| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajd. Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder. Molecules (Basel, Switzerland). vol 29. issue 22. 2024-11-27. PMID:39598660. |
while the etiology and pathophysiology of autism spectrum disorder are still not fully understood, recent studies have suggested that wide alterations in the gabaergic, glutamatergic, cholinergic, and serotonergic systems play a key role in its development and progression. |
2024-11-27 |
2024-11-29 |
Not clear |
| Guilherme Lodetti, Samira Leila Baldin, Ana Carolina Salvador de Farias, Karolyne de Pieri Pickler, Amanda Gomes Teixeira, Eduardo Ronconi Dondossola, Henrique Teza Bernardo, Caio Maximino, Eduardo Pacheco Ric. Repeated exposure to ethanol alters memory acquisition and neurotransmission parameters in zebrafish brain. Pharmacology, biochemistry, and behavior. 2024-11-25. PMID:39586362. |
therefore, we investigated the effects of repetitive exposure to ethanol (ree) and the nmda receptor antagonist dizocilpine (mk-801) on memory acquisition and glutamatergic and cholinergic neurotransmission. |
2024-11-25 |
2024-11-28 |
zebrafish |
| Pascal Grumbach, Jan Kasper, Joerg F Hipp, Anna Forsyth, Sofie L Valk, Suresh Muthukumaraswamy, Simon B Eickhoff, Leonhard Schilbach, Juergen Dukar. Local activity alterations in autism spectrum disorder correlate with neurotransmitter properties and ketamine induced brain changes. medRxiv : the preprint server for health sciences. 2024-11-06. PMID:39502665. |
these lcor alterations negatively co-localized with dopaminergic (d1, d2, dat), glutamatergic (nmda, mglur5), gabaergic (gabaa) and cholinergic neurotransmission (vacht). |
2024-11-06 |
2024-11-08 |
human |
| Elisa Mantovani, Alice Martini, Alessandro Dinoto, Chiara Zucchella, Sergio Ferrari, Sara Mariotto, Michele Tinazzi, Stefano Tamburi. Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses. NPJ Parkinson's disease. vol 10. issue 1. 2024-11-03. PMID:39488513. |
diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (csf) alzheimer's disease (ad) biomarkers, cortical rhythm slowing, reduced cortical cholinergic and glutamatergic and increased cortical gabaergic activity, delayed p300 latency, increased plasma homocysteine and cystatin c and decreased vitamin b12 and folate, increased csf/serum albumin quotient, and serum neurofilament light chain. |
2024-11-03 |
2024-11-05 |
Not clear |
| Huize Pang, Xiaolu Li, Ziyang Yu, Hongmei Yu, Shuting Bu, Juzhou Wang, Mengwan Zhao, Yu Liu, Yueluan Jiang, Guoguang Fa. Disentangling gray matter atrophy and its neurotransmitter architecture in drug-naïve Parkinson's disease: an atlas-based correlation analysis. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 10. 2024-10-18. PMID:39420471. |
cognitively impaired parkinson's disease patients showed gray matter atrophy in the left middle temporal atrophy, which is associated with serotoninergic, dopaminergic, cholinergic, and glutamatergic receptors (fdr-p < 0.05). |
2024-10-18 |
2024-10-20 |
Not clear |
| Ran Tao, Chunmei Yue, Zhijie Guo, Wenke Guo, Yao Yao, Xianfa Yang, Zhen Shao, Chao Gao, Jianqing Ding, Lu Shen, Shengdi Chen, Naihe Jin. Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer's disease. Cell regeneration (London, England). vol 13. issue 1. 2024-10-10. PMID:39388038. |
both cortical glutamatergic neurons and basal forebrain cholinergic neurons (bfcns) in the ad brain are selectively vulnerable. |
2024-10-10 |
2024-10-16 |
Not clear |
| Antonia Giacco, Stefania Iervolino, Federica Cioffi, Teresa Peluso, Giovanna Mercurio, Luca Roberto, Valeria de Rosa, Mariarosaria Cammarota, Silvia Varricchio, Stefania Staibano, Francesca Boscia, Lorella Maria Teresa Canzoniero, Mario De Felice, Concetta Ambrosino, Maria Moreno, Elena Silvestr. Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations. Molecular neurobiology. 2024-10-07. PMID:39375286. |
compared to wt controls, dhtp mice, bearing both systemic and brain hypothyroidism, showed altered expression of synaptic markers, generic and cholinergic (corroborated by immunohistochemistry in caudate, putamen, hippocampus, and basal forebrain) and glutamatergic ones, and reduced expression of key proteins of synaptic plasticity potency and several isoforms of glutamate receptors. |
2024-10-07 |
2024-10-10 |
mouse |
| Jacopo Sapienza, Giulia Agostoni, Stefano Comai, Sofia Nasini, Stefano Dall'Acqua, Stefania Sut, Marco Spangaro, Francesca Martini, Margherita Bechi, Mariachiara Buonocore, Giorgia Bigai, Federica Repaci, Daniela Nocera, Chiara Ave, Carmelo Guglielmino, Federica Cocchi, Roberto Cavallaro, Giacomo Deste, Marta Bosi. Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise. Schizophrenia research. Cognition. vol 38. 2024-09-16. PMID:39281320. |
in the last decade, the kynurenine pathway (kp) has gained attention in the pathogenesis of cognitive impairment in schizophrenia being at the croassroad between neuroinflammation and glutamatergic and cholinergic neurotransmission. |
2024-09-16 |
2024-09-19 |
Not clear |
| Leon D Lotter, Amin Saberi, Justine Y Hansen, Bratislav Misic, Casey Paquola, Gareth J Barker, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H Fröhner, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Frauke Nees, Tobias Banaschewski, Simon B Eickhoff, Juergen Dukar. Regional patterns of human cortex development correlate with underlying neurobiology. Nature communications. vol 15. issue 1. 2024-09-16. PMID:39284858. |
in contrast, modeled cortical thickness change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. |
2024-09-16 |
2024-09-19 |
human |
| Michael Aschner, Anatoly V Skalny, Rongzhu Lu, Airton C Martins, Aristidis Tsatsakis, Sergey A Miroshnikov, Abel Santamaria, Alexey A Tinko. Molecular mechanisms of zinc oxide nanoparticles neurotoxicity. Chemico-biological interactions. 2024-09-15. PMID:39278458. |
znonps exposure is associated with altered cholinergic, dopaminergic, serotoninergic, as well as glutamatergic and γ-aminobutyric acid (gaba)-ergic neurotransmission, thus contributing to impaired neuronal signal transduction. |
2024-09-15 |
2024-09-18 |
human |
| Jinquan Li, Yanjun Liu, Chuhui Yin, Yan Zeng, Yufei Me. Structural and functional remodeling of neural networks in β-amyloid driven hippocampal hyperactivity. Ageing research reviews. 2024-09-01. PMID:39218080. |
therefore, in this narrative review, we discuss the role of aβ-induced altered intrinsic neuronal properties as well as structural and functional remodeling of glutamatergic, gabaergic, cholinergic, noradrenergic, serotonergic circuits in hippocampal hyperactivity. |
2024-09-01 |
2024-09-04 |
Not clear |
| Ehsan Raeis-Abdollahi, Payman Raise-Abdullahi, Ali Rashidy-Pour, Morvarid Meamar, Hassan Askar. Coffee's protective mechanisms against neurodegeneration. Progress in brain research. vol 288. 2024-08-21. PMID:39168556. |
coffee modulates neurotransmitter systems, including dopaminergic, cholinergic, and glutamatergic pathways implicated in neurodegeneration. |
2024-08-21 |
2024-08-24 |
Not clear |
| Michel Fallah, Kenea C Udobi, Aleksandra E Swiatek, Chelsea B Scott, Rebekah C Evan. Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors. bioRxiv : the preprint server for biology. 2024-08-16. PMID:39149277. |
the gpe selectively inhibits caudal glutamatergic and gabaergic neurons, avoiding both cholinergic and rostral cells. |
2024-08-16 |
2024-08-18 |
Not clear |
| Megan E Barra, Ken Solt, Xin Yu, Brian L Edlo. Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-17. PMID:39019729. |
however, the relative contributions of monoaminergic, glutamatergic, cholinergic, gabaergic, and orexinergic neurotransmitter systems to recovery of consciousness after severe brain injury are unknown, and personalized approaches to targeted therapy have yet to be developed. |
2024-07-17 |
2024-07-20 |
Not clear |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Carmen Costas-Ferreira, Rafael Durán, Lilian R F Far. Evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum. Journal of applied toxicology : JAT. 2024-06-03. PMID:38828527. |
evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum. |
2024-06-03 |
2024-06-05 |
rat |
| Carmen Costas-Ferreira, Rafael Durán, Lilian R F Far. Evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum. Journal of applied toxicology : JAT. 2024-06-03. PMID:38828527. |
so, the main objective of this mechanistic study was to evaluate the possible mediation of the glutamatergic, cholinergic, and nitrergic systems in the gly-induced in vivo dopamine release from rat dorsal striatum. |
2024-06-03 |
2024-06-05 |
rat |
| Leon D Lotter, Amin Saberi, Justine Y Hansen, Bratislav Misic, Casey Paquola, Gareth J Barker, Arun L W Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Juliane H Froehner, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Frauke Nees, Tobias Banaschewski, Simon B Eickhoff, Juergen Dukar. Regional patterns of human cortex development colocalize with underlying neurobiology. bioRxiv : the preprint server for biology. 2024-05-10. PMID:37205539. |
in contrast, modeled cortical change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. |
2024-05-10 |
2024-05-27 |
human |
| Swetha K Godavarthi, Masaki Hiramoto, Yuri Ignatyev, Jacqueline B Levin, Hui-Quan Li, Marta Pratelli, Jennifer Borchardt, Cynthia Czajkowski, Laura N Borodinsky, Lora Sweeney, Hollis T Cline, Nicholas C Spitze. Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 15. 2024-04-03. PMID:38568976. |
here, we show that blockade of endogenous postsynaptic acetylcholine receptors (achr) at the neuromuscular junction destabilizes the cholinergic phenotype in motor neurons and stabilizes an earlier, developmentally transient glutamatergic phenotype. |
2024-04-03 |
2024-04-06 |
Not clear |
| Boxuan Li, Shizhe Deng, Hailun Jiang, Weiming Zhu, Bifang Zhuo, Yuzheng Du, Zhihong Men. The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review. Frontiers in neuroscience. vol 18. 2024-03-19. PMID:38500484. |
here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (gabaergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. |
2024-03-19 |
2024-03-21 |
Not clear |