| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Tian, Jinghui Wang, Yangyang Zhu, Yi Zhang, Liwei Chen, Cheng H. Mast cell promotes obesity by activating microglia in hypothalamus. Frontiers in endocrinology. vol 16. 2025-04-07. PMID:40190403. |
mast cell promotes obesity by activating microglia in hypothalamus. |
2025-04-07 |
2025-04-09 |
Not clear |
| Martin Valdearcos, Emily R McGrath, Stephen M Brown Mayfield, Melissa G Jacuinde, Andrew Folick, Rachel T Cheang, Ruoyu Li, Tomas P Bachor, Rachel N Lippert, Allison W Xu, Suneil K Koliwa. Microglia mediate the early-life programming of adult glucose control. Cell reports. vol 44. issue 3. 2025-03-14. PMID:40085644. |
here, we show that the phagocytic activity of microglia in the mediobasal hypothalamus (mbh) is induced following birth, regresses upon weaning from maternal milk, and is exacerbated by feeding dams a high-fat diet while lactating. |
2025-03-14 |
2025-03-17 |
Not clear |
| Lucas Zangerolamo, Marina Carvalho, Carina Solon, Davi Sidarta-Oliveira, Gabriela M Soares, Carine Marmentini, Antonio C Boschero, Yu-Hua Tseng, Licio A Velloso, Helena C L Barbos. Central FGF19 signaling enhances energy homeostasis and adipose tissue thermogenesis through sympathetic activation in obese mice. American journal of physiology. Endocrinology and metabolism. 2025-03-10. PMID:40059865. |
using single-cell rna sequencing of the adult murine hypothalamus, we found that fgf19 has the potential to target multiple cell populations, including astrocytes-tanycytes, microglia, neurons, and oligodendrocytes. |
2025-03-10 |
2025-03-12 |
mouse |
| Shaolian Zang, Fei Wang, Yang Ouyang, Weiwei Cheng, Pin Li, Xiaoqin Yi. Exposure to polyethylene and polyvinylchloride microplastics caused advanced puberty onset in females through promoting hypothalamic GnRH expression. Ecotoxicology and environmental safety. vol 291. 2025-02-20. PMID:39978134. |
immunohistochemical staining demonstrated that mps exposure during puberty could activate microglia, astrocytes and promote gnrh expression in the hypothalamus, which leading to an earlier pubertal onset. |
2025-02-20 |
2025-02-23 |
mouse |
| Natalia Mendes, Ariane Zanesco, Cristhiane Aguiar, Gabriela F Rodrigues-Luiz, Dayana Silva, Jonathan Campos, Niels Olsen Saraiva Camara, Pedro Moraes-Vieira, Eliana Araujo, Licio A Vellos. CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction. eLife. vol 13. 2024-11-13. PMID:39535032. |
a few hours after a high-fat diet (hfd), hypothalamic microglia shift to an inflammatory phenotype, and prolonged fat consumption leads to the recruitment of bone marrow-derived cells to the hypothalamus. |
2024-11-13 |
2024-11-17 |
mouse |
| Prashant Tarale, Shaista Chaudhary, Sayani Mukherjee, Dipak K Sarka. Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus. Journal of neuroinflammation. vol 21. issue 1. 2024-10-31. PMID:39478585. |
microglia, a type of resident immune cells within the central nervous system, have been implicated in ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (pomc) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. |
2024-10-31 |
2024-11-02 |
rat |
| Gabriela C De Paula, Rui F Simões, Alba M Garcia-Serrano, João M N Duart. High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice. Neurochemical research. 2024-09-20. PMID:39302596. |
we determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers iba1, cd68, gfap and emr1 in the hypothalamus, and analyzed morphology of microglia (iba-1 |
2024-09-20 |
2024-09-22 |
mouse |
| Masaaki Nishihara, Keisuke Shinohara, Shota Ikeda, Tomohiko Akahoshi, Hiroyuki Tsutsu. Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease. Journal of intensive care. vol 12. issue 1. 2024-09-02. PMID:39223624. |
activation of microglia in the paraventricular nucleus of the hypothalamus (pvn) has been implicated in sna. |
2024-09-02 |
2024-09-05 |
Not clear |
| Haley N Mendoza-Romero, Jessica E Biddinger, Michelle N Bedenbaugh, Richard B Simerl. Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185162. |
microglia are required for developmental specification of agrp innervation in the hypothalamus of offspring exposed to maternal high fat diet during lactation. |
2024-08-26 |
2024-08-28 |
mouse |
| M Valdearcos, E R McGrath, S M Brown Mayfield, A Folick, R T Cheang, L Li, T P Bachor, R N Lippert, A W Xu, S K Koliwa. Microglia mediate the early-life programming of adult glucose control. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005380. |
here, we show that microglia in the mediobasal hypothalamus (mbh) of mice actively engage in synaptic pruning during early life. |
2024-07-15 |
2024-07-18 |
mouse |
| Yi Chen, Siyan Zhang, Liu Ye, Hong Chen, Ping Ma, Dandong W. High-intensity interval training improves hypothalamic inflammation by suppressing HIF-1α signaling in microglia of male C57BL/6J mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-12. PMID:38995817. |
the state of microglia and microglial nf-κb signaling in the hypothalamus were also examined in vivo. |
2024-07-12 |
2024-07-15 |
mouse |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Ping Yu, Yuangeng Li, Wenwen Fu, Xiaofeng Yu, Dayun Sui, Huali Xu, Weilun Su. Microglia Caspase11 non-canonical inflammasome drives fever. Acta physiologica (Oxford, England). 2024-06-12. PMID:38864370. |
in this study, we investigate the role of the preoptic area of the hypothalamus (po/ah) microglia casp11 in fever. |
2024-06-12 |
2024-06-14 |
Not clear |
| Lucie Barateau, Anis Krache, Alexandre Da Costa, Michel Lecendreux, Rachel Debs, Sofiene Chenini, Nicolas Arlicot, Patrick Vourc'h, Elisa Evangelista, Mathieu Alonso, Anne-Sophie Salabert, Stein Silva, Séverine Béziat, Isabelle Jaussent, Denis Mariano-Goulart, Pierre Payoux, Yves Dauvillier. Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1. Neurology. vol 102. issue 10. 2024-04-26. PMID:38669634. |
we aimed to explore microglia density in the hypothalamus and thalamus in nt1 compared with controls using [ |
2024-04-26 |
2024-04-29 |
Not clear |
| Ning-Ning Ji, Zhi-Yan Li, Shuang Cao, Bei Pei, Chen-Yu Jin, Yi-Fan Li, Peng Mao, Hong Jiang, Bi-Fa Fan, Ming Xi. Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice. Journal of gastrointestinal oncology. vol 15. issue 1. 2024-03-14. PMID:38482229. |
given the pivotal role of neuroinflammation in chronic pain and that the paraventricular nucleus of the hypothalamus (pvn) is a crucial brain region involved in visceral pain regulation, we sought to investigate whether the targeted modulation of microglia and astrocytes in the pvn could ameliorate pancreatic cancer-induced visceral pain (pcvp) in mice. |
2024-03-14 |
2024-03-16 |
mouse |
| Dan-Dan Xu, Zhi-Qi Hou, Ya-Yun Xu, Jun Liang, Ye-Jun Gao, Chen Zhang, Fan Guo, Dan-Dan Huang, Jin-Fang Ge, Qing-Rong Xi. Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm". Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-02-02. PMID:38305948. |
furthermore, protein expression levels of the circadian locomotor output cycles kaput, cryptochrome 2, and period 2 was significantly reduced in the hippocampus of lps-challenged rats, whereas bmal1 expression was significantly increased in the hippocampus but decreased in the hypothalamus, where it was co-located with neurons, microglia, and astrocytes. |
2024-02-02 |
2024-02-04 |
rat |
| Samantha Papadakis, Jacqueline R Thompson, Eric Feczko, Oscar Miranda-Dominguez, Geoffrey A Dunn, Matthew Selby, A J Mitchell, Elinor L Sullivan, Damien A Fai. Perinatal Western-style Diet Exposure associated with Decreased Microglial Counts throughout the Arcuate Nucleus of the Hypothalamus in Japanese Macaques. Journal of neurophysiology. 2024-01-10. PMID:38197176. |
neuroinflammation was approximated in one-year-old offspring by counting resident microglia and peripherally-derived macrophages in the region of the hypothalamus examined in the fetal study, the arcuate nucleus (arc). |
2024-01-10 |
2024-01-13 |
Not clear |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. |
2023-12-23 |
2023-12-25 |
rat |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
microglia labeled with iba1 in frozen sections of rat hypothalamus were scanned and photographed at multiple levels using confocal microscopy. |
2023-12-23 |
2023-12-25 |
rat |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
in summary, chronic restraint stress promoted the conversion of microglia in the rat hypothalamus to a less complex form, manifested as larger soma, shorter and fewer branches, more uniform and dense texture, and increased circularity; indeed, the shape of these microglia resembled that of amoeba and they displayed strong phagocytosis activity. |
2023-12-23 |
2023-12-25 |
rat |