| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoko Hirata, Toshiharu Nagats. Rotenone and CCCP inhibit tyrosine hydroxylation in rat striatal tissue slices. Toxicology. vol 216. issue 1. 2005-12-20. PMID:16115719. |
these results suggest that tyrosine hydroxylation is inhibited in dopaminergic neurons soon after exposure to sub-micromolar concentrations of rotenone and cccp, leading to dopamine depletion. |
2005-12-20 |
2023-08-12 |
rat |
| Ronald L Klein, Robert D Dayton, Wen-Lang Lin, Dennis W Dickso. Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiology of disease. vol 20. issue 1. 2005-12-19. PMID:16137567. |
the mutant tau vector caused progressive loss of pars compacta dopaminergic neurons over time, reduced striatal dopamine content, and amphetamine-stimulated rotational behavior consistent with a specific lesion effect. |
2005-12-19 |
2023-08-12 |
human |
| Manuel Miranda, Christine C Wu, Tatiana Sorkina, Davin R Korstjens, Alexander Sorki. Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. The Journal of biological chemistry. vol 280. issue 42. 2005-12-13. PMID:16109712. |
enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase c. dopamine transporter (dat) localization in dopaminergic neurons plays an important role in regulating dopamine signaling. |
2005-12-13 |
2023-08-12 |
human |
| Chiho Sumi-Ichinose, Fumi Urano, Atsushi Shimomura, Takashi Sato, Kazuhisa Ikemoto, Hiroaki Shiraishi, Takao Senda, Hiroshi Ichinose, Takahide Nomur. Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. Journal of neurochemistry. vol 95. issue 3. 2005-12-13. PMID:16135092. |
in this present work, we rescued pts(-/-) mice by transgenic introduction of human pts cdna under the control of the dopamine beta-hydroxylase promoter to examine regional differences in the sensitivity of dopaminergic neurons to bh4-insufficiency. |
2005-12-13 |
2023-08-12 |
mouse |
| Frans J M Feron, Jos G M Hendriksen, Marinus J P G van Kroonenburgh, Ciska Blom-Coenjaerts, Alfons G H Kessels, Jelle Jolles, Wim E J Weber, Johan S H Vle. Dopamine transporter in attention-deficit hyperactivity disorder normalizes after cessation of methylphenidate. Pediatric neurology. vol 33. issue 3. 2005-12-13. PMID:16139732. |
the observed upregulation of dopamine transporter activity might support the assumption that methylphenidate does not lead to permanent damage of the nigrostriatal dopaminergic pathways. |
2005-12-13 |
2023-08-12 |
Not clear |
| Vincent Seuti. Dopaminergic neurones: much more than dopamine? British journal of pharmacology. vol 146. issue 2. 2005-12-09. PMID:16025140. |
dopaminergic neurones: much more than dopamine? |
2005-12-09 |
2023-08-12 |
Not clear |
| Ikuko Miyazaki, Masato Asanuma, Francisco J Diaz-Corrales, Ko Miyoshi, Norio Ogaw. Dopamine agonist pergolide prevents levodopa-induced quinoprotein formation in parkinsonian striatum and shows quenching effects on dopamine-semiquinone generated in vitro. Clinical neuropharmacology. vol 28. issue 4. 2005-12-07. PMID:16062092. |
the neurotoxicity of dopamine (da) quinones that appears in dopaminergic neuron-specific oxidative stress has recently been shown to play a role in the pathogenesis and/or progression of parkinson disease. |
2005-12-07 |
2023-08-12 |
mouse |
| Bankole A Johnso. Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function. CNS drugs. vol 19. issue 10. 2005-12-07. PMID:16185095. |
since corticomesolimbic dopaminergic neurons interact with other neurotransmitters that modulate the effects of dopamine in the nucleus accumbens, would it not be possible to control these dopaminergic effects more reliably with a medication that acts contemporaneously on more than one neuromodulator of dopaminergic function? |
2005-12-07 |
2023-08-12 |
Not clear |
| Michelino Puopolo, Bruce P Bean, Elio Raviol. Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb. Journal of neurophysiology. vol 94. issue 5. 2005-12-02. PMID:16033943. |
these results show that dopaminergic periglomerular cells have intrinsic pacemaking activity, supporting the possibility that they can maintain a tonic release of dopamine to modulate the sensitivity of the olfactory system during odor detection. |
2005-12-02 |
2023-08-12 |
mouse |
| Jordi Bové, Jordi Serrats, Guadalupe Mengod, Roser Cortés, Eduardo Tolosa, Concepció Mari. Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways. Experimental brain research. vol 165. issue 3. 2005-12-01. PMID:15968457. |
in parkinson's disease (pd), the striatal dopamine depletion and the following overactivation of the indirect pathway of the basal ganglia leads to very early disinhibition of the subthalamic nucleus (stn) that may contribute to the progression of pd by glutamatergic overstimulation of the dopaminergic neurons in the substantia nigra. |
2005-12-01 |
2023-08-12 |
rat |
| I Léna, S Parrot, O Deschaux, S Muffat-Joly, V Sauvinet, B Renaud, M-F Suaud-Chagny, C Gottesman. Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. Journal of neuroscience research. vol 81. issue 6. 2005-11-30. PMID:16041801. |
the latter results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep-wake cycle. |
2005-11-30 |
2023-08-12 |
rat |
| I Léna, S Parrot, O Deschaux, S Muffat-Joly, V Sauvinet, B Renaud, M-F Suaud-Chagny, C Gottesman. Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. Journal of neuroscience research. vol 81. issue 6. 2005-11-30. PMID:16041801. |
the elevated levels of dopamine during waking and rem sleep in the medial prefrontal cortex and the nucleus accumbens could result from changes during these two states in afferent modulation at the level of cell bodies or at the level of dopaminergic terminals. |
2005-11-30 |
2023-08-12 |
rat |
| Akihiro Tamae, Terumasa Nakatsuka, Kohei Koga, Go Kato, Hidemasa Furue, Toshihiko Katafuchi, Megumu Yoshimur. Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors. The Journal of physiology. vol 568. issue Pt 1. 2005-11-28. PMID:15975975. |
to understand the cellular mechanisms of antinociception mediated by descending dopaminergic pathways, we examined the actions of dopamine (da) on nociceptive transmission by using behavioural studies and whole-cell patch-clamp recordings from substantia gelatinosa (sg) neurones in the spinal cord. |
2005-11-28 |
2023-08-12 |
rat |
| b' Esa Meririnne, Miina Kajos, Aino Kankaanp\\xc3\\xa4\\xc3\\xa4, Meri Koistinen, Kalervo Kiianmaa, Timo Sepp\\xc3\\xa4l\\xc3\\xa. Rewarding properties of the stereoisomers of 4-methylaminorex: involvement of the dopamine system. Pharmacology, biochemistry, and behavior. vol 81. issue 4. 2005-11-28. PMID:15982727.' |
furthermore, the involvement of the brain dopaminergic system in the 4-methylaminorex reward was tested with the dopamine d1- and d2-receptor antagonists sch 23390 and raclopride administered systemically, or with the neurotoxin 6-hydroxydopamine injected into the nucleus accumbens. |
2005-11-28 |
2023-08-12 |
rat |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. |
2005-11-28 |
2023-08-12 |
mouse |
| C L Parish, J Nunan, D I Finkelstein, F N McNamara, J Y Wong, J L Waddington, R M Brown, A J Lawrence, M K Horne, J Drag. Mice lacking the alpha4 nicotinic receptor subunit fail to modulate dopaminergic neuronal arbors and possess impaired dopamine transporter function. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16077034. |
neuronal nicotinic acetylcholine receptors (nachrs) at presynaptic sites can modulate dopaminergic synaptic transmission by regulating dopamine (da) release and uptake. |
2005-11-28 |
2023-08-12 |
mouse |
| J Vaamonde-Gamo, J M Flores-Barragán, R Ibáñez, M Gudín, A Hernánde. [DaT-SCAN SPECT in the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease]. Revista de neurologia. vol 41. issue 5. 2005-11-23. PMID:16138284. |
in dlb there is 40-70% loss of striatal dopamine and the loss of dopaminergic cell is accompanied by loss of the dopamine transporter. |
2005-11-23 |
2023-08-12 |
Not clear |
| J Vaamonde-Gamo, J M Flores-Barragán, R Ibáñez, M Gudín, A Hernánde. [DaT-SCAN SPECT in the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease]. Revista de neurologia. vol 41. issue 5. 2005-11-23. PMID:16138284. |
the loss of dopaminergic neurons in dlb can be confirmed in vivo with i-fp-cit (dat-scan), a pre-synaptic dopamine transporter marker. |
2005-11-23 |
2023-08-12 |
Not clear |
| B Dass, M M Iravani, C Huang, J Barsoum, T M Engber, A Galdes, P Jenne. Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15586304. |
following treatment with 4x10(7) viral particles of aav-shh the loss of striatal dopamine content was reduced and there was marked preservation of nigral dopaminergic cells. |
2005-11-22 |
2023-08-12 |
rat |
| L Yavich, A Yline. Spreading depression in the cortex differently modulates dopamine release in rat mesolimbic and nigrostriatal terminal fields. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16084513. |
it is proposed that depression and activation of evoked dopamine release in the nucleus caudatus and nucleus accumbens following sd are indicative of tonic activation of the nigrostriatal and tonic inhibition of the mesolimbic dopaminergic terminals by cortex in normal conditions. |
2005-11-22 |
2023-08-12 |
human |