal cord injury (sci) is a pivotal pathological process of secondary injury. |
2025-01-11 |
2025-01-16 |
Not clear |
| Bin Xia, Cheng Yu, Jin Liu, Jiezhao Lin, Jiao Lyu, Xin Wang, Lixin Zh. DANCR Knockdown Alleviates Neuroinflammation and Functional Recovery after Spinal Cord Injury via Regulating the ACTN4 / STAT3 Axis. Archives of biochemistry and biophysics. 2025-01-11. PMID:39798643. |
our findings indicate that the dancr level in microglia is increased after sci and that its knockdown can promote microglial m2-type polarization; suppress inflammatory cytokines, oxidative stress, and neuronal apoptosis; and facilitate nerve regeneration as well as spinal cord functional recovery. |
2025-01-11 |
2025-01-16 |
Not clear |
| Zhonghua Xu, Manhui Zhu, Hua Xie, Jiacheng Zhu, Hongming Zheng, Xiaojuan Liu, Yuting Zhang, Jinbo Li. SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia. Scientific reports. vol 15. issue 1. 2025-01-09. PMID:39779741. |
six1 aggravates the progression of spinal cord injury in mice by promoting m1 polarization of microglia. |
2025-01-09 |
2025-01-13 |
mouse |
| Wanjie Wu, Yingzhu He, Yujun Chen, Yiming Fu, Sicong He, Kai Liu, Jianan Y Q. Author Correction: In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons. Nature communications. vol 15. issue 1. 2024-12-20. PMID:39706827. |
author correction: in vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons. |
2024-12-20 |
2024-12-24 |
mouse |
| Beatriz Godínez-Chaparro, Maria Cristina Rodríguez-Ramos, María Guadalupe Martínez-Lorenzana, Estefanía González-Morales, Karen Pamela Pérez-Ruíz, Antonio Espinosa de Los Monteros-Zuñiga, Felipe Mendoza-Pérez, Miguel Condes-Lar. Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 247. 2024-12-18. PMID:39675389. |
moreover, ppx (1 and 3 mg/kg, i.p./10 days, n = 10 per group) inhibited the bilateral mechanical hypersensitivity, and ppx (3 mg/kg/i.p./10 days) reduced 6-ohda-induced astrocyte and microglia activation, as well as reduced nf-κb/p-p65 expression only in astrocytes of dorsal horn spinal cord in the l5-l6. |
2024-12-18 |
2024-12-21 |
rat |
| Beatriz Godínez-Chaparro, Maria Cristina Rodríguez-Ramos, María Guadalupe Martínez-Lorenzana, Estefanía González-Morales, Karen Pamela Pérez-Ruíz, Antonio Espinosa de Los Monteros-Zuñiga, Felipe Mendoza-Pérez, Miguel Condes-Lar. Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 247. 2024-12-18. PMID:39675389. |
these findings suggest that ppx could alleviate pain by decreasing the activation of microglia and astrocytes through the nf-κb/p-p65 pathway in the dorsal horn spinal cord. |
2024-12-18 |
2024-12-21 |
rat |
| Daniela Buonvicino, Alessandra Pistolesi, Giuseppe Ranieri, Maura Calvani, Daniele Guasti, Alberto Chiarug. Microglial suppression by myeloperoxidase inhibitor does not delay neurodegeneration in a mouse model of progressive multiple sclerosis. Experimental neurology. 2024-12-14. PMID:39674307. |
we found that daily treatment with verdiperstat did not affect the pattern of progression as well as survival, despite its ability to reduce mitochondrial reactive oxygen species and microglia activation in the spinal cord of immunized mice. |
2024-12-14 |
2024-12-21 |
mouse |
| Zijian Wei, Deshui Yu, Yunlong Bi, Yang Ca. [Retracted] A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. Molecular medicine reports. vol 31. issue 2. 2024-12-13. PMID:39670308. |
[retracted] a disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. |
2024-12-13 |
2024-12-22 |
Not clear |
| Wenping Lin, Ziming Cai, Jinzhu Liang, Ping Miao, Ye Ruan, Pian Li, Shuhui Lin, He Tian, Qinghe Yu, Xu H. Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. Drug development research. vol 85. issue 8. 2024-12-11. PMID:39660541. |
heme oxygenase-1 overexpression activates the irf1/drp1 signaling pathway to promote m2-type polarization of spinal cord microglia. |
2024-12-11 |
2024-12-13 |
rat |
| Wenping Lin, Ziming Cai, Jinzhu Liang, Ping Miao, Ye Ruan, Pian Li, Shuhui Lin, He Tian, Qinghe Yu, Xu H. Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. Drug development research. vol 85. issue 8. 2024-12-11. PMID:39660541. |
microglia-mediated neuroinflammatory responses have a critical function in the spinal cord injury (sci) mechanism, and targeted modulation of microglia activity has emerged as a new therapeutic strategy for sci. |
2024-12-11 |
2024-12-13 |
rat |
| Wenping Lin, Ziming Cai, Jinzhu Liang, Ping Miao, Ye Ruan, Pian Li, Shuhui Lin, He Tian, Qinghe Yu, Xu H. Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. Drug development research. vol 85. issue 8. 2024-12-11. PMID:39660541. |
we cultivated primary rat spinal cord microglia and bv2 cell lines and used lipopolysaccharide (lps) to stimulate microglia to establish an in vitro model. |
2024-12-11 |
2024-12-13 |
rat |
| Jiaqi Li, Gang Li. Lentiviral Injection of Inter-α-Trypsin Inhibitor Heavy Chain 4 Promotes Female Spinal Cord Injury Mice Recuperation by Diminishing Peripheral and Central Inflammation. Inflammation. 2024-12-08. PMID:39648260. |
moreover, lv-itih4 reduced microglia m1 polarization compared with lv-nc in spinal cord of sci mice. |
2024-12-08 |
2024-12-11 |
mouse |
| Zhenxing Li, Binbin Zhou, Guanghui Chen, Xiangyu Yang, Han Su, Bolin L. Blocking of Tim-3 Ameliorates Spinal Cord Ischemia-Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1-to-M2 Phenotypic Polarization of Microglia. Immunity, inflammation and disease. vol 12. issue 12. 2024-12-06. PMID:39641284. |
blocking of tim-3 ameliorates spinal cord ischemia-reperfusion injury through inhibiting neuroinflammation and promoting m1-to-m2 phenotypic polarization of microglia. |
2024-12-06 |
2024-12-08 |
Not clear |
| Wencui Zhang, Bo Jiao, Shangchen Yu, Kaiwen Zhang, Jiaoli Sun, Baowen Liu, Xianwei Zhan. Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia. Free radical biology & medicine. 2024-12-05. PMID:39638264. |
here, we discovered that spared nerve injury (sni)-induced mechanical allodynia in rats were associated with m1-like microglia activation, oxidative stress and overactivity of ace/ang ii/at1r axis in the spinal cord. |
2024-12-05 |
2024-12-08 |
rat |
| Wencui Zhang, Bo Jiao, Shangchen Yu, Kaiwen Zhang, Jiaoli Sun, Baowen Liu, Xianwei Zhan. Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia. Free radical biology & medicine. 2024-12-05. PMID:39638264. |
intrathecal administration of lop effectively inhibited sni-induced nox2 overactivation in microglia and suppressed the hmgb1/nf-kb pathway, reducing oxidative stress and shifting the microglia polarization from m1 to m2 in the spinal cord, thereby attenuating neuroinflammation and pain hypersensitivity. |
2024-12-05 |
2024-12-08 |
rat |
| Chongxi Xu, Xuebing Jiang, Wumeng Yin, Liang Lyu, Huixin Tan, Wenbo He, Wangyang Wang, Zhengyu Zhou, Hongyu Zhou, Bin Xu, Yang Yu, Yuelong Wang, Peizhi Zhou, Yi Liu, Jianguo Xu, Maling Gou, Yu H. Microgel-encapsulated tetrandrine nanoparticles promote spinal cord repair by sustaining neuroinflammation inhibition. Journal of materials chemistry. B. 2024-12-02. PMID:39620256. |
traumatic spinal cord injury (sci) initiates an intricate secondary injury cascade, characterized by persistent inflammatory responses with neurotoxic microglia and astrocyte activation. |
2024-12-02 |
2024-12-06 |
Not clear |
| A V Timofeeva, E R Akhmetzyanova, A A Rizvanov, Y O Mukhamedshin. Interaction of microglia with the microenvironment in spinal cord injury. Neuroscience. 2024-12-02. PMID:39622381. |
interaction of microglia with the microenvironment in spinal cord injury. |
2024-12-02 |
2024-12-06 |
Not clear |
| A V Timofeeva, E R Akhmetzyanova, A A Rizvanov, Y O Mukhamedshin. Interaction of microglia with the microenvironment in spinal cord injury. Neuroscience. 2024-12-02. PMID:39622381. |
this article discusses the peculiarities of microglia behaviour and their interaction with other cells of the central nervous system (cns) during neural tissue injury with a focus on spinal cord injury (sci). |
2024-12-02 |
2024-12-06 |
Not clear |
| Rosmara Infantino, Francesca Gargano, Serena Boccella, Carmela Belardo, Andrea Maria Morace, Francesca Guida, Sabatino Maione, Livio Luong. Lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia. Neural regeneration research. vol 20. issue 10. 2024-11-29. PMID:39610094. |
lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia. |
2024-11-29 |
2024-12-01 |
Not clear |
| Wei Zhang, Yubao Lu, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Xingxing Fang, Liangming Zhang, Bin Liu, Limin Ron. Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury. Neural regeneration research. vol 20. issue 10. 2024-11-29. PMID:39610106. |
inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury. |
2024-11-29 |
2024-12-01 |
mouse |