| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Li. Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism. Journal of neuroinflammation. vol 21. issue 1. 2024-10-19. PMID:39425203. |
at the cellular level, plx5622 restores the morphology and/or number of microglia in the somatosensory cortex, striatum, and hippocampal ca1 regions of the two models. |
2024-10-19 |
2024-10-21 |
mouse |
| Duilin Liu, Caiyun Zhu, Hui Wei, Qi X. A mouse model of schizophrenia induced by autoantibodies against SFT2D2. Neuroscience. 2024-07-27. PMID:39067681. |
our results showed an increased density of microglia and activated astrocytes in the primary somatosensory cortex of the anti-sft2d2-igg-infused mice. |
2024-07-27 |
2024-08-02 |
mouse |
| Sabrina L McIlwrath, Amanda C Carroll-Portillo, Henry C Lin, Karin N Westlun. In vivo imaging of cathepsin B in activated glia in the brain after orofacial formalin test. Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402255. |
post-mortem immunohistochemical analysis of the somatosensory cortex detected the greatest amount of nir fluorescence localized on microglia and astrocytes in the 100 pmol imaging probe group. |
2024-02-24 |
2024-02-27 |
rat |
| Xiaochun Gu, Zhong Zhao, Xueli Chen, Lifeng Zhang, Huaqiang Fang, Ting Zhao, Shenghong Ju, Weizheng Gao, Xiaoyu Qian, Xianhua Wang, Jue Zhang, Heping Chen. Imaging microglia surveillance during sleep-wake cycles in freely behaving mice. eLife. vol 12. 2023-12-22. PMID:38132088. |
to address this question, we used miniature two-photon microscopy (mtpm) to acquire time-lapse high-resolution microglia images of the somatosensory cortex, along with eeg/emg recordings and behavioral video, in freely-behaving mice. |
2023-12-22 |
2023-12-24 |
mouse |
| Yoshifumi Ueta, Mariko Miyat. Functional and structural synaptic remodeling mechanisms underlying somatotopic organization and reorganization in the thalamus. Neuroscience and biobehavioral reviews. 2023-07-31. PMID:37524138. |
the remodeling process is initiated with local activation of microglia in the brainstem somatosensory nucleus downstream to injured nerves and heterosynaptically controlled by input from gabaergic and cortical neurons to thalamic neurons. |
2023-07-31 |
2023-08-14 |
mouse |
| Makoto Tsuda, Takahiro Masuda, Keita Kohn. Microglial diversity in neuropathic pain. Trends in neurosciences. 2023-05-27. PMID:37244781. |
microglia play pivotal roles in controlling cns functions in diverse physiological and pathological contexts, including neuropathic pain, a chronic pain condition caused by lesions or diseases of the somatosensory nervous system. |
2023-05-27 |
2023-08-14 |
Not clear |
| Barbara Fülöp, Ágnes Hunyady, Noémi Bencze, Viktória Kormos, Nikolett Szentes, Ádám Dénes, Nikolett Lénárt, Éva Borbély, Zsuzsanna Helye. IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982563. |
increased iba1+ integrated density in the central nucleus of amygdala, primary somatosensory cortex hind limb representation part, hippocampus cornu ammonis area 3 (ca3) and periaqueductal gray matter (pag) was present, accompanied by a cell number increase in iba1+ microglia in stressed female wts but not in il-1 kos. |
2023-03-29 |
2023-08-14 |
mouse |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
in this model, fasudil significantly suppressed nerve injury-induced inflammatory microglia production in the dorsal horn of the spinal cord and prevented subsequent somatosensory cortical rewiring. |
2022-10-16 |
2023-08-14 |
rat |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
our recent study using minamata disease model rats demonstrated that mehg-mediated neurodegeneration in the sensory nervous system may induce inflammatory microglia production in the dorsal horn of the spinal cord and subsequent somatosensory cortical rewiring, leading to neuropathic pain. |
2022-10-16 |
2023-08-14 |
rat |
| Sarah Katharina Steffens, Tarja Helena Stenberg, Henna-Kaisa Margareta Wigre. Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse. Glia. 2022-10-05. PMID:36196985. |
as microglia express regional heterogeneity and are influenced by local neuronal activity, we chose to investigate three interconnected and functionally well-characterized brain areas: the somatosensory cortex (sc), the dorsal hippocampus (hc), and the basal forebrain (bf). |
2022-10-05 |
2023-08-14 |
mouse |
| YuShan Tu, Milind M Muley, Simon Beggs, Michael W Salte. Microglia-independent peripheral neuropathic pain in male and female mice. Pain. 2022-04-06. PMID:35384869. |
the dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. |
2022-04-06 |
2023-08-13 |
mouse |
| Leah C Dorman, Phi T Nguyen, Caroline C Escoubas, Ilia D Vainchtein, Yinghong Xiao, Peter V Lidsky, Haruna Nakajo, Nicholas J Silva, Christian Lagares-Linares, Ellen Y Wang, Sunrae E Taloma, Beatriz Cuevas, Hiromi Nakao-Inoue, Brianna M Rivera, Bjoern Schwer, Carlo Condello, Raul Andino, Tomasz J Nowakowski, Anna V Molofsk. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis. bioRxiv : the preprint server for biology. 2022-03-02. PMID:35233577. |
using single cell rna sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type i interferon (ifn-i) responsive microglia population that expanded with this developmental stressor. |
2022-03-02 |
2023-08-13 |
Not clear |
| Olga Bakina, Helmut Kettenmann, Christiane Nolt. Microglia form satellites with different neuronal subtypes in the adult murine central nervous system. Journal of neuroscience research. 2022-02-25. PMID:35213755. |
we quantified satellite microglia associated with gabaergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar purkinje cell neurons. |
2022-02-25 |
2023-08-13 |
mouse |
| Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihar. Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice. Brain research bulletin. vol 163. 2021-09-29. PMID:32726668. |
in this study, we investigated the effects of status epilepticus on astrocytes, microglia, and extracellular matrix (ecm) molecules in the somatosensory cortex and piriform cortex of mice. |
2021-09-29 |
2023-08-13 |
mouse |
| Elissa L Wong, Alexandra Strohm, Jason Atlas, Cassandra Lamantia, Ania K Majewsk. Dynamics of microglia and dendritic spines in early adolescent cortex after developmental alcohol exposure. Developmental neurobiology. vol 81. issue 6. 2021-09-17. PMID:34228891. |
rodent studies have shown that alcohol exposure during the brain growth spurt (bgs) can lead to acute neuronal apoptosis and an immunological response by microglia in the somatosensory cortex. |
2021-09-17 |
2023-08-13 |
mouse |
| Masatake Fujimura, Fusako Usuki, Atsushi Nakamur. Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats. Archives of toxicology. vol 95. issue 6. 2021-08-02. PMID:33847776. |
in conclusion, mehg-mediated dorsal horn neuronal activation with inflammatory microglia might induce somatosensory cortical rewiring, leading to hyperalgesia/allodynia. |
2021-08-02 |
2023-08-13 |
rat |
| Giustino Varrassi, Mariella Fusco, Stephen D Skaper, Daniele Battelli, Panagiotis Zis, Stefano Coaccioli, Maria Caterina Pace, Antonella Paladin. A Pharmacological Rationale to Reduce the Incidence of Opioid Induced Tolerance and Hyperalgesia: A Review. Pain and therapy. vol 7. issue 1. 2020-09-30. PMID:29594972. |
persistent mast cell activation sensitizes nociceptors and initiates central nervous system inflammatory processes, involving microglial cell activation and sensitization of spinal somatosensory neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mohammad Nasser, Nissrine Ballout, Sarah Mantash, Fabienne Bejjani, Farah Najdi, Naify Ramadan, Jihane Soueid, Kazem Zibara, Firas Kobeiss. Transplantation of Embryonic Neural Stem Cells and Differentiated Cells in a Controlled Cortical Impact (CCI) Model of Adult Mouse Somatosensory Cortex. Frontiers in neurology. vol 9. 2020-09-30. PMID:30405520. |
indeed, ipsilateral lesioned somatosensory area expressed high levels of iba-1+ microglia within the different groups after 1 and 4 weeks. |
2020-09-30 |
2023-08-13 |
mouse |
| Harry Ward, Steven J Wes. Microglia: sculptors of neuropathic pain? Royal Society open science. vol 7. issue 6. 2020-09-28. PMID:32742693. |
in this review, we aim to explore the evidence for microglia in sculpting nervous system structure and function, as well as their important role in neuropathic pain, and finally integrate these studies to synthesize a new model for microglia in somatosensory circuit remodelling, composed of six key and inter-related mechanisms. |
2020-09-28 |
2023-08-13 |
Not clear |
| Helena Morrison, Kimberly Young, Mahir Qureshi, Rachel K Rowe, Jonathan Lifshit. Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury. Scientific reports. vol 7. issue 1. 2019-06-25. PMID:29038483. |
microglia morphology was quantified from histological sections using image j skeleton and fractal analysis procedures at three time points and in three regions post-mfpi: impact site, primary somatosensory cortex barrel field (s1bf), and a remote region. |
2019-06-25 |
2023-08-13 |
rat |