| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryuji Kaji, Satoshi Goto, Gen Tamiya, L V Le. [Molecular and anatomical bases of dystonia: X-linked recessive dystonia-parkinsonism (DYT3)]. Rinsho shinkeigaku = Clinical neurology. vol 45. issue 11. 2006-02-15. PMID:16447732. |
because striosomal neurons inhibit nigrostriatal dopaminergic neurons via gabaergic innervation, the striosomal lesion could account for dopamine excess in the striatum, which in turn causes a hyperkinetic state or dystonia. |
2006-02-15 |
2023-08-12 |
Not clear |
| Nobutaka Hattori, Yutaka Machida, Kazuyuki Nod. [Pathogenesis of Parkinson's disease: a common pathway between alpha-synuclein and parkin and the mechanism of Lewy bodies formation]. Rinsho shinkeigaku = Clinical neurology. vol 45. issue 11. 2006-02-15. PMID:16447759. |
here we show that antisense knockdown of parkin causes apoptotic cell death of human dopaminergic sh-sy5y cells associated with caspase activation and accompanied by accumulation of oxidative dopamine (da) metabolites due to auto-oxidation of dopa and da. |
2006-02-15 |
2023-08-12 |
human |
| Miguel Angel Sánchez-González, Miguel Angel García-Cabezas, Beatriz Rico, Carmen Cavad. The primate thalamus is a key target for brain dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987937. |
we show that dopaminergic axons profusely target the human and macaque monkey thalamus using immunolabeling with three markers of the dopaminergic phenotype (tyrosine hydroxylase, dopamine, and the dopamine transporter). |
2006-02-14 |
2023-08-12 |
human |
| Miguel Angel Sánchez-González, Miguel Angel García-Cabezas, Beatriz Rico, Carmen Cavad. The primate thalamus is a key target for brain dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987937. |
the dopamine innervation is especially prominent in specific association, limbic, and motor thalamic nuclei, where the densities of dopaminergic axons are as high as or higher than in the cortical area with the densest dopamine innervation. |
2006-02-14 |
2023-08-12 |
human |
| Miguel Angel Sánchez-González, Miguel Angel García-Cabezas, Beatriz Rico, Carmen Cavad. The primate thalamus is a key target for brain dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987937. |
the origin of thalamic dopamine is multiple, and thus more complex, than in any other dopaminergic system defined to date: dopaminergic neurons of the hypothalamus, periaqueductal gray matter, ventral mesencephalon, and the lateral parabrachial nucleus project bilaterally to the monkey thalamus. |
2006-02-14 |
2023-08-12 |
human |
| Benjamin Floran, Brenda Gonzalez, Leonor Florán, David Erlij, Jorge Aceve. Interactions between adenosine A(2a) and dopamine D2 receptors in the control of [(3)H]GABA release in the globus pallidus of the rat. European journal of pharmacology. vol 520. issue 1-3. 2006-02-10. PMID:16137674. |
the stimulation of release caused by activation of a(2a) receptors was blocked when dopaminergic influences were eliminated with three independent methods: a) antagonism of d2 receptors with sulpiride; b) alkylation of these receptors with n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (eedq); c) depletion of dopamine with reserpine. |
2006-02-10 |
2023-08-12 |
rat |
| Benjamin Floran, Brenda Gonzalez, Leonor Florán, David Erlij, Jorge Aceve. Interactions between adenosine A(2a) and dopamine D2 receptors in the control of [(3)H]GABA release in the globus pallidus of the rat. European journal of pharmacology. vol 520. issue 1-3. 2006-02-10. PMID:16137674. |
the dopamine dependence and the large effects of activating a(2a) receptors on the potency of dopaminergic agonists clarify some of the therapeutic properties of a(2a) antagonists in parkinsonian animals and patients. |
2006-02-10 |
2023-08-12 |
rat |
| Nicolás Cuenca, María-Trinidad Herrero, Antonia Angulo, Emilio de Juan, Gema C Martínez-Navarrete, Salvador López, Carlos Barcia, José Martín-Niet. Morphological impairments in retinal neurons of the scotopic visual pathway in a monkey model of Parkinson's disease. The Journal of comparative neurology. vol 493. issue 2. 2006-02-09. PMID:16255027. |
in both parkinsonian patients and animal models, low levels of dopamine and loss of dopaminergic cells in the retina have been reported. |
2006-02-09 |
2023-08-12 |
monkey |
| Michael S Cowen, Cameron Adams, Tracey Kraehenbuehl, Valentina Vengeliene, Andrew J Lawrenc. The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system. Addiction biology. vol 10. issue 3. 2006-02-08. PMID:16109584. |
interestingly, acute acamprosate was also shown to cause increased dopamine transporter density and decreased dopamine d2-like receptor density within the nucleus accumbens but not in the caudate-putamen, suggesting a link between the decreased motivational salience of the ethanol cue and altered dopaminergic signalling within the nucleus accumbens. |
2006-02-08 |
2023-08-12 |
human |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |
| Tomoyoshi Kond. Levodopa therapy from the neuroprotection viewpoint. From a clinical outlook. Journal of neurology. vol 252 Suppl 4. 2006-02-03. PMID:16222435. |
dopamine (da) supplemented by levodopa acts as a neural transmitter and as a dopaminergic receptor-mediated trophic agent. |
2006-02-03 |
2023-08-12 |
Not clear |
| Norio Ogawa, Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Ko Miyosh. L-DOPA treatment from the viewpoint of neuroprotection. Possible mechanism of specific and progressive dopaminergic neuronal death in Parkinson's disease. Journal of neurology. vol 252 Suppl 4. 2006-02-03. PMID:16222434. |
with regard to the mechanism of selective dopaminergic neuronal death, experimental results of studies on the neurotoxicity of mptp and rotenone indicate that degeneration of dopamine neurons is closely related to mitochondrial dysfunction, inflammatory process and oxidative stress, particularly with regard to the generation of quinones as dopamine neuron-specific oxidative stress. |
2006-02-03 |
2023-08-12 |
Not clear |
| Norio Ogawa, Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Ko Miyosh. L-DOPA treatment from the viewpoint of neuroprotection. Possible mechanism of specific and progressive dopaminergic neuronal death in Parkinson's disease. Journal of neurology. vol 252 Suppl 4. 2006-02-03. PMID:16222434. |
thus, it is now clear that the presence of high levels of discompartmentalized free dopamine in dopaminergic neurons may explain the specific vulnerability of dopaminergic neurons through the generation of highly toxic quinones. |
2006-02-03 |
2023-08-12 |
Not clear |
| Ryuji Kaji, Satoshi Goto, Gen Tamiya, Satoshi Ando, Satoshi Makino, L V Le. Molecular dissection and anatomical basis of dystonia: X-linked recessive dystonia-parkinsonism (DYT3). The journal of medical investigation : JMI. vol 52 Suppl. 2006-02-03. PMID:16366515. |
because striosomal neurons inhibit nigrostriatal dopaminergic neurons via gabaergic innervation, the striosomal lesion could account for dopamine excess in the striatum, which in turn causes a hyperkinetic state or dystonia. |
2006-02-03 |
2023-08-12 |
Not clear |
| Michal J Besser, Yonatan Ganor, Mia Levit. Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFalpha or both. Journal of neuroimmunology. vol 169. issue 1-2. 2006-01-25. PMID:16150496. |
dopamine by itself activates either d2, d3 or d1/d5 dopaminergic receptors in normal human t-cells and triggers the selective secretion of either il-10, tnfalpha or both. |
2006-01-25 |
2023-08-12 |
human |
| Shun Yu, Kenji Uéda, Piu Cha. Alpha-synuclein and dopamine metabolism. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953825. |
formation of alpha-syn protofibrils triggered by factors such as gene mutations and environmental toxins can make the molecule lose its normal functions, leading to disrupted homeostasis of dopamine metabolism, increased cytoplasmic dopamine levels, and enhanced oxidative stress in dopaminergic neurons. |
2006-01-24 |
2023-08-12 |
Not clear |
| Weihong Feng, Huailing Wei, Geng Tao Li. Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953829. |
flz also remarkably protected dopaminergic pc-12 cells against dopamine and mpp+ induced injury and apoptosis in vitro. |
2006-01-24 |
2023-08-12 |
mouse |
| Manuchair Ebadi, Sushil K Sharma, Pedram Ghafourifar, Holly Brown-Borg, H El Refae. Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins. Methods in enzymology. vol 396. 2006-01-24. PMID:16291239. |
sin-1-induced oxidation of dopamine (da) to dihydroxyphenylacetaldehyde (dopal) was attenuated in metallothionein-transgenic fetal stem cells and in cells transfected with a mitochondrial genome, and was enhanced in aging mitochondrial genome knockout cells, in metallothionein double-knockout cells, and caspase-3 gene-overexpressing dopaminergic neurons. |
2006-01-24 |
2023-08-12 |
Not clear |
| Z D Zhou, B P Yap, A Y T Gung, S M Leong, S T Ang, T M Li. Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein. Experimental cell research. vol 312. issue 2. 2006-01-24. PMID:16297908. |
we conclude that wt alpha-syn is beneficial to dopaminergic neurons but its overexpression in the presence of endogenous dopamine makes it a potential threat to the cells. |
2006-01-24 |
2023-08-12 |
human |
| Monica Lisa Berlanga, Taylor Kathryn Simpson, Adriana Angelica Alcantar. Dopamine D5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release. The Journal of comparative neurology. vol 492. issue 1. 2006-01-23. PMID:16175554. |
dopamine d5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release. |
2006-01-23 |
2023-08-12 |
rat |