| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Belliveau, Reza Rahimian, Gohar Fakhfouri, Clémentine Hosdey, Sophie Simard, Maria Antonietta Davoli, Dominique Mirault, Bruno Giros, Gustavo Turecki, Naguib Mechawa. Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex. Brain, behavior, and immunity. 2024-12-13. PMID:39672240. |
microglia, known for their diverse roles in the central nervous system, have recently been recognized for their involvement in degrading the extracellular matrix. |
2024-12-13 |
2024-12-21 |
human |
| Claudia Belliveau, Reza Rahimian, Gohar Fakhfouri, Clémentine Hosdey, Sophie Simard, Maria Antonietta Davoli, Dominique Mirault, Bruno Giros, Gustavo Turecki, Naguib Mechawa. Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex. Brain, behavior, and immunity. 2024-12-13. PMID:39672240. |
to explore potential underlying mechanisms, we employed a comprehensive approach in similar postmortem vmpfc samples, combining a human matrix metalloproteinase and chemokine array, isolation of cd11b-positive microglia and enzyme-linked immunosorbent assays (elisa). |
2024-12-13 |
2024-12-21 |
human |
| Gengfan Ye, Zhigang Wang, Pandi Chen, Junyi Ye, Shiwei Li, Maosong Chen, Jiugeng Feng, Hongcai Wang, Wei Che. Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury. Neuroscience. 2024-11-29. PMID:39613247. |
serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury. |
2024-11-29 |
2024-12-02 |
Not clear |
| Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A C Harle. Glioblastoma Drives Protease-Independent Extracellular Matrix Invasion of Microglia. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605524. |
glioblastoma drives protease-independent extracellular matrix invasion of microglia. |
2024-11-28 |
2024-11-30 |
Not clear |
| Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A C Harle. Glioblastoma Drives Protease-Independent Extracellular Matrix Invasion of Microglia. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605524. |
further, gbm conditioned media resulted in significantly increased collagen hydrogel contraction, suggesting the importance of microglia contractility to physically remodel the local extracellular matrix (ecm). |
2024-11-28 |
2024-11-30 |
Not clear |
| Marta Tiffany Lombardo, Martina Gabrielli, Florence Julien-Marsollier, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Deborah D'Aliberti, Nicola Pelizzi, Camilla Halimi, Silvia Spinelli, Juliette Van Steenwinckel, Elisabetta A M Verderio, Pierre Gressens, Rocco Piazza, Claudia Verderi. Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia. Cells. vol 13. issue 19. 2024-10-15. PMID:39404427. |
human umbilical cord-mesenchymal stem cells promote extracellular matrix remodeling in microglia. |
2024-10-15 |
2024-10-17 |
human |
| Marta Tiffany Lombardo, Martina Gabrielli, Florence Julien-Marsollier, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Deborah D'Aliberti, Nicola Pelizzi, Camilla Halimi, Silvia Spinelli, Juliette Van Steenwinckel, Elisabetta A M Verderio, Pierre Gressens, Rocco Piazza, Claudia Verderi. Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia. Cells. vol 13. issue 19. 2024-10-15. PMID:39404427. |
using an in vitro coculture approach combined with transcriptomic analysis, we identified the extracellular matrix as the most relevant pathway altered by the human mesenchymal stem cell secretome in the response of microglia to inflammatory cytokines. |
2024-10-15 |
2024-10-17 |
human |
| Marta Tiffany Lombardo, Martina Gabrielli, Florence Julien-Marsollier, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Deborah D'Aliberti, Nicola Pelizzi, Camilla Halimi, Silvia Spinelli, Juliette Van Steenwinckel, Elisabetta A M Verderio, Pierre Gressens, Rocco Piazza, Claudia Verderi. Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia. Cells. vol 13. issue 19. 2024-10-15. PMID:39404427. |
we confirmed extracellular matrix remodeling in microglia exposed to the mesenchymal stem cell secretome via immunofluorescence analysis of the matrix component fibronectin and the extracellular crosslinking enzyme transglutaminase-2. |
2024-10-15 |
2024-10-17 |
human |
| Marta Tiffany Lombardo, Martina Gabrielli, Florence Julien-Marsollier, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Deborah D'Aliberti, Nicola Pelizzi, Camilla Halimi, Silvia Spinelli, Juliette Van Steenwinckel, Elisabetta A M Verderio, Pierre Gressens, Rocco Piazza, Claudia Verderi. Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia. Cells. vol 13. issue 19. 2024-10-15. PMID:39404427. |
furthermore, an analysis of hallmark microglial functions revealed that changes in the extracellular matrix enhance ruffle formation by microglia and cell motility. |
2024-10-15 |
2024-10-17 |
human |
| Bingxin Wu, Dabiao Zhou, Zhigang Me. Targeting the neurovascular unit: Therapeutic potential of traditional Chinese medicine for the treatment of stroke. Heliyon. vol 10. issue 19. 2024-10-10. PMID:39386825. |
the neurovascular unit (nvu), a new concept encompassing neurons, brain microvascular endothelial cells, pericytes, astrocytes, microglia, and the extracellular matrix, has gained prominence in recent years. |
2024-10-10 |
2024-10-12 |
Not clear |
| Jiapei Chen, Elizabeth E Crouch, Miriam E Zawadzki, Kyle A Jacobs, Lakyn N Mayo, Jennifer Ja-Yoon Choi, Pin-Yeh Lin, Saba Shaikh, Jessica Tsui, Susana Gonzalez-Granero, Shamari Waller, Avani Kelekar, Gugene Kang, Edward J Valenzuela, Janeth Ochoa Birrueta, Loukas N Diafos, Kaylee Wedderburn-Pugh, Barbara Di Marco, Wenlong Xia, Claudia Z Han, Nicole G Coufal, Christopher K Glass, Stephen P J Fancy, Julieta Alfonso, Arnold R Kriegstein, Michael C Oldham, Jose Manuel Garcia-Verdugo, Matthew L Kutys, Maria K Lehtinen, Alexis J Combes, Eric J Huan. Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. Nature neuroscience. 2024-09-30. PMID:39349662. |
here we show that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduces angiogenesis in the ganglionic eminences, which correspond to the human germinal matrix. |
2024-09-30 |
2024-10-03 |
mouse |
| Reza Rahimian, Claudia Belliveau, Sophie Simard, Gustavo Turecki, Naguib Mechawa. Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? Biomolecules. vol 14. issue 9. 2024-09-28. PMID:39334854. |
recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in extracellular matrix remodeling under both physiological and pathological conditions. |
2024-09-28 |
2024-10-01 |
human |
| Ligia Gabriela Tataranu, Serban Turliuc, Amira Kamel, Radu Eugen Rizea, Anica Dricu, Georgiana-Adeline Staicu, Stefania Carina Baloi, Silvia Mara Baez Rodriguez, Andrada Ioana Maria Manol. Glioblastoma Tumor Microenvironment: An Important Modulator for Tumoral Progression and Therapy Resistance. Current issues in molecular biology. vol 46. issue 9. 2024-09-27. PMID:39329940. |
the main components of the gbm tme are represented by the extracellular matrix (ecm), glioma cells and glioma stem cells (gscs), immune cells (microglia, macrophages, neutrophils, lymphocytes), neuronal cells, all of them having dynamic interactions and being able to influence the tumoral growth, progression, and drug resistance thus being a potential therapeutic target. |
2024-09-27 |
2024-09-29 |
Not clear |
| Jia Liu, Xiqian Chen, Junxian Liu, Hainan Zhang, Wei L. HSV-1 immune escapes in microglia by down-regulating GM130 to inhibit TLR3-mediated innate immune responses. Virology journal. vol 21. issue 1. 2024-09-17. PMID:39285274. |
to investigate the mechanism of golgi matrix protein 130(gm130) regulating the antiviral immune response of tlr3 after herpes simplex virus type 1(hsv-1) infection of microglia cells. |
2024-09-17 |
2024-09-19 |
Not clear |
| Haley A Vecchiarelli, Luana Tenorio Lopes, Rosa C Paolicelli, Beth Stevens, Hiroaki Wake, Marie-Ève Trembla. Synapse Regulation. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207693. |
depending on the nature of these changes, microglia can thicken and retract their processes, proliferate and migrate, release numerous signaling factors and compounds influencing neuronal physiology (e.g., cytokines and trophic factors), in addition to secreting proteases able to transform the extracellular matrix, and phagocytosing various types of cellular debris, etc. |
2024-08-29 |
2024-09-04 |
Not clear |
| Sang Won Cheung, Emily F Willis, David G Simmons, Mark C Bellingham, Peter G Noake. Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43 Neurobiology of disease. 2024-07-27. PMID:39067491. |
phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing mmp-9 in tdp-43 perineuronal nets (pnns) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. |
2024-07-27 |
2024-08-02 |
Not clear |
| Stephanie Debette, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Murali Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Hans Markus Munter, Dan Auld, Iana Astafeva, Raquel Puerta, Jerome Rotter, Bruce Psaty, Joshua Bis, Will Longstreth, Thierry Couffinhal, Pablo Garcia-Gonzalez, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore Launer, Joanna Wardlaw, Myriam Heiman, Agustin Ruiz, Paul Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchag. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. Research square. 2024-07-16. PMID:39011113. |
csvd-proteins were enriched in extracellular matrix and immune response pathways, and in genes enriched in microglia and specific microglial states (integration with single-nucleus rna sequencing). |
2024-07-16 |
2024-07-18 |
Not clear |
| Carla Cangalaya, Weilun Sun, Stoyan Stoyanov, Ildiko Rita Dunay, Alexander Dityate. Integrity of neural extracellular matrix is required for microglia-mediated synaptic remodeling. Glia. 2024-07-01. PMID:38946065. |
microglia continuously remodel synapses, which are embedded in the extracellular matrix (ecm). |
2024-07-01 |
2024-07-03 |
mouse |
| Davide Marangon, Juliana Helena Castro E Silva, Valentina Cerrato, Enrica Boda, Davide Lecc. Oligodendrocyte Progenitors in Glial Scar: A Bet on Remyelination. Cells. vol 13. issue 12. 2024-06-26. PMID:38920654. |
adult opcs become immediately activated; they migrate at the lesion site and proliferate to replenish the damaged area, but their efficiency is hampered by the presence of a glial scar-a barrier mainly formed by reactive astrocytes, microglia and the deposition of inhibitory extracellular matrix components. |
2024-06-26 |
2024-06-29 |
Not clear |
| Sang Won Cheung, Ekta Bhavnani, David G Simmons, Mark C Bellingham, Peter G Noake. Perineuronal nets are phagocytosed by MMP-9 expressing microglia and astrocytes in the SOD1 Neuropathology and applied neurobiology. vol 50. issue 3. 2024-05-14. PMID:38742276. |
perineuronal nets are phagocytosed by mmp-9 expressing microglia and astrocytes in the sod1 perineuronal nets (pnns) are an extracellular matrix structure that encases excitable neurons. |
2024-05-14 |
2024-05-27 |
Not clear |