| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristian De Gregorio, Javiera Gallardo, Pablo Berríos-Cárcamo, Álex Handy, Daniela Santapau, Antonia González-Madrid, Marcelo Ezquer, Paola Morales, Alejandro Luarte, Daniela Corvalán, Úrsula Wyneken, Fernando Ezque. Methadone directly impairs central nervous system cells in vitro. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043899. |
in animal models, prenatal methadone exposure results in detrimental consequences to the central nervous system, such as: (i) increased neuronal apoptosis; (ii) disruption of oligodendrocyte maturation and increased apoptosis and (iii) increased microglia and astrocyte activation. |
2024-07-23 |
2024-07-26 |
rat |
| Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Guang-Hui Xu, Ji-Xiao Zhu, Li-Tao Y. Role of ginsenoside Rb1 in attenuating depression-like symptoms through astrocytic and microglial complement C3 pathway. Metabolic brain disease. 2024-07-21. PMID:39034364. |
in conclusion, our results demonstrate that ginsenoside rb1 produces the antidepressant-like effects by inhibiting astrocyte tlr4/nf-κb/c3 signaling to covert microglia from a pro-inflammatory phenotype (amoeboid) towards an anti-inflammatory phenotype (ramified), which inhibit the synaptic pruning in the hippocampus. |
2024-07-21 |
2024-07-24 |
mouse |
| Yuning Mai, Zhen Cheng, Ze Wang, Tao Hu, Yuanyuan Zhang, Xiya Yuan, Xing Xu, Yu Fan, Feifei Ge, Pengbo Shi, Jun Wang, Xin Yang, Xiaowei Gua. Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 7. 2024-07-09. PMID:38981852. |
pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice. |
2024-07-09 |
2024-07-12 |
mouse |
| Nan Wu, Yun Zhao, Minjun Xiao, Hui Liu, Hongliang Chen, Bin Liu, Xuezhen Wang, Xueli Fa. Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways. Inflammation. 2024-07-09. PMID:38980500. |
we evaluated the effects of mp on disease progression, cns inflammatory cell infiltration and myelination, microglia and astrocyte activation, as well as tfr/tfh ratio and related molecules/inflammatory factors in eae mice. |
2024-07-09 |
2024-07-12 |
mouse |
| Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok K. Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation. Brain : a journal of neurology. 2024-07-08. PMID:38976650. |
gut inoculation of α-syn pff increased lewy body accumulation in the hippocampal dentate gyrus, with heightened microglia and astrocyte activation and worsened non-motor symptoms. |
2024-07-08 |
2024-07-12 |
mouse |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
furthermore, we investigated the colocalization of the aforementioned proteins with neurons, microglia, and astrocyte markers in the spinal cord tissue. |
2024-06-26 |
2024-06-29 |
mouse |
| Sean D Carey, Katherine Conant, Kathleen A Maguire-Zeis. Short-term exposure to HIV Tat induces glial activation and changes in perineuronal nets. The European journal of neuroscience. 2024-06-06. PMID:38844747. |
moreover, direct injection of tat protein into mouse hippocampus increases the expression of astrocyte and microglia markers as well as mmp-9. |
2024-06-06 |
2024-06-10 |
mouse |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
| Yong-Ho Choe, Min Gi Jo, Bo Gyu Kim, Sangwon Lee, Bina Lee, Seon-Hee Kim, Hyemin Seong, Woong-Sun Yoo, Minkyeong Kim, Dong-Kun Lee, Seong Jae Kim, Seung Pil Yun, Mingyo Ki. The autoimmune response induced by α-synuclein peptides drives neuronal cell death and glial cell activation. Journal of autoimmunity. vol 147. 2024-05-24. PMID:38788538. |
treatment with conditioned media from α-syn peptide-immunized splenocytes induced microglia and toxic a1-type astrocyte activation. |
2024-05-24 |
2024-05-27 |
mouse |
| Araceli Seiffe, Nadia Kazlauskas, Marcos Campolongo, Amaicha Mara Depin. Juvenile peripheral LPS exposure overrides female resilience to prenatal VPA effects on adult sociability in mice. Scientific reports. vol 14. issue 1. 2024-05-19. PMID:38763939. |
surprisingly, we observed reduced astrocyte and microglia density in the cerebellum of vpa-lps animals. |
2024-05-19 |
2024-05-27 |
mouse |
| b' Macarena Lorena Herrera, Leandro Gabriel Champarini, Osvaldo Mart\\xc3\\xadn Basmadjian, Mar\\xc3\\xada Jos\\xc3\\xa9 Bellini, Claudia Beatriz Here\\xc3\\xb1\\xc3\\xb. IGF-1 gene therapy prevents spatial memory deficits and modulates dopaminergic neurodegeneration and inflammation in a parkinsonism model. Brain, behavior, and immunity. vol 119. 2024-05-17. PMID:38750702.' |
in addition, the therapy resulted in significant changes in several parameters (area, perimeter, roundness, ramification, and skeleton ́s analyses) related to microglia and astrocyte phenotypes, particularly in the cpu and dorsal hippocampal areas. |
2024-05-17 |
2024-05-27 |
rat |
| Chuantong He, Jiahui Jiang, Junxin Liu, Longjian Zhou, Yuewei Ge, Zhiyou Yan. Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology via regulating the microbiota-gut-brain axis in 5 × FAD mice. International journal of biological macromolecules. 2024-05-16. PMID:38750854. |
additionally, ph-ps restored intestinal barrier function; ameliorated peripheral inflammation by reducing the secretion of inflammatory cytokines, thereby converting m1 microglia and a1 astrocyte toward beneficial m2 and a2 phenotypes; and contributed to aβ plaques clearance by upregulation of insulin degradation enzyme and neprilysin. |
2024-05-16 |
2024-05-27 |
mouse |
| Kai Chen, Xiaojin Wei, Wenjuan Zhang, Ruixuan Wang, Yaping Wang, Lin Yan. Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte. Brain, behavior, and immunity. 2024-05-12. PMID:38735405. |
bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte. |
2024-05-12 |
2024-05-27 |
Not clear |
| Radhika Joshi, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szab. IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-24. PMID:38654824. |
here, we show that global irf3 deficiency delays tlr4-mediated signaling in microglia and attenuates the hallmark features of lps-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and inflammasome activation. |
2024-04-24 |
2024-04-28 |
Not clear |
| Pengjun Wang, Chen Chen, Min Sha. Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways. Journal of biochemical and molecular toxicology. vol 38. issue 5. 2024-04-17. PMID:38629493. |
microglial and astrocyte activation was examined through immunofluorescence staining of iba-1 (microglia marker) and gfap (astrocyte marker) in the sn. |
2024-04-17 |
2024-04-19 |
mouse |
| Michele Joana Alves, Brigitte M Browe, Ana Carolina Rodrigues Dias, Juliet Torres, Giuliana Zaza, Suzy Bangudi, Jessica Blackburn, Wesley Wang, Silvio de Araujo Fernandes-Junior, Paollo Fadda, Amanda Toland, Lisa A Baer, Kristin I Stanford, Catherine Czeisler, Alfredo J Garcia, José Javier Oter. Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits. Brain, behavior, and immunity. 2024-04-01. PMID:38561095. |
brainstem neurons, microglia, and astrocyte gene expression analyses showed unique responses to tlr ligands. |
2024-04-01 |
2024-04-04 |
mouse |
| Lauren A Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L Giacometti, Peter J Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantla, Jacqueline M Barke. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. Communications biology. vol 7. issue 1. 2024-03-30. PMID:38553542. |
behavioral alterations are accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. |
2024-03-30 |
2024-04-01 |
mouse |
| Pegah Haghighi, Mandee K Schaub, Adam H Shebindu, Gayathri Vijayakumar, Armaan Sood, Rafael Granja-Vazquez, Sourav S Patnaik, Caroline N Jones, Gregory O Dussor, Joseph J Pancrazi. In Vitro Pharmacological Modulation of PIEZO1 Channels in Frontal Cortex Neuronal Networks. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539612. |
piezo1 has been implicated in astrocyte, microglia, capillary, and oligodendrocyte signaling in the mammalian cortex. |
2024-03-28 |
2024-03-30 |
Not clear |
| Ran Liu, Raymond Berry, Linshu Wang, Kiran Chaudhari, Ali Winters, Yuanhong Sun, Claire Caballero, Hannah Ampofo, Yiwei Shi, Bibek Thata, Luis Colon-Perez, Nathalie Sumien, Shao-Hua Yan. Experimental Ischemic Stroke Induces Secondary Bihemispheric White Matter Degeneration and Long-Term Cognitive Impairment. Translational stroke research. 2024-03-15. PMID:38488999. |
additionally, microglia and astrocyte activation were identified in the bilateral corpus callosum after stroke. |
2024-03-15 |
2024-03-18 |
rat |
| Maryam Raoofi Nejad, Elham Siasi, Mohammad Amin Abdollahifar, Abbas Aliaghaei, Elham Sias. Elderberry diet enhances motor performance and reduces neuroinflammation-induced cell death in cerebellar ataxia rat models. Journal of chemical neuroanatomy. 2024-02-24. PMID:38401660. |
the results showed that eb diet administration in a 3-ap ataxia model improved motor coordination, locomotor activity and neuro-muscular function, prevented purkinje neurons degeneration, increased microglia and astrocyte complexity and reduced cell soma size. |
2024-02-24 |
2024-02-27 |
rat |