| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
dopamine (da) has been postulated to play a role in the loss of dopaminergic substantia nigra (sn) neurons in parkinson's disease because of its propensity to oxidize and form quinones and other reactive oxygen species that can alter cellular function. |
2006-03-13 |
2023-08-12 |
mouse |
| Michelle S Mazei-Robison, R Steven Couch, Richard C Shelton, Mark A Stein, Randy D Blakel. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16171832. |
the activity of the presynaptic dopamine (da) transporter (dat) is critical in mediating the magnitude and duration of dopaminergic signaling in the brain. |
2006-03-10 |
2023-08-12 |
human |
| Jacques Barik, Susan Wonnacot. Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal. Molecular pharmacology. vol 69. issue 2. 2006-03-10. PMID:16269536. |
striatal [(3)h]dopamine ([(3)h]da) release is regulated by presynaptic nachr on dopaminergic terminals and alpha7 nachr on neighboring glutamatergic afferents. |
2006-03-10 |
2023-08-12 |
rat |
| Mar Cuadrado-Tejedor, M Teresa Sesma, José Manuel Giménez-Amaya, Lourdes Orti. Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice. Neurobiology of disease. vol 20. issue 3. 2006-03-09. PMID:16005240. |
parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (da) levels in the striatum. |
2006-03-09 |
2023-08-12 |
mouse |
| Ana Saavedra, Graça Baltazar, Caetana M Carvalho, Emília P Duart. GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures. Free radical biology & medicine. vol 39. issue 12. 2006-03-07. PMID:16298686. |
in this work we investigated ho-1 expression in rat substantia nigra postnatal cell cultures under conditions mimicking dopamine toxicity and its modulation by glial cell line-derived neurotrophic factor (gdnf), a potent neuroprotective factor for dopaminergic neurons. |
2006-03-07 |
2023-08-12 |
rat |
| Syed Z Imam, Joseph Jankovic, Syed F Ali, John T Skinner, Wenjie Xie, Orla M Conneely, Wei-Dong L. Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 11. 2006-03-06. PMID:16126911. |
reduced expression of nurr1 increases the vulnerability of mesencephalic dopamine neurons to dopaminergic toxins. |
2006-03-06 |
2023-08-12 |
mouse |
| Björn Maul, Winfried Krause, Kristin Pankow, Matthias Becker, Florian Gembardt, Natalia Alenina, Thomas Walther, Michael Bader, Wolf-Eberhard Siem. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 11. 2006-03-06. PMID:16126915. |
furthermore, the dopamine concentration in the ventral tegmental area (vta) is markedly reduced in rats with low central ang ii, strengthening our hypothesis of a role of dopaminergic transmission in ang ii-controlled alcohol preference. |
2006-03-06 |
2023-08-12 |
mouse |
| Sung-Wan Kim, Il-Seon Shin, Jae-Min Kim, Su-Jin Yang, Hee-Young Shin, Jin-Sang Yoo. Bupropion may improve restless legs syndrome: a report of three cases. Clinical neuropharmacology. vol 28. issue 6. 2006-03-02. PMID:16340389. |
restless legs syndrome (rls) is a common disorder for which agents that enhance dopaminergic activity, including dopamine agonists and levodopa, are the treatment of choice. |
2006-03-02 |
2023-08-12 |
Not clear |
| Sung-Wan Kim, Il-Seon Shin, Jae-Min Kim, Su-Jin Yang, Hee-Young Shin, Jin-Sang Yoo. Bupropion may improve restless legs syndrome: a report of three cases. Clinical neuropharmacology. vol 28. issue 6. 2006-03-02. PMID:16340389. |
bupropion, an inhibitor of dopamine and noradrenalin reuptake, is an antidepressant that modulates dopaminergic systems. |
2006-03-02 |
2023-08-12 |
Not clear |
| S Horschitz, R Hummerich, T Lau, M Rietschel, P Schlos. A dopamine transporter mutation associated with bipolar affective disorder causes inhibition of transporter cell surface expression. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16103889. |
the dopamine transporter (dat) plays a crucial role in dopaminergic neurotransmission as it clears the extracellular space of dopamine (da) and thus controls the concentration of active neurotransmitter. |
2006-03-01 |
2023-08-12 |
human |
| Takashi Okamoto, Mark T Harnett, Hitoshi Morikaw. Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. Journal of neurophysiology. vol 95. issue 2. 2006-02-28. PMID:16148268. |
ethanol stimulates the firing activity of midbrain dopamine (da) neurons, leading to enhanced dopaminergic transmission in the mesolimbic system. |
2006-02-28 |
2023-08-12 |
mouse |
| Jill M Daniel, Jesse K Sulzer, Jerielle L Huls. Estrogen increases the sensitivity of ovariectomized rats to the disruptive effects produced by antagonism of D2 but not D1 dopamine receptors during performance of a response learning task. Hormones and behavior. vol 49. issue 1. 2006-02-27. PMID:15936760. |
in spite of the robust effects that estrogen exerts on nigrostriatal dopaminergic neurons, the role of dopamine in the estrogen-induced effects on procedural memory tasks remains unexplored. |
2006-02-27 |
2023-08-12 |
rat |
| Wenbo Zhou, Curt R Free. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. The Journal of biological chemistry. vol 280. issue 52. 2006-02-27. PMID:16227205. |
in the rat dopaminergic cell line, n27, and in primary dopamine neurons, overexpression of wild type dj-1 protected cells from death induced by hydrogen peroxide and 6-hydroxydopamine. |
2006-02-27 |
2023-08-12 |
human |
| A H Evans, A D Lawrence, J Potts, S Appel, A J Lee. Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease. Neurology. vol 65. issue 10. 2006-02-27. PMID:16301483. |
in the course of treatment, a small group of patients with parkinson disease (pd) develop a harmful pattern of compulsive dopaminergic drug use, called the dopamine dysregulation syndrome (dds). |
2006-02-27 |
2023-08-12 |
Not clear |
| Hans-Christian Pap. GABAergic neurons: gate masters of the amygdala, mastered by dopamine. Neuron. vol 48. issue 6. 2006-02-24. PMID:16364892. |
these gaba neurons mediate inhibition from cortical afferents to both the major input and output station of the amygdala, are inhibited during action of dopamine via d1 receptors, and are thus likely to represent important cellular players during dopaminergic disinhibition related to increased affective behavior. |
2006-02-24 |
2023-08-12 |
mouse |
| Anne Marowsky, Yuchio Yanagawa, Kunihiko Obata, Kaspar Emanuel Vog. A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function. Neuron. vol 48. issue 6. 2006-02-24. PMID:16364905. |
however, dopamine excites most amygdala interneurons, suggesting that this dopaminergic gate may be mediated by an unknown subpopulation of interneurons. |
2006-02-24 |
2023-08-12 |
mouse |
| Petra Kok, Ferdinand Roelfsema, Janneke G Langendonk, Caroline C de Wit, Marijke Frölich, Jacobus Burggraaf, A Edo Meinders, Hanno Pij. Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women. American journal of physiology. Endocrinology and metabolism. vol 290. issue 2. 2006-02-22. PMID:16144819. |
prl release is inhibited by dopamine 2 receptor (d2r) activation, and dietary restriction/weight loss are associated with increased dopaminergic signaling in animals. |
2006-02-22 |
2023-08-12 |
Not clear |
| Armando P Signore, Zhongfang Weng, Teresa Hastings, Amber D Van Laar, Qinghua Liang, Yong J Lee, Jun Che. Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death. Journal of neurochemistry. vol 96. issue 2. 2006-02-17. PMID:16336625. |
using both the dopaminergic cell line, mn9d, and primary dopamine neurons, we show that erythropoietin (1-3 u/ml) is neuroprotective against the dopaminergic neurotoxin, 6-hydroxydopamine. |
2006-02-17 |
2023-08-12 |
mouse |
| Michael X Cohen, Jennifer Young, Jong-Min Baek, Christopher Kessler, Charan Ranganat. Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain research. Cognitive brain research. vol 25. issue 3. 2006-02-15. PMID:16289773. |
psychologists have linked the personality trait extraversion both to differences in reward sensitivity and to dopamine functioning, but little is known about how these differences are reflected in the functioning of the brain's dopaminergic neural reward system. |
2006-02-15 |
2023-08-12 |
human |
| Léder Leal Xavier, Giordano Gubert Viola, Anete Curte Ferraz, Claudio Da Cunha, Janyana Marcela Doro Deonizio, Carlos Alexandre Netto, Matilde Achava. A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area. Brain research. Brain research protocols. vol 16. issue 1-3. 2006-02-15. PMID:16310404. |
tyrosine hydroxylase (th) is a rate-limiting enzyme for dopamine synthesis, therefore immunohistochemistry for th can be used as an important marker of dopaminergic cell loss in these regions. |
2006-02-15 |
2023-08-12 |
Not clear |