| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaaki Nishihara, Keisuke Shinohara, Shota Ikeda, Tomohiko Akahoshi, Hiroyuki Tsutsu. Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease. Journal of intensive care. vol 12. issue 1. 2024-09-02. PMID:39223624. |
activation of microglia in the paraventricular nucleus of the hypothalamus (pvn) has been implicated in sna. |
2024-09-02 |
2024-09-05 |
Not clear |
| Haley N Mendoza-Romero, Jessica E Biddinger, Michelle N Bedenbaugh, Richard B Simerl. Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185162. |
microglia are required for developmental specification of agrp innervation in the hypothalamus of offspring exposed to maternal high fat diet during lactation. |
2024-08-26 |
2024-08-28 |
mouse |
| M Valdearcos, E R McGrath, S M Brown Mayfield, A Folick, R T Cheang, L Li, T P Bachor, R N Lippert, A W Xu, S K Koliwa. Microglia mediate the early-life programming of adult glucose control. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005380. |
here, we show that microglia in the mediobasal hypothalamus (mbh) of mice actively engage in synaptic pruning during early life. |
2024-07-15 |
2024-07-18 |
mouse |
| Yi Chen, Siyan Zhang, Liu Ye, Hong Chen, Ping Ma, Dandong W. High-intensity interval training improves hypothalamic inflammation by suppressing HIF-1α signaling in microglia of male C57BL/6J mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-12. PMID:38995817. |
the state of microglia and microglial nf-κb signaling in the hypothalamus were also examined in vivo. |
2024-07-12 |
2024-07-15 |
mouse |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Ping Yu, Yuangeng Li, Wenwen Fu, Xiaofeng Yu, Dayun Sui, Huali Xu, Weilun Su. Microglia Caspase11 non-canonical inflammasome drives fever. Acta physiologica (Oxford, England). 2024-06-12. PMID:38864370. |
in this study, we investigate the role of the preoptic area of the hypothalamus (po/ah) microglia casp11 in fever. |
2024-06-12 |
2024-06-14 |
Not clear |
| Lucie Barateau, Anis Krache, Alexandre Da Costa, Michel Lecendreux, Rachel Debs, Sofiene Chenini, Nicolas Arlicot, Patrick Vourc'h, Elisa Evangelista, Mathieu Alonso, Anne-Sophie Salabert, Stein Silva, Séverine Béziat, Isabelle Jaussent, Denis Mariano-Goulart, Pierre Payoux, Yves Dauvillier. Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1. Neurology. vol 102. issue 10. 2024-04-26. PMID:38669634. |
we aimed to explore microglia density in the hypothalamus and thalamus in nt1 compared with controls using [ |
2024-04-26 |
2024-04-29 |
Not clear |
| Ning-Ning Ji, Zhi-Yan Li, Shuang Cao, Bei Pei, Chen-Yu Jin, Yi-Fan Li, Peng Mao, Hong Jiang, Bi-Fa Fan, Ming Xi. Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice. Journal of gastrointestinal oncology. vol 15. issue 1. 2024-03-14. PMID:38482229. |
given the pivotal role of neuroinflammation in chronic pain and that the paraventricular nucleus of the hypothalamus (pvn) is a crucial brain region involved in visceral pain regulation, we sought to investigate whether the targeted modulation of microglia and astrocytes in the pvn could ameliorate pancreatic cancer-induced visceral pain (pcvp) in mice. |
2024-03-14 |
2024-03-16 |
mouse |
| Dan-Dan Xu, Zhi-Qi Hou, Ya-Yun Xu, Jun Liang, Ye-Jun Gao, Chen Zhang, Fan Guo, Dan-Dan Huang, Jin-Fang Ge, Qing-Rong Xi. Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm". Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-02-02. PMID:38305948. |
furthermore, protein expression levels of the circadian locomotor output cycles kaput, cryptochrome 2, and period 2 was significantly reduced in the hippocampus of lps-challenged rats, whereas bmal1 expression was significantly increased in the hippocampus but decreased in the hypothalamus, where it was co-located with neurons, microglia, and astrocytes. |
2024-02-02 |
2024-02-04 |
rat |
| Samantha Papadakis, Jacqueline R Thompson, Eric Feczko, Oscar Miranda-Dominguez, Geoffrey A Dunn, Matthew Selby, A J Mitchell, Elinor L Sullivan, Damien A Fai. Perinatal Western-style Diet Exposure associated with Decreased Microglial Counts throughout the Arcuate Nucleus of the Hypothalamus in Japanese Macaques. Journal of neurophysiology. 2024-01-10. PMID:38197176. |
neuroinflammation was approximated in one-year-old offspring by counting resident microglia and peripherally-derived macrophages in the region of the hypothalamus examined in the fetal study, the arcuate nucleus (arc). |
2024-01-10 |
2024-01-13 |
Not clear |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. |
2023-12-23 |
2023-12-25 |
rat |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
microglia labeled with iba1 in frozen sections of rat hypothalamus were scanned and photographed at multiple levels using confocal microscopy. |
2023-12-23 |
2023-12-25 |
rat |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
in summary, chronic restraint stress promoted the conversion of microglia in the rat hypothalamus to a less complex form, manifested as larger soma, shorter and fewer branches, more uniform and dense texture, and increased circularity; indeed, the shape of these microglia resembled that of amoeba and they displayed strong phagocytosis activity. |
2023-12-23 |
2023-12-25 |
rat |
| Annelie Zimmermann, Natalie Böge, Katharina Schuster, Anna Staffeld, Stephan Lang, Sadaf Gill, Hanna Rupprecht, Linda Frintro. Glial cell changes in the corpus callosum in chronically-starved mice. Journal of eating disorders. vol 11. issue 1. 2023-12-19. PMID:38111061. |
astrocytes and microglia influence neuronal circuits, we investigated the glial changes underlying pathophysiology of starvation in the corpus callosum (cc) and hypothalamus. |
2023-12-19 |
2023-12-21 |
mouse |
| Haorun Huang, Xixian Liao, An Zhang, Binghui Qiu, Fen Mei, Fan Liu, Kai Zeng, Chunen Yang, Haidie Ma, Wenjie Ding, Songtao Qi, Yun Ba. Cerebrospinal Fluid from Patients After Craniotomy with the Appearance of Interleukin-6 Storm Can Activate Microglia to Damage the Hypothalamic Neurons in Mice. Molecular neurobiology. 2023-11-04. PMID:37924484. |
csf from patients after craniotomy caused disturbance of consciousness in mice, affected neuronal damage in the hypothalamus, activation of microglia in the hypothalamus, and decreased expression of barrier proteins in the hypothalamus and brain. |
2023-11-04 |
2023-11-08 |
mouse |
| Haorun Huang, Xixian Liao, An Zhang, Binghui Qiu, Fen Mei, Fan Liu, Kai Zeng, Chunen Yang, Haidie Ma, Wenjie Ding, Songtao Qi, Yun Ba. Cerebrospinal Fluid from Patients After Craniotomy with the Appearance of Interleukin-6 Storm Can Activate Microglia to Damage the Hypothalamic Neurons in Mice. Molecular neurobiology. 2023-11-04. PMID:37924484. |
high levels of il-6 in the cerebrospinal fluid derived from astrocytes after craniotomy may lead to disruption of the brain-cerebrospinal fluid barrier, most notably around the hypothalamus, which might result in inflammatory activation of microglia to damage the hypothalamic neurons and impaired cognitive function/more gradual cognitive repairment in patients after craniotomy with the appearance of il-6 storm. |
2023-11-04 |
2023-11-08 |
mouse |
| Miwako Katagi, Yuki Nakae, Junko Okano, Kazunori Fujino, Tomoki Tanaka, Itsuko Miyazawa, Natsuko Ohashi, Takahiko Nakagawa, Hideto Kojim. Aberrant bone marrow-derived microglia in the hypothalamus may dysregulate appetite in diabetes. Biochemical and biophysical research communications. vol 682. 2023-10-08. PMID:37806251. |
aberrant bone marrow-derived microglia in the hypothalamus may dysregulate appetite in diabetes. |
2023-10-08 |
2023-10-15 |
mouse |
| Miwako Katagi, Yuki Nakae, Junko Okano, Kazunori Fujino, Tomoki Tanaka, Itsuko Miyazawa, Natsuko Ohashi, Takahiko Nakagawa, Hideto Kojim. Aberrant bone marrow-derived microglia in the hypothalamus may dysregulate appetite in diabetes. Biochemical and biophysical research communications. vol 682. 2023-10-08. PMID:37806251. |
bone marrow derived cells (bmdcs) migrate into the hypothalamus, where those cells give rise to microglia to regulate food intake. |
2023-10-08 |
2023-10-15 |
mouse |
| Yang Tae Kim, Byong Seo Park, Hye Rim Yang, Se On Yi, Il Seong Nam-Goong, Jae Geun Ki. Exploring the potential hypothalamic role in mediating cisplatin-induced negative energy balance. Chemico-biological interactions. 2023-09-28. PMID:37769865. |
in addition, we observed activation of microglia and inflammation in the hypothalamus following treatment with cisplatin. |
2023-09-28 |
2023-10-07 |
mouse |
| Vaibhave Ubba, Serene Joseph, Olubusayo Awe, Dustin Jones, Milan K Dsilva, Mingxiao Feng, Junjiang Wang, Xiaomin Fu, Razeen J Akbar, Brittany H Bodnar, Wenhui Hu, Hong Wang, Xiaofeng Yang, Ling Yang, Peixin Yang, Rexford Ahima, Sara Divall, Sheng W. Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess. Endocrinology. 2023-09-22. PMID:37738624. |
western blot studies show that markers of inflammation and microglia activation, such as nf-kb p-65 and iba1, increased in the hypothalamus of con-dht mice compared to con-veh. |
2023-09-22 |
2023-10-07 |
mouse |