| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Amoriello, Clara Ballerin. Immunofluorescence Staining of Murine Spinal Cord Sections to Evaluate Microglial Activation and Astrogliosis. Methods in molecular biology (Clifton, N.J.). vol 2857. 2024-09-30. PMID:39348064. |
aging impacts microglia and astrocytes by promoting the production of pro-inflammatory cytokines, impairing microglial phagocytosis and motility and astrocyte glutamate uptake. |
2024-09-30 |
2024-10-02 |
mouse |
| Alma Karen Lomeli-Lepe, José Luis Castañeda-Cabral, Mónica E Ureña-Guerrero, Graciela Gudiño Cabrera, Silvia Josefina López-Pére. Bee Venom Reduces Early Inflammation and Oxidative Stress Associated with Lipopolysaccharide-induced Alpha-synuclein in the Substantia Nigra-striatum Axis. Cell biochemistry and biophysics. 2024-09-29. PMID:39342536. |
in addition, we observed lower microglia and astrocyte activation in sn and str. |
2024-09-29 |
2024-10-01 |
rat |
| Congcong Fu, Lu Huang, Chun Lian, Jiajia Yue, Peihao Lin, Lufen Xu, Wendong Lai, Cong Gao, Chuo Li, Youming Lon. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain research. 2024-09-11. PMID:39260790. |
in the nmosd mouse model, magnesium l-threonate (mgt) pretreatment alleviated nmo-igg-induced effects, including aqp4 loss, leukocyte infiltration, astrocyte and microglia activation, demyelination, decreased tight junction (tj) protein expression, and neurological deficits. |
2024-09-11 |
2024-09-14 |
mouse |
| Xiaoyu Zheng, Qian Xiang, Xiaoxu Dong, Yang Shen, Wei Fang, Hongna Yan. [Research progress on the changes of blood-brain barrier in sepsis-associated encephalopathy]. Zhonghua wei zhong bing ji jiu yi xue. vol 36. issue 8. 2024-09-06. PMID:39238417. |
above these damages caused glial cell activation (microglia and astrocyte), the imbalance of neurotransmitters, mitochondrial dysfunction and neural apoptosis, which also reversely contributed to the damage to the integrity and permeability of bbb via decreasing the expression of tight junctional protein between cells. |
2024-09-06 |
2024-09-08 |
Not clear |
| Jonathan W VanRyzin, Ashley E Marquardt, Margaret M McCarth. Feminization of social play behavior depends on microglia. bioRxiv : the preprint server for biology. 2024-09-04. PMID:39229086. |
this data, combined with our previous finding that male-like patterns of astrocyte density are sculpted by developmental microglial phagocytosis, reveals that sexual differentiation of the medial amygdala involves opposing tensions between active masculinization and active feminization, both of which require microglia but are achieved via distinct processes. |
2024-09-04 |
2024-09-06 |
Not clear |
| Radhika Joshi, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szab. IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-08-31. PMID:39215356. |
here, we show that global irf3 deficiency delays tlr4-mediated signaling in microglia and attenuates the hallmark features of lps-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and inflammasome activation. |
2024-08-31 |
2024-09-04 |
Not clear |
| Vittoria Borgonetti, Martina Morozzi, Nicoletta Galeott. Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain. Neuropharmacology. 2024-08-19. PMID:39159835. |
in coincidence with the peak of scratching behavior, sni mice showed a spinal overexpression of iba1 and gfap, microglia and astrocyte markers respectively. |
2024-08-19 |
2024-08-22 |
mouse |
| Platon Megagiannis, Yuan Mei, Rachel E Yan, Lin Yuan, Jonathan J Wilde, Hailey Eckersberg, Rahul Suresh, Xinzhu Tan, Hong Chen, W Todd Farmer, Kuwook Cha, Phuong Uyen Le, Helene Catoire, Daniel Rochefort, Tony Kwan, Brian A Yee, Patrick Dion, Arjun Krishnaswamy, Jean-Francois Cloutier, Stefano Stifani, Kevin Petrecca, Gene W Yeo, Keith K Murai, Guoping Feng, Guy A Rouleau, Trey Ideker, Neville E Sanjana, Yang Zho. Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. Cell reports. vol 43. issue 8. 2024-08-18. PMID:39154337. |
conditional chd8 deletion in astrocytes, but not microglia, suppresses reactive gliosis by impeding astrocyte proliferation and morphological elaboration. |
2024-08-18 |
2024-08-21 |
mouse |
| Jae Soo Kim, Mi-Hye Kim, Myeung Ju Kim, Hee Jung Ki. Licochalcone A attenuates NMDA-induced neurotoxicity. Animal cells and systems. vol 28. issue 1. 2024-08-14. PMID:39139398. |
the response of astrocyte and microglia was also evaluated by immunostaining for glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor molecule 1 (iba-1) and tumor necrosis factor alpha (tnf-α). |
2024-08-14 |
2024-08-16 |
rat |
| Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Oj. PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI. Journal of neuroinflammation. vol 21. issue 1. 2024-08-03. PMID:39097742. |
we revealed that pioglitazone treatment attenuated spatial learning and memory impairments at 6 months post-injury and reduced the expression of reactive microglia and astrocyte markers in the cortex, hippocampus, and corpus callosum. |
2024-08-03 |
2024-08-06 |
mouse |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
| Katharina Ritter, Markus Baalmann, Christopher Dolderer, Ulrike Ritz, Michael K E Schäfe. Brain-Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39061973. |
bone fractures did not aggravate neuropathology or neuroinflammation assessed by cerebral lesion size, hippocampal integrity, astrocyte and microglia activation, and gene expression. |
2024-07-27 |
2024-07-29 |
mouse |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. 2024-07-25. PMID:39051915. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-07-25 |
2024-07-28 |
mouse |
| Cristian De Gregorio, Javiera Gallardo, Pablo Berríos-Cárcamo, Álex Handy, Daniela Santapau, Antonia González-Madrid, Marcelo Ezquer, Paola Morales, Alejandro Luarte, Daniela Corvalán, Úrsula Wyneken, Fernando Ezque. Methadone directly impairs central nervous system cells in vitro. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043899. |
in animal models, prenatal methadone exposure results in detrimental consequences to the central nervous system, such as: (i) increased neuronal apoptosis; (ii) disruption of oligodendrocyte maturation and increased apoptosis and (iii) increased microglia and astrocyte activation. |
2024-07-23 |
2024-07-26 |
rat |
| Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Guang-Hui Xu, Ji-Xiao Zhu, Li-Tao Y. Role of ginsenoside Rb1 in attenuating depression-like symptoms through astrocytic and microglial complement C3 pathway. Metabolic brain disease. 2024-07-21. PMID:39034364. |
in conclusion, our results demonstrate that ginsenoside rb1 produces the antidepressant-like effects by inhibiting astrocyte tlr4/nf-κb/c3 signaling to covert microglia from a pro-inflammatory phenotype (amoeboid) towards an anti-inflammatory phenotype (ramified), which inhibit the synaptic pruning in the hippocampus. |
2024-07-21 |
2024-07-24 |
mouse |
| Yuning Mai, Zhen Cheng, Ze Wang, Tao Hu, Yuanyuan Zhang, Xiya Yuan, Xing Xu, Yu Fan, Feifei Ge, Pengbo Shi, Jun Wang, Xin Yang, Xiaowei Gua. Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 7. 2024-07-09. PMID:38981852. |
pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. |
2024-07-09 |
2024-07-12 |
mouse |
| Nan Wu, Yun Zhao, Minjun Xiao, Hui Liu, Hongliang Chen, Bin Liu, Xuezhen Wang, Xueli Fa. Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways. Inflammation. 2024-07-09. PMID:38980500. |
we evaluated the effects of mp on disease progression, cns inflammatory cell infiltration and myelination, microglia and astrocyte activation, as well as tfr/tfh ratio and related molecules/inflammatory factors in eae mice. |
2024-07-09 |
2024-07-12 |
mouse |
| Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok K. Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation. Brain : a journal of neurology. 2024-07-08. PMID:38976650. |
gut inoculation of α-syn pff increased lewy body accumulation in the hippocampal dentate gyrus, with heightened microglia and astrocyte activation and worsened non-motor symptoms. |
2024-07-08 |
2024-07-12 |
mouse |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
furthermore, we investigated the colocalization of the aforementioned proteins with neurons, microglia, and astrocyte markers in the spinal cord tissue. |
2024-06-26 |
2024-06-29 |
mouse |
| Sean D Carey, Katherine Conant, Kathleen A Maguire-Zeis. Short-term exposure to HIV Tat induces glial activation and changes in perineuronal nets. The European journal of neuroscience. 2024-06-06. PMID:38844747. |
moreover, direct injection of tat protein into mouse hippocampus increases the expression of astrocyte and microglia markers as well as mmp-9. |
2024-06-06 |
2024-06-10 |
mouse |